NO20011929L - Bicyclic nitrogen heterocycles - Google Patents

Bicyclic nitrogen heterocycles

Info

Publication number
NO20011929L
NO20011929L NO20011929A NO20011929A NO20011929L NO 20011929 L NO20011929 L NO 20011929L NO 20011929 A NO20011929 A NO 20011929A NO 20011929 A NO20011929 A NO 20011929A NO 20011929 L NO20011929 L NO 20011929L
Authority
NO
Norway
Prior art keywords
lower alkyl
heteroaryl
aryl
cycloalkyl
alkyl
Prior art date
Application number
NO20011929A
Other languages
Norwegian (no)
Other versions
NO318802B1 (en
NO20011929D0 (en
Inventor
William Harris
Christopher Huw Hill
Ian Edward David Smith
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26314565&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20011929(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9823277.0A external-priority patent/GB9823277D0/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO20011929D0 publication Critical patent/NO20011929D0/en
Publication of NO20011929L publication Critical patent/NO20011929L/en
Publication of NO318802B1 publication Critical patent/NO318802B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

Amino-substituted dihydropyrimido[4,5-d]pyrimidinones of the formula in which R1 represents hydrogen, lower alkyl, aryl, aryl-lower alkyl, heteroaryl, heteroaryl-lower alkyl, lower cycloalkyl or lower cycloalkyl-lower alkyl, R2 represents lower alkyl, aryl, aryl-lower alkyl, heteroaryl, heteroaryl-lower alkyl, lower cycloalkyl or lower cycloalkyl-lower alkyl, and R3 represents hydrogen, lower alkyl, aryl, aryl-lower alkyl, heteroaryl, heteroaryl-lower alkyl, lower cycloalkyl, lower cycloalkenyl or lower cycloalkyl-lower alkyl, and pharmaceutically acceptable salts thereof are protein kinase inhibitors. They can be used in the treatment or prophylaxis of inflammatory, immunological, oncological, bronchopulmonary, dermatological and cardiovascular disorders, in the treatment of asthma, central nervous system disorders or diabetic complications or for the prevention of graft rejection following transplant surgery.
NO20011929A 1998-10-23 2001-04-19 Bicyclic nitrogen heterocycles NO318802B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9823277.0A GB9823277D0 (en) 1998-10-23 1998-10-23 Bicycle nitrogen heterocycles
GBGB9920044.6A GB9920044D0 (en) 1998-10-23 1999-08-24 Biciclic nitrogen heterocycles
PCT/EP1999/007675 WO2000024744A1 (en) 1998-10-23 1999-10-13 Bicyclic nitrogen heterocycles

Publications (3)

Publication Number Publication Date
NO20011929D0 NO20011929D0 (en) 2001-04-19
NO20011929L true NO20011929L (en) 2001-04-19
NO318802B1 NO318802B1 (en) 2005-05-09

Family

ID=26314565

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20011929A NO318802B1 (en) 1998-10-23 2001-04-19 Bicyclic nitrogen heterocycles

Country Status (25)

