NO20021686D0 - Methods for Preparation of Target Molecules in a Transgenic Animal and Purification of the Target Molecule - Google Patents
Methods for Preparation of Target Molecules in a Transgenic Animal and Purification of the Target MoleculeInfo
- Publication number
- NO20021686D0 NO20021686D0 NO20021686A NO20021686A NO20021686D0 NO 20021686 D0 NO20021686 D0 NO 20021686D0 NO 20021686 A NO20021686 A NO 20021686A NO 20021686 A NO20021686 A NO 20021686A NO 20021686 D0 NO20021686 D0 NO 20021686D0
- Authority
- NO
- Norway
- Prior art keywords
- methods
- purification
- target molecules
- target
- preparation
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000000746 purification Methods 0.000 title abstract 2
- 230000009261 transgenic effect Effects 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 238000012250 transgenic expression Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Environmental Sciences (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Animal Husbandry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
The invention provides systems and methods for the production and purification of target molecules present in biological systems. The systems and methods according to the invention utilize transgenic expression of multivalent binding polypeptides, as affinity media, to purify such target molecules. The transgenic multivalent binding polypeptides bind both the target molecules, e.g., a bindable epitope of a target molecule, and a matrix.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15974899P | 1999-10-14 | 1999-10-14 | |
US20466200P | 2000-05-17 | 2000-05-17 | |
PCT/US2000/028589 WO2001026455A1 (en) | 1999-10-14 | 2000-10-16 | Methods of producing a target molecule in a transgenic animal and purification of the target molecule |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20021686D0 true NO20021686D0 (en) | 2002-04-10 |
NO20021686L NO20021686L (en) | 2002-06-12 |
Family
ID=26856252
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20021686A NO20021686L (en) | 1999-10-14 | 2002-04-10 | Methods for Preparation of Target Molecules in a Transgenic Animal and Purification of the Target Molecule |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP1220606A4 (en) |
JP (1) | JP2003511048A (en) |
KR (1) | KR100772465B1 (en) |
CN (1) | CN1322003C (en) |
AU (1) | AU781944B2 (en) |
BR (1) | BR0014860A (en) |
CA (1) | CA2382741A1 (en) |
HU (1) | HUP0203537A2 (en) |
IL (1) | IL149003A0 (en) |
MX (1) | MXPA02003702A (en) |
NO (1) | NO20021686L (en) |
NZ (1) | NZ518263A (en) |
RU (1) | RU2002112460A (en) |
WO (1) | WO2001026455A1 (en) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030049694A1 (en) * | 2001-09-10 | 2003-03-13 | Chung-Hsiun Wu | Production of fusion proteins and use for identifying binding molecules |
US6800462B2 (en) * | 2001-09-10 | 2004-10-05 | Abgenomics Corporation | Production of recombinant proteins in vivo and use for generating antibodies |
CN1283785C (en) * | 2002-05-20 | 2006-11-08 | 上海杰隆生物工程股份有限公司 | Method of producing human forcing erythrogenin using transgene animal mammary gland |
WO2007052096A2 (en) * | 2005-06-29 | 2007-05-10 | Cameron Malcolm Lang Clokie | Production of bone morphogenic proteins (bmps) in transgenic mammals |
RU2010100911A (en) * | 2007-06-13 | 2011-07-20 | Стэрнбэлт Байэутекнолэджай Нос Эмерикэ, Инк. (US) | PLASMIDA CONTAINING A NUCLEOTIDE SEQUENCE ENCODING A MODIFIED INSULIN PREVENTOR, AND THE METHOD OF ITS TRANSFECTION IN MAMMAL-LIVING CELLS IS MULTIER |
WO2010036976A2 (en) | 2008-09-25 | 2010-04-01 | Transgenrx, Inc. | Novel vectors for production of antibodies |
WO2010036978A2 (en) | 2008-09-25 | 2010-04-01 | Transgenrx, Inc. | Novel vectors for production of growth hormone |
