NO149733C - Analogifremgangsmaate ved fremstilling av nye, terapeutisk aktive acylderivater av carnitin - Google Patents

Analogifremgangsmaate ved fremstilling av nye, terapeutisk aktive acylderivater av carnitin

Info

Publication number
NO149733C
NO149733C NO792137A NO792137A NO149733C NO 149733 C NO149733 C NO 149733C NO 792137 A NO792137 A NO 792137A NO 792137 A NO792137 A NO 792137A NO 149733 C NO149733 C NO 149733C
Authority
NO
Norway
Prior art keywords
acyld
carnitin
derivatives
preparation
new
Prior art date
Application number
NO792137A
Other languages
English (en)
Other versions
NO792137L (no
NO149733B (no
Inventor
Paolo De Witt
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of NO792137L publication Critical patent/NO792137L/no
Publication of NO149733B publication Critical patent/NO149733B/no
Publication of NO149733C publication Critical patent/NO149733C/no

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/01Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/12Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00Thiocarboxylic acids
    • C07C327/20Esters of monothiocarboxylic acids
    • C07C327/32Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C07C327/34Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups with amino groups bound to the same hydrocarbon radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO792137A 1978-06-27 1979-06-26 Analogifremgangsmaate ved fremstilling av nye, terapeutisk aktive acylderivater av carnitin NO149733C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT50065/78A IT1156840B (it) 1978-06-27 1978-06-27 Acil derivati della carnitina

Publications (3)

Publication Number Publication Date
NO792137L NO792137L (no) 1979-12-28
NO149733B NO149733B (no) 1984-03-05
NO149733C true NO149733C (no) 1984-06-13

Family

ID=11272207

Family Applications (1)

Application Number Title Priority Date Filing Date
NO792137A NO149733C (no) 1978-06-27 1979-06-26 Analogifremgangsmaate ved fremstilling av nye, terapeutisk aktive acylderivater av carnitin

Country Status (20)

Country Link
US (1) US4401827A (no)
JP (1) JPS5543065A (no)
AT (1) AT375335B (no)
AU (1) AU526995B2 (no)
BE (1) BE877310A (no)
CA (1) CA1145765A (no)
CH (1) CH640824A5 (no)
DE (1) DE2925945A1 (no)
DK (1) DK148300C (no)
ES (1) ES482097A1 (no)
FR (1) FR2429776A1 (no)
GB (1) GB2028826B (no)
GR (1) GR67648B (no)
IE (1) IE48652B1 (no)
IL (1) IL57662A (no)
IT (1) IT1156840B (no)
LU (1) LU81428A1 (no)
NL (1) NL7905015A (no)
NO (1) NO149733C (no)
SE (1) SE446334B (no)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1145362B (it) * 1980-03-06 1986-11-05 Sigma Tau Ind Farmaceuti Classe di acil-derivati della carnitina procedimento per la loro preparazione e loro uso terapeutico
IT1145371B (it) * 1980-05-30 1986-11-05 Sigma Tau Ind Farmaceuti Alcossi-acil carnitine procedimento per la loro preparazione e composizioni farmaceutiche che le contengono
IT1147079B (it) * 1980-05-30 1986-11-19 Sigma Tau Ind Farmacuetiche Ri Esteri di alcossi-acil derivati della carnitina procedimento per la loro preparatione e composizioni farmaceutiche che li contengono
IT1170862B (it) * 1981-03-31 1987-06-03 Sigma Tau Ind Farmaceuti Mercaptoacil-carnitine procedimento per la loro preparazione e loro uso terapeutico
IT8322185V0 (it) * 1983-06-22 1983-06-22 Victor Wassilieff Dispositivo di chiusura per contenitori di fluidi.
IT1209564B (it) * 1984-06-29 1989-08-30 Magis Farmaceutici Derivati della l-carnitina o di l-acil carnitina.
US4742081A (en) * 1986-01-06 1988-05-03 Alfred Stracher Carnitine coupled pharmaceutical agents
US4866040A (en) * 1986-01-06 1989-09-12 Alfred Stracher Aminocarnitine directed pharmaceutical agents
US5008288A (en) * 1986-01-06 1991-04-16 Alfred Stracher Carnitine directed pharmaceutical agents
IT1208753B (it) * 1986-07-02 1989-07-10 Sigma Tau Ind Farmaceuti L-amminoacil derivati della l-carnitina, procedimento per la loro preparazione e composizioni farmaceutiche ad attivita' epatoprotettrice che li contengono
JPH0662521B2 (ja) * 1988-02-24 1994-08-17 日東紡績株式会社 新規コリン誘導体及びそれを用いた血清コリンエステラーゼ活性測定法
IT1240790B (it) * 1990-03-06 1993-12-17 Sigma Tau Ind Farmaceuti Alfa-ammino-omega-alchiltioacilcarnitine e composizioni farmaceutiche contenenti tali composti ad attivita' sul sistema cardiovascolare.
CH679856A5 (no) * 1990-07-04 1992-04-30 Lonza Ag
US20040034091A1 (en) * 1991-01-29 2004-02-19 Sigma Tau Industrie Farmaceutiche Riunite S.P.A. Derivative of dicarboxylic acids having six to twelve carbon atoms and use of these derivatives and dicarboxylic acids alone in the preparation of pharmaceutical compositions for enteral and parenteral nutrition
IT1261688B (it) * 1993-05-28 1996-05-29 Avantgarde Spa Uso di esteri sull'ossidrile della l-carnitina per produrre composizioni farmaceutiche per il trattamento di affezioni cutanee.
IT1274156B (it) * 1994-09-08 1997-07-15 Avantgarde Spa "sale della l-carnitina e composizioni farmaceutiche che lo contengonoper il trattamento di affezioni cutanee"
US6417231B1 (en) 1996-12-23 2002-07-09 Frank L. Greenway Method and composition for delivering therapeutically effective amounts of pyruvate to a mammal
AU7828200A (en) 1999-09-23 2001-04-24 Juvenon Corporation Nutritional supplement for increased energy and stamina
US6562869B1 (en) 1999-09-23 2003-05-13 Juvenon, Inc. Nutritional supplement for increased energy and stamina
WO2001032168A1 (en) 1999-11-03 2001-05-10 Juvenon, Inc. Method of treating benign forgetfulness
DE10133200A1 (de) * 2001-07-07 2003-01-23 Beiersdorf Ag Carnitin enthaltende kosmetische und dermatologische Zubereitungen zur Behandlung und aktiven Prävention trockener Haut und anderer negativer Veränderungen der physiologischen Homöostase der gesunden Haut
US7842726B2 (en) 2005-09-30 2010-11-30 Showa Denko K.K. Carnitine derivative, salt thereof, external skin preparation and cosmetic material
JP5047507B2 (ja) * 2005-09-30 2012-10-10 昭和電工株式会社 カルニチン誘導体及びその塩、皮膚外用剤ならびに化粧料
JP6473352B2 (ja) * 2015-03-10 2019-02-20 利幸 糸井 虚血性疾患治療薬