Country Link
US (1) US6150373A (en)
EP (1) EP1123295B1 (en)
JP (1) JP3593035B2 (en)
CN (1) CN1150195C (en)
AT (1) ATE277931T1 (en)
AU (1) AU769989B2 (en)
BR (1) BR9914677A (en)
CA (1) CA2347474C (en)
CZ (1) CZ20011394A3 (en)
DE (1) DE69920732T2 (en)
ES (1) ES2228123T3 (en)
HK (1) HK1041483B (en)
HR (1) HRP20010274A2 (en)
HU (1) HUP0104199A3 (en)
ID (1) ID28276A (en)
MA (1) MA27678A1 (en)
MY (1) MY126478A (en)
NO (1) NO318802B1 (en)
NZ (1) NZ510760A (en)
PL (1) PL347432A1 (en)
PT (1) PT1123295E (en)
RU (1) RU2256662C2 (en)
TR (1) TR200101102T2 (en)
TW (1) TWI227235B (en)
WO (1) WO2000024744A1 (en)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW517055B (en) * 1997-07-02 2003-01-11 Smithkline Beecham Corp Novel substituted imidazole compounds
WO1999032121A1 (en) 1997-12-19 1999-07-01 Smithkline Beecham Corporation Compounds of heteroaryl substituted imidazole, their pharmaceutical compositions and uses
US20040044012A1 (en) * 1998-05-26 2004-03-04 Dobrusin Ellen Myra Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation
US6858617B2 (en) 1998-05-26 2005-02-22 Smithkline Beecham Corporation Substituted imidazole compounds
ID27589A (en) 1998-05-26 2001-04-12 Warner Lambert Comapny BICYCLIC PYYRIMINE AND DIHYDROPIRYMIDINE BICYCLIC 3,4 AS A RESULTS OF MOBILE PROLIFERATION
EP1112070B1 (en) 1998-08-20 2004-05-12 Smithkline Beecham Corporation Novel substituted triazole compounds
AU1909200A (en) * 1998-11-04 2000-05-22 Smithkline Beecham Corporation Pyridin-4-yl or pyrimidin-4-yl substituted pyrazines
ATE353329T1 (en) 1999-10-21 2007-02-15 Hoffmann La Roche HETEROALKYLAMINO-SUBSTITUTED BICYCLIC NITROGEN HETEROCYCLES
CN1156477C (en) * 1999-10-21 2004-07-07 霍夫曼-拉罗奇有限公司 Alkylamino substituted bicyclic nitrogen heterocycles as inhibitors of P38 protein kinase
AU1781601A (en) 1999-11-23 2001-06-04 Smithkline Beecham Corporation 3,4-dihydro-(1h)quinazolin-2-one compounds as csbp/p38 kinase inhibitors
ATE305787T1 (en) 1999-11-23 2005-10-15 Smithkline Beecham Corp 3,4-DIHYDRO-(1H)CHINAZOLINE-2-ONE COMPOUNDS AS CSBP/P39 KINASE INHIBITORS
DE60020595T2 (en) 1999-11-23 2006-03-16 Smithkline Beecham Corp. 3,4-DIHYDRO- (1H) CHINAZOLIN-2-ON COMPOUNDS AS CSBP / P38 KINASE INHIBITORS
US6759410B1 (en) * 1999-11-23 2004-07-06 Smithline Beecham Corporation 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors
US7101869B2 (en) 1999-11-30 2006-09-05 Pfizer Inc. 2,4-diaminopyrimidine compounds useful as immunosuppressants
MY141144A (en) * 2000-03-02 2010-03-15 Smithkline Beecham Corp 1, 5-disubstituted-3,4-dihydro-1h-pyrimido 4,5-dipyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
US7235551B2 (en) * 2000-03-02 2007-06-26 Smithkline Beecham Corporation 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
CZ20031125A3 (en) 2000-10-23 2003-10-15 Smithkline Beecham Corporation Novel compounds
ES2291455T3 (en) 2001-03-12 2008-03-01 Avanir Pharmaceuticals BENCIMIDAZOL COMPOUNDS TO MODULATE IGE AND INHIBIT THE CELL PROLIFERATION.
US7119111B2 (en) 2002-05-29 2006-10-10 Amgen, Inc. 2-oxo-1,3,4-trihydroquinazolinyl derivatives and methods of use
US7196090B2 (en) 2002-07-25 2007-03-27 Warner-Lambert Company Kinase inhibitors
DE10235312A1 (en) * 2002-08-01 2004-02-12 Basf Ag Process for the preparation of aminoalkoxybenzylamines and aminoalkoxybenzonitriles as intermediates
US7084270B2 (en) * 2002-08-14 2006-08-01 Hoffman-La Roche Inc. Pyrimido compounds having antiproliferative activity
AU2003270426A1 (en) 2002-09-12 2004-04-30 Avanir Pharmaceuticals PHENYL-INDOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION
US7112676B2 (en) * 2002-11-04 2006-09-26 Hoffmann-La Roche Inc. Pyrimido compounds having antiproliferative activity
TW200413381A (en) 2002-11-04 2004-08-01 Hoffmann La Roche Novel amino-substituted dihydropyrimido [4,5-d]pyrimidinone derivatives, their manufacture and use as pharmaceutical agents
US7098332B2 (en) 2002-12-20 2006-08-29 Hoffmann-La Roche Inc. 5,8-Dihydro-6H-pyrido[2,3-d]pyrimidin-7-ones
EP1615928A1 (en) 2003-04-10 2006-01-18 F.Hoffmann-La Roche Ag Pyrimido compounds
NZ541188A (en) * 2003-04-23 2008-01-31 Japan Tobacco Inc calcium receptor antagonists
MXPA06001098A (en) 2003-07-29 2006-04-24 Irm Llc Compounds and compositions as protein kinase inhibitors.
EP1768662A2 (en) 2004-06-24 2007-04-04 Novartis Vaccines and Diagnostics, Inc. Small molecule immunopotentiators and assays for their detection
RU2007111758A (en) 2004-08-31 2008-10-10 Ф.Хоффманн-Ля Рош Аг (Ch) AMINO DERIVATIVES 7- AMINO-3-Phenyldihydropyrimido [4,5-D] PYRIMIDINONES, THEIR PRODUCTION AND APPLICATION AS PROTEINKINASE INHIBITORS
