NO120499B - - Google Patents

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Publication number: NO120499B
Authority: NO; Norway
Prior art keywords: solution; novobiocin; volume; approx; crystals
Prior art date: 1966-11-14

Application number

NO170449A

Other languages

English (en)

Norwegian (no)

Inventor

K Holm

S Nord

B Berglund

Original Assignee

Uddeholms Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1966-11-14

Filing date

1967-11-08

Publication date

1970-10-26

1967-11-08 Application filed by Uddeholms Ab filed Critical Uddeholms Ab

1970-10-26 Publication of NO120499B publication Critical patent/NO120499B/no

Links

229960002950 novobiocin Drugs 0.000 claims description 45
YJQPYGGHQPGBLI-UHFFFAOYSA-N Novobiocin Natural products O1C(C)(C)C(OC)C(OC(N)=O)C(O)C1OC1=CC=C(C(O)=C(NC(=O)C=2C=C(CC=C(C)C)C(O)=CC=2)C(=O)O2)C2=C1C YJQPYGGHQPGBLI-UHFFFAOYSA-N 0.000 claims description 44
YJQPYGGHQPGBLI-KGSXXDOSSA-N novobiocin Chemical compound O1C(C)(C)[C@H](OC)[C@@H](OC(N)=O)[C@@H](O)[C@@H]1OC1=CC=C(C(O)=C(NC(=O)C=2C=C(CC=C(C)C)C(O)=CC=2)C(=O)O2)C2=C1C YJQPYGGHQPGBLI-KGSXXDOSSA-N 0.000 claims description 44
239000000243 solution Substances 0.000 claims description 40
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 20
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 17
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 16
LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 14
239000013078 crystal Substances 0.000 claims description 13
239000007787 solid Substances 0.000 claims description 13
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
238000000034 method Methods 0.000 claims description 10
239000003208 petroleum Substances 0.000 claims description 9
238000000855 fermentation Methods 0.000 claims description 8
230000004151 fermentation Effects 0.000 claims description 8
239000000126 substance Substances 0.000 claims description 7
239000012670 alkaline solution Substances 0.000 claims description 6
239000000284 extract Substances 0.000 claims description 6
PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 4
239000012141 concentrate Substances 0.000 claims description 4
239000012535 impurity Substances 0.000 claims description 4
150000008044 alkali metal hydroxides Chemical class 0.000 claims description 3
230000001476 alcoholic effect Effects 0.000 claims description 2
239000004615 ingredient Substances 0.000 claims description 2
239000002023 wood Substances 0.000 claims 1
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 12
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
244000005700 microbiome Species 0.000 description 9
TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 9
241000191967 Staphylococcus aureus Species 0.000 description 8
230000000694 effects Effects 0.000 description 8
238000001914 filtration Methods 0.000 description 8
238000000746 purification Methods 0.000 description 7
239000003242 anti bacterial agent Substances 0.000 description 6
229940088710 antibiotic agent Drugs 0.000 description 6
239000002609 medium Substances 0.000 description 6
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 5
230000004071 biological effect Effects 0.000 description 5
239000012065 filter cake Substances 0.000 description 5
150000003839 salts Chemical class 0.000 description 5
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
241000186227 Corynebacterium diphtheriae Species 0.000 description 3
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
241001454746 Streptomyces niveus Species 0.000 description 3
239000007864 aqueous solution Substances 0.000 description 3
238000000605 extraction Methods 0.000 description 3
239000000706 filtrate Substances 0.000 description 3
239000007788 liquid Substances 0.000 description 3
239000000203 mixture Substances 0.000 description 3
239000000047 product Substances 0.000 description 3
239000002689 soil Substances 0.000 description 3
241000894007 species Species 0.000 description 3
238000003756 stirring Methods 0.000 description 3
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
241000196324 Embryophyta Species 0.000 description 2
239000005909 Kieselgur Substances 0.000 description 2
241000191938 Micrococcus luteus Species 0.000 description 2
241000588650 Neisseria meningitidis Species 0.000 description 2
229930182555 Penicillin Natural products 0.000 description 2
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 2
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
230000002378 acidificating effect Effects 0.000 description 2
239000012736 aqueous medium Substances 0.000 description 2
230000009286 beneficial effect Effects 0.000 description 2
230000003115 biocidal effect Effects 0.000 description 2
239000002021 butanolic extract Substances 0.000 description 2
239000000356 contaminant Substances 0.000 description 2
238000002425 crystallisation Methods 0.000 description 2
230000008025 crystallization Effects 0.000 description 2
238000009826 distribution Methods 0.000 description 2
239000012530 fluid Substances 0.000 description 2
235000015097 nutrients Nutrition 0.000 description 2
229940049954 penicillin Drugs 0.000 description 2
239000002244 precipitate Substances 0.000 description 2
238000001953 recrystallisation Methods 0.000 description 2
