NL300015I1 - 1,3-Dihydro-4- (aroyl) -2H-imidazole-2-ones and anti-hypertensive, cardiotonic and anti-thrombotic active pharmaceutical composition. - Google Patents

1,3-Dihydro-4- (aroyl) -2H-imidazole-2-ones and anti-hypertensive, cardiotonic and anti-thrombotic active pharmaceutical composition.

Info

Publication number: NL300015I1
Authority: NL; Netherlands
Prior art keywords: cardiotonic; aroyl; hypertensive; dihydro; imidazole
Prior art date: 1979-06-18

Application number

NL300015C

Other languages

Dutch (nl)

Other versions

NL300015I2 (en

Original Assignee

Merrell Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-06-18

Filing date

2000-09-04

Publication date

2000-11-01

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26727558&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NL300015(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2000-09-04 Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc

2000-10-02 Publication of NL300015I2 publication Critical patent/NL300015I2/en

2000-11-01 Publication of NL300015I1 publication Critical patent/NL300015I1/en

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

NL300015C 1979-06-18 2000-09-04 1,3-Dihydro-4- (aroyl) -2H-imidazole-2-ones and anti-hypertensive, cardiotonic and anti-thrombotic active pharmaceutical composition. NL300015I1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US4980879A	1979-06-18	1979-06-18
US11920780A	1980-02-07	1980-02-07

Publications (2)

Publication Number	Publication Date
NL300015I2 NL300015I2 (en)	2000-10-02
NL300015I1 true NL300015I1 (en)	2000-11-01

Family

ID=26727558

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
NL8003498A NL193752C (en)	1979-06-18	1980-06-17	1,3-Dihydro-4- (aroyl) -2H-imidazole-2-ones and anti-hypertensive, cardiotonic and anti-thrombotic active pharmaceutical composition.
NL300015C NL300015I1 (en)	1979-06-18	2000-09-04	1,3-Dihydro-4- (aroyl) -2H-imidazole-2-ones and anti-hypertensive, cardiotonic and anti-thrombotic active pharmaceutical composition.

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
NL8003498A NL193752C (en)	1979-06-18	1980-06-17	1,3-Dihydro-4- (aroyl) -2H-imidazole-2-ones and anti-hypertensive, cardiotonic and anti-thrombotic active pharmaceutical composition.

Country Status (20)

Country	Link
AT (1)	AT375349B (en)
AU (1)	AU532783B2 (en)
CA (1)	CA1132554A (en)
CH (1)	CH646155A5 (en)
DE (1)	DE3021792A1 (en)
DK (1)	DK160269C (en)
ES (1)	ES8105299A1 (en)
FR (1)	FR2459233A1 (en)
GB (1)	GB2055364B (en)
HK (1)	HK61486A (en)
HU (1)	HU186736B (en)
IE (1)	IE50646B1 (en)
IL (1)	IL60243A (en)
IT (1)	IT1143922B (en)
MY (1)	MY8600709A (en)
NL (2)	NL193752C (en)
NO (1)	NO152841C (en)
NZ (1)	NZ193935A (en)
PH (1)	PH18683A (en)
SE (2)	SE447107B (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PH18106A (en) *	1981-02-18	1985-03-21	Merrell Dow Pharma	Novel-4-aroylimidazol-2-ones
US4405628A (en) *	1981-03-05	1983-09-20	Merrell Dow Pharmaceuticals Inc.	4-Pyridylimidazolones and method of use
CA1167853A (en) *	1981-05-04	1984-05-22	J. Martin Grisar	4-oxymethyl-5-acyl-1,3-dihydro-2h-imidazol-2-ones
US4329471A (en) *	1981-05-04	1982-05-11	Merrell Dow Pharmaceuticals Inc.	4-(4-Phenyl-1-piperidinyl)methyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones
US4329470A (en) *	1981-05-04	1982-05-11	Merrell Dow Pharmaceuticals Inc.	5-(4-Phenyl 1-piperidinyl)methyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives
US4381393A (en) *	1981-05-04	1983-04-26	Merrell Dow Pharmaceuticals Inc.	4-Aminomethyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones
US4526981A (en) *	1981-05-04	1985-07-02	Merrell Dow Pharmaceuticals Inc.	[1,2-Dihydro-4(5)-acyl-2-oxo-2H-imidazol-4(5)-yl] methyl nitrates
US4371737A (en) *	1981-05-04	1983-02-01	Merrell Dow Pharmaceuticals Inc.	5-Aminomethyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives
US4410540A (en) *	1981-11-04	1983-10-18	Merrell Dow Pharmaceuticals Inc.	Cardiotonic 4-aroylimidazolidin-2-ones
US4367236A (en)	1981-11-04	1983-01-04	Merrell Dow Pharmaceuticals Inc.	Method for the treatment of cardiac failure with alkanoylimidazol-2-one derivatives
US7772188B2 (en)	2003-01-28	2010-08-10	Ironwood Pharmaceuticals, Inc.	Methods and compositions for the treatment of gastrointestinal disorders
CA2560538A1 (en) *	2004-03-22	2005-10-06	Myogen, Inc.	(r)-enoximone sulfoxide and its use in the treatment of pde-iii mediated diseases
US20060025463A1 (en) *	2004-03-22	2006-02-02	Michael Bristow	Enoximone sulfoxide enantiomers and their use in the treatment of PDE-III mediated diseases
CN101355876B (en)	2005-11-09	2012-09-05	康宾纳特克斯公司	Compositions for the eye adminstration
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2170930B3 (en)	2007-06-04	2013-10-02	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
JP2011522828A (en)	2008-06-04	2011-08-04	シナジーファーマシューティカルズインコーポレイテッド	Guanylate cyclase agonists useful for the treatment of gastrointestinal disorders, inflammation, cancer, and other disorders
AU2009270833B2 (en)	2008-07-16	2015-02-19	Bausch Health Ireland Limited	Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
DK2681236T3 (en)	2011-03-01	2018-04-16	Synergy Pharmaceuticals Inc	PROCEDURE FOR MANUFACTURING GUANYLATE CYCLASE-C-AGONISTS
EP2804603A1 (en)	2012-01-10	2014-11-26	President and Fellows of Harvard College	Beta-cell replication promoting compounds and methods of their use
EP2958577A2 (en)	2013-02-25	2015-12-30	Synergy Pharmaceuticals Inc.	Guanylate cyclase receptor agonists for use in colonic cleansing
WO2014151206A1 (en)	2013-03-15	2014-09-25	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase and their uses
CA2905435A1 (en)	2013-03-15	2014-09-25	Synergy Pharmaceuticals Inc.	Compositions useful for the treatment of gastrointestinal disorders
EP3004138B1 (en)	2013-06-05	2024-03-13	Bausch Health Ireland Limited	Ultra-pure agonists of guanylate cyclase c, method of making and using same
AU2014305843B2 (en)	2013-08-09	2019-08-29	Ardelyx, Inc.	Compounds and methods for inhibiting phosphate transport
US20200368223A1 (en)	2019-05-21	2020-11-26	Ardelyx, Inc.	Methods for inhibiting phosphate transport
CN114539157B (en) *	2022-03-03	2023-12-22	曲靖师范学院	Method for preparing 4-iodo-N-aryl pyrazole compound by iodine-promoted oxidation method

