NO173783C - Analogifremgangsmaate for fremstilling av terapeutisk aktive, kondenserte heterodykliske derivater av 1,2,3,4-tetrahydroakridiner - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive, kondenserte heterodykliske derivater av 1,2,3,4-tetrahydroakridiner

Info

Publication number: NO173783C
Authority: NO; Norway
Prior art keywords: loweralkyl; hydrogen; heterodyclic; tetrahydroacridines; derivatives
Prior art date: 1988-11-25

Application number

NO894698A

Other languages

English (en)

Norwegian (no)

Other versions

NO173783B (no

NO894698D0 (no

NO894698L (no

Inventor

Gregory M Shutske

Kevin J Kapples

Original Assignee

Hoechst Roussel Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-11-25

Filing date

1989-11-24

Publication date

1994-02-02

1989-11-24 Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma

1989-11-24 Publication of NO894698D0 publication Critical patent/NO894698D0/no

1990-05-28 Publication of NO894698L publication Critical patent/NO894698L/no

1993-10-25 Publication of NO173783B publication Critical patent/NO173783B/no

1994-02-02 Publication of NO173783C publication Critical patent/NO173783C/no

Links

238000000034 method Methods 0.000 title abstract 2
RXBYRTSOWREATF-UHFFFAOYSA-N 1,2,3,4-tetrahydroacridine Chemical class C1=CC=C2C=C(CCCC3)C3=NC2=C1 RXBYRTSOWREATF-UHFFFAOYSA-N 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 2
208000024827 Alzheimer disease Diseases 0.000 abstract 1
101100097467 Arabidopsis thaliana SYD gene Chemical group 0.000 abstract 1
101100495925 Schizosaccharomyces pombe (strain 972 / ATCC 24843) chr3 gene Chemical group 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
230000006949 cholinergic function Effects 0.000 abstract 1
230000003247 decreasing effect Effects 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
230000007074 memory dysfunction Effects 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Hydrogenated Pyridines (AREA)

NO894698A 1988-11-25 1989-11-24 Analogifremgangsmaate for fremstilling av terapeutisk aktive, kondenserte heterodykliske derivater av 1,2,3,4-tetrahydroakridiner NO173783C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/276,259 US4927820A (en)	1988-11-25	1988-11-25	Fused heterocyclic derivatives of 1,2,3,4-tetrahydroacridine

Publications (4)

Publication Number	Publication Date
NO894698D0 NO894698D0 (no)	1989-11-24
NO894698L NO894698L (no)	1990-05-28
NO173783B NO173783B (no)	1993-10-25
NO173783C true NO173783C (no)	1994-02-02

Family

ID=23055896

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO894698A NO173783C (no)	1988-11-25	1989-11-24	Analogifremgangsmaate for fremstilling av terapeutisk aktive, kondenserte heterodykliske derivater av 1,2,3,4-tetrahydroakridiner

Country Status (18)

Country	Link
US (1)	US4927820A (da)
EP (1)	EP0370449B1 (da)
JP (1)	JPH085881B2 (da)
KR (1)	KR0143235B1 (da)
AT (1)	ATE104298T1 (da)
AU (1)	AU623452B2 (da)
CA (1)	CA2003837C (da)
DE (1)	DE68914600T2 (da)
DK (1)	DK592589A (da)
ES (1)	ES2051965T3 (da)
FI (1)	FI90871C (da)
HU (1)	HU203551B (da)
IE (1)	IE63120B1 (da)
IL (1)	IL92420A (da)
NO (1)	NO173783C (da)
NZ (1)	NZ231494A (da)
PT (1)	PT92389B (da)
ZA (1)	ZA898989B (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4920117A (en) *	1989-06-09	1990-04-24	Hoechst-Roussel Pharmaceuticals Inc.	4,5,5a,6-tetrahydro-3H-isoxazolo(5,4,3-kl)acridines, pharmaceutical compositions and use
US4994452A (en) *	1989-11-28	1991-02-19	Hoechst-Roussel Pharmaceuticals Inc.	Hexahydro-1H-quino[4,3,2-ef][1,4]benzoxazepines and related compounds
US5112829A (en) *	1989-11-28	1992-05-12	Hoechst-Roussel Pharmaceuticals Inc.	Hexahydro-1H-quino[4,3,2-ef][1,4]benzoxazepines and related compounds
US5861398A (en) *	1996-08-26	1999-01-19	Alanex Corporation	Benzoperimidine-carboxylic acids and derivatives thereof
JP5406215B2 (ja) *	2008-01-25	2014-02-05	ハイポイントファーマシューティカルズ，リミティドライアビリティカンパニー	ＴＮＦ−α合成の調節因子及びＰＤＥ４阻害剤としての三環系化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4695573A (en) *	1984-10-25	1987-09-22	Hoechst-Roussel Pharmaceuticals Inc.	9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds
DE3582995D1 (de) *	1984-10-25	1991-07-04	Hoechst Roussel Pharma	9-amino-1,2,3,4-tetrahydroacridin-1-ol und verwandte verbindungen, verfahren zu ihrer herstellung und verwendung als arzneimittel.
WO1989002739A1 (en) *	1987-10-05	1989-04-06	Pfizer Inc.	4-aminopyridine derivatives
US4920117A (en) *	1989-06-09	1990-04-24	Hoechst-Roussel Pharmaceuticals Inc.	4,5,5a,6-tetrahydro-3H-isoxazolo(5,4,3-kl)acridines, pharmaceutical compositions and use

