NO144138B - APPARATUS FOR THE CONVERSION OF A PREPARABLE MATERIAL TO FIBER - Google Patents
APPARATUS FOR THE CONVERSION OF A PREPARABLE MATERIAL TO FIBER Download PDFInfo
- Publication number
- NO144138B NO144138B NO792844A NO792844A NO144138B NO 144138 B NO144138 B NO 144138B NO 792844 A NO792844 A NO 792844A NO 792844 A NO792844 A NO 792844A NO 144138 B NO144138 B NO 144138B
- Authority
- NO
- Norway
- Prior art keywords
- preparable
- fiber
- conversion
- oxides
- formula
- Prior art date
Links
- 238000006243 chemical reaction Methods 0.000 title 1
- 239000000463 material Substances 0.000 title 1
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 230000003647 oxidation Effects 0.000 claims description 3
- 238000007254 oxidation reaction Methods 0.000 claims description 3
- 125000000217 alkyl group Chemical group 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- KPIIGXWUNXGGCP-UHFFFAOYSA-N pyridine-4-carbothioamide Chemical compound NC(=S)C1=CC=NC=C1 KPIIGXWUNXGGCP-UHFFFAOYSA-N 0.000 claims description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000007800 oxidant agent Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000013543 active substance Substances 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- RCCPEORTSYDPMB-UHFFFAOYSA-N hydroxy benzenecarboximidothioate Chemical compound OSC(=N)C1=CC=CC=C1 RCCPEORTSYDPMB-UHFFFAOYSA-N 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 150000003556 thioamides Chemical class 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
- G01N33/539—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody involving precipitating reagent, e.g. ammonium sulfate
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03B—MANUFACTURE, SHAPING, OR SUPPLEMENTARY PROCESSES
- C03B37/00—Manufacture or treatment of flakes, fibres, or filaments from softened glass, minerals, or slags
- C03B37/01—Manufacture of glass fibres or filaments
- C03B37/06—Manufacture of glass fibres or filaments by blasting or blowing molten glass, e.g. for making staple fibres
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- General Physics & Mathematics (AREA)
- Manufacturing & Machinery (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- General Life Sciences & Earth Sciences (AREA)
- Geochemistry & Mineralogy (AREA)
- Microbiology (AREA)
- Materials Engineering (AREA)
- Organic Chemistry (AREA)
- Nonwoven Fabrics (AREA)
- Spinning Methods And Devices For Manufacturing Artificial Fibers (AREA)
- Manufacture, Treatment Of Glass Fibers (AREA)
- Reinforced Plastic Materials (AREA)
- Moulding By Coating Moulds (AREA)
- Preliminary Treatment Of Fibers (AREA)
- Yarns And Mechanical Finishing Of Yarns Or Ropes (AREA)
- Inorganic Fibers (AREA)
- Glass Compositions (AREA)
- Surface Treatment Of Glass Fibres Or Filaments (AREA)
- Glass Melting And Manufacturing (AREA)
- Laminated Bodies (AREA)
Description
Fremgangsmåte for fremstilling av tuberkulostatisk aktive S-oksyder av "-alkylisothionikotinamider. Process for the production of tuberculostatically active S-oxides of "-alkylisothionicotinamides.
Nærværende oppfinnelse vedrører en fremgangsmåte for fremstilling av hittil ukjente tuberkulostatisk aktive S-oksyder av visse a-alkylisothionikotinamider. The present invention relates to a process for the production of hitherto unknown tuberculostatically active S-oxides of certain α-alkylisothionicotinamides.
Ifølge nærværende oppfinnelse frem-stilles hittil ukjente S-oksyder av a alkylisothionikotinamider med den generelle formel: hvor R betyr en alkylgruppe med tre til fem carbonatomer, ved en fremgangsmåte som består i å oksydere ved hjelp av hydrogenperoksyd et isothionikotinamid med formelen: According to the present invention, hitherto unknown S-oxides are produced from a alkylisothionicotinamides with the general formula: where R means an alkyl group with three to five carbon atoms, by a method which consists in oxidizing with the aid of hydrogen peroxide an isothionicotinamide with the formula:
hvor R er som foran definert. Oksydasjo-nen utføres i et inert organisk eller vandig organisk medium, f. eks. ethanol for-tynnet med vann, fortrinnsvis ved en temperatur under 50° C. where R is as defined above. The oxidation is carried out in an inert organic or aqueous organic medium, e.g. ethanol diluted with water, preferably at a temperature below 50°C.
S-oksyder av a-alkylisothionikitinami-der oppnådd ved fremgangsmåten etter oppfinnelsen er i besiddelse av en tuber-(144138). S-oxides of α-alkylisothionikitinamides obtained by the method according to the invention possess a tuber-(144138).
kulostatisk aktivitet liknende den for de tilsvarende ikke oksyderte forbindelser med formel II og har god gastrisk toleranse. coulostatic activity similar to that of the corresponding non-oxidized compounds of formula II and has good gastric tolerance.