159000000000 sodium salts Chemical class 0.000 description 2
229910001220 stainless steel Inorganic materials 0.000 description 2
239000010935 stainless steel Substances 0.000 description 2
239000000725 suspension Substances 0.000 description 2
VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 2
238000001665 trituration Methods 0.000 description 2
WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 1
RYPVUNGPPCYIDC-UHFFFAOYSA-N 1,4-dioxane;propan-2-one Chemical compound CC(C)=O.C1COCCO1 RYPVUNGPPCYIDC-UHFFFAOYSA-N 0.000 description 1
IMSODMZESSGVBE-UHFFFAOYSA-N 2-Oxazoline Chemical compound C1CN=CO1 IMSODMZESSGVBE-UHFFFAOYSA-N 0.000 description 1
UIHCLUNTQKBZGK-UHFFFAOYSA-N 3-methyl-2-pentanone Chemical compound CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 description 1
229920001817 Agar Polymers 0.000 description 1
208000035143 Bacterial infection Diseases 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical class OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
241000186216 Corynebacterium Species 0.000 description 1
241000186246 Corynebacterium renale Species 0.000 description 1
229920000742 Cotton Polymers 0.000 description 1
241000221785 Erysiphales Species 0.000 description 1
241000282414 Homo sapiens Species 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
241000364057 Peoria Species 0.000 description 1
235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
244000046052 Phaseolus vulgaris Species 0.000 description 1
KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical class [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
241000295644 Staphylococcaceae Species 0.000 description 1
241000193998 Streptococcus pneumoniae Species 0.000 description 1
241000194062 Xanthomonas phaseoli Species 0.000 description 1
206010048222 Xerosis Diseases 0.000 description 1
239000002253 acid Substances 0.000 description 1
239000003929 acidic solution Substances 0.000 description 1
239000011149 active material Substances 0.000 description 1
239000008272 agar Substances 0.000 description 1
238000013019 agitation Methods 0.000 description 1
239000002518 antifoaming agent Substances 0.000 description 1
239000004599 antimicrobial Substances 0.000 description 1
208000022362 bacterial infectious disease Diseases 0.000 description 1
244000052616 bacterial pathogen Species 0.000 description 1
229940088623 biologically active substance Drugs 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
BTANRVKWQNVYAZ-UHFFFAOYSA-N butan-2-ol Chemical compound CCC(C)O BTANRVKWQNVYAZ-UHFFFAOYSA-N 0.000 description 1
239000006227 byproduct Substances 0.000 description 1
239000002775 capsule Substances 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
150000004649 carbonic acid derivatives Chemical class 0.000 description 1
239000003610 charcoal Substances 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
CYDMQBQPVICBEU-UHFFFAOYSA-N chlorotetracycline Natural products C1=CC(Cl)=C2C(O)(C)C3CC4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-UHFFFAOYSA-N 0.000 description 1
229960004475 chlortetracycline Drugs 0.000 description 1
CYDMQBQPVICBEU-XRNKAMNCSA-N chlortetracycline Chemical compound C1=CC(Cl)=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-XRNKAMNCSA-N 0.000 description 1
235000019365 chlortetracycline Nutrition 0.000 description 1
238000004587 chromatography analysis Methods 0.000 description 1
238000004140 cleaning Methods 0.000 description 1
239000002178 crystalline material Substances 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
239000000469 ethanolic extract Substances 0.000 description 1
238000011534 incubation Methods 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
239000002054 inoculum Substances 0.000 description 1
238000002955 isolation Methods 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
239000000463 material Substances 0.000 description 1
235000013372 meat Nutrition 0.000 description 1
238000002844 melting Methods 0.000 description 1
230000008018 melting Effects 0.000 description 1
239000002480 mineral oil Substances 0.000 description 1
235000010446 mineral oil Nutrition 0.000 description 1
238000002156 mixing Methods 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
150000002894 organic compounds Chemical class 0.000 description 1
230000020477 pH reduction Effects 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
230000000241 respiratory effect Effects 0.000 description 1
230000035939 shock Effects 0.000 description 1
WWPRGAYLRGSOSU-DUZLMVPISA-M sodium;4-[[7-[(2r,3s,4s,5r)-4-carbamoyloxy-3-hydroxy-5-methoxy-6,6-dimethyloxan-2-yl]oxy-4-hydroxy-8-methyl-2-oxochromen-3-yl]carbamoyl]-2-(3-methylbut-2-enyl)phenolate Chemical compound [Na+].O1C(C)(C)[C@H](OC)[C@@H](OC(N)=O)[C@H](O)[C@@H]1OC1=CC=C(C(O)=C(NC(=O)C=2C=C(CC=C(C)C)C([O-])=CC=2)C(=O)O2)C2=C1C WWPRGAYLRGSOSU-DUZLMVPISA-M 0.000 description 1
239000011343 solid material Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000007921 spray Substances 0.000 description 1
239000008223 sterile water Substances 0.000 description 1
239000011800 void material Substances 0.000 description 1
238000005406 washing Methods 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1

