NL300194I2 - Nieuwe tricyclische verbindingen. - Google Patents

Nieuwe tricyclische verbindingen.

Info

Publication number: NL300194I2
Authority: NL; Netherlands
Prior art keywords: alkyl; amino; alkoxy; halogen; optionally substituted
Prior art date: 1989-11-28

Application number

NL300194C

Other languages

English (en)

Other versions

NL300194I1 (nl

Original Assignee

Roche Palo Alto Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-11-28

Filing date

2005-04-20

Publication date

2005-07-01

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23755479&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NL300194(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2005-04-20 Application filed by Roche Palo Alto Llc filed Critical Roche Palo Alto Llc

2005-07-01 Publication of NL300194I2 publication Critical patent/NL300194I2/nl

2005-07-01 Publication of NL300194I1 publication Critical patent/NL300194I1/nl

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, ***e
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Anesthesiology (AREA)
Cardiology (AREA)
Nutrition Science (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Saccharide Compounds (AREA)

NL300194C 1989-11-28 2005-04-20 Nieuwe tricyclische verbindingen. NL300194I1 (nl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US44208289A	1989-11-28	1989-11-28

Publications (2)

Publication Number	Publication Date
NL300194I2 true NL300194I2 (nl)	2005-07-01
NL300194I1 NL300194I1 (nl)	2005-07-01

Family

ID=23755479

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL300194C NL300194I1 (nl)	1989-11-28	2005-04-20	Nieuwe tricyclische verbindingen.

Country Status (23)

