NO176126B - Implantat og fremgangsmåte for fremstilling derav - Google Patents
Implantat og fremgangsmåte for fremstilling derav Download PDFInfo
- Publication number
- NO176126B NO176126B NO905392A NO905392A NO176126B NO 176126 B NO176126 B NO 176126B NO 905392 A NO905392 A NO 905392A NO 905392 A NO905392 A NO 905392A NO 176126 B NO176126 B NO 176126B
- Authority
- NO
- Norway
- Prior art keywords
- implant
- tissue
- biological material
- stem
- layer
- Prior art date
Links
- 239000007943 implant Substances 0.000 title claims abstract description 36
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 5
- 238000000034 method Methods 0.000 title description 3
- 239000012620 biological material Substances 0.000 claims abstract description 17
- 239000000203 mixture Substances 0.000 claims abstract description 15
- 235000015097 nutrients Nutrition 0.000 claims abstract description 8
- 239000000463 material Substances 0.000 claims description 17
- 210000001519 tissue Anatomy 0.000 claims description 14
- 238000004873 anchoring Methods 0.000 claims description 13
- 239000010410 layer Substances 0.000 claims description 11
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 8
- 239000010936 titanium Substances 0.000 claims description 7
- 229910052719 titanium Inorganic materials 0.000 claims description 7
- 239000002344 surface layer Substances 0.000 claims description 5
- 229940036811 bone meal Drugs 0.000 claims description 4
- 239000002374 bone meal Substances 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 230000035876 healing Effects 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 210000000689 upper leg Anatomy 0.000 description 2
- 239000003462 bioceramic Substances 0.000 description 1
- 239000005312 bioglass Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 229910010293 ceramic material Inorganic materials 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
- 238000001465 metallisation Methods 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 238000002601 radiography Methods 0.000 description 1
- 238000005245 sintering Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C13/00—Dental prostheses; Making same
- A61C13/0003—Making bridge-work, inlays, implants or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
- A61C8/0013—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy with a surface layer, coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30756—Cartilage endoprostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3645—Connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30756—Cartilage endoprostheses
- A61F2002/30762—Means for culturing cartilage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30841—Sharp anchoring protrusions for impaction into the bone, e.g. sharp pins, spikes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30878—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves with non-sharp protrusions, for instance contacting the bone for anchoring, e.g. keels, pegs, pins, posts, shanks, stems, struts
- A61F2002/30891—Plurality of protrusions
- A61F2002/30892—Plurality of protrusions parallel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
- A61F2002/30957—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques using a positive or a negative model, e.g. moulds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2/4644—Preparation of bone graft, bone plugs or bone dowels, e.g. grinding or milling bone material
- A61F2002/4648—Means for culturing bone graft
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00011—Metals or alloys
- A61F2310/00023—Titanium or titanium-based alloys, e.g. Ti-Ni alloys
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Vascular Medicine (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dentistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Ceramic Engineering (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Zoology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Electrotherapy Devices (AREA)
Description
Foreliggende oppfinnelse vedrører et implantat og en fremgangsmåte for fremstilling av det.
Implantater som består av eller har et overflatelag av vevforenlig materiale, slik som titan og visse typer keram-iske materialer, er allerede kjent, f.eks. fra SE-7902035-0.
Et felles trekk ved de fleste av disse implantatene er at de er utformet for å ligge tett an mot det biologiske vev, slik at dette hurtig kommer i kontakt med og vokser inn i implantatet. For dette formål utformes ofte lårproteser f.eks. med utspring hvorved protesen får et feste på den innvendige vegg i hulrommet i lårbenet.
Dette resulterer imidlertid i en uelastisk tilknyt-ning mellom overflaten av implantatet og det motstående kroppsvev, noe som er ufordelaktig spesielt i tilfellet med svampvev, slik som i kjever.
Til tross for at utspring er tilveiebrakt, vil til-helingsprosessen ta ganske lang tid, noe som ikke bare for-årsaker ulempe for pasienten, men som også kan gi opphav til dannelse av bindevev i sammenføyningen mellom implantatet og vevet.
Formålet ved foreliggende oppfinnelse er å overvinne, eller i det minste i det vesentlige redusere, de ovenfor nevnte ulemper ved kjente implantater.
Ifølge oppfinnelsen oppnås dette formål ved et implantat (en protese) som omfatter biologisk materiale i den overflate som er ment å vende mot kroppsvevet, og som er kjennetegnet ved at overflaten er dannet av et lag av materiale tilveiebrakt på en protesestamme eller et lag av materiale hvorfra ett eller flere lagforankrende elementer stikker frem, idet stammen eller forankringselementene består av eller har et overflatelag av vevforenlig materiale, idet laget av materiale består av en blanding av korn/pulver-materiale av vevforenlig type og desintegrert, vevforenlig, biologisk materiale, slik som benmel, som ved tilsetning av næring har fått vokse både ut til overflaten og inn til stammen eller forankringselementene for forankring til disse, hvor tilveksten også binder sammen bestanddelene i blandingen, og hvor det biologiske materiale er vev av den samme type som implantatet skal hhv. innføres eller plasseres i eller mot.
