NO134061B - - Google Patents

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Info

Publication number: NO134061B
Authority: NO; Norway
Prior art keywords: antibiotic; medium; acid; approx; rosaria
Prior art date: 1970-01-22

Application number

NO218/71A

Other languages

English (en)

Norwegian (no)

Other versions

NO134061C (xx

Inventor

M J Weinstein

G H Wagman

J A Marquez

Original Assignee

Scherico Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1970-01-22

Filing date

1971-01-21

Publication date

1976-05-03

1971-01-21 Application filed by Scherico Ltd filed Critical Scherico Ltd

1976-05-03 Publication of NO134061B publication Critical patent/NO134061B/no

1976-08-11 Publication of NO134061C publication Critical patent/NO134061C/no

Links

IUPCWCLVECYZRV-JZMZINANSA-N rosaramicin Chemical compound O([C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H]([C@@H]2O[C@@]2(C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)C)CC)[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O IUPCWCLVECYZRV-JZMZINANSA-N 0.000 claims description 53
230000003115 biocidal effect Effects 0.000 claims description 44
241000218940 Micromonospora rosaria Species 0.000 claims description 28
238000000034 method Methods 0.000 claims description 23
150000003839 salts Chemical class 0.000 claims description 23
238000004519 manufacturing process Methods 0.000 claims description 19
244000005700 microbiome Species 0.000 claims description 16
235000015097 nutrients Nutrition 0.000 claims description 10
239000013543 active substance Substances 0.000 claims description 4
ZUHRLTIPDRLJHR-UHFFFAOYSA-N Rosamicin Natural products CCC1OC(=O)CC(O)C(C)C(OC2OC(C)CC(C2O)N(C)C)C(CC=O)CC(C)C(=O)C=CC3OC3C1C ZUHRLTIPDRLJHR-UHFFFAOYSA-N 0.000 claims description 2
239000002609 medium Substances 0.000 description 55
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 34
238000000855 fermentation Methods 0.000 description 25
230000004151 fermentation Effects 0.000 description 25
239000000203 mixture Substances 0.000 description 19
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 18
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 18
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 18
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CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 9
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WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 2
RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 description 2
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LSPHULWDVZXLIL-UHFFFAOYSA-N Camphoric acid Natural products CC1(C)C(C(O)=O)CCC1(C)C(O)=O LSPHULWDVZXLIL-UHFFFAOYSA-N 0.000 description 2
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ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
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235000013372 meat Nutrition 0.000 description 1
WCYAALZQFZMMOM-UHFFFAOYSA-N methanol;sulfuric acid Chemical compound OC.OS(O)(=O)=O WCYAALZQFZMMOM-UHFFFAOYSA-N 0.000 description 1
235000013336 milk Nutrition 0.000 description 1
239000008267 milk Substances 0.000 description 1
210000004080 milk Anatomy 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
235000019796 monopotassium phosphate Nutrition 0.000 description 1
WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
230000014075 nitrogen utilization Effects 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
239000002674 ointment Substances 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
239000011368 organic material Substances 0.000 description 1
TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
229940066779 peptones Drugs 0.000 description 1
230000000737 periodic effect Effects 0.000 description 1
206010034674 peritonitis Diseases 0.000 description 1
PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
235000018102 proteins Nutrition 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
238000012827 research and development Methods 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1
239000002689 soil Substances 0.000 description 1
239000011877 solvent mixture Substances 0.000 description 1
239000004455 soybean meal Substances 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
239000012258 stirred mixture Substances 0.000 description 1
239000001384 succinic acid Substances 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
125000001302 tertiary amino group Chemical group 0.000 description 1
CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
229960001322 trypsin Drugs 0.000 description 1
238000005303 weighing Methods 0.000 description 1
239000002023 wood Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
- C07G11/00—Antibiotics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NO218/71A 1970-01-22 1971-01-21 NO134061C (xx)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US491670A	1970-01-22	1970-01-22

Publications (2)

Publication Number	Publication Date
NO134061B true NO134061B (xx)	1976-05-03
NO134061C NO134061C (xx)	1976-08-11

Family

ID=21713168

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO218/71A NO134061C (xx)	1970-01-22	1971-01-21

Country Status (30)