CA2576818A1 (en) 2004-08-31 2006-03-09 F. Hoffmann-La Roche Ag Amide derivatives of 3-phenyl dihydropyrimido[4,5-d]pyrimidinones, their manufacture and use as pharmaceutical agents
PE20100737A1 (en) 2005-03-25 2010-11-27 Glaxo Group Ltd NEW COMPOUNDS
CN101374840B (en) 2006-01-31 2011-09-28 霍夫曼-拉罗奇有限公司 7h-pyrido[3,4-d]pyrimidin-8-ones, their manufacture and use as protein kinase inhibitors
US7897762B2 (en) * 2006-09-14 2011-03-01 Deciphera Pharmaceuticals, Llc Kinase inhibitors useful for the treatment of proliferative diseases
US8754114B2 (en) 2010-12-22 2014-06-17 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
CN102816162B (en) * 2011-06-10 2016-04-27 中国科学院广州生物医药与健康研究院 Pyrimido-pyrimidine ketone compounds and medicinal compositions thereof and application
GB201204384D0 (en) 2012-03-13 2012-04-25 Univ Dundee Anti-flammatory agents
ME03300B (en) 2012-06-13 2019-07-20 Incyte Holdings Corp Substituted tricyclic compounds as fgfr inhibitors
WO2014026125A1 (en) 2012-08-10 2014-02-13 Incyte Corporation Pyrazine derivatives as fgfr inhibitors
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
EP3943087A1 (en) 2013-03-15 2022-01-26 Celgene CAR LLC Heteroaryl compounds and uses thereof
CN111793068A (en) 2013-03-15 2020-10-20 西建卡尔有限责任公司 Heteroaryl compounds and uses thereof
US9321786B2 (en) 2013-03-15 2016-04-26 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
DK2986610T5 (en) 2013-04-19 2018-12-10 Incyte Holdings Corp BICYCLIC HETEROCYCLES AS FGFR INHIBITORS
WO2016014542A1 (en) 2014-07-21 2016-01-28 Dana-Farber Cancer Institute, Inc. Imidazolyl kinase inhibitors and uses thereof
EP3172213B1 (en) 2014-07-21 2021-09-22 Dana-Farber Cancer Institute, Inc. Macrocyclic kinase inhibitors and uses thereof
AU2015300782B2 (en) 2014-08-08 2020-04-16 Dana-Farber Cancer Institute, Inc. Uses of salt-inducible kinase (SIK) inhibitors
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
EA038045B1 (en) 2015-02-20 2021-06-28 Инсайт Корпорейшн Bicyclic heterocycles as fgfr inhibitors
MA41551A (en) 2015-02-20 2017-12-26 Incyte Corp BICYCLIC HETEROCYCLES USED AS FGFR4 INHIBITORS
WO2016134294A1 (en) 2015-02-20 2016-08-25 Incyte Corporation Bicyclic heterocycles as fgfr4 inhibitors
WO2017031116A1 (en) * 2015-08-18 2017-02-23 The Arizona Board Of Regents On Behalf Of The University Of Arizona Small molecule inhibitors of ku70/80 and uses thereof
KR20190075043A (en) * 2016-07-05 2019-06-28 더 브로드 인스티튜트, 인코퍼레이티드 Bicyclic urea kinase inhibitors and uses thereof
WO2018053373A1 (en) 2016-09-16 2018-03-22 The General Hospital Corporation Uses of satl-inducible kinase (sik) inhibitors for treating osteoporosis
RU2019129727A (en) * 2017-02-28 2021-03-30 Зэ Дженерал Хоспитал Корпорэйшн APPLICATIONS OF PYRIMIDOPYRIMIDINONES AS SIK INHIBITORS
AR111960A1 (en) 2017-05-26 2019-09-04 Incyte Corp CRYSTALLINE FORMS OF A FGFR INHIBITOR AND PROCESSES FOR ITS PREPARATION
CA3087886A1 (en) 2018-01-19 2019-07-25 Idorsia Pharmaceuticals Ltd C5a receptor modulators
JP7281470B2 (en) * 2018-01-19 2023-05-25 イドーシア ファーマシューティカルズ リミテッド C5A receptor modulator
EA202092649A1 (en) 2018-05-04 2021-06-21 Инсайт Корпорейшн FGFR INHIBITOR SALTS
US11466004B2 (en) 2018-05-04 2022-10-11 Incyte Corporation Solid forms of an FGFR inhibitor and processes for preparing the same
CA3124678A1 (en) * 2018-12-27 2020-07-02 Zenon D. Konteatis Aza-heterobicyclic inhibitors of mat2a and methods of use for treating cancer
EP3902801A4 (en) * 2018-12-28 2022-12-14 SPV Therapeutics Inc. Cyclin-dependent kinase inhibitors
US11628162B2 (en) 2019-03-08 2023-04-18 Incyte Corporation Methods of treating cancer with an FGFR inhibitor
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
US20220274991A1 (en) * 2019-07-16 2022-09-01 Arizona Board Of Regents On Behalf Of The University Of Arizona Small molecule inhibitors of ku70/80 and uses thereof
IL291901A (en) 2019-10-14 2022-06-01 Incyte Corp Bicyclic heterocycles as fgfr inhibitors
WO2021076728A1 (en) 2019-10-16 2021-04-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
GB201915828D0 (en) * 2019-10-31 2019-12-18 Cancer Research Tech Ltd Compounds, compositions and therapeutic uses thereof
KR20220131900A (en) 2019-12-04 2022-09-29 인사이트 코포레이션 Derivatives of FGFR inhibitors
WO2021113479A1 (en) 2019-12-04 2021-06-10 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
CA3177164A1 (en) * 2020-04-28 2021-11-04 Peter Sennhenn Bicyclic kinase inhibitors and uses thereof
AR126102A1 (en) 2021-06-09 2023-09-13 Incyte Corp TRICYCLIC HETEROCYCLES AS FGFR INHIBITORS

