NO152935C - Analogifremgangsmaate for fremstilling av anti-inflammatorisk virksomme tioetiansyrederivater. - Google Patents

Analogifremgangsmaate for fremstilling av anti-inflammatorisk virksomme tioetiansyrederivater.

Info

Publication number: NO152935C
Authority: NO; Norway
Prior art keywords: tioetic; inflammatorally; preparation; effective; acid derivatives
Prior art date: 1978-04-05

Application number

NO791140A

Other languages

English (en)

Norwegian (no)

Other versions

NO791140L (no

NO152935B (no

Inventor

John A Edwards

Original Assignee

Syntex Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-04-05

Filing date

1979-04-04

Publication date

1985-12-18

1979-04-04 Application filed by Syntex Inc filed Critical Syntex Inc

1979-10-08 Publication of NO791140L publication Critical patent/NO791140L/no

1985-09-09 Publication of NO152935B publication Critical patent/NO152935B/no

1985-12-18 Publication of NO152935C publication Critical patent/NO152935C/no

Links

239000002253 acid Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NO791140A 1978-04-05 1979-04-04 Analogifremgangsmaate for fremstilling av anti-inflammatorisk virksomme tioetiansyrederivater. NO152935C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US05/893,388 US4188385A (en)	1978-04-05	1978-04-05	Thioetianic acid derivatives

Publications (3)

Publication Number	Publication Date
NO791140L NO791140L (no)	1979-10-08
NO152935B NO152935B (no)	1985-09-09
NO152935C true NO152935C (no)	1985-12-18

Family

ID=25401484

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO791140A NO152935C (no)	1978-04-05	1979-04-04	Analogifremgangsmaate for fremstilling av anti-inflammatorisk virksomme tioetiansyrederivater.

Country Status (28)

