NO20010203L - Diacylhydrazinderivater som integrininhibitorer - Google Patents

Diacylhydrazinderivater som integrininhibitorer

Info

Publication number
NO20010203L
NO20010203L NO20010203A NO20010203A NO20010203L NO 20010203 L NO20010203 L NO 20010203L NO 20010203 A NO20010203 A NO 20010203A NO 20010203 A NO20010203 A NO 20010203A NO 20010203 L NO20010203 L NO 20010203L
Authority
NO
Norway
Prior art keywords
integrin inhibitors
diacylhydrazine derivatives
diacylhydrazine
derivatives
arteriosclerosis
Prior art date
Application number
NO20010203A
Other languages
English (en)
Other versions
NO20010203D0 (no
Inventor
Guenter Hoelzemann
Simon Goodman
Horst Kessler
Christoph Gibson
Joerg Simon Schmitt
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of NO20010203L publication Critical patent/NO20010203L/no
Publication of NO20010203D0 publication Critical patent/NO20010203D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
    • C07D271/113—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/06—Compounds containing any of the groups, e.g. semicarbazides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical

Abstract

Forbindelser med formel (I) '' ? f yyvv* hvor X, Y, Z, R1 og R2 har de i krav l angitte betydninger, samt deres salter og solvater, kan anvendes som integrin- inhibitorer, særlig til profylakse og behandling av sykdommer i blodomløpet, ved trombose, hjerteinfarkt, koronare hjertesykdommer, arteriosklerose, ved patologiske hendelser som underholdes eller propageres gjennom angiogenese, og innen tumorterapien.
NO20010203A 1998-07-15 2001-01-12 Diacylhydrazinderivater som integrininhibitorer NO20010203D0 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19831710A DE19831710A1 (de) 1998-07-15 1998-07-15 Diacylhydrazinderivate
PCT/EP1999/004673 WO2000003973A1 (de) 1998-07-15 1999-07-06 Diacylhydrazinderivate als integrin-inhibitoren

Publications (2)

Publication Number Publication Date
NO20010203L true NO20010203L (no) 2001-01-12
NO20010203D0 NO20010203D0 (no) 2001-01-12

Family

ID=7874107

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20010203A NO20010203D0 (no) 1998-07-15 2001-01-12 Diacylhydrazinderivater som integrininhibitorer

Country Status (22)

Country Link
US (1) US6326403B1 (no)
EP (1) EP1097127B1 (no)
JP (1) JP2002520382A (no)
KR (1) KR20010079520A (no)
CN (1) CN1309633A (no)
AR (1) AR019777A1 (no)
AT (1) ATE234276T1 (no)
AU (1) AU753333B2 (no)
BR (1) BR9912072A (no)
CA (1) CA2337305A1 (no)
DE (2) DE19831710A1 (no)
DK (1) DK1097127T3 (no)
ES (1) ES2194486T3 (no)
HU (1) HUP0102602A3 (no)
ID (1) ID27168A (no)
NO (1) NO20010203D0 (no)
PL (1) PL345398A1 (no)
PT (1) PT1097127E (no)
SK (1) SK412001A3 (no)
TW (1) TW448145B (no)
WO (1) WO2000003973A1 (no)
ZA (1) ZA200101267B (no)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2557768T3 (es) 1999-06-01 2016-01-28 Biogen Ma Inc. Un anticuerpo monoclonal bloqueante frente a VLA-1 y su uso para el tratamiento de trastornos inflamatorios
US20020002152A1 (en) 2000-04-14 2002-01-03 Craig Richard A. Hydrazide and alkoxyamide angiogenesis inhibitors
AR028537A1 (es) * 2000-04-14 2003-05-14 Abbott Lab Hidrazidas y alcoxiamidas inhibidoras de la angiogénesis
DE10040103A1 (de) 2000-08-17 2002-02-28 Merck Patent Gmbh Peptid- und Peptidmimetika-Derivate mit Integrin-Inhibitor-Eigenschaften II
DE10040105A1 (de) 2000-08-17 2002-02-28 Merck Patent Gmbh Peptid- und Peptidmimetika-Derivate mit Integrin-Inhibitor-Eigenschaften
DZ3415A1 (fr) * 2000-08-31 2002-03-07 Chiron Corp Guanidinobenzamides comme mc4-r agonistes.
EP1385823B1 (en) 2001-04-09 2006-12-13 Chiron Corporation Guanidino compounds as melanocortin-4 receptor (mc4-r) agonists
IL158376A0 (en) 2001-04-13 2004-05-12 Biogen Inc Antibodies to vla-1
JP2005531583A (ja) 2002-05-23 2005-10-20 カイロン コーポレイション 置換キナゾリノン化合物
US7226577B2 (en) 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
US7304161B2 (en) 2003-02-10 2007-12-04 Intrexon Corporation Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex
US7456315B2 (en) 2003-02-28 2008-11-25 Intrexon Corporation Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
JP2007501861A (ja) 2003-05-23 2007-02-01 カイロン コーポレイション Ｍｃ４−ｒアゴニストとしてのグアニジノ置換キナゾリノン化合物
DE10325049A1 (de) * 2003-06-02 2004-12-23 Merck Patent Gmbh Peptid- und Peptidmimetika-Derivate mit Integrin-Inhibitor-Eigenschaften III
MXPA06005736A (es) 2003-11-19 2006-12-14 Chiron Corp Compuestos de quinazolinona con bioacumulacion reducida.
US7528106B2 (en) 2004-06-04 2009-05-05 The Scripps Research Institute Compositions and methods for treatment of neovascular diseases
JP4745175B2 (ja) * 2005-12-28 2011-08-10 本田技研工業株式会社 自動二輪車
PL2034830T3 (pl) 2006-05-25 2015-04-30 Biogen Ma Inc Przeciwciało anty-VLA-1 do leczenia udaru
CA2689137C (en) 2007-05-29 2017-05-02 Intrexon Corporation Chiral diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US10316095B2 (en) 2012-02-16 2019-06-11 Santarus, Inc. Antibody formulations
NZ712167A (en) 2013-03-15 2018-05-25 Intrexon Corp Boron-containing diacylhydrazines
KR20160147007A (ko) 2014-05-30 2016-12-21 화이자 인코포레이티드 선택적인 안드로겐 수용체 조절제로서의 카보니트릴 유도체
CN104027805B (zh) * 2014-06-18 2017-02-15 北京大学 抑制整合素α5的物质在制备预防内皮细胞激活和/或动脉粥样硬化的产品中的新用途
JP6567657B2 (ja) 2014-09-17 2019-08-28 イントレキソン コーポレーション ホウ素含有ジアシルヒドラジン化合物
TN2020000059A1 (en) 2017-11-01 2022-01-06 Arrowhead Pharmaceuticals Inc Integrin ligands and uses thereof
WO2023275715A1 (en) 2021-06-30 2023-01-05 Pfizer Inc. Metabolites of selective androgen receptor modulators

