NO176840C - Analogifremgangsmåte for fremstilling av 2,9-disubstituerte-4H-pyrido[1,2-aÅpyrimidin-4-oner - Google Patents

Analogifremgangsmåte for fremstilling av 2,9-disubstituerte-4H-pyrido[1,2-aÅpyrimidin-4-oner

Info

Publication number: NO176840C
Authority: NO; Norway
Prior art keywords: 4alkyl; compounds; methyl; pyrido; pyrimidin
Prior art date: 1990-04-19

Application number

NO911525A

Other languages

English (en)

Other versions

NO911525D0 (no

NO911525L (no

NO176840B (no

Inventor

Ludo Edmond Josephine Kennis

Jan Vandenberk

Albertus Hendricus Mar Heertum

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-04-19

Filing date

1991-04-18

Publication date

1995-06-07

1991-04-18 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

1991-04-18 Publication of NO911525D0 publication Critical patent/NO911525D0/no

1991-10-21 Publication of NO911525L publication Critical patent/NO911525L/no

1995-02-27 Publication of NO176840B publication Critical patent/NO176840B/no

1995-06-07 Publication of NO176840C publication Critical patent/NO176840C/no

Links

150000001875 compounds Chemical class 0.000 abstract 4
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
-1 5-methyl-2-furanyl Chemical group 0.000 abstract 2
KPCZJLGGXRGYIE-UHFFFAOYSA-N [C]1=CC=CN=C1 Chemical group [C]1=CC=CN=C1 KPCZJLGGXRGYIE-UHFFFAOYSA-N 0.000 abstract 2
VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
MBVFRSJFKMJRHA-UHFFFAOYSA-N 4-fluoro-1-benzofuran-7-carbaldehyde Chemical compound FC1=CC=C(C=O)C2=C1C=CO2 MBVFRSJFKMJRHA-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
208000028017 Psychotic disease Diseases 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
230000001154 acute effect Effects 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
229960003638 dopamine Drugs 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychiatry (AREA)
Pharmacology & Pharmacy (AREA)
Neurosurgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyridine Compounds (AREA)
Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)

NO911525A 1990-04-19 1991-04-18 Analogifremgangsmåte for fremstilling av 2,9-disubstituerte-4H-pyrido[1,2-aÅpyrimidin-4-oner NO176840C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB909008850A GB9008850D0 (en)	1990-04-19	1990-04-19	Novel 2,9-disubstituted-4h-pyridol(1,2-a)pyrimidin-4-ones

Publications (4)

Publication Number	Publication Date
NO911525D0 NO911525D0 (no)	1991-04-18
NO911525L NO911525L (no)	1991-10-21
NO176840B NO176840B (no)	1995-02-27
NO176840C true NO176840C (no)	1995-06-07

Family

ID=10674694

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO911525A NO176840C (no)	1990-04-19	1991-04-18	Analogifremgangsmåte for fremstilling av 2,9-disubstituerte-4H-pyrido[1,2-aÅpyrimidin-4-oner

Country Status (26)

