NL6908527A - Benzomorphanes as analgesics and morphine- - autogenists - Google Patents
Benzomorphanes as analgesics and morphine- - autogenistsInfo
- Publication number
- NL6908527A NL6908527A NL6908527A NL6908527A NL6908527A NL 6908527 A NL6908527 A NL 6908527A NL 6908527 A NL6908527 A NL 6908527A NL 6908527 A NL6908527 A NL 6908527A NL 6908527 A NL6908527 A NL 6908527A
- Authority
- NL
- Netherlands
- Prior art keywords
- benzomorphanes
- morphine
- analgesics
- autogenists
- dimethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Substituted 6,7-benzomorphanes of basic structure: in which the two Rs are lower alkyls or together and in combination with the ring carbon atom form a cycloalkane ring. The ring system may be substituted. Optically active form and salts are included. As examples are given e.g. methyl-2,2-dimethyl-4-(p-methoxyphenyl)-acetylacetate; methyl 3-benzylamino-2,2-dimethyl-4-phenyl-butyrate. The compounds are useful pharmaceuticals e.g. as analgesics and morphine-antagonists.
Priority Applications (34)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL6908527A NL6908527A (en) | 1969-06-04 | 1969-06-04 | Benzomorphanes as analgesics and morphine- - autogenists |
IE412/73A IE34236B1 (en) | 1969-06-04 | 1970-05-26 | 2-benzyl-4-piperidine compounds |
IE679/70A IE34235B1 (en) | 1969-06-04 | 1970-05-26 | 6,7-benzomorphans and their preparation |
BE750985D BE750985A (en) | 1969-06-04 | 1970-05-27 | Benzomorphanes as analgesics and morphine- - autogenists |
US00041079A US3764606A (en) | 1969-06-04 | 1970-05-27 | 9,9-di-substituted -6,7-benzomorphans |
LU61000D LU61000A1 (en) | 1969-06-04 | 1970-05-27 | |
ZA703636A ZA703636B (en) | 1969-06-04 | 1970-05-28 | New 6,7-benzomorphan derivatives,methods for the preparation thereof and new intermediates |
GB26345/70A GB1299669A (en) | 1969-06-04 | 1970-06-01 | 6,7-benzomorphans and their preparation |
HUCE000870 HU164208B (en) | 1969-06-04 | 1970-06-01 | |
DE19702027077 DE2027077A1 (en) | 1969-06-04 | 1970-06-02 | 6,7-Benzomorphans, process for their preparation and their use |
NO2165/70A NO133496C (en) | 1969-06-04 | 1970-06-03 | |
PL1970141075A PL82622B1 (en) | 1969-06-04 | 1970-06-03 | |
IT68879/70A IT1043829B (en) | 1969-06-04 | 1970-06-03 | PROCEDURE FOR THE PREPARATION OF 6.7 BENZOHORFANI |
AT697271A AT306718B (en) | 1969-06-04 | 1970-06-03 | Process for the preparation of new 2-benzyl-4-piperidinols and their salts |
CH829770A CH566989A5 (en) | 1969-06-04 | 1970-06-03 | |
CH726873A CH546241A (en) | 1969-06-04 | 1970-06-03 | PROCESS FOR THE PREPARATION OF 6,7-BENZOMORPHANES. |
FR7020440A FR2052930B1 (en) | 1969-06-04 | 1970-06-03 | |
DK288270A DK132172C (en) | 1969-06-04 | 1970-06-03 | ANALOGICAL PROCEDURE FOR THE PREPARATION OF 6,7-BENZOMORPHANES OR SALTS THEREOF |
ES380352A ES380352A1 (en) | 1969-06-04 | 1970-06-03 | 9,9-di-substituted -6,7-benzomorphans |
SE7007767A SE374368B (en) | 1969-06-04 | 1970-06-04 | |
JP45047674A JPS496907B1 (en) | 1969-06-04 | 1970-06-04 | |
FI1599/70A FI53310C (en) | 1969-06-04 | 1970-06-04 | FOERFARANDE FOER FRAMSTAELLNING AV ANALGETISKT OCH / ELLER MORFINANTAGONISTISKT VERKANDE 9,9-DISUBSTITUERADE 6,7-BENSOMORFANER SAMT DESSAS OPTISKA ENANTIOMERER OCH TERAPEUTISKT GODTAGBARA SYRAADDITION |
CA084689A CA935430A (en) | 1969-06-04 | 1970-06-04 | Benzomorphans |
PH11504A PH10082A (en) | 1969-06-04 | 1970-06-04 | New 6,7-benzomorphan derivatives and pharmaceutical compositions thereof |
JP771372A JPS5420503B1 (en) | 1969-06-04 | 1972-01-21 | |
DK135672A DK142619B (en) | 1969-06-04 | 1972-03-22 | Substituted 2-benzyl-4-piperidones for use as intermediates in the preparation of benzomorphans, and process for their preparation. |
DK135572A DK135586B (en) | 1969-06-04 | 1972-03-22 | Substituted 2-benzyl-4-piperidinols for use as intermediates in the preparation of benzomorphans. |
DK135472A DK130831B (en) | 1969-06-04 | 1972-03-22 | Substituted 2-benzyl-4-piperidones for use as intermediates in the preparation of benzomorphans, and process for their preparation. |
ES407194A ES407194A1 (en) | 1969-06-04 | 1972-09-30 | 9,9-di-substituted -6,7-benzomorphans |
ES407195A ES407195A1 (en) | 1969-06-04 | 1972-09-30 | 9,9-di-substituted -6,7-benzomorphans |
SE7311827A SE400277B (en) | 1969-06-04 | 1973-08-30 | NEW SUBSTITUTED 2-BENZYL-4-PIPERIDE COMPOUNDS, INTENDED AS INTERMEDIATE PRODUCTS IN THE MANUFACTURE OF NEW 6,7-BENZOMORPHENE DERIVATIVES, WHICH ARE TO BE USED AS ANALGETICS |
CA181,117A CA993876A (en) | 1969-06-04 | 1973-09-14 | Substituted 2-benzyl-4-piperidine compounds |
US05/543,352 US4012392A (en) | 1969-06-04 | 1975-01-23 | 2-Benzyl-4-piperidones useful as intermediates in the production of 6,7-benzomorphan derivatives |
NO751399A NO137091C (en) | 1969-06-04 | 1975-04-18 | SUBSTITUTED 2-BENZYL-4-PIPERIDONES FOR USE AS INTERMEDIATE PRODUCTS IN THE MANUFACTURE OF THERAPEUTIC ACTIVITIES 6,7-BENZOMORPHANS |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL6908527A NL6908527A (en) | 1969-06-04 | 1969-06-04 | Benzomorphanes as analgesics and morphine- - autogenists |
Publications (1)
Publication Number | Publication Date |
---|---|
NL6908527A true NL6908527A (en) | 1970-12-08 |
Family
ID=19807107
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NL6908527A NL6908527A (en) | 1969-06-04 | 1969-06-04 | Benzomorphanes as analgesics and morphine- - autogenists |
Country Status (3)
Country | Link |
---|---|
AT (1) | AT306718B (en) |
NL (1) | NL6908527A (en) |
ZA (1) | ZA703636B (en) |
-
1969
- 1969-06-04 NL NL6908527A patent/NL6908527A/en unknown
-
1970
- 1970-05-28 ZA ZA703636A patent/ZA703636B/en unknown
- 1970-06-03 AT AT697271A patent/AT306718B/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AT306718B (en) | 1973-04-25 |
ZA703636B (en) | 1971-01-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
BN | A decision not to publish the application has become irrevocable |