NO129682B - - Google Patents

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Publication number: NO129682B
Authority: NO; Norway
Prior art keywords: pepstatin; methanol; pepsin; growth; inhibition
Prior art date: 1969-06-13

Application number

NO02289/70A

Other languages

English (en)

Norwegian (no)

Inventor

H Umezawa

T Takeuchi

T Aoyagi

M Hamada

K Maeda

Y Okami

Original Assignee

Microbial Chem Res Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1969-06-13

Filing date

1970-06-12

Publication date

1974-05-13

1970-06-12 Application filed by Microbial Chem Res Found filed Critical Microbial Chem Res Found

1974-05-13 Publication of NO129682B publication Critical patent/NO129682B/no

Links

108010091212 pepstatin Proteins 0.000 claims description 160
229950000964 pepstatin Drugs 0.000 claims description 160
FAXGPCHRFPCXOO-LXTPJMTPSA-N pepstatin A Chemical compound OC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)CC(C)C FAXGPCHRFPCXOO-LXTPJMTPSA-N 0.000 claims description 158
102000057297 Pepsin A Human genes 0.000 claims description 40
108090000284 Pepsin A Proteins 0.000 claims description 40
229940111202 pepsin Drugs 0.000 claims description 40
238000000034 method Methods 0.000 claims description 24
150000002148 esters Chemical class 0.000 claims description 19
150000003839 salts Chemical class 0.000 claims description 16
241000187747 Streptomyces Species 0.000 claims description 7
150000001408 amides Chemical class 0.000 claims description 7
239000003112 inhibitor Substances 0.000 claims description 7
235000015097 nutrients Nutrition 0.000 claims description 6
241000958254 Streptomyces argenteolus Species 0.000 claims description 4
230000008569 process Effects 0.000 claims description 2
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 135
230000012010 growth Effects 0.000 description 39
230000005764 inhibitory process Effects 0.000 description 33
239000000843 powder Substances 0.000 description 32
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 30
239000000049 pigment Substances 0.000 description 23
LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 22
239000000243 solution Substances 0.000 description 22
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 21
239000000706 filtrate Substances 0.000 description 21
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 21
239000002609 medium Substances 0.000 description 17
238000000855 fermentation Methods 0.000 description 16
230000004151 fermentation Effects 0.000 description 16
239000012488 sample solution Substances 0.000 description 16
241000700159 Rattus Species 0.000 description 15
238000004519 manufacturing process Methods 0.000 description 15
150000004702 methyl esters Chemical class 0.000 description 15
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 14
239000013078 crystal Substances 0.000 description 14
239000000284 extract Substances 0.000 description 13
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 12
-1 Sakaguchi Chemical compound 0.000 description 12
239000008103 glucose Substances 0.000 description 12
229920001817 Agar Polymers 0.000 description 11
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 11
208000007107 Stomach Ulcer Diseases 0.000 description 11
239000008272 agar Substances 0.000 description 11
239000008101 lactose Substances 0.000 description 11
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 10
230000002401 inhibitory effect Effects 0.000 description 10
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HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
229920002472 Starch Polymers 0.000 description 9
239000003610 charcoal Substances 0.000 description 9
238000000746 purification Methods 0.000 description 9
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241000186361 Actinobacteria <class> Species 0.000 description 8
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 8
239000001888 Peptone Substances 0.000 description 8
108010080698 Peptones Proteins 0.000 description 8
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 8
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
229940041514 candida albicans extract Drugs 0.000 description 8
229910052799 carbon Inorganic materials 0.000 description 8
235000019319 peptone Nutrition 0.000 description 8
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239000011575 calcium Substances 0.000 description 7
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239000011777 magnesium Substances 0.000 description 7
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QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 6
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 6
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238000001704 evaporation Methods 0.000 description 6
230000008020 evaporation Effects 0.000 description 6
238000000605 extraction Methods 0.000 description 6
IOLCXVTUBQKXJR-UHFFFAOYSA-M potassium bromide Chemical compound [K+].[Br-] IOLCXVTUBQKXJR-UHFFFAOYSA-M 0.000 description 6
239000002244 precipitate Substances 0.000 description 6
239000011734 sodium Substances 0.000 description 6
VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 description 6
244000061456 Solanum tuberosum Species 0.000 description 5
235000002595 Solanum tuberosum Nutrition 0.000 description 5
240000008042 Zea mays Species 0.000 description 5
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235000002017 Zea mays subsp mays Nutrition 0.000 description 5
239000002021 butanolic extract Substances 0.000 description 5
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235000014633 carbohydrates Nutrition 0.000 description 5
239000005018 casein Substances 0.000 description 5
BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 5
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OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 4
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical class [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 4
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 4
QSJXEFYPDANLFS-UHFFFAOYSA-N Diacetyl Chemical group CC(=O)C(C)=O QSJXEFYPDANLFS-UHFFFAOYSA-N 0.000 description 4
YXHKONLOYHBTNS-UHFFFAOYSA-N Diazomethane Chemical compound C=[N+]=[N-] YXHKONLOYHBTNS-UHFFFAOYSA-N 0.000 description 4
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 4
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239000004365 Protease Substances 0.000 description 4
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
UGZVBQBZBBMPMB-UHFFFAOYSA-N acetic acid butan-1-ol butyl acetate hydrate Chemical compound O.CC(O)=O.CCCCO.CCCCOC(C)=O UGZVBQBZBBMPMB-UHFFFAOYSA-N 0.000 description 4
230000002378 acidificating effect Effects 0.000 description 4
PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 4
SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 4
GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 4
229910052791 calcium Inorganic materials 0.000 description 4
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239000011780 sodium chloride Substances 0.000 description 4
WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 3
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 3
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 3
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XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
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244000068988 Glycine max Species 0.000 description 3
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OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 3
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UREBWPXBXRYXRJ-UHFFFAOYSA-N ethyl acetate;methanol Chemical compound OC.CCOC(C)=O UREBWPXBXRYXRJ-UHFFFAOYSA-N 0.000 description 3
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/8142—Aspartate protease (E.C. 3.4.23) inhibitors, e.g. HIV protease inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/803—Physical recovery methods, e.g. chromatography, grinding
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Gastroenterology & Hepatology (AREA)
AIDS & HIV (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Enzymes And Modification Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NO02289/70A 1969-06-13 1970-06-12 NO129682B (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP4616669		1969-06-13