Country	Link
US (1)	US5482943A (no)
EP (1)	EP0453042B1 (no)
JP (1)	JP3216889B2 (no)
KR (1)	KR100190297B1 (no)
CN (1)	CN1027506C (no)
AT (1)	ATE186301T1 (no)
AU (1)	AU636969B2 (no)
BG (1)	BG60394B1 (no)
CA (1)	CA2040086C (no)
CZ (1)	CZ281135B6 (no)
DE (1)	DE69131759T2 (no)
DK (1)	DK0453042T3 (no)
ES (1)	ES2140381T3 (no)
FI (1)	FI96206C (no)
GB (1)	GB9008850D0 (no)
GR (1)	GR3032122T3 (no)
HU (1)	HUT57763A (no)
IE (1)	IE911301A1 (no)
IL (1)	IL97892A (no)
NO (1)	NO176840C (no)
NZ (1)	NZ237713A (no)
PL (2)	PL169744B1 (no)
PT (1)	PT97395B (no)
RU (1)	RU2037495C1 (no)
SK (1)	SK279005B6 (no)
ZA (1)	ZA912913B (no)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2050069B1 (es) *	1992-07-10	1994-12-16	Vita Invest Sa	Procedimiento para la obtencion de 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-il)piperidino)etil)-2-metil-6,7,8,9-tetrahidro-4h-pirido(1,2-a) pirimidin-4-ona.
JPH07508741A (ja)	1992-07-13	1995-09-28	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	新規４−（３−ベンゾフラニル）ピペリジニル及び４−（３−ベンゾチエニル）ピペリジニル誘導体，ならびにそれらを含む製薬学的組成物
SI0730594T1 (en) *	1993-11-23	1999-12-31	Janssen Pharmaceutica N.V.	9-HYDROXY-PYRIDO (1,2-a)PYRIMIDIN-4-ONE ETHER DERIVATIVES
ES2085234B1 (es) *	1994-02-24	1997-01-16	Vita Invest Sa	Agente activo sobre el sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
JP3274579B2 (ja) *	1995-01-12	2002-04-15	住友製薬株式会社	脳血管障害に伴う精神症候治療剤
ES2141671B1 (es) *	1997-12-26	2001-01-01	Vita Invest Sa	Compuesto pirimidinico activo sobre el sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
HU227118B1 (en) *	2001-11-13	2010-07-28	Egis Gyogyszergyar Nyilvanosan	Process for the preparation of 3-{2-[4-(6-fluoro-1,2-benzizoxazol-3-yl)-1-piperidinyl]-ethyl}-6,7,8,9-tetrahydro-2-methyl-4h-pyrido[1,2-a]pyrimidin-4-one
ES2197801B1 (es) *	2002-03-05	2005-03-16	Ferrer Internacional,S.A	Procedimiento de obtencion de la 3-(2-(4-(6-fluoro-benzo(d)isoxazol-3-il) piperidin-1-il)-etil)-2-metil-6,7,8,9-tetrahidro-4h-pirido-(1,2-a ) pirimidin-4-ona.
WO2004009591A1 (en) *	2002-07-22	2004-01-29	Aurobindo Pharma Ltd.	A process for the preparation of antipsychotic risperidone
AU2003256006A1 (en) *	2002-08-30	2004-03-19	Sunil Sadanand Nadkarni	Improved process for preparation of risperidone
KR20040025224A (ko) *	2002-09-18	2004-03-24	주식회사 대웅	2-(2-메틸-4-옥소-6,7,8,9-테트라하이드로-4Ｈ-피리도[1,2-ａ]피리미딘-3-일)아세트알데히드 및 그 제조방법
EP1560814A1 (en)	2002-11-13	2005-08-10	Synthon B.V.	Process for making risperidone and intermediates therefor
EP1615923A1 (en) *	2003-04-22	2006-01-18	Synthon B.V.	Risperidone monohydrochloride
HUP0401379A3 (en) *	2004-07-08	2006-04-28	Richter Gedeon Vegyeszet	Process for the preparation of risperidon
HUP0402163A2 (en) *	2004-10-25	2006-05-29	Richter Gedeon Vegyeszet	Process for the preparation of risperidone
EP1690540A1 (en)	2005-02-15	2006-08-16	Neuro3D	Composition comprising ocaperidone
EP1695973A1 (en) *	2005-02-24	2006-08-30	Neuro3D	Ocaperidone salt and pharmaceutical compositions containing the same
JO2769B1 (en) *	2005-10-26	2014-03-15	جانسين فارماسوتيكا ان. في	Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor
WO2009077551A1 (en) *	2007-12-18	2009-06-25	Janssen Pharmaceutica Nv	Process for preparing risperidone
WO2023135528A1 (en)	2022-01-11	2023-07-20	Suven Life Sciences Limited	Heteroalicyclic derivatives and their use in the treatment of cns disorders

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4485107A (en) *	1982-11-01	1984-11-27	Janssen Pharmaceutica N.V.	[[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones
US4804663A (en) *	1985-03-27	1989-02-14	Janssen Pharmaceutica N.V.	3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
NZ223654A (en) *	1987-03-09	1990-03-27	Janssen Pharmaceutica Nv	1-alkyl-substituted-benzimidazole-4-piperidinamines and pharmaceutical compositions
US4777252A (en) *	1987-08-13	1988-10-11	E. R. Squibb & Sons, Inc.	2-oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines
CA2000786C (en) *	1988-11-07	1999-01-26	Cornelus G. M. Janssen	3-piperidinyl-1,2-benzisoxazoles
GB8900382D0 (en) *	1989-01-09	1989-03-08	Janssen Pharmaceutica Nv	2-aminopyrimidinone derivatives