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5679683A (en) * 1994-01-25 1997-10-21 Warner-Lambert Company Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family
IL117923A (en) * 1995-05-03 2000-06-01 Warner Lambert Co Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds
GB9619284D0 (en) * 1996-09-16 1996-10-30 Celltech Therapeutics Ltd Chemical compounds
US6057329A (en) * 1996-12-23 2000-05-02 Celltech Therapeutics Limited Fused polycyclic 2-aminopyrimidine derivatives
ID27589A (en) * 1998-05-26 2001-04-12 Warner Lambert Comapny BICYCLIC PYYRIMINE AND DIHYDROPIRYMIDINE BICYCLIC 3,4 AS A RESULTS OF MOBILE PROLIFERATION

Also Published As

Publication number Publication date
CA2347474A1 (en) 2000-05-04
AU769989B2 (en) 2004-02-12
HRP20010274A2 (en) 2002-06-30
CA2347474C (en) 2008-08-26
TR200101102T2 (en) 2002-01-21
MA27678A1 (en) 2006-01-02
PL347432A1 (en) 2002-04-08
NO318802B1 (en) 2005-05-09
NO20011929D0 (en) 2001-04-19
CN1324360A (en) 2001-11-28
MY126478A (en) 2006-10-31
ID28276A (en) 2001-05-10
EP1123295A1 (en) 2001-08-16
ATE277931T1 (en) 2004-10-15
DE69920732T2 (en) 2006-02-23
WO2000024744A1 (en) 2000-05-04
CN1150195C (en) 2004-05-19
PT1123295E (en) 2005-01-31
NZ510760A (en) 2003-08-29
JP3593035B2 (en) 2004-11-24
DE69920732D1 (en) 2004-11-04
TWI227235B (en) 2005-02-01
CZ20011394A3 (en) 2001-12-12
HK1041483B (en) 2004-12-24
US6150373A (en) 2000-11-21
RU2256662C2 (en) 2005-07-20
HUP0104199A2 (en) 2002-04-29
AU1036300A (en) 2000-05-15
ES2228123T3 (en) 2005-04-01
JP2002528455A (en) 2002-09-03
HUP0104199A3 (en) 2002-12-28
HK1041483A1 (en) 2002-07-12
EP1123295B1 (en) 2004-09-29
BR9914677A (en) 2001-07-17

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