Country	Link
JP (1)	JPS5020157B1 (xx)
AT (1)	AT309677B (xx)
BE (1)	BE761922A (xx)
BG (2)	BG21241A3 (xx)
CA (1)	CA985193A (xx)
CH (2)	CH575420A5 (xx)
CS (1)	CS162739B2 (xx)
CY (1)	CY851A (xx)
DE (2)	DE2167020A1 (xx)
DK (1)	DK127008B (xx)
ES (2)	ES387479A1 (xx)
FI (1)	FI48286C (xx)
FR (1)	FR2081448B1 (xx)
GB (1)	GB1302142A (xx)
HK (1)	HK31176A (xx)
IE (1)	IE35230B1 (xx)
IL (1)	IL36043A (xx)
KE (1)	KE2615A (xx)
LU (1)	LU62469A1 (xx)
MY (1)	MY7600142A (xx)
NL (1)	NL158223B (xx)
NO (1)	NO134061C (xx)
OA (1)	OA03679A (xx)
PH (1)	PH9705A (xx)
PL (1)	PL87225B1 (xx)
RO (1)	RO61396A (xx)
SE (1)	SE370248B (xx)
SU (1)	SU493972A3 (xx)
YU (1)	YU35162B (xx)
ZA (1)	ZA71402B (xx)

1971
- 1971-01-19 NL NL7100704.A patent/NL158223B/xx not_active IP Right Cessation
- 1971-01-20 CH CH1529473A patent/CH575420A5/xx not_active IP Right Cessation
- 1971-01-20 PH PH12121*UA patent/PH9705A/en unknown
- 1971-01-20 CH CH77171A patent/CH552583A/xx not_active IP Right Cessation
- 1971-01-21 DE DE19712167020 patent/DE2167020A1/de active Pending
- 1971-01-21 FR FR7101947A patent/FR2081448B1/fr not_active Expired
- 1971-01-21 SE SE7100706A patent/SE370248B/xx unknown
- 1971-01-21 DE DE19712102718 patent/DE2102718A1/de not_active Withdrawn
- 1971-01-21 BG BG22168A patent/BG21241A3/xx unknown
- 1971-01-21 CS CS442A patent/CS162739B2/cs unknown
- 1971-01-21 ES ES387479A patent/ES387479A1/es not_active Expired
- 1971-01-21 NO NO218/71A patent/NO134061C/no unknown
- 1971-01-21 SU SU1816333A patent/SU493972A3/ru active
- 1971-01-21 DK DK25671AA patent/DK127008B/da not_active Application Discontinuation
- 1971-01-21 ZA ZA710402A patent/ZA71402B/xx unknown
- 1971-01-21 IE IE76/71A patent/IE35230B1/xx unknown
- 1971-01-21 LU LU62469D patent/LU62469A1/xx unknown
- 1971-01-21 BG BG16629A patent/BG22408A3/xx unknown
- 1971-01-21 CA CA103,488A patent/CA985193A/en not_active Expired
- 1971-01-21 PL PL1971145760A patent/PL87225B1/pl unknown
- 1971-01-21 AT AT49071A patent/AT309677B/de active
- 1971-01-22 YU YU149/71A patent/YU35162B/xx unknown
- 1971-01-22 RO RO65688A patent/RO61396A/ro unknown
- 1971-01-22 IL IL36043A patent/IL36043A/xx unknown
- 1971-01-22 FI FI710173A patent/FI48286C/fi active
- 1971-01-22 BE BE761922A patent/BE761922A/xx not_active IP Right Cessation
- 1971-01-22 JP JP46001638A patent/JPS5020157B1/ja active Pending
- 1971-01-22 OA OA54146A patent/OA03679A/xx unknown
- 1971-04-19 GB GB2014771A patent/GB1302142A/en not_active Expired
- 1971-04-19 CY CY851A patent/CY851A/xx unknown
1973
- 1973-06-01 ES ES415478A patent/ES415478A1/es not_active Expired
1976
- 1976-04-02 KE KE2615*UA patent/KE2615A/xx unknown
- 1976-06-03 HK HK311/76*UA patent/HK31176A/xx unknown
- 1976-12-30 MY MY142/76A patent/MY7600142A/xx unknown