1990
- 1990-04-19 GB GB909008850A patent/GB9008850D0/en active Pending
1991
- 1991-03-28 US US07/676,681 patent/US5482943A/en not_active Expired - Lifetime
- 1991-04-05 NZ NZ237713A patent/NZ237713A/en unknown
- 1991-04-09 CA CA002040086A patent/CA2040086C/en not_active Expired - Lifetime
- 1991-04-11 AU AU74366/91A patent/AU636969B2/en not_active Expired
- 1991-04-16 DE DE69131759T patent/DE69131759T2/de not_active Expired - Lifetime
- 1991-04-16 JP JP10968691A patent/JP3216889B2/ja not_active Expired - Lifetime
- 1991-04-16 EP EP91200897A patent/EP0453042B1/en not_active Expired - Lifetime
- 1991-04-16 ES ES91200897T patent/ES2140381T3/es not_active Expired - Lifetime
- 1991-04-16 DK DK91200897T patent/DK0453042T3/da active
- 1991-04-16 AT AT91200897T patent/ATE186301T1/de not_active IP Right Cessation
- 1991-04-17 IL IL9789291A patent/IL97892A/en not_active IP Right Cessation
- 1991-04-17 KR KR1019910006108A patent/KR100190297B1/ko not_active IP Right Cessation
- 1991-04-18 NO NO911525A patent/NO176840C/no not_active IP Right Cessation
- 1991-04-18 FI FI911885A patent/FI96206C/fi active
- 1991-04-18 PL PL91312561A patent/PL169744B1/pl unknown
- 1991-04-18 ZA ZA912913A patent/ZA912913B/xx unknown
- 1991-04-18 SK SK1099-91A patent/SK279005B6/sk not_active IP Right Cessation
- 1991-04-18 PT PT97395A patent/PT97395B/pt not_active IP Right Cessation
- 1991-04-18 CZ CS911099A patent/CZ281135B6/cs not_active IP Right Cessation
- 1991-04-18 BG BG94282A patent/BG60394B1/bg unknown
- 1991-04-18 RU SU914895183A patent/RU2037495C1/ru active
- 1991-04-18 PL PL91289935A patent/PL169740B1/pl unknown
- 1991-04-18 IE IE130191A patent/IE911301A1/en not_active IP Right Cessation
- 1991-04-19 CN CN91102516A patent/CN1027506C/zh not_active Expired - Lifetime
- 1991-04-19 HU HU911301A patent/HUT57763A/hu unknown
1999
- 1999-12-14 GR GR990403201T patent/GR3032122T3/el unknown

Also Published As

Publication number	Publication date
RU2037495C1 (ru)	1995-06-19
PT97395B (pt)	1998-08-31
HU911301D0 (en)	1991-10-28
ES2140381T3 (es)	2000-03-01
DE69131759T2 (de)	2000-06-21
AU7436691A (en)	1991-10-24
PL169744B1 (pl)	1996-08-30
SK279005B6 (sk)	1998-05-06
IL97892A0 (en)	1992-06-21
US5482943A (en)	1996-01-09
EP0453042B1 (en)	1999-11-03
NZ237713A (en)	1992-09-25
CZ281135B6 (cs)	1996-06-12
PL169740B1 (pl)	1996-08-30
NO911525D0 (no)	1991-04-18
PT97395A (pt)	1992-01-31
CA2040086C (en)	2003-12-30
KR910018380A (ko)	1991-11-30
AU636969B2 (en)	1993-05-13
IE911301A1 (en)	1991-10-23
JP3216889B2 (ja)	2001-10-09
ZA912913B (en)	1992-12-30
PL289935A1 (en)	1992-04-06
FI911885A0 (fi)	1991-04-18
IL97892A (en)	1995-03-30
DE69131759D1 (de)	1999-12-09
FI96206B (fi)	1996-02-15
CA2040086A1 (en)	1991-10-20
CS9101099A2 (en)	1991-11-12
NO911525L (no)	1991-10-21
FI96206C (fi)	1996-05-27
JPH04234882A (ja)	1992-08-24
CN1055929A (zh)	1991-11-06
DK0453042T3 (da)	2000-04-25
CN1027506C (zh)	1995-01-25
BG60394B1 (bg)	1995-02-28
ATE186301T1 (de)	1999-11-15
GR3032122T3 (en)	2000-04-27
NO176840B (no)	1995-02-27
EP0453042A1 (en)	1991-10-23
GB9008850D0 (en)	1990-06-13
KR100190297B1 (ko)	1999-06-01
HUT57763A (en)	1991-12-30
FI911885A (fi)	1991-10-20

Legal Events

Date	Code	Title	Description
2011-05-16	MK1K	Patent expired

Publication	Publication Date	Title
NO176840C (no)	1995-06-07	Analogifremgangsmåte for fremstilling av 2,9-disubstituerte-4H-pyrido[1,2-aÅpyrimidin-4-oner
DK0482208T3 (da)	2000-09-18	Pyridazinonderivat
ATE51621T1 (de)	1990-04-15	Bicyclische kondensierte n-(4-piperidinyl)-2imidazolamin-derivate.
TNSN90003A1 (fr)	1991-03-05	Derives de 2-aminopyrimidinones utiles notamment comme antagonistes des neurotransmetteurs et procede pour leur preparation
DE68914292T2 (de)	1995-09-28	Zusammensetzung zur Behandlung von ischämischen Störungen in Organen.
NO167803C (no)	1991-12-11	Analogifremgangsmaate til fremstilling av terapeutiskordskilleaktive n-(4-piperidinyl)bicyklisk kondenserte 2-imidazolaminderivater.
NO176608C (no)	1995-05-03	Analogifremgangsmåte for fremstilling av terapeutisk aktive 3-piperidinylindazol-derivater
DE3884878T2 (de)	1994-02-17	Uricosuretische Zusammensetzung.