Country	Link
US (1)	US5202333A (nl)
EP (1)	EP0430190B1 (nl)
JP (1)	JPH0662607B2 (nl)
KR (1)	KR970007917B1 (nl)
AT (1)	ATE124698T1 (nl)
AU (1)	AU642178B2 (nl)
BR (1)	BR1100680A (nl)
CA (1)	CA2030718C (nl)
DE (2)	DE122005000027I2 (nl)
DK (1)	DK0430190T3 (nl)
ES (1)	ES2075121T3 (nl)
FI (1)	FI98367C (nl)
HK (1)	HK36097A (nl)
HU (1)	HU218654B (nl)
IE (1)	IE68434B1 (nl)
IL (2)	IL96486A (nl)
LU (1)	LU91162I2 (nl)
NL (1)	NL300194I1 (nl)
NO (2)	NO175309C (nl)
NZ (1)	NZ236225A (nl)
PL (3)	PL166272B1 (nl)
PT (1)	PT96001B (nl)
ZA (1)	ZA909529B (nl)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0662607B2 (ja) *	1989-11-28	1994-08-17	シンテックス（ユー・エス・エイ）インコーポレイテッド	新規三環式化合物
US5491148A (en) *	1991-04-26	1996-02-13	Syntex (U.S.A.) Inc.	Isoquinolinone and dihydroisoquinolinone 5-HT3 receptor antagonists
ES2149767T5 (es)	1991-09-20	2005-06-16	Glaxo Group Limited	Nuevo uso medico para antagonistas de taquiquininas.
US6582728B1 (en) *	1992-07-08	2003-06-24	Inhale Therapeutic Systems, Inc.	Spray drying of macromolecules to produce inhaleable dry powders
US6673335B1 (en) *	1992-07-08	2004-01-06	Nektar Therapeutics	Compositions and methods for the pulmonary delivery of aerosolized medicaments
DK0679088T3 (da) *	1992-09-29	2002-10-28	Inhale Therapeutic Syst	Pulmonal levering af aktive fragmenter af parathyreoideaea hormon
AU689217B2 (en) *	1994-03-07	1998-03-26	Novartis Ag	Methods and compositions for pulmonary delivery of insulin
US20030113273A1 (en) *	1996-06-17	2003-06-19	Patton John S.	Methods and compositions for pulmonary delivery of insulin
GB2288732B (en) *	1994-04-13	1998-04-29	Quadrant Holdings Cambridge	Pharmaceutical compositions
ATE299892T1 (de) *	1994-05-18	2005-08-15	Nektar Therapeutics	Methoden und zusammensetzungen für die trockenpuderarznei aus interferonen
US5567818A (en) *	1994-07-08	1996-10-22	Syntex (U.S.A.) Inc.	Processes for preparing 2-(1-azabicyclo[2.2.2]oct-3-yl)-1H-benz[de] isoquinolin-1-one derivatives and intermediates useful therein
US5510486A (en) *	1994-07-26	1996-04-23	Syntex (U.S.A.) Inc.	Process for preparing 2-(1-azabicyclo 2.2.2!oct-3-yl)-2,3,3A,4,5,6-hexahydro-1H-benz de!isoquinolin-1-one
US5492914A (en) *	1994-07-28	1996-02-20	Syntex (U.S.A.) Inc.	2-(1-azabicyclo[2.2.2]oct-3 s-yl)-6-hydroxy-2,4,5,6-tetrahydro-1H-benz[DE]is[2.2.2]oct-3's-yl)-6-hydroxy-2,3,3a,4,5,6-hexahydro-1h-benz [DE]isoquinolin-1-one and individual stereoisomers thereof
US6290991B1 (en) *	1994-12-02	2001-09-18	Quandrant Holdings Cambridge Limited	Solid dose delivery vehicle and methods of making same
US5723103A (en) *	1994-12-09	1998-03-03	Vanderbilt University	Substituted benzamides and radioligand analogs and methods of use
US20030035778A1 (en) *	1997-07-14	2003-02-20	Robert Platz	Methods and compositions for the dry powder formulation of interferon
US20060165606A1 (en)	1997-09-29	2006-07-27	Nektar Therapeutics	Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6565885B1 (en) *	1997-09-29	2003-05-20	Inhale Therapeutic Systems, Inc.	Methods of spray drying pharmaceutical compositions
US6309623B1 (en) *	1997-09-29	2001-10-30	Inhale Therapeutic Systems, Inc.	Stabilized preparations for use in metered dose inhalers
JP2002537245A (ja) *	1999-02-18	2002-11-05	ノバルティスアクチエンゲゼルシャフト	５−ｈｔ３レセプターアンタゴニストの使用
US7871598B1 (en)	2000-05-10	2011-01-18	Novartis Ag	Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US8404217B2 (en)	2000-05-10	2013-03-26	Novartis Ag	Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
TWI290473B (en)	2000-05-10	2007-12-01	Alliance Pharma	Phospholipid-based powders for drug delivery
US20050042194A1 (en) *	2000-05-11	2005-02-24	A.P. Pharma, Inc.	Semi-solid delivery vehicle and pharmaceutical compositions
AU2001261606A1 (en) *	2000-05-18	2001-11-26	Glaxo Group Limited	Method for treating functional dyspepsia
MXPA04005865A (es)	2001-12-19	2004-09-13	Nektar Therapeutics	Suministro de aminoglucosidos a los pulmones.
EP1478646A1 (en) *	2002-02-20	2004-11-24	PHARMACIA & UPJOHN COMPANY	Azabicyclic compounds with alfa7 nicotinic acetylcholine receptor activity
US20030187017A1 (en) *	2002-11-14	2003-10-02	Mangel Allen Wayne	Method for treating functional dyspepsia
AU2003302072A1 (en) *	2002-11-15	2004-06-15	Helsinn Healthcare Sa	Palonosetron for the treatment of chemotherapy-induced emesis
JO2735B1 (en) *	2003-01-30	2013-09-15	هيلسين هيلث كير أس ايه.	Liquid pharmaceutical formations of balloonosterone
US8598219B2 (en)	2003-01-30	2013-12-03	Helsinn Healthcare Sa	Liquid pharmaceutical formulations of palonosetron
TWI355936B (en)	2003-02-18	2012-01-11	Helsinn Healthcare Sa	Uses of palonosetron hydrochloride
US20060167072A1 (en) *	2004-01-30	2006-07-27	Helsinn Healthcare Sa	Liquid pharmaceutical formulations of palonosetron
CN100336508C (zh) *	2005-02-23	2007-09-12	重庆医药工业研究院有限责任公司	一种稳定的帕洛诺司琼注射液
US20070031342A1 (en) *	2005-06-22	2007-02-08	Nektar Therapeutics	Sustained release microparticles for pulmonary delivery
US20080004260A1 (en) *	2006-06-29	2008-01-03	Transcept Pharmaceuticals, Inc.	Compositions of 5-HT3 antagonists and dopamine D2 antagonists for treatment of dopamine-associated chronic conditions
US8614225B2 (en) *	2006-08-30	2013-12-24	Dr. Reddy's Laboratories Limited	Process for the purification of palonosetron or its salt
WO2008051539A2 (en) *	2006-10-23	2008-05-02	Sicor Inc.	Processes for preparing palonosetron salts
MX2009004461A (es) *	2006-10-24	2009-09-16	Helsinn Healthcare Sa	Formas de dosificacion del clorhidrato de palonosetron que tienen estabilidad y biodisponibilidad mejorada.
EP2099298A4 (en) *	2006-12-07	2010-01-06	Helsinn Healthcare Sa	CRYSTALLINE AND AMORPHOUS FORMS OF PALONOSETRON HYDROCHLORIDE
US8334388B2 (en) *	2007-05-29	2012-12-18	Chemagis Ltd.	Palonosetron salts and processes for preparation and purification thereof
US20090227623A1 (en) *	2007-09-15	2009-09-10	Protia, Llc	Deuterium-enriched palosetron
CN101157691B (zh) *	2007-10-18	2011-01-12	杭州九源基因工程有限公司	一种盐酸帕洛诺司琼的生产工艺
AR069625A1 (es) *	2007-12-13	2010-02-03	Glenmark Generics Ltd	Base libre de palonosetron y procedimiento para su preparacion
WO2009087643A1 (en) *	2008-01-11	2009-07-16	Natco Pharma Limited	Novel crystalline forms of palonosetron hydrochloride
WO2009136405A1 (en) *	2008-05-05	2009-11-12	Natco Pharma Limited	High purity palonosetron base and its solid state characteristics
US20100048607A1 (en) *	2008-08-25	2010-02-25	Chandrashekhar Kocherlakota	Formulations comprising palonosetron
US20100099701A1 (en) *	2008-10-20	2010-04-22	Auspex Pharmaceuticals, Inc.	Isoquinolinone modulators of 5-ht3 receptors
WO2010056656A2 (en) *	2008-11-11	2010-05-20	Dr. Reddy's Laboratories Ltd.	Preparation of crystalline palonosetron hydrochloride
EP2364138A2 (en)	2008-12-08	2011-09-14	Teva Pharmaceutical Industries Ltd.	Palonosetron formulation
US20100152227A1 (en) *	2008-12-11	2010-06-17	A.P. Pharma, Inc.	Methods for Enhancing Stability of Polyorthoesters and Their Formulations
CN101851233B (zh) *	2009-04-03	2013-03-06	四川滇虹医药开发有限公司	盐酸帕洛诺司琼和其前体化合物及制备
CN101849904A (zh) *	2009-04-03	2010-10-06	南京长澳医药科技有限公司	一种帕洛诺司琼注射液及其制备方法
US20100298397A1 (en) *	2009-05-19	2010-11-25	Singh Nikhilesh N	Method of treatment of obsessive compulsive disorder with ondansetron
ES2664599T3 (es)	2009-05-20	2018-04-20	INSERM (Institut National de la Santé et de la Recherche Médicale)	Antagonistas del receptor 5-HT3 de serotonina para uso en el tratamiento de trastornos vestibulares lesionales
EP2253316B1 (en)	2009-05-20	2013-08-14	INSERM (Institut National de la Santé et de la Recherche Médicale)	Serotonin 5-HT3 receptor antagonists for use in the treatment or prevention of an inner ear pathology with vestibular deficits
US20120267533A1 (en)	2009-06-30	2012-10-25	Ranbaxy Laboratories Limited	Processes for the preparation of form i and form ii of palonosetron hydrochloride
AU2010273732A1 (en)	2009-07-14	2012-02-09	Albany Molecular Research, Inc.	5-HT3 receptor modulators, methods of making, and use thereof
WO2011013095A1 (en)	2009-07-31	2011-02-03	Ranbaxy Laboratories Limited	Processes for the preparation of palonosetron
JP2013510843A (ja) *	2009-11-13	2013-03-28	ヘルシンヘルスケアソシエテアノニム	パロノセトロン代謝産物先行出願との関連本出願は２００９年１１月１３日に出願された米国仮出願第６１／２６０，９１６号の優先権を主張する。
EP2722045B1 (en)	2009-11-18	2016-07-06	Helsinn Healthcare SA	Compositions for treating centrally mediated nausea and vomiting
CN106421793B (zh)	2009-11-18	2023-06-16	赫尔森保健股份公司	用于治疗中枢介导的恶心及呕吐的组合物及方法
EP2744497B1 (en)	2011-10-18	2016-04-06	Helsinn Healthcare SA	Therapeutic combinations of netupitant and palonosetron
CN102688185B (zh) *	2012-06-01	2013-07-10	齐鲁制药(海南)有限公司	一种稳定的帕洛诺司琼注射液及其制备方法
CN105934247A (zh)	2013-12-23	2016-09-07	株式会社三养生物制药	包含帕洛诺司琼的药物组合物
US20180250270A1 (en)	2015-09-11	2018-09-06	Chase Pharmaceuticals Corporation	Muscarinic combination and its use for combating hypocholinergic disorders of the central nervous system
WO2019038656A1 (en)	2017-08-21	2019-02-28	Leiutis Pharmaceuticals Pvt, Ltd	NEW TRIPLE COMBINATION FORMULATIONS FOR ANTIEMETIC THERAPY
EP4385500A1 (en)	2022-12-12	2024-06-19	Alfred E. Tiefenbacher (GmbH & Co. KG)	Fixed dose combination comprising netupitant and palonosetron
WO2024126408A1 (en)	2022-12-12	2024-06-20	Alfred E. Tiefenbacher (Gmbh & Co. Kg)	Antioxidant-free fixed dose combination of netupitant and palonosetron
WO2024126398A1 (en)	2022-12-12	2024-06-20	Alfred E. Tiefenbacher (Gmbh & Co. Kg)	Fixed dose combination comprising netupitant and palonosetron
EP4385497A1 (en)	2022-12-12	2024-06-19	Alfred E. Tiefenbacher (GmbH & Co. KG)	Antioxidant-free fixed dose combination of netupitant and palonosetron

