NL190071C - 4-oxo-pyrimido-(2,1-a)-isochinoline-derivaat met een anti-allergische activiteit, werkwijze ter bereiding daarvan en farmaceutisch preparaat daaruit vervaardigd. - Google Patents

4-oxo-pyrimido-(2,1-a)-isochinoline-derivaat met een anti-allergische activiteit, werkwijze ter bereiding daarvan en farmaceutisch preparaat daaruit vervaardigd.

Info

Publication number
NL190071C
NL190071C NLAANVRAGE7809626,A NL7809626A NL190071C NL 190071 C NL190071 C NL 190071C NL 7809626 A NL7809626 A NL 7809626A NL 190071 C NL190071 C NL 190071C
Authority
NL
Netherlands
Prior art keywords
preparation
isochinoline
pyrimido
oxo
derivative
Prior art date
Application number
NLAANVRAGE7809626,A
Other languages
English (en)
Other versions
NL190071B (nl
NL7809626A (nl
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NL7809626A publication Critical patent/NL7809626A/nl
Publication of NL190071B publication Critical patent/NL190071B/nl
Application granted granted Critical
Publication of NL190071C publication Critical patent/NL190071C/nl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C331/00Derivatives of thiocyanic acid or of isothiocyanic acid
    • C07C331/16Isothiocyanates
    • C07C331/18Isothiocyanates having isothiocyanate groups bound to acyclic carbon atoms
    • C07C331/22Isothiocyanates having isothiocyanate groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C331/24Isothiocyanates having isothiocyanate groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
NLAANVRAGE7809626,A 1977-09-21 1978-09-21 4-oxo-pyrimido-(2,1-a)-isochinoline-derivaat met een anti-allergische activiteit, werkwijze ter bereiding daarvan en farmaceutisch preparaat daaruit vervaardigd. NL190071C (nl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/835,266 US4127720A (en) 1977-09-21 1977-09-21 Pyrimido[2,1-a]isoquinoline derivatives having antiallergy activity

Publications (3)

Publication Number Publication Date
NL7809626A NL7809626A (nl) 1979-03-23
NL190071B NL190071B (nl) 1993-05-17
NL190071C true NL190071C (nl) 1993-10-18

Family

ID=25269074

Family Applications (1)

Application Number Title Priority Date Filing Date
NLAANVRAGE7809626,A NL190071C (nl) 1977-09-21 1978-09-21 4-oxo-pyrimido-(2,1-a)-isochinoline-derivaat met een anti-allergische activiteit, werkwijze ter bereiding daarvan en farmaceutisch preparaat daaruit vervaardigd.

Country Status (18)

Country Link
US (1) US4127720A (nl)
JP (1) JPS5463099A (nl)
AU (1) AU522646B2 (nl)
BE (1) BE870634A (nl)
CA (1) CA1108613A (nl)
CH (1) CH642967A5 (nl)
DE (1) DE2841126A1 (nl)
DK (1) DK164553C (nl)
FI (1) FI65246C (nl)
FR (1) FR2404010A1 (nl)
GB (1) GB2004876B (nl)
GR (1) GR72144B (nl)
IE (1) IE47189B1 (nl)
LU (1) LU80272A1 (nl)
NL (1) NL190071C (nl)
SE (1) SE438335B (nl)
YU (2) YU41598B (nl)
ZA (1) ZA785354B (nl)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4209620A (en) * 1978-06-19 1980-06-24 Bristol-Myers Company Substituted 3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives having antiallergy activity
US4472401A (en) * 1981-11-27 1984-09-18 Roussel Uclaf Pyrimido-quinoxalines having antiallergic properties
NO162019C (no) * 1983-11-23 1989-10-25 Fujisawa Pharmaceutical Co Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrimidoiskinolinderivater.
GB8331228D0 (en) * 1983-11-23 1983-12-29 Fujisawa Pharmaceutical Co Pyrimidoisoquinoline derivatives
US4661592A (en) * 1984-06-27 1987-04-28 G. D. Searle & Co. 4H-pyrimido[2,1-a]isoquinolin-4-one derivatives
SK134698A3 (en) * 1996-04-13 1999-06-11 Astra Pharma Prod Aminoisoquinolines and aminothienopyridine derivatives and their use as anti-inflammatory agents
WO2006068932A2 (en) * 2004-12-20 2006-06-29 Wyeth Rapamycin analogues and the uses thereof in the treatment of neurological, proliferative, and inflammatory disorders
WO2006068905A2 (en) * 2004-12-20 2006-06-29 Wyeth Rapamycin derivatives and the uses thereof in the treatment of neurological disorders
EP4320117A2 (en) * 2021-04-04 2024-02-14 Baruch S. Blumberg Institute Novel hepatoselective polyadenylating polymerases inhibitors and their method of use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1356937A (en) * 1970-08-27 1974-06-19 Wellcome Found Pyrimido-isoquinolines
BE792648A (fr) * 1971-12-13 1973-06-12 May & Baker Ltd Derives de l'isoquinoleine
CA1033731A (en) * 1974-04-01 1978-06-27 Saul B. Kadin Process for preparing 1-oxo-1h-6-hydroxypyrimido (1,2-a)quinoline-2-carboxylic acids and derivatives
US4066766A (en) * 1975-03-03 1978-01-03 Pfizer Inc. 1-Oxo-6-substituted pyrimido [1,2-a]quinoline-2-carboxylic acids and derivatives thereof and their use as antiallergy agents
SU685156A3 (ru) * 1975-08-01 1979-09-05 Пфайзер Инк (Фирма) Способ получени -(5-тетразолил(1-оксо-1н-пиримидо-)1,2-а) хинолин-2-карбоксамида
US4017625A (en) * 1975-08-01 1977-04-12 Pfizer Inc. Anti-allergic N-(5-tetrazolyl)-1-oxo-1H-6-alkoxypyrimido-[1,2-a]quinoline-2-carboxamides and intermediates therefor
US4033961A (en) * 1975-10-07 1977-07-05 Warner-Lambert Company Pyrido[2-1-b]quinazolin-ones and their methods of preparation