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5051405A (en) * 1989-10-10 1991-09-24 Rhone-Poulenc Rorer Pharmaceuticals Inc. Anti-thrombotic peptides and pseudopeptides
WO1992013552A1 (en) * 1991-02-05 1992-08-20 Smithkline Beecham Corporation Anti-aggregatory peptides containing an aromatic ester or amide
US5530028A (en) * 1992-11-23 1996-06-25 Rohm And Haas Company Insecticidal N'-substituted-N,N'-diacylhydrazines
US5726192A (en) * 1992-12-29 1998-03-10 Smithkline Beecham Corporation Platelet aggregation inhibiting compounds
AU701776B2 (en) 1994-05-27 1999-02-04 Merck & Co., Inc. Compounds for inhibiting osteoclast-mediated bone resorption
US5482962A (en) * 1994-07-22 1996-01-09 Rohm And Haas Company Insecticidal N,N'-disubstituted-N-N'-diacylhydrazines
EP0880511A4 (en) * 1996-01-16 1999-06-16 Merck & Co Inc INTEGRIN RECEPTOR ANTAGONISTS

Also Published As

Publication number Publication date
DE59904547D1 (de) 2003-04-17
TW448145B (en) 2001-08-01
DK1097127T3 (da) 2003-06-10
KR20010079520A (ko) 2001-08-22
HUP0102602A2 (hu) 2002-01-28
ATE234276T1 (de) 2003-03-15
US6326403B1 (en) 2001-12-04
PL345398A1 (en) 2001-12-17
WO2000003973A1 (de) 2000-01-27
AU753333B2 (en) 2002-10-17
ID27168A (id) 2001-03-08
AR019777A1 (es) 2002-03-13
JP2002520382A (ja) 2002-07-09
NO20010203D0 (no) 2001-01-12
ZA200101267B (en) 2002-10-04
CA2337305A1 (en) 2000-01-27
DE19831710A1 (de) 2000-01-20
SK412001A3 (en) 2001-08-06
CN1309633A (zh) 2001-08-22
BR9912072A (pt) 2001-09-25
ES2194486T3 (es) 2003-11-16
AU5031399A (en) 2000-02-07
EP1097127B1 (de) 2003-03-12
HUP0102602A3 (en) 2002-02-28
EP1097127A1 (de) 2001-05-09
PT1097127E (pt) 2003-07-31

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