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3341528A (en) *	1963-11-07	1967-09-12	Warner Lambert Pharmaceutical	Substituted benzoquinolines
US3896132A (en) *	1969-08-19	1975-07-22	Hoffmann La Roche	Process for preparing 1,2,3,8,9,9a-hexahydro-5,6-dialkoxy-1-alkyl-benzo(d,e)quinolin-7-ore compounds
US4309543A (en) *	1980-03-17	1982-01-05	Dynapol	Process for preparing cyclic amides
EP0093488A3 (en) *	1982-03-18	1984-05-23	Beecham Group Plc	Nortropyl benzopyrrolinone compounds, process for their preparation and pharmaceutical compositions containing them
US4571396A (en) *	1984-04-16	1986-02-18	Warner-Lambert Company	Antibacterial agents
WO1988004292A1 (en) *	1986-12-11	1988-06-16	The Upjohn Company	Antipsychotic amino-polyhydro-benz-(iso)quinolines and intermediates
EP0315390B1 (en) *	1987-11-04	1994-07-20	Beecham Group Plc	Novel 4-oxobenzotriazines and 4-oxoquinazolines
JPH0662607B2 (ja) *	1989-11-28	1994-08-17	シンテックス（ユー・エス・エイ）インコーポレイテッド	新規三環式化合物
AU7618991A (en) *	1990-05-14	1991-11-14	Syntex (U.S.A.) Inc.	Novel tricyclic compounds
US5189041A (en) *	1990-11-16	1993-02-23	Syntex (U.S.A.) Inc.	Tricyclic 5-ht3 receptor antagonists