For å fremme slik vekst gjøres det bruk av en egnet, kommersielt tilgjengelig næringsoppløsning.
Stammen eller dens overflatelag er fortrinnsvis av titan, og dens ytre overflate er fortrinnsvis porøs for optimal vevforankring.
De vevforenlige korn kan være valgt fra forskjellige materialer, hovedsakelig titan, men andre materialer som er kjent for fagfolk innen teknikken, kan anvendes, slik som bio-keramer, bioglass og hydroxyapatitt.
Det vil forstås at implantatet ifølge oppfinnelsen som inneholder biologisk materiale i sitt overflatelag, vil redusere tiden som er påkrevet for tilheling etter implanta-sjonen, dvs. tiden som er påkrevet for biologisk forankring av implantatet i eller mot kroppsvev.
Ifølge oppfinnelsen er det videre tilveiebrakt en fremgangsmåte for fremstilling av implantatet, kjennetegnet ved at en implantatstamme eller implantatforankringselementer og en blanding av korn/pulver-materiale av vevforenlig type og desintegrert, biologisk materiale, samt en næringsoppløsning for det sistnevnte, plasseres i en støpeform hvor det biologiske materiale får vokse, både ut til avgrensningsveggen for formrommet og inn til implantatstammen.
Implantatet ifølge oppfinnelsen lages fortrinnsvis i en form hvor hulrommet inneholder stammen (eller delen derav som skal forsynes med laget) og en blanding av materialet i rommet mellom stammen og den avgrensende vegg i formhulrommet. Til denne blandingen inneholdt i formhulrommet, tilsettes en næringsoppløsning som fremmer (eventuelt etter påfylling) veksten av det biologiske materiale i blandingen. Vekstpara-metrene er tilgjengelige i litteraturen for fagfolk innen teknikken.
En fordel ved en slik teknikk er at implantatet lett kan skreddersys for pasienten. Formhulrommet formes prelimi-nært etter f.eks. en tannseng, og eventuelle modifikasjoner av implantatet som senere kan være påkrevet, bestemmes ved hjelp av radiografi etter implantering av implantatet formet i støpeformen. Modifikasjoner av støpeformhulrommet utføres så for å oppnå et mer korrekt implantat.
På den vedlagte tegning er det vist to utførelses-former av oppfinnelsen. Figur 1 viser en tannprotese 1 som skal skrus inn i en kjeve. Stammen 2 i protesen er av vewekstfremmende titan med en porøs ytre overflate (erholdt ved sintring, metall-avsetning ved fordampning etc). Til stammen er det festet et lag 3 bestående av en blanding av benmel 4 oppmalt fra kjeve-benvev tatt fra pasienten, og titanpulver 5. Blandingen er blitt tilført en næringsoppløsning 6 som får benmelet i blandingen til å vokse og danne vev 7 som forbinder bestanddelene 4, 5 i lag 3 til hverandre og til stammen 2. Protesen er blitt laget i en silikonform 8 med gjenger 9 på innsiden, slik at det dannes gjenger 10 på utsiden av tannprotesen. Figur 2 viser et bruskimplantat 11 som er forsynt med flere titanstifter 12 som i én ende er innelukket i et lag 13 av blandingen beskrevet ovenfor. Med de motsatte, frie endene av stiftene 12 kan implantatet 11 festes til kroppsvev.
Claims (5)
1. Implantat (protese) som omfatter biologisk materiale i den overflate som er ment å vende mot kroppsvevet, karakterisert ved at overflaten er dannet av et lag av materiale (3) tilveiebrakt på en protesestamme (2) eller et lag av materiale (13) hvorfra ett eller flere lagforankrende elementer (12) stikker frem, idet stammen eller forankringselementene består av eller har et overflatelag av vevforenlig materiale, idet laget av materiale (3, 13) består av en blanding av korn/pulver-materiale (5) av vevforenlig type og desintegrert, vevforenlig, biologisk materiale (4), slik som benmel, som ved tilsetning av næring har fått vokse både ut til overflaten og inn til stammen eller forankringselementene for forankring til disse, hvor tilveksten også binder sammen bestanddelene (4, 5) i blandingen, og hvor det biologiske materiale (4) er vev av den samme type som implantatet skal hhv. innføres eller plasseres i eller mot.
