NO174207C - Analogous Process for Preparation of Therapeutically Active Conjugate of Diaphragm Anchor - Google Patents

Analogous Process for Preparation of Therapeutically Active Conjugate of Diaphragm Anchor

Info

Publication number
NO174207C
NO174207C NO862511A NO862511A NO174207C NO 174207 C NO174207 C NO 174207C NO 862511 A NO862511 A NO 862511A NO 862511 A NO862511 A NO 862511A NO 174207 C NO174207 C NO 174207C
Authority
NO
Norway
Prior art keywords
active ingredient
preparation
therapeutically active
analogous process
active conjugate
Prior art date
Application number
NO862511A
Other languages
Norwegian (no)
Other versions
NO862511D0 (en
NO174207B (en
NO862511L (en
Inventor
Gunther Jung
Karl-Heinz Wiesmuller
Jorg Metzger
Hans-Jorg Buhring
Gerhard Becker
Wolfgang Bessler
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of NO862511D0 publication Critical patent/NO862511D0/en
Publication of NO862511L publication Critical patent/NO862511L/en
Priority to NO920356A priority Critical patent/NO920356D0/en
Publication of NO174207B publication Critical patent/NO174207B/en
Publication of NO174207C publication Critical patent/NO174207C/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6018—Lipids, e.g. in lipopeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6068—Other bacterial proteins, e.g. OMP
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fodder In General (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Conjugates are described in which the active ingredient is covalently bonded to the anchoring membrane, which is a compound of the formulae <IMAGE> in which A can be: sulphur, oxygen, disulphide (-S-S-), methylene (-CH2-) or -NH-; n = 0 to 5; m = 1 or 2; C* = an asymmetric carbon atom of R or S configuration, R, R' and R'' are identical or different and are an alkyl, alkenyl or alkynyl group having 7 to 25 carbon atoms or are hydrogen which can optionally be substituted by hydroxyl, amino, oxo, acyl, alkyl or cycloalkyl groups and R1 and R2 are identical or different and are defined as R, R' or R'' or can be -OR, -OCOR, -COOR, -NHCOR or -CONHR and X is an active ingredient or a spacer active ingredient group. The anchoring membrane active ingredient conjugates increase antibody formation.
NO862511A 1985-06-24 1986-06-23 Analogous Process for Preparation of Therapeutically Active Conjugate of Diaphragm Anchor NO174207C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NO920356A NO920356D0 (en) 1985-06-24 1992-01-27 ANALOGUE PROCEDURE FOR PREPARING A CONJUGATE OF A MEMBRANEOUS-ACTIVE SUBSTANCE

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3522512 1985-06-24
DE19853546150 DE3546150A1 (en) 1985-06-24 1985-12-27 MEMBRANE ANCHOR ACTIVE CONJUGATE, ITS PRODUCTION AND USE

Publications (4)

Publication Number Publication Date
NO862511D0 NO862511D0 (en) 1986-06-23
NO862511L NO862511L (en) 1986-12-29
NO174207B NO174207B (en) 1993-12-20
NO174207C true NO174207C (en) 1994-03-30

Family

ID=25833375

Family Applications (1)

Application Number Title Priority Date Filing Date
NO862511A NO174207C (en) 1985-06-24 1986-06-23 Analogous Process for Preparation of Therapeutically Active Conjugate of Diaphragm Anchor

Country Status (12)

