NL7802583A - 4-Alkyl-alkanoyl-7-hydroxy-coumarin prepn. in good yield - by alkanoylating corresp. unsubstituted cpd. using Friedel-Crafts catalyst - Google Patents

4-Alkyl-alkanoyl-7-hydroxy-coumarin prepn. in good yield - by alkanoylating corresp. unsubstituted cpd. using Friedel-Crafts catalyst

Info

Publication number
NL7802583A
NL7802583A NL7802583A NL7802583A NL7802583A NL 7802583 A NL7802583 A NL 7802583A NL 7802583 A NL7802583 A NL 7802583A NL 7802583 A NL7802583 A NL 7802583A NL 7802583 A NL7802583 A NL 7802583A
Authority
NL
Netherlands
Prior art keywords
alkyl
alkanoyl
corresp
friedel
alkanoylating
Prior art date
Application number
NL7802583A
Other languages
Dutch (nl)
Original Assignee
Fisons Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fisons Ltd filed Critical Fisons Ltd
Priority to NL7802583A priority Critical patent/NL7802583A/en
Publication of NL7802583A publication Critical patent/NL7802583A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

4-Alkyl-6 (or 8)-alkanoyl-7-hydroxycoumarins of formula (I):- (where R is unsubstd. alkyl; and R1 is alkanoyl ortho to the 7-OH) are prepd. by reacting a corresp. 4-alkyl-7-hydroxycoumarin (II) with an alkanoylating agent in presence of a Friedel-crafts catalyst. Good yields of (I) in a simple process compared with the previously used Fries rearrangement; (I) are intermediates for pharmacologically active cpds.
NL7802583A 1978-03-09 1978-03-09 4-Alkyl-alkanoyl-7-hydroxy-coumarin prepn. in good yield - by alkanoylating corresp. unsubstituted cpd. using Friedel-Crafts catalyst NL7802583A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NL7802583A NL7802583A (en) 1978-03-09 1978-03-09 4-Alkyl-alkanoyl-7-hydroxy-coumarin prepn. in good yield - by alkanoylating corresp. unsubstituted cpd. using Friedel-Crafts catalyst

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL7802583A NL7802583A (en) 1978-03-09 1978-03-09 4-Alkyl-alkanoyl-7-hydroxy-coumarin prepn. in good yield - by alkanoylating corresp. unsubstituted cpd. using Friedel-Crafts catalyst

Publications (1)

Publication Number Publication Date
NL7802583A true NL7802583A (en) 1979-09-11

Family

ID=19830468

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7802583A NL7802583A (en) 1978-03-09 1978-03-09 4-Alkyl-alkanoyl-7-hydroxy-coumarin prepn. in good yield - by alkanoylating corresp. unsubstituted cpd. using Friedel-Crafts catalyst

Country Status (1)

Country Link
NL (1) NL7802583A (en)

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Legal Events

Date Code Title Description
A85 Still pending on 85-01-01
BA A request for search or an international-type search has been filed
BB A search report has been drawn up
BV The patent application has lapsed