Classifications

- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D1/00—Evaporating
- B01D1/0082—Regulation; Control
- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23G—CLEANING OR DE-GREASING OF METALLIC MATERIAL BY CHEMICAL METHODS OTHER THAN ELECTROLYSIS
- C23G5/00—Cleaning or de-greasing metallic material by other methods; Apparatus for cleaning or de-greasing metallic material with organic solvents
- C23G5/02—Cleaning or de-greasing metallic material by other methods; Apparatus for cleaning or de-greasing metallic material with organic solvents using organic solvents
- C23G5/04—Apparatus
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S203/00—Distillation: processes, separatory
- Y10S203/19—Sidestream

Landscapes

Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Materials Engineering (AREA)
Mechanical Engineering (AREA)
Metallurgy (AREA)
Organic Chemistry (AREA)
Cleaning By Liquid Or Steam (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NO170449A 1966-11-14 1967-11-08 NO120499B (sv)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE1556866		1966-11-14

Publications (1)

Publication Number	Publication Date
NO120499B true NO120499B (sv)	1970-10-26

Family

ID=20300852

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO170449A NO120499B (sv)	1966-11-14	1967-11-08

Country Status (4)

Country	Link
US (1)	US3498885A (sv)
FI (1)	FI46405C (sv)
GB (1)	GB1205624A (sv)
NO (1)	NO120499B (sv)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3891510A (en) *	1973-04-18	1975-06-24	Drostholm F H	Integrated apparatus for distilling batches of contaminated solvents
US4556457A (en) *	1981-08-08	1985-12-03	Mccord James W	Safety control device for vapor generating and recovering apparatus
GB2132228B (en) *	1982-12-22	1985-09-04	Philips Electronic Associated	Producing a controlled unsaturated vapour pressure of a volatile liquid in a heat treatment chamber
DE3583247D1 (de) *	1984-02-21	1991-07-25	Mccord James W	Dampferzeugungs- und rueckgewinnungsverfahren fuer dampfzurueckhaltung, zurueckgewinnung und wiederverwendung.
JP2742238B2 (ja) *	1995-03-16	1998-04-22	中外炉工業株式会社	有機溶剤を使用する洗浄装置

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3123083A (en) *		1964-03-03		Metal degreasing apparatus
US1973426A (en) *	1932-11-07	1934-09-11	Ici Ltd	Apparatus for the degreasing of materials by means of volatile solvents
US2447840A (en) *	1938-11-19	1948-08-24	Mabor Company Inc	Vapor phase degreasing apparatus, including temperature control of vapor condensers
US2253579A (en) *	1940-06-03	1941-08-26	Dow Chemical Co	Portable degreasing unit
US2527349A (en) *	1944-11-18	1950-10-24	Circo Products Company	Degreasing apparatus with automatic controls
GB679718A (en) *	1949-01-07	1952-09-24	Tore T Son Fridholm	Improvements in apparatus for the cleaning of objects by means of condensing vapour
US3242933A (en) *	1963-10-21	1966-03-29	Simplicity Eng Co	Automatic degreaser unit

1967
- 1967-11-03 US US680585A patent/US3498885A/en not_active Expired - Lifetime
- 1967-11-06 FI FI672984A patent/FI46405C/sv active
- 1967-11-08 NO NO170449A patent/NO120499B/no unknown
- 1967-11-09 GB GB51112/67A patent/GB1205624A/en not_active Expired

Also Published As

Publication number	Publication date
DE1621673A1 (de)	1971-06-03
GB1205624A (en)	1970-09-16
DE1621673B2 (de)	1972-06-22
FI46405C (sv)	1973-03-12
FI46405B (sv)	1972-11-30
US3498885A (en)	1970-03-03

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US3833723A (en)	1974-09-03	Alamethicin and production therefor
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DE1034818B (de)	1958-07-24	Verfahren zum Isolieren und Reinigen von Novobiocin