2. Implantat ifølge krav 1,
karakterisert ved at stammen (2) eller forankringselementene (12) omfatter titan med en porøs ytre overflate.
3. Implantat ifølge et av kravene 1-2, karakterisert ved at det granulære/pulver-formige materiale (5) omfatter titan.
4. Implantat ifølge et av kravene 1-3, karakterisert ved at det biologiske materiale (4) er endogent.
5. Fremgangsmåte for fremstilling av et implantat ifølge hvilket som helst av kravene 1-4,
karakterisert ved at en implantatstamme eller implantatforankringselementer og en blanding av korn/pulver-materiale av vevforenlig type og desintegrert, biologisk materiale, samt en næringsoppløsning for det sistnevnte, plasseres i en støpeform hvor det biologiske materiale får vokse, både ut til avgrensningsveggen for formrommet og inn til implantatstammen.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE8802214A SE465064B (sv) | 1988-06-14 | 1988-06-14 | Implantat och saett att framstaella det |
PCT/SE1989/000333 WO1989012472A1 (en) | 1988-06-14 | 1989-06-13 | Implant and method of making it |
Publications (4)
Publication Number | Publication Date |
---|---|
NO905392L NO905392L (no) | 1990-12-13 |
NO905392D0 NO905392D0 (no) | 1990-12-13 |
NO176126B true NO176126B (no) | 1994-10-31 |
NO176126C NO176126C (no) | 1995-02-08 |
Family
ID=20372608
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO905392A NO176126C (no) | 1988-06-14 | 1990-12-13 | Implantat og fremgangsmåte for fremstilling derav |
Country Status (17)
Country | Link |
---|---|
US (1) | US5217496A (no) |
EP (1) | EP0419548B1 (no) |
JP (1) | JP2543605B2 (no) |
KR (1) | KR970011447B1 (no) |
AT (1) | ATE93148T1 (no) |
AU (1) | AU615771B2 (no) |
BR (1) | BR8907486A (no) |
CA (1) | CA1338930C (no) |
DE (1) | DE68908554T2 (no) |
DK (1) | DK169861B1 (no) |
ES (1) | ES2018723A6 (no) |
FI (1) | FI96383C (no) |
MX (1) | MX169887B (no) |
NO (1) | NO176126C (no) |
RU (1) | RU2071354C1 (no) |
SE (1) | SE465064B (no) |
WO (1) | WO1989012472A1 (no) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2649885B1 (fr) * | 1989-07-21 | 1994-03-25 | Matteis Gerard De | Prothese de hanche |
JP3471967B2 (ja) * | 1995-03-28 | 2003-12-02 | カネボウ株式会社 | ハイブリッド型人工歯根 |
DE19630034A1 (de) * | 1996-07-25 | 1998-04-23 | Huels Chemische Werke Ag | Biohybrides Zahnimplantat |
SE515572C2 (sv) * | 1998-09-09 | 2001-09-03 | Lanka Ltd | Implantat, sätt att framställa det och användning av det |
SE515227C2 (sv) | 1999-04-28 | 2001-07-02 | Bruce Medical Ab | Kropp för åstadkommande av in- och tillväxt av benvävnad och/ eller bindväv och sätt för framställning av kroppen |
US6960215B2 (en) | 2002-05-08 | 2005-11-01 | Boston Scientific Scimed, Inc. | Tactical detachable anatomic containment device and therapeutic treatment system |
US20030220696A1 (en) * | 2002-05-23 | 2003-11-27 | Levine David Jerome | Implantable porous metal |
EP1695676A1 (de) * | 2005-02-25 | 2006-08-30 | WALDEMAR LINK GmbH & Co. KG | Verfahren zum Herstellen eines medizinischen Implantats aus einer Beta-Titan-Molybdän-Legierung und entsprechendes Implantat |
US8562616B2 (en) | 2007-10-10 | 2013-10-22 | Biomet Manufacturing, Llc | Knee joint prosthesis system and method for implantation |
US8328873B2 (en) | 2007-01-10 | 2012-12-11 | Biomet Manufacturing Corp. | Knee joint prosthesis system and method for implantation |
US8163028B2 (en) | 2007-01-10 | 2012-04-24 | Biomet Manufacturing Corp. | Knee joint prosthesis system and method for implantation |
US8187280B2 (en) | 2007-10-10 | 2012-05-29 | Biomet Manufacturing Corp. | Knee joint prosthesis system and method for implantation |
JP5448842B2 (ja) | 2007-01-10 | 2014-03-19 | バイオメト マニファクチャリング コーポレイション | 膝関節プロテーゼシステムおよび埋込み方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3605123A (en) * | 1969-04-29 | 1971-09-20 | Melpar Inc | Bone implant |
US3905047A (en) * | 1973-06-27 | 1975-09-16 | Posta Jr John J | Implantable ceramic bone prosthesis |
US3918000A (en) * | 1973-08-16 | 1975-11-04 | Signacom Systems Inc | Annunciator system communicating via a minimum available communication channel |
US3918100A (en) * | 1974-05-13 | 1975-11-11 | Us Navy | Sputtering of bone on prostheses |
US4539716A (en) * | 1981-03-19 | 1985-09-10 | Massachusetts Institute Of Technology | Fabrication of living blood vessels and glandular tissues |
US4505266A (en) * | 1981-10-26 | 1985-03-19 | Massachusetts Institute Of Technology | Method of using a fibrous lattice |
US4936852A (en) * | 1985-04-30 | 1990-06-26 | Vitek, Inc. | Temporomandibular mini condyle prosthesis |
DE3615732A1 (de) * | 1986-05-09 | 1987-11-12 | Leitz Ernst Gmbh | Kompositwerkstoff fuer prothetische zwecke, verfahren zu dessen herstellung sowie verwendung des kompositwerkstoffs bzw. anwendung des herstellungsverfahrens zur beschichtung von prothesen |
US5002488A (en) * | 1988-04-12 | 1991-03-26 | Hadaco, Ltd. | Dental implants with resorption preventing means |
-
1988
- 1988-06-14 SE SE8802214A patent/SE465064B/sv not_active IP Right Cessation
-
1989
- 1989-06-13 EP EP89907345A patent/EP0419548B1/en not_active Expired - Lifetime
- 1989-06-13 ES ES8902072A patent/ES2018723A6/es not_active Expired - Fee Related
- 1989-06-13 BR BR898907486A patent/BR8907486A/pt not_active IP Right Cessation
- 1989-06-13 WO PCT/SE1989/000333 patent/WO1989012472A1/en active IP Right Grant
- 1989-06-13 JP JP1507073A patent/JP2543605B2/ja not_active Expired - Fee Related
- 1989-06-13 RU SU894894340A patent/RU2071354C1/ru not_active IP Right Cessation
- 1989-06-13 DE DE89907345T patent/DE68908554T2/de not_active Expired - Fee Related
- 1989-06-13 AT AT89907345T patent/ATE93148T1/de not_active IP Right Cessation
- 1989-06-13 KR KR1019900700291A patent/KR970011447B1/ko not_active IP Right Cessation
- 1989-06-13 AU AU38371/89A patent/AU615771B2/en not_active Ceased
- 1989-06-13 CA CA000602589A patent/CA1338930C/en not_active Expired - Fee Related
- 1989-06-14 MX MX016462A patent/MX169887B/es unknown
-
1990
- 1990-12-04 DK DK288490A patent/DK169861B1/da not_active IP Right Cessation
- 1990-12-13 FI FI906131A patent/FI96383C/fi not_active IP Right Cessation
- 1990-12-13 NO NO905392A patent/NO176126C/no unknown
-
1992
- 1992-09-30 US US07/953,770 patent/US5217496A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ATE93148T1 (de) | 1993-09-15 |
AU615771B2 (en) | 1991-10-10 |
FI96383C (fi) | 1996-06-25 |
MX169887B (es) | 1993-07-29 |
SE8802214L (sv) | 1989-12-15 |
FI906131A0 (fi) | 1990-12-13 |
SE465064B (sv) | 1991-07-22 |
CA1338930C (en) | 1997-02-25 |
EP0419548A1 (en) | 1991-04-03 |
BR8907486A (pt) | 1991-05-28 |
NO905392L (no) | 1990-12-13 |
ES2018723A6 (es) | 1991-05-01 |
DE68908554D1 (de) | 1993-09-23 |
SE8802214D0 (sv) | 1988-06-14 |
DK288490D0 (da) | 1990-12-04 |
KR900701331A (ko) | 1990-12-01 |
DE68908554T2 (de) | 1994-03-10 |
RU2071354C1 (ru) | 1997-01-10 |
JPH03505050A (ja) | 1991-11-07 |
WO1989012472A1 (en) | 1989-12-28 |
EP0419548B1 (en) | 1993-08-18 |
DK169861B1 (da) | 1995-03-20 |
KR970011447B1 (ko) | 1997-07-11 |
NO905392D0 (no) | 1990-12-13 |
JP2543605B2 (ja) | 1996-10-16 |
DK288490A (da) | 1990-12-12 |
FI96383B (fi) | 1996-03-15 |
US5217496A (en) | 1993-06-08 |
AU3837189A (en) | 1990-01-12 |
NO176126C (no) | 1995-02-08 |
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