NO20001510L - Specific immunophilin ligands such as anti-asthmatic, anti-allergic, anti-rheumatic, immunosuppressive, antipsychotic and neuroprotective agents - Google Patents

Specific immunophilin ligands such as anti-asthmatic, anti-allergic, anti-rheumatic, immunosuppressive, antipsychotic and neuroprotective agents

Info

Publication number
NO20001510L
NO20001510L NO20001510A NO20001510A NO20001510L NO 20001510 L NO20001510 L NO 20001510L NO 20001510 A NO20001510 A NO 20001510A NO 20001510 A NO20001510 A NO 20001510A NO 20001510 L NO20001510 L NO 20001510L
Authority
NO
Norway
Prior art keywords
asthmatic
rheumatic
immunosuppressive
allergic
antipsychotic
Prior art date
Application number
NO20001510A
Other languages
Norwegian (no)
Other versions
NO20001510D0 (en
Inventor
Dietmar Reichert
Bernhard Kutscher
Stefan Szelenyi
Hildegard Poppe
Gerhard Quinkert
Kay Brune
Holger Bang
Holger Deppe
Original Assignee
Asta Medica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica Ag filed Critical Asta Medica Ag
Publication of NO20001510D0 publication Critical patent/NO20001510D0/en
Publication of NO20001510L publication Critical patent/NO20001510L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

De nye spesifikke immunofilin-ligander med den generelle Formel (I) har anti-astmatisk, anti-allergisk, anti-reumatisk, anti-betennelses-, immunsuppressiv, anti-psoriatisk og neuroprotektiv virkning og egner seg for fremstilling av legemidler.The novel specific immunophilin ligands of general Formula (I) have anti-asthmatic, anti-allergic, anti-rheumatic, anti-inflammatory, immunosuppressive, anti-psoriatic and neuroprotective effects and are suitable for drug preparation.

NO20001510A 1997-09-25 2000-03-23 Specific immunophilin ligands such as anti-asthmatic, anti-allergic, anti-rheumatic, immunosuppressive, antipsychotic and neuroprotective agents NO20001510L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19742263A DE19742263A1 (en) 1997-09-25 1997-09-25 New specific immunophilin ligands as anti-asthmatic, anti-allergic, anti-rheumatic, immunosuppressive, anti-psoriatic, neuroprotective
PCT/EP1998/005300 WO1999015501A1 (en) 1997-09-25 1998-08-20 Specific immunophilin ligands useful as anti-asthmatic, anti-allergic, anti-rheumatic, immunosuppressive, antipsoriatic and neuroprotective agents

Publications (2)

Publication Number Publication Date
NO20001510D0 NO20001510D0 (en) 2000-03-23
NO20001510L true NO20001510L (en) 2000-05-22

Family

ID=7843549

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20001510A NO20001510L (en) 1997-09-25 2000-03-23 Specific immunophilin ligands such as anti-asthmatic, anti-allergic, anti-rheumatic, immunosuppressive, antipsychotic and neuroprotective agents

Country Status (12)

Country Link
EP (1) EP1017673A1 (en)
JP (1) JP2001517653A (en)
KR (1) KR20010040253A (en)
AU (1) AU9345098A (en)
BR (1) BR9813226A (en)
CA (1) CA2304451A1 (en)
DE (1) DE19742263A1 (en)
HU (1) HUP0004294A3 (en)
IL (1) IL133246A0 (en)
NO (1) NO20001510L (en)
WO (1) WO1999015501A1 (en)
ZA (1) ZA987819B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9815882A (en) 1998-06-03 2002-09-17 Gpi Nil Holding Inc Sulfonamides linked by n of non-heterocyclic carboxylic acids or isosters of carboxylic acids
US6300341B1 (en) * 1998-09-30 2001-10-09 The Procter & Gamble Co. 2-substituted heterocyclic sulfonamides
US6417189B1 (en) 1999-11-12 2002-07-09 Gpi Nil Holdings, Inc. AZA compounds, pharmaceutical compositions and methods of use
US7253169B2 (en) 1999-11-12 2007-08-07 Gliamed, Inc. Aza compounds, pharmaceutical compositions and methods of use
DE60026568D1 (en) 1999-12-21 2006-05-04 Mgi Gp Inc HYDANTOINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHOD FOR THEIR USE
AU2005254783A1 (en) * 2004-06-18 2005-12-29 Biolipox Ab Indoles useful in the treatment of inflammation
ES2315877T3 (en) 2004-06-18 2009-04-01 Biolipox Ab USEFUL INDOLES IN THE TREATMENT OF INFLAMMATIONS.
CA2571710A1 (en) 2004-06-24 2006-11-02 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
WO2006077366A1 (en) 2005-01-19 2006-07-27 Biolipox Ab Indoles useful in the treatment of inflammation
US10266490B2 (en) * 2012-03-16 2019-04-23 Georgetown University Radioprotector compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5192773A (en) * 1990-07-02 1993-03-09 Vertex Pharmaceuticals, Inc. Immunosuppressive compounds
MX9202466A (en) * 1991-05-24 1994-06-30 Vertex Pharma NOVELTY IMMUNOSUPPRESSIVE COMPOUNDS.
US5385918A (en) * 1993-02-09 1995-01-31 Miles Inc. Aminomethylene-peptides as immunosuppressants
US5859031A (en) * 1995-06-07 1999-01-12 Gpi Nil Holdings, Inc. Small molecule inhibitors of rotamase enzyme activity
US5614547A (en) * 1995-06-07 1997-03-25 Guilford Pharmaceuticals Inc. Small molecule inhibitors of rotamase enzyme
US5795890A (en) * 1995-09-27 1998-08-18 Ono Pharmaceutical Co., Ltd. Sulfonamide derivatives
DE19542189A1 (en) * 1995-11-13 1997-05-15 Hoechst Ag New cyclic alpha-imino:hydroxamic acid derivatives
DE19616509A1 (en) * 1996-04-25 1998-01-15 Asta Medica Ag New specific immunophilin ligands as anti-asthmatics, immunosuppressants

Also Published As

Publication number Publication date
HUP0004294A3 (en) 2001-11-28
JP2001517653A (en) 2001-10-09
AU9345098A (en) 1999-04-12
WO1999015501A1 (en) 1999-04-01
IL133246A0 (en) 2001-04-30
NO20001510D0 (en) 2000-03-23
EP1017673A1 (en) 2000-07-12
BR9813226A (en) 2000-08-29
HUP0004294A2 (en) 2001-05-28
KR20010040253A (en) 2001-05-15
CA2304451A1 (en) 1999-04-01
DE19742263A1 (en) 1999-04-01
ZA987819B (en) 1999-04-07

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Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application