US9150881B2 (en) | 2009-04-09 | 2015-10-06 | Proteovec Holding, L.L.C. | Production of proteins using transposon-based vectors |
CA2858825A1 (en) * | 2011-12-19 | 2013-06-27 | Lfb Usa, Inc. | Recombinant human alpha-1-antitrypsin for the treatment of inflammatory disorders |
CN105263319A (en) | 2013-02-13 | 2016-01-20 | 法国化学与生物科技实验室 | Proteins with modified glycosylation and methods of production thereof |
JP2016508515A (en) | 2013-02-13 | 2016-03-22 | ラボラトワール フランセ デュ フラクショヌマン エ デ ビオテクノロジーLaboratoire Francais du Fractionnement et des Biotechnologies | Highly galactosylated anti-TNF-α antibody and use thereof |
AU2014285971A1 (en) | 2013-07-05 | 2016-02-04 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Affinity chromatography matrix |
FR3025515B1 (en) | 2014-09-05 | 2016-09-09 | Lab Francais Du Fractionnement | PROCESS FOR PURIFYING MONOCLONAL ANTIBODY |
FR3034420A1 (en) | 2015-03-31 | 2016-10-07 | Lab Francais Du Fractionnement | ANTI-CD303 MONOCLONAL ANTIBODIES |
JP6712125B2 (en) * | 2015-09-04 | 2020-06-17 | 株式会社フジクラ | Connection structure of oxide superconducting wire and method for manufacturing the same |
FR3060394B1 (en) | 2016-12-16 | 2019-05-24 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | COMBINATION OF ANTI-CD303 AND ANTI-AMHRII ANTIBODIES |
FR3060395B1 (en) | 2016-12-16 | 2019-05-24 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | COMBINATION OF ANTI-CD303 AND ANTI-HER2 ANTIBODIES |
FR3076294B1 (en) | 2017-12-29 | 2022-01-28 | Lab Francais Du Fractionnement | METHOD FOR PURIFYING ANTIBODIES FROM RAW MILK |
CA3223956A1 (en) | 2021-12-20 | 2023-06-29 | Vetoquinol Sa | Anti-canine interleukine-31-receptor a (il-31ra) antibodies and the uses thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK580789D0 (en) * | 1989-11-20 | 1989-11-20 | Novo Nordisk As | PROCEDURE FOR PURIFICATION OF POLYPEPTIDES |
US5639940A (en) * | 1994-03-03 | 1997-06-17 | Pharmaceutical Proteins Ltd. | Production of fibrinogen in transgenic animals |
CN1114357A (en) * | 1994-07-01 | 1996-01-03 | 唐勇炜 | Process for producing recombinative polypeptide using transgene animal |
-
2000
- 2000-10-16 CA CA002382741A patent/CA2382741A1/en not_active Abandoned
- 2000-10-16 BR BR0014860-1A patent/BR0014860A/en not_active Application Discontinuation
- 2000-10-16 NZ NZ518263A patent/NZ518263A/en unknown
- 2000-10-16 JP JP2001529255A patent/JP2003511048A/en active Pending
- 2000-10-16 KR KR1020027004804A patent/KR100772465B1/en not_active IP Right Cessation
- 2000-10-16 EP EP00970945A patent/EP1220606A4/en not_active Withdrawn
- 2000-10-16 CN CNB008152802A patent/CN1322003C/en not_active Expired - Fee Related
- 2000-10-16 RU RU2002112460/13A patent/RU2002112460A/en unknown
- 2000-10-16 AU AU80254/00A patent/AU781944B2/en not_active Ceased
- 2000-10-16 IL IL14900300A patent/IL149003A0/en unknown
- 2000-10-16 HU HU0203537A patent/HUP0203537A2/en unknown
- 2000-10-16 MX MXPA02003702A patent/MXPA02003702A/en not_active Application Discontinuation
- 2000-10-16 WO PCT/US2000/028589 patent/WO2001026455A1/en active IP Right Grant
-
2002
- 2002-04-10 NO NO20021686A patent/NO20021686L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU8025400A (en) | 2001-04-23 |
EP1220606A1 (en) | 2002-07-10 |
CN1387399A (en) | 2002-12-25 |
KR100772465B1 (en) | 2007-11-02 |
AU781944B2 (en) | 2005-06-23 |
MXPA02003702A (en) | 2002-09-18 |
HUP0203537A2 (en) | 2003-02-28 |
CN1322003C (en) | 2007-06-20 |
WO2001026455A1 (en) | 2001-04-19 |
NZ518263A (en) | 2004-03-26 |
IL149003A0 (en) | 2002-11-10 |
CA2382741A1 (en) | 2001-04-19 |
KR20030022759A (en) | 2003-03-17 |
JP2003511048A (en) | 2003-03-25 |
BR0014860A (en) | 2003-07-08 |
EP1220606A4 (en) | 2004-04-14 |
RU2002112460A (en) | 2004-02-27 |
NO20021686L (en) | 2002-06-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |