NO177270C - Meth. for the preparation of therapeutically active human granulocyte macrophage "colony-stimulating" factor proteins (GM-CSF), bacterial expression vector capable of expressing GM-CSF, and bacterial cell containing the vector - Google Patents

Meth. for the preparation of therapeutically active human granulocyte macrophage "colony-stimulating" factor proteins (GM-CSF), bacterial expression vector capable of expressing GM-CSF, and bacterial cell containing the vector

Info

Publication number
NO177270C
NO177270C NO865191A NO865191A NO177270C NO 177270 C NO177270 C NO 177270C NO 865191 A NO865191 A NO 865191A NO 865191 A NO865191 A NO 865191A NO 177270 C NO177270 C NO 177270C
Authority
NO
Norway
Prior art keywords
csf
colony
stimulating
meth
expressing
Prior art date
Application number
NO865191A
Other languages
Norwegian (no)
Other versions
NO865191D0 (en
NO865191L (en
NO177270B (en
Inventor
Paul Habermann
Hubert Mullner
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of NO865191D0 publication Critical patent/NO865191D0/en
Publication of NO865191L publication Critical patent/NO865191L/en
Publication of NO177270B publication Critical patent/NO177270B/en
Publication of NO177270C publication Critical patent/NO177270C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

CSF proteins which are biologically active are obtained by expression of a gene coding for human granulocyte macrophage colony stimulating factor (CSF) in bacteria. Biologically active derivatives with a modified amino acid sequence are obtained by altering the natural or synthetic gene structure.
NO865191A 1985-12-21 1986-12-19 Meth. for the preparation of therapeutically active human granulocyte macrophage "colony-stimulating" factor proteins (GM-CSF), bacterial expression vector capable of expressing GM-CSF, and bacterial cell containing the vector NO177270C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853545568 DE3545568A1 (en) 1985-12-21 1985-12-21 GM-CSF-PROTEIN, ITS DERIVATIVES, PRODUCTION OF SUCH PROTEINS AND THEIR USE

Publications (4)

Publication Number Publication Date
NO865191D0 NO865191D0 (en) 1986-12-19
NO865191L NO865191L (en) 1987-06-22
NO177270B NO177270B (en) 1995-05-08
NO177270C true NO177270C (en) 1995-08-16

Family

ID=6289242

Family Applications (1)

Application Number Title Priority Date Filing Date
NO865191A NO177270C (en) 1985-12-21 1986-12-19 Meth. for the preparation of therapeutically active human granulocyte macrophage "colony-stimulating" factor proteins (GM-CSF), bacterial expression vector capable of expressing GM-CSF, and bacterial cell containing the vector

Country Status (17)

Country Link
EP (1) EP0228018B1 (en)
JP (1) JP2575367B2 (en)
KR (1) KR940005585B1 (en)
AT (1) ATE71144T1 (en)
AU (2) AU601959B2 (en)
CA (1) CA1341197C (en)
DE (2) DE3545568A1 (en)
DK (1) DK170346B1 (en)
ES (1) ES2055686T3 (en)
FI (1) FI91168C (en)
GR (1) GR3003999T3 (en)
HU (1) HU202584B (en)
IE (1) IE59779B1 (en)
IL (1) IL81020A (en)
NO (1) NO177270C (en)
PT (1) PT83972B (en)
ZA (1) ZA869557B (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5078996A (en) * 1985-08-16 1992-01-07 Immunex Corporation Activation of macrophage tumoricidal activity by granulocyte-macrophage colony stimulating factor
WO1987002060A1 (en) * 1985-10-03 1987-04-09 Biogen N.V. Human granulocyte-macrophage colony stimulating factor-like polypeptides and processes for producing them in high yields in microbial cells
DE3712985A1 (en) * 1987-04-16 1988-11-03 Hoechst Ag BIFUNCTIONAL PROTEINS
US5359035A (en) * 1985-12-21 1994-10-25 Hoechst Aktiengesellschaft Bifunctional proteins including interleukin-2 (IL-2) and granuloctyte macrophage colony stimulating factor (GM-CSF)
JP2583770B2 (en) * 1986-09-17 1997-02-19 大塚製薬株式会社 gene
JPS6420097A (en) * 1987-03-02 1989-01-24 Sumitomo Chemical Co Human granulocyte-macrophage colony stimulating factor
PT87133B (en) * 1987-04-02 1992-07-31 Amrad Corp Ltd METHOD OF PURIFICATION OF THE LEUKEMIA INHIBITOR FACTOR (LIF) AND PHARMACEUTICAL COMPOSITIONS CONTAINING POLIPEPTIDES WITH LIF ACTIVITY
AU609128B2 (en) * 1987-04-02 1991-04-26 Amrad Operations Pty. Limited Leukaemia-inhibitory factor
DE3853590T2 (en) * 1987-06-25 1996-01-04 Immunex Corp CATTLE GRANULOCYT MACROPHAGE COLONY STIMULATING FACTOR.
WO1989004173A1 (en) * 1987-11-12 1989-05-18 Schering Corporation Acceleration of bone formation with gm-csf
GB2212159B (en) * 1987-11-13 1992-01-22 British Bio Technology Synthetic gene for human granulocyte/macrophage colony stimulating factor.
AU615550B2 (en) * 1988-04-21 1991-10-03 Medvet Science Pty. Ltd. Human gm-csf variants
AU5355790A (en) * 1989-04-19 1990-11-16 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
DK0489116T3 (en) * 1989-08-22 1994-05-02 Immunex Corp Fusion proteins comprising GM-CSF and IL-3
NZ236819A (en) * 1990-02-03 1993-07-27 Max Planck Gesellschaft Enzymatic cleavage of fusion proteins; fusion proteins; recombinant dna and pharmaceutical compositions
US5270181A (en) * 1991-02-06 1993-12-14 Genetics Institute, Inc. Peptide and protein fusions to thioredoxin and thioredoxin-like molecules
WO1997012054A1 (en) * 1995-09-28 1997-04-03 Otsuka Pharmaceutical Co., Ltd. Neutrophil chemotactic lymphokine, and drug and kit for the diagnosis of drug hypersensitive granulocytopenia containing the same
KR100448021B1 (en) * 2001-12-28 2004-09-08 크레아젠 주식회사 Transgenic Escherichia coli transformed with pGM-CSF vector expressing recombinant mouse granulocyte-macrophage colony stimulating factor and method for mass production of the recombinant protein
KR101589951B1 (en) * 2009-12-23 2016-01-29 그래댈리스, 인코포레이티드 Furin-knockdown and gm-csf-augmented (fang) cancer vaccine
SG181881A1 (en) 2009-12-23 2012-07-30 Gradalis Inc Furin-knockdown bi-functional rna