Also Published As

Publication number	Publication date
BE761922A (fr)	1971-07-22
SE370248B (xx)	1974-10-07
IL36043A0 (en)	1971-03-24
BG22408A3 (xx)	1977-02-20
ES415478A1 (es)	1976-10-16
HK31176A (en)	1976-06-11
FI48286B (xx)	1974-04-30
CA985193A (en)	1976-03-09
LU62469A1 (xx)	1971-09-06
AT309677B (de)	1973-08-27
DE2167020A1 (de)	1977-06-30
CS162739B2 (xx)	1975-07-15
KE2615A (en)	1976-04-30
DK127008B (da)	1973-09-10
ZA71402B (en)	1971-10-27
YU35162B (en)	1980-09-25
IE35230B1 (en)	1975-12-24
PH9705A (en)	1976-02-19
NL158223B (nl)	1978-10-16
NL7100704A (xx)	1971-07-26
SU493972A3 (ru)	1975-11-28
IL36043A (en)	1975-03-13
CH575420A5 (xx)	1976-05-14
FI48286C (fi)	1974-08-12
RO61396A (xx)	1976-12-15
IE35230L (en)	1971-07-22
CH552583A (de)	1974-08-15
CY851A (en)	1976-09-10
MY7600142A (en)	1976-12-31
FR2081448B1 (xx)	1974-09-27
OA03679A (fr)	1971-12-24
DE2102718A1 (de)	1971-07-29
PL87225B1 (xx)	1976-06-30
ES387479A1 (es)	1974-09-01
FR2081448A1 (xx)	1971-12-03
NO134061C (xx)	1976-08-11
BG21241A3 (xx)	1976-03-20
GB1302142A (xx)	1973-01-04
JPS5020157B1 (xx)	1975-07-12
YU14971A (en)	1980-03-15

Publication	Publication Date	Title
US4918174A (en)	1990-04-17	Tiacumicin compounds
US4161523A (en)	1979-07-17	Rosamicin esters, acid addition salts and methods for production thereof
Wax et al.	1976	Efrotomycin, a new antibiotic from Streptomyces lactamdurans
US3344024A (en)	1967-09-26	Antibiotic am-684 and method of production
Boeck et al.	1975	NEW AZASTEROIDAL ANTIFUNGAL ANTIBIOTICS FROM GEOTRICHU FLAVO-BRUNNEUM I. DISCOVERY AND FERMENTATION STUDIES
RU2196826C2 (ru)	2003-01-20	Способ биотрансформации соединений колхициноидов в соответствующие 3-гликозилпроизводные
US4992425A (en)	1991-02-12	Antibiotics BU-3608D and BU-3608E
Isono et al.	1957	Studies on homomycin. II
DK158739B (da)	1990-07-09	Svovlholdige antibiotiske og cytotoxiske forbindelser, betegnet cl-1577d og cl-1577e, fremgangsmaade til fremstilling af disse, samt farmaceutiske praeparater indeholdende forbindelserne
US4234690A (en)	1980-11-18	Method for producing rosaramicin (rosamicin)
US4384043A (en)	1983-05-17	Process for producing the antibiotic nosiheptide
Kim et al.	1974	STUDIES ON MIKAMYCIN B LACTONASE I. DEGRADATION OF MIKAMYCIN B BY STREPTOMYCES MITAKAENSIS
CA1079213A (en)	1980-06-10	Antibiotic and processes for its manufacture
CA1158579A (en)	1983-12-13	Antibiotic ar-5 complex, derivatives thereof and methods for production thereof
NO134061B (xx)	1976-05-03
HUT60526A (en)	1992-09-28	Fermenting process for producing staurosporin
KR100536676B1 (ko)	2005-12-14	콜히콘 화합물로부터 효소법에 의한 대응하는 3-글리코실유도체로의 변형방법
NO803356L (no)	1981-05-11	Fremgangsmaate ved fremstilling av macrolidantibiotika
US4440751A (en)	1984-04-03	Broad spectrum antibiotic complex produced by a novel micromonospora
US4358584A (en)	1982-11-09	Antibiotics A6888C and A6888X
US4078056A (en)	1978-03-07	Antibiotic complex from micromonospora arborensis
US8795986B2 (en)	2014-08-05	Microbial method for the biotransformation of colchicinoid compounds
US3377242A (en)	1968-04-09	Neutramycin and a method for producing by using streptomyces rimosus
US4205164A (en)	1980-05-27	Antibiotic A201C, A201D and A201E
US5096817A (en)	1992-03-17	Process for producing antibiotics BU-3608 D and BU-3608 E