NO20021475L - Vasopressin antagonist, formulation and method - Google Patents

Vasopressin antagonist, formulation and method

Info

Publication number
NO20021475L
NO20021475L NO20021475A NO20021475A NO20021475L NO 20021475 L NO20021475 L NO 20021475L NO 20021475 A NO20021475 A NO 20021475A NO 20021475 A NO20021475 A NO 20021475A NO 20021475 L NO20021475 L NO 20021475L
Authority
NO
Norway
Prior art keywords
component
formulation
pharmaceutically acceptable
vasopressin antagonist
formulations
Prior art date
Application number
NO20021475A
Other languages
Norwegian (no)
Other versions
NO20021475D0 (en
Inventor
Joseph Kyuwung Yoon
Richard William Saunders
Mahdi Bakir Fawzi
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of NO20021475D0 publication Critical patent/NO20021475D0/en
Publication of NO20021475L publication Critical patent/NO20021475L/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics

Abstract

Det er beskrevet nye formuleringer for N-[4-(5H-pyrrolo[2,1-c][1,4]benzo- diazepin-10(11H)ylkarbonyl)-3-klorfenyl]-5-fluor-2-metyl-benzamid eller et farmasøytisk akseptabelt salt derav, og fremgangsmåter for fremstilling av disse, idet formuleringene omfatter fra omtrent 1 % til omtrent 20 % aktiv ingrediens, fra omtrent 1 % til omtrent 18 % av en overflateaktiv middel- komponenet, fra omtrent 50 % til omtrent 80 % av en komponent av en eller flere polyetylenglykoler, fra omtrent 1 % til omtrent 20 % av en komponent av en eller flere sukrosefettsyrer og/eller polyvinylpyrrolidon, og eventuelt en eller flere farmasøytisk akseptable konserveringsmidler eller antioksydanter.New formulations for N- [4- (5H-pyrrolo [2,1-c] [1,4] benzodiazepin-10 (11H) ylcarbonyl) -3-chlorophenyl] -5-fluoro-2-methyl are described. benzamide or a pharmaceutically acceptable salt thereof, and processes for their preparation, the formulations comprising from about 1% to about 20% of active ingredient, from about 1% to about 18% of a surfactant component, from about 50% to about 80% of a component of one or more polyethylene glycols, from about 1% to about 20% of a component of one or more sucrose fatty acids and / or polyvinylpyrrolidone, and optionally one or more pharmaceutically acceptable preservatives or antioxidants.

NO20021475A 1999-09-27 2002-03-25 Vasopressin antagonist, formulation and method NO20021475L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40577299A 1999-09-27 1999-09-27
PCT/US2000/026369 WO2001022945A1 (en) 1999-09-27 2000-09-26 Vasopressin antagonist formulation and process

Publications (2)

Publication Number Publication Date
NO20021475D0 NO20021475D0 (en) 2002-03-25
NO20021475L true NO20021475L (en) 2002-04-16

Family

ID=23605168

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20021475A NO20021475L (en) 1999-09-27 2002-03-25 Vasopressin antagonist, formulation and method

Country Status (18)

Country Link
EP (1) EP1216033A1 (en)
JP (1) JP2003510269A (en)
KR (1) KR20020039354A (en)
CN (1) CN1391466A (en)
AR (1) AR025780A1 (en)
AU (1) AU7615000A (en)
BR (1) BR0014351A (en)
CA (1) CA2388474A1 (en)
CZ (1) CZ20021083A3 (en)
EA (1) EA200200414A1 (en)
HK (1) HK1045109A1 (en)
HU (1) HUP0202972A3 (en)
IL (1) IL148541A0 (en)
MX (1) MXPA02003189A (en)
NO (1) NO20021475L (en)
PL (1) PL354282A1 (en)
WO (1) WO2001022945A1 (en)
ZA (1) ZA200203312B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030105144A1 (en) * 2001-04-17 2003-06-05 Ping Gao Stabilized oral pharmaceutical composition
JP4632288B2 (en) * 2002-02-27 2011-02-16 塩野義製薬株式会社 Solid formulation with improved absorption of poorly water-soluble drugs
JP5873375B2 (en) * 2012-04-03 2016-03-01 中日本カプセル 株式会社 Soft capsule and method for producing soft capsule

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5516774A (en) * 1993-07-29 1996-05-14 American Cyanamid Company Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
US6287594B1 (en) * 1998-01-20 2001-09-11 Edward S. Wilson Oral liquid compositions

Also Published As

Publication number Publication date
CZ20021083A3 (en) 2002-06-12
CA2388474A1 (en) 2001-04-05
CN1391466A (en) 2003-01-15
HUP0202972A2 (en) 2002-12-28
EA200200414A1 (en) 2002-12-26
JP2003510269A (en) 2003-03-18
WO2001022945A1 (en) 2001-04-05
BR0014351A (en) 2002-06-11
PL354282A1 (en) 2003-12-29
MXPA02003189A (en) 2002-09-30
NO20021475D0 (en) 2002-03-25
ZA200203312B (en) 2003-12-31
IL148541A0 (en) 2002-09-12
EP1216033A1 (en) 2002-06-26
AU7615000A (en) 2001-04-30
AR025780A1 (en) 2002-12-11
KR20020039354A (en) 2002-05-25
HUP0202972A3 (en) 2003-07-28
HK1045109A1 (en) 2002-11-15

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Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application