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4438032A (en) * 1981-01-30 1984-03-20 The Regents Of The University Of California Unique T-lymphocyte line and products derived therefrom
SE8300693L (en) * 1983-02-09 1984-08-10 Sven Lofdahl SET TO MAKE AND ISOLATE PROTEINS AND POLYPEPTIDES, AND A HYBRID VECTOR FOR THIS
IL71991A (en) * 1983-06-06 1994-05-30 Genentech Inc Preparation of mature human IGF and EGF via prokaryotic recombinant DNA technology
AU594014B2 (en) * 1984-03-21 1990-03-01 Research Corporation Technologies, Inc. Recombinant DNA molecules
ATE67244T1 (en) * 1984-07-06 1991-09-15 Sandoz Ag PRODUCTION AND PURIFICATION OF LYMPHOKINES.
ZA856108B (en) * 1984-10-29 1986-10-29 Immunex Corp Cloning of human granulocyte-macrophage colony simulating factor gene
AU588819B2 (en) * 1984-10-29 1989-09-28 Immunex Corporation Cloning of human granulocyte-macrophage colony stimulating factor gene
ES8705470A1 (en) * 1984-11-20 1987-05-01 Schering Biotech Corp cDNA CLONES CODING FOR POLYPEPTIDES EXHIBITING HUMAN GRANULOCYTE MACROPHAGE AND EOSINOPHIL CELLULAR GROWTH FACTOR ACTIVITY.
WO1987002060A1 (en) * 1985-10-03 1987-04-09 Biogen N.V. Human granulocyte-macrophage colony stimulating factor-like polypeptides and processes for producing them in high yields in microbial cells
DE3636903A1 (en) * 1985-12-21 1987-07-02 Hoechst Ag FUSION PROTEINS WITH EUKARYOTIC BALLASTES
DE3541856A1 (en) * 1985-11-27 1987-06-04 Hoechst Ag EUKARYOTIC FUSION PROTEINS, THEIR PRODUCTION AND USE, AND MEANS FOR CARRYING OUT THE PROCESS

Also Published As

Publication number Publication date
DE3545568A1 (en) 1987-07-16
DK619086A (en) 1987-06-22
JP2575367B2 (en) 1997-01-22
NO865191D0 (en) 1986-12-19
AU637139B2 (en) 1993-05-20
NO865191L (en) 1987-06-22
IL81020A0 (en) 1987-03-31
ATE71144T1 (en) 1992-01-15
ZA869557B (en) 1987-10-28
PT83972A (en) 1987-01-01
IE863335L (en) 1987-06-21
EP0228018A2 (en) 1987-07-08
DK170346B1 (en) 1995-08-07
AU601959B2 (en) 1990-09-27
EP0228018B1 (en) 1992-01-02
DE3683267D1 (en) 1992-02-13
FI91168B (en) 1994-02-15
AU6675686A (en) 1987-06-25
FI865186A0 (en) 1986-12-18
GR3003999T3 (en) 1993-03-16
CA1341197C (en) 2001-03-06
NO177270B (en) 1995-05-08
AU6268390A (en) 1990-12-13
HU202584B (en) 1991-03-28
FI865186A (en) 1987-06-22
KR940005585B1 (en) 1994-06-21
HUT44615A (en) 1988-03-28
IE59779B1 (en) 1994-04-06
EP0228018A3 (en) 1987-12-02
IL81020A (en) 1995-11-27
DK619086D0 (en) 1986-12-19
KR870006188A (en) 1987-07-09
PT83972B (en) 1989-07-31
JPS62164695A (en) 1987-07-21
ES2055686T3 (en) 1994-09-01
FI91168C (en) 1994-05-25

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