NL7403524A - Pharmaceutical compsn. - contg. alpha-dithiosemicarbazone active against trichomonas vaginalis - Google Patents

Pharmaceutical compsn. - contg. alpha-dithiosemicarbazone active against trichomonas vaginalis

Info

Publication number
NL7403524A
NL7403524A NL7403524A NL7403524A NL7403524A NL 7403524 A NL7403524 A NL 7403524A NL 7403524 A NL7403524 A NL 7403524A NL 7403524 A NL7403524 A NL 7403524A NL 7403524 A NL7403524 A NL 7403524A
Authority
NL
Netherlands
Prior art keywords
alkyl
opt
alkoxy
ring
carries
Prior art date
Application number
NL7403524A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB3146659A external-priority patent/GB966849A/en
Application filed filed Critical
Publication of NL7403524A publication Critical patent/NL7403524A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom

Abstract

Pharmaceutical compositions useful in the treatment against Trichomonas vaginalis comprise, as active ingredient, an alpha-dithiosemicarbazone of the formula wherein R3 and R4 are H or 1-10C alkyl provided that when R3 and R4 are both alkyl the total in the two is 2-12C and opt. carrying a terminal hydroxy or carboxy or is phenyl or benzyl wherein the phenyl ring opt. carries one or more substituents, each of which is halogen hydroxy, alkyl, alkoxy, amino, alkylamino, dialkylamino, carboxy or alkoxy-carbonyl, or is a 2-thienyl, 2-thenyl, 2-furyl, or 2-furfuryl wherein the ring opt carries one or more substituents, each of which is halogen or alkyl, or R3--C--C--R4 is a cyclopentane, -hexane, or -heptane ring opt carrying a fused benzene ring, and either ring opt carries one or more alkyl and X1 and X2 are H or 1-6C alkyl and opt carrying a hydroxy or alkoxy group (the groups "alkyl" and "alkoxy" in R13R14X1 and X2 containing 1-4C except where otherwise stated) together with an acceptable carrier. Acceptable carriers do not include unsterilized water, saline solutions nor organic solvents which are normally used in organic chemistry for the preparation of compounds, nor culture mediums which contain metabolites and are normally used in pharmacological research, nor a non-ionic surface-active dispersing agent alone.
NL7403524A 1959-09-15 1974-03-15 Pharmaceutical compsn. - contg. alpha-dithiosemicarbazone active against trichomonas vaginalis NL7403524A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB3146759 1959-09-15
GB3146859 1959-09-15
GB3146659A GB966849A (en) 1959-09-15 1959-09-15 Thiosemicarbazones and their preparation
GB2783660 1960-08-11

Publications (1)

Publication Number Publication Date
NL7403524A true NL7403524A (en) 1974-05-27

Family

ID=27448719

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7403524A NL7403524A (en) 1959-09-15 1974-03-15 Pharmaceutical compsn. - contg. alpha-dithiosemicarbazone active against trichomonas vaginalis

Country Status (1)

Country Link
NL (1) NL7403524A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997007103A2 (en) * 1995-08-15 1997-02-27 Novartis Ag Pesticidal indazole derivatives
US11596651B2 (en) 2017-09-01 2023-03-07 Oregon State University Therapeutic metal complexes and ligands and methods of making and using the same

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997007103A2 (en) * 1995-08-15 1997-02-27 Novartis Ag Pesticidal indazole derivatives
WO1997007103A3 (en) * 1995-08-15 1997-03-20 Ciba Geigy Ag Pesticidal indazole derivatives
US5935908A (en) * 1995-08-15 1999-08-10 Novartis Crop Protection, Inc. Pesticidal indazole derivatives
US11596651B2 (en) 2017-09-01 2023-03-07 Oregon State University Therapeutic metal complexes and ligands and methods of making and using the same

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