Country	Link
US (1)	US4188385A (da)
EP (1)	EP0004741B1 (da)
JP (2)	JPS54141758A (da)
AR (1)	AR226035A1 (da)
AT (1)	AT368168B (da)
AU (1)	AU526025B2 (da)
CA (1)	CA1134345A (da)
CS (1)	CS203956B2 (da)
DE (2)	DE2960096D1 (da)
DK (1)	DK147735C (da)
ES (1)	ES479271A1 (da)
FI (1)	FI66393C (da)
FR (1)	FR2421912A1 (da)
GB (1)	GB2018256B (da)
GR (1)	GR67275B (da)
HK (1)	HK41284A (da)
HU (1)	HU179314B (da)
IL (1)	IL56972A0 (da)
IT (1)	IT1120954B (da)
MY (1)	MY8500575A (da)
NO (1)	NO152935C (da)
NZ (1)	NZ190076A (da)
PL (1)	PL121469B1 (da)
PT (1)	PT69409A (da)
SG (1)	SG6786G (da)
SU (1)	SU1052161A3 (da)
YU (1)	YU40929B (da)
ZA (1)	ZA791635B (da)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4261984A (en) *	1978-04-05	1981-04-14	Syntex (U.S.A.) Inc.	17β-thiocarboxylic acid esters of 3-oxo-4-halo-16β-methylandrost-4-enes
US4263289A (en) *	1978-04-05	1981-04-21	Syntex (U.S.A.) Inc.	Thio etianic acid derivatives
US4310466A (en) *	1979-08-31	1982-01-12	Syntex (U.S.A.) Inc.	Thio etianic acid derivatives
GB2137206B (en) *	1980-02-15	1985-04-03	Glaxo Group Ltd	Androstane 17-carbothioc acid derivatives
CA1201114A (en) *	1980-02-15	1986-02-25	Gordon H. Phillipps	Androstane carbothioates
NL191792C (nl) *	1980-02-15	1996-08-02	Glaxo Group Ltd	Esters van een androstaan-17beta-carbothiozuur, werkwijze ter bereiding van deze esters, en farmaceutische preparaten, die deze esters bevatten.
US4578221A (en) *	1980-04-23	1986-03-25	Glaxo Group Limited	Androstane carbothioic acids
SE449106B (sv) *	1980-07-10	1987-04-06	Otsuka Pharma Co Ltd	Steroid med anti-inflammatorisk verkan samt komposition innehallande denna
IL78144A0 (en) *	1985-04-04	1986-07-31	Draco Ab	Novel androstane-17beta-carboxylic acid esters
GB9225923D0 (en) *	1992-12-11	1993-02-03	Rhone Poulenc Rorer Ltd	New compositions of matter
CZ159195A3 (en) *	1992-12-24	1996-03-13	Rhone Poulenc Rorer Ltd	Novel steroids, process of their preparation and pharmaceutical compositions containing thereof
BR9612309A (pt) *	1995-12-29	1999-07-13	Glaxo Group Ltd	Composto uso de um composto composição farmacêutica formulação farmacêutica de aerossol combinação e processos para o tratamento de um indivíduo humano ou animal com uma condição anti-inflamatória e/ou alérgica e para a preparação de um composto
US5981517A (en) *	1996-05-09	1999-11-09	Soft Drugs, Inc.	Androstene derivatives
US20020133032A1 (en) *	2000-02-25	2002-09-19	Jufang Barkalow	Method for the preparation of fluticasone and related 17beta-carbothioic esters using a novel carbothioic acid synthesis and novel purification methods
GB0017988D0 (en) *	2000-07-21	2000-09-13	Glaxo Group Ltd	Novel process
US6777399B2 (en) *	2000-08-05	2004-08-17	Smithkline Beecham Corporation	Anti-inflammatory androstane derivative compositions
US6787532B2 (en) *	2000-08-05	2004-09-07	Smithkline Beecham Corporation	Formulation containing anti-inflammatory androstane derivatives
US6750210B2 (en) *	2000-08-05	2004-06-15	Smithkline Beecham Corporation	Formulation containing novel anti-inflammatory androstane derivative
AR032471A1 (es) *	2000-08-05	2003-11-12	Glaxo Group Ltd	Derivado de androstano y solvatos del mismo, su uso para la fabricacion de medicamentos, composiciones farmaceuticas que los comprenden, procesos para preparar tales derivados, intermediarios utiles en la preparacion de tales derivados, procesos para preparar tales intermediarios, y compuestos inter
US6777400B2 (en) *	2000-08-05	2004-08-17	Smithkline Beecham Corporation	Anti-inflammatory androstane derivative compositions
GB0019172D0 (en) *	2000-08-05	2000-09-27	Glaxo Group Ltd	Novel compounds
US6759398B2 (en)	2000-08-05	2004-07-06	Smithkline Beecham Corporation	Anti-inflammatory androstane derivative
US6858593B2 (en) *	2000-08-05	2005-02-22	Smithkline Beecham Corporation	Anti-inflammatory androstane derivative compositions
US6858596B2 (en) *	2000-08-05	2005-02-22	Smithkline Beecham Corporation	Formulation containing anti-inflammatory androstane derivative
UA77656C2 (en) *	2001-04-07	2007-01-15	Glaxo Group Ltd	S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
CA2445839A1 (en) *	2001-04-30	2002-11-07	Glaxo Group Limited	Anti-inflammatory 17.beta.-carbothioate ester derivatives of androstane with a cyclic ester group in position 17.alpha
US20040248867A1 (en) *	2001-06-12	2004-12-09	Keith Biggadike	Novel anti-inflammatory 17.alpha.-heterocyclic-esters of 17.beta.carbothioate androstane derivatives
US20050175545A1 (en) *	2002-02-04	2005-08-11	Keith Biggadike	Formulation for inhalation comprising a glucocorticoid and a beta 2-adrenoreceptor agonist
GB0202635D0 (en) *	2002-02-05	2002-03-20	Glaxo Wellcome Mfg Pte Ltd	Formulation containing novel anti-inflammatory androstane derivative
GB2389530B (en) *	2002-06-14	2007-01-10	Cipla Ltd	Pharmaceutical compositions
IL150654A (en)	2002-07-09	2006-12-10	Ori Lerman	Method for acid isolation 6α, 9α - difluoro - ß, 17α11 - dihydroxy - 16α - methylfargana - 3 - oxo - 1, 4 - diene - 17ß - carboxylate
WO2004087731A1 (en) *	2003-04-04	2004-10-14	Alpharma Aps	Process for the preparation of steroidal carbothioic acid derivatives and intermediates
GB0507165D0 (en) *	2005-04-08	2005-05-18	Glaxo Group Ltd	Novel crystalline pharmaceutical product
TWI374147B (en) *	2006-01-27	2012-10-11	Sun Pharma Advance Res Company Ltd	Novel 11β-hydroxyandrosta-4-ene-3-ones
GB0615108D0 (en) *	2006-07-28	2006-09-06	Glaxo Group Ltd	Novel formulations
WO2009085879A2 (en) *	2007-12-21	2009-07-09	Schering Corporation	C20-c21 substituted glucocorticoid receptor agonists
JP2012530140A (ja)	2009-06-16	2012-11-29	メルク・シャープ・アンド・ドーム・コーポレーション	グルココルチコイド受容体アゴニストとしての新規［３，２−ｃ］ヘテロアリールステロイド、組成物およびこの使用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2509171A (en) *	1946-02-06	1950-05-23	Ciba Ltd	Primary alcohols from thiocarboxylic acids and esters
US3636010A (en) *	1968-12-23	1972-01-18	Ciba Geigy Corp	Esters of steroid-17-carboxylic acids
US3989686A (en) *	1972-06-15	1976-11-02	Glaxo Laboratories Limited	Anaesthetic steroids of the androstane series and process for preparing same
GB1438940A (en) *	1972-07-19	1976-06-09	Glaxo Lab Ltd	17beta-haloalkoxycarbonyl-17alpha-oxysteroids
CH628355A5 (de) *	1976-02-24	1982-02-26	Ciba Geigy Ag	Verfahren zur herstellung neuer androstadien-17beta-carbonsaeuren und ihrer ester und salze.