For anvendelse ved behandlingen av tuberkulose kan forbindelsene med den generelle formel I forenes med en farmasøy-tisk bærer, og blandingene fremstilt på i og for seg kjent måte til faste former er egnet for oral administrasjon, slik som granuler eller tabletter eller som suppositorer. I hu-manterapi skal slike blandinger vanligvis administreres slik at de gir et voksent in-divid 0,25 til 1 g aktivt stoff (fortrinnsvis i flere mindre mengder) pr. dag. For use in the treatment of tuberculosis, the compounds of the general formula I can be combined with a pharmaceutical carrier, and the mixtures prepared in a manner known per se into solid forms are suitable for oral administration, such as granules or tablets or as suppositories. In human therapy, such mixtures should usually be administered so that they give an adult individual 0.25 to 1 g of active substance (preferably in several smaller amounts) per day.
De følgende eksempler illustrerer oppfinnelsen. The following examples illustrate the invention.
Eksempel 1. Example 1.
Hydrogenperoksydoppløsning (110 vol. Hydrogen peroxide solution (110 vol.
20 cc) tilsettes i løpet av 20 minutter, uten 20 cc) is added within 20 minutes, without
at temperaturen overskrider 30 °C til en suspensjon av 2-n-propyl-isothionikotinamid (30 g) i absolutt alkohol (318 cc) og vann (17 cc). Etter omrøring i 5 timer er oppløsning praktisk talt komplett og tre-kull (2 g) tilsettes for å spalte det over-skytende hydrogenperoksyd. Et rått produkt (31,1 g) oppnås, etter filtrering og konsentrering under et trykk på 0,1 mm Hg ved en temperatur under 55°C. Ved å rive dette produkt i isopropanol, oppnås 2-n-propyl-isothionikotinamid-S-oksyd (4,45 g), s.p. 117—118°C. that the temperature exceeds 30 °C to a suspension of 2-n-propylisothionicotinamide (30 g) in absolute alcohol (318 cc) and water (17 cc). After stirring for 5 hours, dissolution is practically complete and charcoal (2 g) is added to decompose the excess hydrogen peroxide. A crude product (31.1 g) is obtained, after filtration and concentration under a pressure of 0.1 mm Hg at a temperature below 55°C. Trituring this product in isopropanol gives 2-n-propylisothionicotinamide S-oxide (4.45 g), m.p. 117-118°C.
Ved å gå frem under de samme betin-gelser som dem beskrevet i eksempel 1 og By proceeding under the same conditions as those described in example 1 and
ved å begynne med 2-n-butyl-isothionikotinamid (30 g) oppnås et rått voksliknen-de produkt (33 g), s.p. ca. 75°C. Ved om-krystallisasjon fra ethylacetat oppnås 2-n-butyl-isothionikotinamid-S-oksyd som først starting with 2-n-butylisothionicotinamide (30 g) a crude wax-like product (33 g) is obtained, m.p. about. 75°C. By recrystallization from ethyl acetate, 2-n-butyl-isothionicotinamide-S-oxide is obtained which first
mykner ved 82—84°C, fulgt av størkning og softens at 82—84°C, followed by solidification and
en annen fullstendig smeltning ved 93—94°another complete melting at 93—94°
C. C.
Fremgangsmåte for fremstilling av S-oksyder av a-alkylisothionikotinamider Process for the production of S-oxides of α-alkylisothionicotinamides
overensstemmende med formel I er også consistent with formula I is also
beskrevet i patent nr. 104 677, men fremgangsmåten etter dette er begrenset til described in patent no. 104 677, but the method according to this is limited to
bruken av uorganiske persalter som oksydasjonsmidler, for utgangsmateriale overensstemmende med formel II, reagenser the use of inorganic persalts as oxidizing agents, for starting material conforming to formula II, reagents
som hittil ikke har vært beskrevet som which has not hitherto been described as
oksydasjonsmidler for thioamider. oxidizing agents for thioamides.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7504970A FR2384723A1 (en) | 1975-02-18 | 1975-02-18 | METHOD AND DEVICES FOR THE MANUFACTURING OF FIBERS FROM THERMOPLASTIC MATERIALS, SUCH AS GLASS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO792844L NO792844L (en) | 1976-08-19 |
| NO144138B true NO144138B (en) | 1981-03-23 |