1990
- 1990-11-27 JP JP2328764A patent/JPH0662607B2/ja not_active Expired - Fee Related
- 1990-11-27 FI FI905839A patent/FI98367C/fi active Protection Beyond IP Right Term
- 1990-11-27 IE IE426990A patent/IE68434B1/en not_active IP Right Cessation
- 1990-11-27 AT AT90122689T patent/ATE124698T1/de active
- 1990-11-27 NO NO905120A patent/NO175309C/no not_active IP Right Cessation
- 1990-11-27 AU AU66963/90A patent/AU642178B2/en not_active Expired
- 1990-11-27 IL IL9648690A patent/IL96486A/en active Protection Beyond IP Right Term
- 1990-11-27 IL IL11062290A patent/IL110622A/en not_active IP Right Cessation
- 1990-11-27 DE DE200512000027 patent/DE122005000027I2/de active Active
- 1990-11-27 PT PT96001A patent/PT96001B/pt not_active IP Right Cessation
- 1990-11-27 PL PL90287961A patent/PL166272B1/pl unknown
- 1990-11-27 NZ NZ236225A patent/NZ236225A/en unknown
- 1990-11-27 DE DE69020694T patent/DE69020694T2/de not_active Expired - Lifetime
- 1990-11-27 PL PL90303660A patent/PL166267B1/pl unknown
- 1990-11-27 EP EP90122689A patent/EP0430190B1/en not_active Expired - Lifetime
- 1990-11-27 DK DK90122689.4T patent/DK0430190T3/da active
- 1990-11-27 HU HU670/90A patent/HU218654B/hu active Protection Beyond IP Right Term
- 1990-11-27 ZA ZA909529A patent/ZA909529B/xx unknown
- 1990-11-27 ES ES90122689T patent/ES2075121T3/es not_active Expired - Lifetime
- 1990-11-27 KR KR1019900019275A patent/KR970007917B1/ko not_active IP Right Cessation
- 1990-11-27 PL PL90303661A patent/PL166277B1/pl unknown
- 1990-11-27 CA CA002030718A patent/CA2030718C/en not_active Expired - Lifetime
1991
- 1991-05-22 US US07/704,565 patent/US5202333A/en not_active Expired - Lifetime
1997
- 1997-03-20 HK HK36097A patent/HK36097A/xx not_active IP Right Cessation
- 1997-05-08 BR BR1100680-3A patent/BR1100680A/pt active IP Right Grant
2005
- 2005-04-18 LU LU91162C patent/LU91162I2/fr unknown
- 2005-04-20 NL NL300194C patent/NL300194I1/nl unknown
- 2005-09-21 NO NO2005023C patent/NO2005023I2/no unknown