1978
- 1978-04-05 US US05/893,388 patent/US4188385A/en not_active Expired - Lifetime
1979
- 1979-03-28 DE DE7979300500T patent/DE2960096D1/de not_active Expired
- 1979-03-28 FR FR7907823A patent/FR2421912A1/fr active Granted
- 1979-03-28 DE DE19792912331 patent/DE2912331A1/de not_active Ceased
- 1979-03-28 IT IT67652/79A patent/IT1120954B/it active
- 1979-03-28 EP EP79300500A patent/EP0004741B1/en not_active Expired
- 1979-03-28 GB GB7910862A patent/GB2018256B/en not_active Expired
- 1979-03-29 CS CS792107A patent/CS203956B2/cs unknown
- 1979-03-29 IL IL56972A patent/IL56972A0/xx not_active IP Right Cessation
- 1979-03-29 AU AU45583/79A patent/AU526025B2/en not_active Ceased
- 1979-03-30 PT PT69409A patent/PT69409A/pt unknown
- 1979-03-30 AR AR276014A patent/AR226035A1/es active
- 1979-03-30 CA CA000324557A patent/CA1134345A/en not_active Expired
- 1979-03-31 GR GR58748A patent/GR67275B/el unknown
- 1979-04-02 NZ NZ190076A patent/NZ190076A/en unknown
- 1979-04-02 FI FI791081A patent/FI66393C/fi not_active IP Right Cessation
- 1979-04-03 DK DK136579A patent/DK147735C/da not_active IP Right Cessation
- 1979-04-03 HU HU79SI1682A patent/HU179314B/hu not_active IP Right Cessation
- 1979-04-04 NO NO791140A patent/NO152935C/no unknown
- 1979-04-04 PL PL1979214676A patent/PL121469B1/pl unknown
- 1979-04-04 AT AT0251979A patent/AT368168B/de not_active IP Right Cessation
- 1979-04-04 SU SU792787402A patent/SU1052161A3/ru active
- 1979-04-04 YU YU803/79A patent/YU40929B/xx unknown
- 1979-04-04 ES ES479271A patent/ES479271A1/es not_active Expired
- 1979-04-05 ZA ZA791635A patent/ZA791635B/xx unknown
- 1979-04-05 JP JP4041479A patent/JPS54141758A/ja active Granted
1984
- 1984-05-10 HK HK412/80A patent/HK41284A/xx unknown
- 1984-07-27 JP JP59155726A patent/JPS6069019A/ja active Granted
1985
- 1985-12-30 MY MY575/85A patent/MY8500575A/xx unknown
1986
- 1986-01-22 SG SG67/86A patent/SG6786G/en unknown

