NL7509661A - Werkwijze voor de bereiding van microkristallijn warfarinzuur. - Google Patents
Werkwijze voor de bereiding van microkristallijn warfarinzuur.Info
- Publication number
- NL7509661A NL7509661A NL7509661A NL7509661A NL7509661A NL 7509661 A NL7509661 A NL 7509661A NL 7509661 A NL7509661 A NL 7509661A NL 7509661 A NL7509661 A NL 7509661A NL 7509661 A NL7509661 A NL 7509661A
- Authority
- NL
- Netherlands
- Prior art keywords
- warpharic
- microcrystalline
- preparation
- acid
- warpharic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
- C07D311/44—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3
- C07D311/46—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3 unsubstituted in the carbocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/496,932 US4113744A (en) | 1974-08-13 | 1974-08-13 | Microcrystalline 3-(alpha-acetonylbenzyl)-4-hydroxycoumarin (warfarin) and methods of making |
Publications (1)
Publication Number | Publication Date |
---|---|
NL7509661A true NL7509661A (nl) | 1976-02-17 |
Family
ID=23974780
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NL7509661A NL7509661A (nl) | 1974-08-13 | 1975-08-13 | Werkwijze voor de bereiding van microkristallijn warfarinzuur. |
Country Status (13)
Country | Link |
---|---|
US (1) | US4113744A (nl) |
JP (1) | JPS5835967B2 (nl) |
BE (1) | BE832395A (nl) |
BR (1) | BR7504996A (nl) |
CA (1) | CA1077502A (nl) |
DE (1) | DE2535228A1 (nl) |
ES (1) | ES440221A1 (nl) |
FR (1) | FR2281754A1 (nl) |
GB (1) | GB1513399A (nl) |
IN (1) | IN141166B (nl) |
LU (1) | LU73199A1 (nl) |
NL (1) | NL7509661A (nl) |
ZA (1) | ZA754795B (nl) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5696274A (en) * | 1995-12-28 | 1997-12-09 | Hoechst Celanese Corporation | Syntheses based on 2-hydroxyacetophenone |
EP1073609A4 (en) * | 1998-03-30 | 2002-08-28 | Sloan Kettering Inst Cancer | BISMUTH-213 GENERATOR AND USES THEREOF |
US6673944B2 (en) | 2001-02-28 | 2004-01-06 | Taro Pharmaceutical Industries, Ltd. | Preparation of warfarin sodium from warfarin acid |
US6512005B2 (en) | 2001-02-28 | 2003-01-28 | Taro Pharmaceutical Industries, Ltd. | Process for synthesis of pure warfarin acid, warfarin alkali metal salts and corresponding clathrates |
RU2003129000A (ru) * | 2001-02-28 | 2005-05-10 | Таро Фармасьютикалз Ю.Эс.Эй., Инк. (Us) | Способ очистки варфариновой кислоты, соли варфарина со щелочными металлами и соответствующие клатраты |
US6610862B2 (en) | 2001-02-28 | 2003-08-26 | Taro Pharmaceutical Industries Ltd. | Preparation of warfarin sodium from warfarin sodium-2-propanol clathrate by solvent expulsion |
EP1589930A2 (en) * | 2003-01-08 | 2005-11-02 | Flacco-Nesselroad Family Trust | Combination therapy for anticoagulation |
GB0329303D0 (en) * | 2003-12-18 | 2004-01-21 | Whelan Ian P | Rodenticide bait system |
CN117169390B (zh) * | 2023-10-18 | 2024-05-03 | 宁波市疾病预防控制中心(宁波市健康教育与促进中心) | 一种测定血液中安妥的方法、试剂盒及应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2666064A (en) * | 1951-07-10 | 1954-01-12 | S B Penick & Company Inc | Manufacture of 3-(alpha-phenyl-beta-acetylethyl)-4-hydroxycoumarin |
US2777859A (en) * | 1953-02-05 | 1957-01-15 | Wisconsin Alumni Res Found | Warfarin-alkali metal derivatives and processes of preparing the same |
US2752360A (en) * | 1953-03-23 | 1956-06-26 | S B Penick & Company Inc | Improvement in the manufacture of 3-substituted 4-hydroxycoumarins |
US2932652A (en) * | 1957-02-11 | 1960-04-12 | Nicholas M Molnar | 3-(1'-(alpha-naphthyl) 3'-oxo-butyl) 4-hydroxy coumarin and salts thereof |
-
1974
- 1974-08-13 US US05/496,932 patent/US4113744A/en not_active Expired - Lifetime
-
1975
- 1975-07-25 ZA ZA754795A patent/ZA754795B/xx unknown
- 1975-07-31 IN IN1515/CAL/1975A patent/IN141166B/en unknown
- 1975-07-31 CA CA232,784A patent/CA1077502A/en not_active Expired
- 1975-08-05 BR BR7504996A patent/BR7504996A/pt unknown
- 1975-08-07 DE DE19752535228 patent/DE2535228A1/de not_active Withdrawn
- 1975-08-07 JP JP50095464A patent/JPS5835967B2/ja not_active Expired
- 1975-08-12 FR FR7525087A patent/FR2281754A1/fr active Granted
- 1975-08-13 ES ES440221A patent/ES440221A1/es not_active Expired
- 1975-08-13 GB GB33672/75A patent/GB1513399A/en not_active Expired
- 1975-08-13 NL NL7509661A patent/NL7509661A/nl not_active Application Discontinuation
- 1975-08-13 BE BE159171A patent/BE832395A/xx unknown
- 1975-08-13 LU LU73199A patent/LU73199A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
LU73199A1 (nl) | 1976-08-13 |
IN141166B (nl) | 1977-01-29 |
FR2281754A1 (fr) | 1976-03-12 |
CA1077502A (en) | 1980-05-13 |
ES440221A1 (es) | 1977-03-01 |
BR7504996A (pt) | 1976-08-31 |
JPS5141361A (nl) | 1976-04-07 |
JPS5835967B2 (ja) | 1983-08-05 |
FR2281754B1 (nl) | 1978-11-10 |
ZA754795B (en) | 1977-03-30 |
BE832395A (fr) | 1976-02-13 |
AU8356175A (en) | 1977-02-03 |
GB1513399A (en) | 1978-06-07 |
US4113744A (en) | 1978-09-12 |
DE2535228A1 (de) | 1976-02-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
BV | The patent application has lapsed |