| NO144138C NO144138C (en) | 1982-12-06 |
Family
ID=9151346
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO760518A NO142168C (en) | 1975-02-18 | 1976-02-17 | APPARATUS FOR THE CONVERSION OF A MELTABLE FIBER MATERIAL TO FIBER. |
| NO792844A NO144138C (en) | 1975-02-18 | 1979-09-03 | APPARATUS FOR THE CONVERSION OF A PREPARABLE MATERIAL TO FIBER |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO760518A NO142168C (en) | 1975-02-18 | 1976-02-17 | APPARATUS FOR THE CONVERSION OF A MELTABLE FIBER MATERIAL TO FIBER. |
Country Status (34)
| Country | Link |
|---|---|
| JP (1) | JPS51105420A (en) |
| AR (1) | AR210752A1 (en) |
| AT (1) | AT367381B (en) |
| AU (1) | AU503308B2 (en) |
| BE (1) | BE838652A (en) |
| BR (1) | BR7600978A (en) |
| CA (1) | CA1075863A (en) |
| CH (1) | CH614686A5 (en) |
| CS (1) | CS209485B2 (en) |
| DD (1) | DD122813A5 (en) |
| DE (1) | DE2606300C2 (en) |
| DK (1) | DK64576A (en) |
| EG (1) | EG11994A (en) |
| ES (1) | ES445155A1 (en) |
| FI (1) | FI59579C (en) |
| FR (1) | FR2384723A1 (en) |
| GB (1) | GB1521343A (en) |
| HU (1) | HU176868B (en) |
| IE (1) | IE43347B1 (en) |
| IL (1) | IL49052A (en) |
| IN (1) | IN144822B (en) |
| IT (1) | IT1055883B (en) |
| LU (1) | LU74363A1 (en) |
| NL (1) | NL7601316A (en) |
| NO (2) | NO142168C (en) |
| NZ (1) | NZ180023A (en) |
| OA (1) | OA05246A (en) |
| PL (1) | PL112503B1 (en) |
| PT (1) | PT64809B (en) |
| RO (1) | RO76342A (en) |
| SE (1) | SE419079B (en) |
| TR (1) | TR19173A (en) |
| YU (1) | YU40076A (en) |
| ZA (1) | ZA76922B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2849357A1 (en) * | 1978-11-14 | 1980-05-29 | Saint Gobain | METHOD AND DEVICE FOR INFLUENCING THE PROPERTIES OF FIBERS IN THE PRODUCTION OF FIBERS FROM THERMOPLASTIC MATERIAL |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2223318B1 (en) * | 1973-03-30 | 1978-03-03 | Saint Gobain |
-
1975
- 1975-02-18 FR FR7504970A patent/FR2384723A1/en active Granted
-
1976
- 1976-02-05 GB GB4585/76A patent/GB1521343A/en not_active Expired
- 1976-02-09 IE IE259/76A patent/IE43347B1/en unknown
- 1976-02-10 NL NL7601316A patent/NL7601316A/en not_active Application Discontinuation
- 1976-02-11 CA CA245,501A patent/CA1075863A/en not_active Expired
- 1976-02-11 AT AT0096576A patent/AT367381B/en not_active IP Right Cessation
- 1976-02-11 AR AR262209A patent/AR210752A1/en active
- 1976-02-11 SE SE7601533A patent/SE419079B/en unknown
- 1976-02-12 JP JP51013321A patent/JPS51105420A/ja active Pending
- 1976-02-13 OA OA55740A patent/OA05246A/en unknown
- 1976-02-13 ES ES445155A patent/ES445155A1/en not_active Expired
- 1976-02-16 CS CS76997A patent/CS209485B2/en unknown
- 1976-02-16 PL PL1976187254A patent/PL112503B1/en unknown
- 1976-02-16 NZ NZ180023A patent/NZ180023A/en unknown
- 1976-02-17 LU LU74363A patent/LU74363A1/xx unknown
- 1976-02-17 DK DK64576*#A patent/DK64576A/en unknown
- 1976-02-17 FI FI760383A patent/FI59579C/en not_active IP Right Cessation
- 1976-02-17 IN IN280/CAL/1976A patent/IN144822B/en unknown
- 1976-02-17 ZA ZA922A patent/ZA76922B/en unknown
- 1976-02-17 NO NO760518A patent/NO142168C/en unknown
- 1976-02-17 DE DE2606300A patent/DE2606300C2/en not_active Expired
- 1976-02-17 AU AU11153/76A patent/AU503308B2/en not_active Expired
- 1976-02-17 HU HU76SA2887A patent/HU176868B/en unknown
- 1976-02-17 PT PT64809A patent/PT64809B/en unknown
- 1976-02-17 DD DD191274A patent/DD122813A5/xx unknown
- 1976-02-17 RO RO7684835A patent/RO76342A/en unknown
- 1976-02-17 CH CH194576A patent/CH614686A5/en not_active IP Right Cessation
- 1976-02-17 BR BR7600978A patent/BR7600978A/en unknown
- 1976-02-17 IL IL49052A patent/IL49052A/en unknown
- 1976-02-17 TR TR19173A patent/TR19173A/en unknown
- 1976-02-17 IT IT20240/76A patent/IT1055883B/en active
- 1976-02-17 BE BE164397A patent/BE838652A/en not_active IP Right Cessation
- 1976-02-18 YU YU00400/76A patent/YU40076A/en unknown
- 1976-02-18 EG EG95/76A patent/EG11994A/en active
-
1979
- 1979-09-03 NO NO792844A patent/NO144138C/en unknown
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