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2441933A (en) *	1945-07-30	1948-05-18	Hoffmann La Roche	Substituted imidazolones and process of making them

1980
- 1980-06-04 NZ NZ193935A patent/NZ193935A/en unknown
- 1980-06-05 IE IE1162/80A patent/IE50646B1/en not_active IP Right Cessation
- 1980-06-06 SE SE8004253A patent/SE447107B/en not_active IP Right Cessation
- 1980-06-06 AU AU59118/80A patent/AU532783B2/en not_active Expired
- 1980-06-06 IL IL60243A patent/IL60243A/en unknown
- 1980-06-09 ES ES492255A patent/ES8105299A1/en not_active Expired
- 1980-06-11 DE DE19803021792 patent/DE3021792A1/en active Granted
- 1980-06-13 AT AT0314280A patent/AT375349B/en not_active IP Right Cessation
- 1980-06-16 PH PH24143A patent/PH18683A/en unknown
- 1980-06-16 CH CH462780A patent/CH646155A5/en not_active IP Right Cessation
- 1980-06-17 NO NO801796A patent/NO152841C/en unknown
- 1980-06-17 HU HU801506A patent/HU186736B/en unknown
- 1980-06-17 CA CA354,197A patent/CA1132554A/en not_active Expired
- 1980-06-17 NL NL8003498A patent/NL193752C/en not_active IP Right Cessation
- 1980-06-17 FR FR8013434A patent/FR2459233A1/en active Granted
- 1980-06-17 DK DK259080A patent/DK160269C/en not_active IP Right Cessation
- 1980-06-17 IT IT48997/80A patent/IT1143922B/en active Protection Beyond IP Right Term
- 1980-06-18 GB GB8019898A patent/GB2055364B/en not_active Expired
1985
- 1985-03-25 SE SE8501452A patent/SE464559B/en not_active IP Right Cessation
1986
- 1986-08-21 HK HK614/86A patent/HK61486A/en not_active IP Right Cessation
- 1986-12-30 MY MY709/86A patent/MY8600709A/en unknown
2000
- 2000-09-04 NL NL300015C patent/NL300015I1/en unknown

Also Published As

Publication number	Publication date
ES492255A0 (en)	1981-06-01
NL193752C (en)	2000-09-04
AT375349B (en)	1984-07-25
DE3021792A1 (en)	1981-01-22
SE8501452D0 (en)	1985-03-25
GB2055364B (en)	1983-06-08
ATA314280A (en)	1983-12-15
SE464559B (en)	1991-05-13
DK160269C (en)	1991-07-22
SE8004253L (en)	1980-12-19
DK160269B (en)	1991-02-18
GB2055364A (en)	1981-03-04
SE447107B (en)	1986-10-27
IL60243A0 (en)	1980-09-16
FR2459233A1 (en)	1981-01-09
MY8600709A (en)	1986-12-31
IL60243A (en)	1987-01-30
IT8048997A0 (en)	1980-06-17
DE3021792C2 (en)	1989-08-10
NO152841C (en)	1985-11-27
CH646155A5 (en)	1984-11-15
NL193752B (en)	2000-05-01
NL8003498A (en)	1980-12-22
AU5911880A (en)	1981-01-08
FR2459233B1 (en)	1983-09-23
SE8501452L (en)	1985-03-25
PH18683A (en)	1985-08-29
NO801796L (en)	1980-12-19
HU186736B (en)	1985-09-30
NL300015I2 (en)	2000-10-02
IT1143922B (en)	1986-10-29
HK61486A (en)	1986-08-29
CA1132554A (en)	1982-09-28
NO152841B (en)	1985-08-19
AU532783B2 (en)	1983-10-13
DK259080A (en)	1980-12-19
NZ193935A (en)	1985-05-31
ES8105299A1 (en)	1981-06-01
IE801162L (en)	1980-12-18
IE50646B1 (en)	1986-06-11

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