Also Published As

Publication number	Publication date
MY8500575A (en)	1985-12-31
DK136579A (da)	1979-10-06
GB2018256A (en)	1979-10-17
IT1120954B (it)	1986-03-26
JPS54141758A (en)	1979-11-05
NO791140L (no)	1979-10-08
JPS6140648B2 (da)	1986-09-10
US4188385A (en)	1980-02-12
NZ190076A (en)	1984-07-31
HK41284A (en)	1984-05-18
PT69409A (en)	1979-04-01
YU80379A (en)	1983-04-30
SG6786G (en)	1986-08-01
DK147735B (da)	1984-11-26
EP0004741A3 (en)	1979-11-14
FI66393C (fi)	1984-10-10
FI66393B (fi)	1984-06-29
GB2018256B (en)	1983-02-02
CS203956B2 (en)	1981-03-31
DE2960096D1 (en)	1981-03-19
EP0004741B1 (en)	1981-01-28
CA1134345A (en)	1982-10-26
JPS6069019A (ja)	1985-04-19
JPS611038B2 (da)	1986-01-13
EP0004741A2 (en)	1979-10-17
IL56972A0 (en)	1979-05-31
ATA251979A (de)	1982-01-15
AT368168B (de)	1982-09-27
AR226035A1 (es)	1982-05-31
FR2421912B1 (da)	1981-03-20
AU526025B2 (en)	1982-12-16
YU40929B (en)	1986-08-31
FR2421912A1 (fr)	1979-11-02
ZA791635B (en)	1980-11-26
IT7967652A0 (it)	1979-03-28
NO152935B (no)	1985-09-09
FI791081A (fi)	1979-10-06
HU179314B (en)	1982-09-28
PL214676A1 (da)	1980-01-02
DK147735C (da)	1985-08-19
PL121469B1 (en)	1982-05-31
DE2912331A1 (de)	1979-10-18
AU4558379A (en)	1979-10-18
GR67275B (da)	1981-06-26
SU1052161A3 (ru)	1983-10-30
ES479271A1 (es)	1980-01-16

Publication	Publication Date	Title
NO152935C (no)	1985-12-18	Analogifremgangsmaate for fremstilling av anti-inflammatorisk virksomme tioetiansyrederivater.
NO790358L (no)	1979-08-07	Fremgangsmaate for fremstilling av alkylendiaminderivater
NO164712C (no)	1990-11-07	Analogifremgangsmaate til fremstilling av metylendifosfonsyre-derivater.
NO153177C (no)	1986-01-29	Analogifremgangsmaate for fremstilling av farmakologisk aktive tetrazolylalkoksy-karbostyrilderivater.
NO156611C (no)	1987-10-21	Analogifremgangsmaate for fremstilling av terapeutiske virksomme derivater av hydroksykarbonylfosfonsyre.
NO159531C (no)	1989-01-11	Analogifremgangsmaate for fremstilling av farmasoeytisk aktive karbostyrilderivater.
NO803470L (no)	1981-07-02	Fremgangsmaate for fremstilling av 7-acylamino-3-vinylcefalosporansyrederivater.
NO791831L (no)	1979-12-04	Fremgangsmaate for fremstilling av aminotiazoler
NO154522C (no)	1986-10-08	Analogifremgangsmaate for fremstilling av terapeutisk virksomme kinolinderivater.
SE8001747L (sv)	1980-03-05	Forfarande for framstellning av 1-fluorerade vitamin d-foreningar
NO153569C (no)	1986-05-21	Analogifremgangsmaate for fremstilling av terapeutisk aktive merkaptoacetyl-prolin-derivater.
NO792404L (no)	1980-01-29	Fremgangsmaate for fremstilling av imidazolderivater
DK149773C (da)	1987-03-23	Analogifremgangsmaade til fremstilling af 3-quinolincarboxylsyrederivater
NO150155C (no)	1984-08-29	Fremgangsmaate for fremstilling av 2-pyrrolidon-forbindelser
NO150799C (no)	1984-12-27	Fremgangsmaate for fremstilling av lysergol-derivater
NO147716C (no)	1983-06-01	Analogifremgangsmaate for fremstilling av antibakterielle erytromycylaminderivater.
FI793367A (fi)	1980-05-04	Foerfarande foer framstaellning av 1,2,3-tiadiazol-5-yl-urinaemnen
NO153853C (no)	1986-06-11	Fremgangsmaate for fremstilling av 17beta-hydroksy-17alfa-pregn-5-en-21-karboksylsyre-gamma-laktoner.
NO151660C (no)	1985-05-15	Analogifremgangsmaate til fremstilling av terapeutisk aktive imidazolderivater.
FI793307A (fi)	1980-04-28	Foerfarande foer framstaellning av 6-piperidino-2,4-diaminopyrimidin-3-oxid
NO791458L (no)	1979-11-05	Fremgangsmaate til fremstilling av 1,2-dikloretan
NO152840C (no)	1985-11-27	Fremgangsmaate for fremstilling av dibenzyletere.
NO147310C (no)	1983-03-16	Fremgangsmaate for fremstilling av substituerte antitumorantracykliner
NO155009C (no)	1987-01-28	Fremgangsmaate for fremstilling av natriumamoxicillin.
NO790328L (no)	1979-08-03	Fremgangsmaate ved fremstilling av derivater av nafthyl-1-eddiksyre.