Also Published As

Publication number	Publication date
KR970007917B1 (ko)	1997-05-17
DE122005000027I2 (de)	2006-03-16
ZA909529B (en)	1992-08-26
FI905839A (fi)	1991-05-29
DE69020694D1 (de)	1995-08-10
IL96486A (en)	1995-03-30
JPH03176486A (ja)	1991-07-31
EP0430190B1 (en)	1995-07-05
BR1100680A (pt)	2000-02-08
PT96001A (pt)	1991-09-30
HU907660D0 (en)	1991-06-28
AU6696390A (en)	1991-06-06
NO175309C (no)	1994-09-28
PL287961A1 (en)	1991-12-02
CA2030718A1 (en)	1991-05-29
IE904269A1 (en)	1991-06-05
ATE124698T1 (de)	1995-07-15
PL166267B1 (pl)	1995-04-28
ES2075121T3 (es)	1995-10-01
NO2005023I1 (no)	2005-10-03
DK0430190T3 (da)	1995-08-21
IE68434B1 (en)	1996-06-12
NZ236225A (en)	1992-09-25
EP0430190A2 (en)	1991-06-05
HK36097A (en)	1997-03-27
DE122005000027I1 (de)	2005-08-04
NO175309B (no)	1994-06-20
HU218654B (hu)	2000-10-28
LU91162I2 (fr)	2005-06-20
US5202333A (en)	1993-04-13
PL166277B1 (pl)	1995-04-28
NO905120L (no)	1991-05-29
IL110622A (en)	1995-03-30
FI98367B (fi)	1997-02-28
NO905120D0 (no)	1990-11-27
IL96486A0 (en)	1991-08-16
AU642178B2 (en)	1993-10-14
KR910009699A (ko)	1991-06-28
PL166272B1 (pl)	1995-04-28
EP0430190A3 (en)	1992-01-22
PT96001B (pt)	1998-01-30
NL300194I1 (nl)	2005-07-01
HUT56368A (en)	1991-08-28
FI98367C (fi)	1997-06-10
NO2005023I2 (no)	2009-10-05
CA2030718C (en)	1998-05-12
JPH0662607B2 (ja)	1994-08-17
FI905839A0 (fi)	1990-11-27
DE69020694T2 (de)	1996-01-18

Publication	Publication Date	Title
NL300194I1 (nl)	2005-07-01	Nieuwe tricyclische verbindingen.
EA200100553A1 (ru)	2001-12-24	Замещенные бициклические производные, полезные в качестве противораковых агентов
EA200000391A1 (ru)	2000-12-25	Производные тиенопиримидина и тиенопиридина, полезные в качестве противораковых агентов
TR199801782T2 (xx)	1998-12-21	Kinoksalindionlar
PT753301E (pt)	2003-08-29	Combinacao de um benzimidazole tendo actividade antagonista da angiotensina ii com um diuretico
ID25477A (id)	2000-10-05	Turunan-turunan spiropiperidin
TW334428B (en)	1998-06-21	Novel benzodiazepine derivatives
ATE151750T1 (de)	1997-05-15	3-(indol-3-yl) propensäurderivate, die als nmda- antagonisten nützlich sind
AP2000002009A0 (en)	2000-12-31	Tetrahydronaphthyridinyl-carboxamides having anti-convulsant activity.
WO1997029077A1 (fr)	1997-08-14	Derives amides substitues
ATE264320T1 (de)	2004-04-15	5-aminoalkyl- und 5-aminocarbonylsubstituierte indole