Publications (1)

Publication Number	Publication Date
NO129682B true NO129682B (es)	1974-05-13

Family

ID=12739413

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO02289/70A NO129682B (es)	1969-06-13	1970-06-12

Country Status (23)

Country	Link
US (1)	US3740319A (es)
AT (1)	AT295454B (es)
AU (1)	AU1584970A (es)
BE (1)	BE751931A (es)
CA (1)	CA928238A (es)
CH (1)	CH550247A (es)
CS (1)	CS171685B2 (es)
DE (1)	DE2028403C3 (es)
DK (1)	DK128124B (es)
ES (1)	ES380545A1 (es)
FI (2)	FI47498B (es)
FR (1)	FR2052964B1 (es)
GB (1)	GB1314231A (es)
IE (1)	IE34196B1 (es)
IL (1)	IL34543A (es)
LU (1)	LU61119A1 (es)
NL (1)	NL166279C (es)
NO (1)	NO129682B (es)
PH (2)	PH9382A (es)
PL (1)	PL81272B1 (es)
RO (1)	RO71556B (es)
SE (1)	SE381673B (es)
YU (1)	YU35272B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5022116B1 (es) *	1970-04-28	1975-07-28
JPS5434837B2 (es) *	1972-02-08	1979-10-29
DK132899C (da) *	1972-04-07	1976-07-26	Takeda Chemical Industries Ltd	Fremgangsmade til fremstilling af de proteaseinhiberende stoffer pepsinostreptiner eller salte deraf
US3963579A (en) *	1973-10-17	1976-06-15	Sanraku-Ocean Co., Ltd.	Microbiological process for the production of pepstatins
US4206283A (en) *	1975-09-12	1980-06-03	Sumitomo Chemical Company, Limited	Protease inhibitors
US4101650A (en) *	1977-04-06	1978-07-18	Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai	Pepstatin floating minicapsules
US5833946A (en) *	1995-06-06	1998-11-10	Bayer Corporation	Dissemination of fungal infections: animal model and method of prophylaxis
GB0807621D0 (en) *	2008-04-25	2008-06-04	Ineos Healthcare Ltd	Use

1970
- 1970-05-14 US US00037165A patent/US3740319A/en not_active Expired - Lifetime
- 1970-05-18 IL IL34543A patent/IL34543A/xx unknown
- 1970-05-18 IE IE644/70A patent/IE34196B1/xx unknown
- 1970-05-18 GB GB2392870A patent/GB1314231A/en not_active Expired
- 1970-06-02 PH PH11496*UA patent/PH9382A/en unknown
- 1970-06-03 AU AU15849/70A patent/AU1584970A/en not_active Expired
- 1970-06-04 AT AT500570A patent/AT295454B/de not_active IP Right Cessation
- 1970-06-05 CS CS3969*BA patent/CS171685B2/cs unknown
- 1970-06-08 YU YU1462/70A patent/YU35272B/xx unknown
- 1970-06-08 ES ES380545A patent/ES380545A1/es not_active Expired
- 1970-06-09 DE DE2028403A patent/DE2028403C3/de not_active Expired
- 1970-06-12 FI FI01670/70A patent/FI47498B/fi active
- 1970-06-12 SE SE7008222A patent/SE381673B/xx unknown
- 1970-06-12 CA CA085332A patent/CA928238A/en not_active Expired
- 1970-06-12 NO NO02289/70A patent/NO129682B/no unknown
- 1970-06-12 PL PL1970141274A patent/PL81272B1/pl unknown
- 1970-06-12 CH CH894270A patent/CH550247A/xx not_active IP Right Cessation
- 1970-06-12 LU LU61119D patent/LU61119A1/xx unknown
- 1970-06-12 DK DK304570AA patent/DK128124B/da not_active IP Right Cessation
- 1970-06-12 FR FR7021557A patent/FR2052964B1/fr not_active Expired
- 1970-06-12 NL NL7008657.A patent/NL166279C/xx not_active IP Right Cessation
- 1970-06-12 FI FI701670A patent/FI47498C/fi active
- 1970-06-12 BE BE751931D patent/BE751931A/xx not_active IP Right Cessation
- 1970-06-13 RO RO76141A patent/RO71556B/ro unknown
1974
- 1974-07-09 PH PH16026A patent/PH10881A/en unknown