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE277963C (no) *
DE719891C (de) * 1938-12-08 1942-04-21 Dr Erich Strack Verfahren zur Herstellung des Methyl- bzw. AEthylesters des acetylierten Carnitins
FR1108125A (fr) * 1953-05-08 1956-01-09 Laboratoires Labaz Soc D Procédé de préparation d'un dérivé stable de la carnitine
BE700864A (no) * 1967-07-03 1967-12-18
US3624887A (en) * 1970-03-02 1971-12-07 Bunker Ramo Pin and socket removal tool
JPS531812B2 (no) * 1972-12-07 1978-01-23
AU518617B2 (en) * 1977-04-29 1981-10-08 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Therapeutic application of acetyl-d, 1-carnitine

Also Published As

Publication number Publication date
NO792137L (no) 1979-12-28
IE791235L (en) 1979-12-27
CA1145765A (en) 1983-05-03
JPH0211579B2 (no) 1990-03-14
AU526995B2 (en) 1983-02-10
SE7905593L (sv) 1979-12-28
LU81428A1 (fr) 1979-09-12
ES482097A1 (es) 1980-08-01
IL57662A0 (en) 1979-10-31
DK148300C (da) 1985-11-11
GB2028826A (en) 1980-03-12
CH640824A5 (it) 1984-01-31
DK270079A (da) 1979-12-28
FR2429776A1 (fr) 1980-01-25
ATA449679A (de) 1983-12-15
DE2925945C2 (no) 1991-06-27
JPS5543065A (en) 1980-03-26
IL57662A (en) 1983-12-30
DK148300B (da) 1985-06-03
US4401827A (en) 1983-08-30
FR2429776B1 (no) 1982-11-12
AT375335B (de) 1984-07-25
NO149733B (no) 1984-03-05
SE446334B (sv) 1986-09-01
IE48652B1 (en) 1985-04-03
BE877310A (fr) 1979-10-15
GB2028826B (en) 1982-11-03
NL7905015A (nl) 1980-01-02
GR67648B (no) 1981-09-01
IT7850065A0 (it) 1978-06-27
AU4838479A (en) 1980-01-03
IT1156840B (it) 1987-02-04
DE2925945A1 (de) 1980-01-10

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