1988
- 1988-11-25 US US07/276,259 patent/US4927820A/en not_active Expired - Fee Related
1989
- 1989-11-21 EP EP89121488A patent/EP0370449B1/en not_active Expired - Lifetime
- 1989-11-21 DE DE68914600T patent/DE68914600T2/de not_active Expired - Fee Related
- 1989-11-21 ES ES89121488T patent/ES2051965T3/es not_active Expired - Lifetime
- 1989-11-21 AT AT89121488T patent/ATE104298T1/de not_active IP Right Cessation
- 1989-11-23 PT PT92389A patent/PT92389B/pt not_active IP Right Cessation
- 1989-11-23 NZ NZ231494A patent/NZ231494A/en unknown
- 1989-11-23 FI FI895605A patent/FI90871C/fi not_active IP Right Cessation
- 1989-11-23 IL IL9242089A patent/IL92420A/en not_active IP Right Cessation
- 1989-11-23 KR KR1019890017024A patent/KR0143235B1/ko not_active IP Right Cessation
- 1989-11-24 NO NO894698A patent/NO173783C/no not_active IP Right Cessation
- 1989-11-24 IE IE375889A patent/IE63120B1/en not_active IP Right Cessation
- 1989-11-24 JP JP1303465A patent/JPH085881B2/ja not_active Expired - Fee Related
- 1989-11-24 DK DK592589A patent/DK592589A/da not_active Application Discontinuation
- 1989-11-24 ZA ZA898989A patent/ZA898989B/xx unknown
- 1989-11-24 HU HU896174A patent/HU203551B/hu not_active IP Right Cessation
- 1989-11-24 CA CA002003837A patent/CA2003837C/en not_active Expired - Fee Related
- 1989-11-24 AU AU45480/89A patent/AU623452B2/en not_active Ceased

Also Published As

Publication number	Publication date
IE63120B1 (en)	1995-03-22
AU4548089A (en)	1990-05-31
EP0370449B1 (en)	1994-04-13
KR900007848A (ko)	1990-06-02
KR0143235B1 (ko)	1998-07-15
EP0370449A1 (en)	1990-05-30
JPH085881B2 (ja)	1996-01-24
ZA898989B (en)	1990-08-29
ES2051965T3 (es)	1994-07-01
IE893758L (en)	1990-05-25
FI895605A0 (fi)	1989-11-23
IL92420A (en)	1994-02-27
DK592589D0 (da)	1989-11-24
AU623452B2 (en)	1992-05-14
HU203551B (en)	1991-08-28
IL92420A0 (en)	1990-07-26
NO173783B (no)	1993-10-25
CA2003837C (en)	2000-01-18
FI90871B (fi)	1993-12-31
ATE104298T1 (de)	1994-04-15
US4927820A (en)	1990-05-22
HU896174D0 (en)	1990-02-28
HUT53107A (en)	1990-09-28
PT92389B (pt)	1995-07-18
JPH02193996A (ja)	1990-07-31
DE68914600T2 (de)	1994-09-15
NZ231494A (en)	1992-04-28
DK592589A (da)	1990-05-26
PT92389A (pt)	1990-05-31
CA2003837A1 (en)	1990-05-25
NO894698D0 (no)	1989-11-24
DE68914600D1 (de)	1994-05-19
NO894698L (no)	1990-05-28
FI90871C (fi)	1994-04-11

Legal Events

Date	Code	Title	Description
2001-07-09	MM1K	Lapsed by not paying the annual fees	Free format text: LAPSED IN MAY 2001

Publication	Publication Date	Title
AU589029B2 (en)	1989-09-28	Alpha-alkyl-4-amino-3-quinolinemethanols and 1-(4-aralkylamino-3-quinolinyl) alkanones, a process for their preparation and their use as medicaments
CA2024572A1 (en)	1991-03-06	N-substituted-4-pyrimidinamines and-pyrimidinediamines, a process for their preparation and their use as medicaments
HU9201290D0 (en)	1992-07-28	1-/pirido/3,4-b/-1,4-oxazinyl-4-yl/-1h-indole derivatives, process for their production and for the production of medical preparations containing them as active agents
NO881835L (no)	1988-10-31	Fremgangsmaate for fremstilling av terapeutisk aktive bicykliske forbindelser.
NO173783C (no)	1994-02-02	Analogifremgangsmaate for fremstilling av terapeutisk aktive, kondenserte heterodykliske derivater av 1,2,3,4-tetrahydroakridiner
HU895830D0 (en)	1990-01-28	Process for the preparation of 1,2,3,4-tetrahydro-1,9-acridine-diamines and pharmaceutical compositions containing said compounds
NO175679C (no)	1994-11-16	Analogifremgangsmåte for fremstilling av en terapeutisk aktiv, substituert aminforbindelse
NO179583C (no)	1996-11-06	Analogifremgangsmåte for fremstilling av terapeutisk aktive 1-(pyridinylalkyl)-1H-indoler
AU590748B2 (en)	1989-11-16	Benzo(C)-1,5-naphthyridines, a process and intermediates for their preparation and their use as medicaments
AU619985B2 (en)	1992-02-06	4,5,5a,6-tetrahydro-3h-isoxazolo(5,4,3-kl)acridines derivatives, a process for their preparation and their use as medicaments
NO178372C (no)	1996-03-13	Analogifremgangsmåte for fremstilling av terapeutisk aktive karbamoyl-1-(pyrindinylalkyl)-1H-indoler