Also Published As

Publication number	Publication date
DE2028403A1 (de)	1971-01-28
DE2028403C3 (de)	1975-11-27
US3740319A (en)	1973-06-19
AT295454B (de)	1972-01-10
FR2052964A1 (es)	1971-04-16
YU35272B (en)	1980-10-31
LU61119A1 (es)	1970-08-12
IE34196L (en)	1970-12-13
YU146270A (en)	1980-04-30
FI47498B (es)	1973-08-31
IE34196B1 (en)	1975-03-05
CS171685B2 (es)	1976-10-29
PH10881A (en)	1977-09-26
ES380545A1 (es)	1972-10-01
RO71556A (ro)	1984-05-23
FI47498C (fi)	1973-12-10
DK128124B (da)	1974-03-04
GB1314231A (en)	1973-04-18
SE381673B (sv)	1975-12-15
RO71556B (ro)	1984-07-30
PH9382A (en)	1975-10-22
AU1584970A (en)	1971-12-09
IL34543A0 (en)	1970-07-19
NL166279B (nl)	1981-02-16
PL81272B1 (es)	1975-08-30
CH550247A (de)	1974-06-14
FR2052964B1 (es)	1974-10-11
CA928238A (en)	1973-06-12
BE751931A (fr)	1970-11-16
NL166279C (nl)	1981-07-15
DE2028403B2 (de)	1975-04-24
NL7008657A (es)	1970-12-15
IL34543A (en)	1974-03-14

Publication	Publication Date	Title
Bajwa et al.	1985	The biology of mycorrhiza in the ricaceae: ix. peptides as nitrogen sources for the ericoid endophyte and for mycorrhizal and non‐mycorrhizal plants
NO149239B (no)	1983-12-05	Offshore-konstruksjon.
US3840516A (en)	1974-10-08	Biologically active substance,pepstatin and production processes thereof
NO129682B (es)	1974-05-13
US4052449A (en)	1977-10-04	Biologically active substance, bestatin, and production thereof
US5013550A (en)	1991-05-07	Antibiotics called "chloropolysporins B and C", a process for their preparation, and their therapeutic and veterinary use
US4029547A (en)	1977-06-14	Biologically active substance, bestatin, and production thereof
US4409210A (en)	1983-10-11	Antibiotic compound
EP0196189B1 (en)	1988-12-21	Novel enzyme inhibiting substance
NO783545L (no)	1979-04-23	Fremgangsmaate til fremstilling av deoksynarasinantibiotisk kompleks
US4014860A (en)	1977-03-29	Plasminostreptin (enzyme inhibitor) and method for producing it from streptomyces
JPS6261037B2 (es)	1987-12-18
NO132240B (es)	1975-06-30
US4066507A (en)	1978-01-03	Process for producing l-leupeptins
JPS6010720B2 (ja)	1985-03-19	抗生物質ｃ―１５００３ｐ―４の製造法
US4533631A (en)	1985-08-06	Fermentation process for preparation of antibiotic Bu-2517
EP0253413B1 (en)	1993-10-13	New antibiotics called "mureidomycins a, b, c and d" a process for their preparation and their therapeutic use
US4169140A (en)	1979-09-25	Antibiotics SF-1771 substance and SF-1771-B substance as well as the production of these substances
US4179573A (en)	1979-12-18	(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid
JP2989662B2 (ja)	1999-12-13	新規酵素阻害物質ベナルチンならびにその製造法
EP0344234A1 (en)	1989-12-06	Antibiotic compounds
US3629406A (en)	1971-12-21	Sparsogenin and sparsogenin a and methods of preparation
JPS6225156B2 (es)	1987-06-01
JP4095815B2 (ja)	2008-06-04	トリプシンの新規インヒビターｔｕ−５３５０物質とその製造法及び用途
NO155701B (no)	1987-02-02	Fremgangsmaate til fremstilling av et terapeutisk aktivt derivat av tallysomycin a eller b