Country Link
EP (1) EP0210412B1 (en)
JP (1) JP2594259B2 (en)
KR (1) KR930008091B1 (en)
AT (1) ATE131491T1 (en)
AU (1) AU611385B2 (en)
CA (1) CA1340656C (en)
DE (2) DE3546150A1 (en)
DK (1) DK172399B1 (en)
ES (1) ES8801677A1 (en)
FI (1) FI94419C (en)
NO (1) NO174207C (en)
PT (1) PT82826B (en)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6074650A (en) * 1985-06-24 2000-06-13 Hoechst Aktiengesellschaft Membrane anchor/active compound conjugate, its preparation and its uses
DE3937412A1 (en) * 1989-11-10 1991-05-16 Hoechst Ag SYNTHETIC VACCINE FOR THE SPECIFIC INDUCTION OF CYTOTOXIC T-LYMPHOZYTES
US6024964A (en) * 1985-06-24 2000-02-15 Hoechst Aktiengesellschaft Membrane anchor/active compound conjugate, its preparation and its uses
DE3813821A1 (en) * 1988-04-22 1989-11-02 Hoechst Ag SYNTHETIC VACCINE AGAINST MOUTH AND CLAUS DISEASE AND METHOD FOR THEIR PRODUCTION
CA1331355C (en) * 1986-04-21 1994-08-09 Bioenterprises Pty. Ltd Immunopotentation
AU619443B2 (en) * 1986-04-21 1992-01-30 Bioenterprises Pty. Ltd. Immunopotentiation
JPS63107742A (en) * 1986-05-20 1988-05-12 Wako Pure Chem Ind Ltd Novel functional liposome and its preparation
DE3700173A1 (en) * 1987-01-05 1988-07-14 Hoechst Ag METHOD FOR PRODUCING LIPOPHILE AMINO ACID DERIVATIVES AND LIPOPHILE AMINO ACID DERIVATIVES
US5976839A (en) * 1987-03-13 1999-11-02 Bioenterprises Pty Limited Immunopotentiation through covalent linkage between immunogen and immunopotentiating molecules
GB2217319A (en) * 1988-04-19 1989-10-25 Synpharm Ltd Racemic and optically active fatty amino acids, their homo- abd hetero-oligomers and conjugates, the process of their production, their pharmaceutical composi
US5120829A (en) * 1989-03-20 1992-06-09 La Jolla Cancer Research Foundation Hydrophobic attachment site for adhesion peptides
DE59103985D1 (en) * 1990-05-30 1995-02-02 Deutsches Krebsforsch Polyethersubstituierte tumormittel.
DE4119856A1 (en) * 1991-06-17 1992-12-24 Hoechst Ag N-ACYL-S- (2-HYDROXYALKYL) -CYSTEINS, THE PRODUCTION AND USE THEREOF AS INTERMEDIATE PRODUCTS FOR THE PRODUCTION OF SYNTHETIC IMMUNE ADJUVANTS AND SYNTHETIC VACCINANTS
AU666789B2 (en) * 1992-12-28 1996-02-22 Takeda Chemical Industries Ltd. 2-amino-6,7-dihydroxy-4-thiaheptanoic acid derivatives, production and use thereof
EP0604945A1 (en) * 1992-12-28 1994-07-06 Takeda Chemical Industries, Ltd. TAN-1511, its derivatives, production and use thereof
DE4325317C2 (en) * 1993-07-29 1998-05-20 Univ Dresden Tech Process for the radioactive labeling of immunoglobulins
DE4329309A1 (en) * 1993-08-31 1995-03-09 Rapp Polymere Gmbh Lipopeptide compounds
EP0641776A3 (en) * 1993-09-08 1997-05-02 Takeda Chemical Industries Ltd Thioglycerol derivatives.
FR2727117A1 (en) * 1994-11-18 1996-05-24 Geffard Michel USE OF POLYLYSIN CONJUGATES FOR THE PREPARATION OF MEDICAMENTS USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISEASES AND DEGENERATIVE DISORDERS OF AUTOIMMUN CHARACTER
US6117940A (en) * 1997-10-17 2000-09-12 Mjalli; Adnan M. M. Amino-ketone solid support templates
IL125908A (en) * 1998-08-24 2005-05-17 Nst Neurosurvival Technologies Peptides and pharmaceutical compositions comprising same
IL131266A0 (en) 1999-08-05 2001-01-28 N S T Neurosurvival Technologi Peptides and pharmaceutical compositions comprising same
GB9915074D0 (en) * 1999-06-28 1999-08-25 Cortecs Plc Ligand-binding composition
DE102009034779A1 (en) 2009-07-25 2011-02-03 Emc Microcollections Gmbh Synthetic analogues of bacterial lipopeptides and their application for the therapy and prophylaxis of allergic diseases
KR101853513B1 (en) * 2010-03-23 2018-04-30 노파르티스 아게 Compounds (cystein based lipopeptides) and compositions as tlr2 agonists used for treating infections, inflammations, respiratory diseases etc.
DE102011018499A1 (en) 2011-04-23 2012-10-25 Emc Microcollections Gmbh Topical nanoparticle vaccine for the immune stimulation of dendritic cells in the skin
US10766928B2 (en) 2012-10-05 2020-09-08 The University Of Kansas Targeted conformationally-constrained kinked endosomal disrupting peptides
US9701715B2 (en) * 2012-10-05 2017-07-11 The University Of Kansas Conformationally-constrained kinked endosomal-disrupting peptides
KR20160147960A (en) 2014-04-25 2016-12-23 아지노모토 가부시키가이샤 Immunostimulating agent
DE102016005550A1 (en) 2016-05-09 2017-11-09 Emc Microcollections Gmbh Adjuvant for the induction of a cellular immune response
WO2019038412A1 (en) 2017-08-24 2019-02-28 Novo Nordisk A/S Glp-1 compositions and uses thereof
AU2021207313A1 (en) 2020-02-18 2022-07-28 Novo Nordisk A/S Pharmaceutical formulations

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0000330B1 (en) * 1977-06-20 1981-08-05 Ciba-Geigy Ag Lipopeptides, process for their preparation and pharmaceutical compositions containing them
US4125569A (en) 1977-08-25 1978-11-14 Mobil Oil Corporation Process for increasing hydrogenation rate of polymerized n-alphaolefins
EP0014815A3 (en) * 1978-12-20 1980-10-29 Ciba-Geigy Ag Peptide derivatives, process for their preparation and intermediates, and pharmaceutical compositions containing one of these compounds
EP0114787B1 (en) * 1983-01-25 1991-09-25 Ciba-Geigy Ag Peptide derivatives

Also Published As

Publication number Publication date
DE3650448D1 (en) 1996-01-25
EP0210412A3 (en) 1990-02-07
PT82826B (en) 1989-01-17
ES8801677A1 (en) 1988-02-16
CA1340656C (en) 1999-07-20
DK172399B1 (en) 1998-05-18
DK294086D0 (en) 1986-06-23
FI862631A0 (en) 1986-06-19
KR930008091B1 (en) 1993-08-25
NO862511D0 (en) 1986-06-23
ATE131491T1 (en) 1995-12-15
FI862631A (en) 1986-12-25
KR870000359A (en) 1987-02-18
NO174207B (en) 1993-12-20
AU5894386A (en) 1987-01-08
FI94419C (en) 1995-09-11
ES556417A0 (en) 1988-02-16
PT82826A (en) 1986-07-01
JPS6263600A (en) 1987-03-20
DK294086A (en) 1986-12-25
AU611385B2 (en) 1991-06-13
NO862511L (en) 1986-12-29
DE3546150A1 (en) 1987-01-22
EP0210412A2 (en) 1987-02-04
JP2594259B2 (en) 1997-03-26
FI94419B (en) 1995-05-31
EP0210412B1 (en) 1995-12-13

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Legal Events

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