Also Published As

Publication number Publication date
JPS5463099A (en) 1979-05-21
SE438335B (sv) 1985-04-15
DE2841126A1 (de) 1979-04-05
NL190071B (nl) 1993-05-17
DK164553C (da) 1992-11-30
YU41598B (en) 1987-10-31
DK164553B (da) 1992-07-13
CA1108613A (en) 1981-09-08
IE47189B1 (en) 1984-01-11
CH642967A5 (de) 1984-05-15
GB2004876B (en) 1982-03-10
JPS6212225B2 (nl) 1987-03-17
DK413578A (da) 1979-03-22
US4127720A (en) 1978-11-28
LU80272A1 (fr) 1979-06-01
IE781897L (en) 1979-03-21
AU4004278A (en) 1980-03-27
DE2841126C2 (nl) 1990-05-17
YU222778A (en) 1984-02-29
FI782849A (fi) 1979-03-22
FI65246B (fi) 1983-12-30
FR2404010A1 (fr) 1979-04-20
YU44501B (en) 1990-08-31
FI65246C (fi) 1984-04-10
BE870634A (fr) 1979-03-20
ZA785354B (en) 1979-09-26
SE7809887L (sv) 1979-03-22
FR2404010B1 (nl) 1980-10-31
GB2004876A (en) 1979-04-11
YU63585A (en) 1986-04-30
NL7809626A (nl) 1979-03-23
GR72144B (nl) 1983-09-20
AU522646B2 (en) 1982-06-17

Similar Documents

Publication Publication Date Title
BE859012A (fr) Derives de 4-n-acylfortimicines b, leur preparation et leur application
IT7829043A0 (it) Polisaccaride avente attivita'anti-tumorale, procedimento per lasua produzione e sostanza anti-tumorale comprendente detto polisaccaride.
NL190702B (nl) 4h-pyrido(1,2-a)pyrimidin-4-on verbinding met anti-allergische werkzaamheid, alsmede farmaceutisch preparaat daarvan.
NL7612286A (nl) Piperidinederivaten en werkwijze voor hun be- reiding.
NL7607338A (nl) Werkwijze voor de bereiding van 1,4-dihydro- pyrinederivaten met vaatverwijdende en bloed- drukverlagende activiteit.
NL183920C (nl) Melk-voedingsprodukt en werkwijze voor de bereiding daarvan.
IT7829387A0 (it) Glucopeptidi e metodo di loro preparazione.
BE860736A (fr) Derives de piperidine et leur preparation.
NL7804345A (nl) Imidazoazinen en imidazodiazinen, werkwijze ter berei- ding daarvan en farmaceutische preparaten.
NL7804230A (nl) N-alkyl-n-acylderivaten van thienamycine, werkwijze ter bereiding daarvan, alsmede farmaceutische preparaten.
NL190520B (nl) Op plaats 1 gesubstitueerde, 7-gesubstitueerde amino-6-halogeen-4-oxo-1,4-dihydrochinoline-3-carbonzuren en farmaceutische preparaten, die deze bevatten.
NL184467C (nl) 6-oxo-prostaglandine eŸ1 derivaten, werkwijze voor de bereiding daarvan en farmaceutische preparaten, die deze bevatten.
NL190071C (nl) 4-oxo-pyrimido-(2,1-a)-isochinoline-derivaat met een anti-allergische activiteit, werkwijze ter bereiding daarvan en farmaceutisch preparaat daaruit vervaardigd.
NL187397C (nl) Farmaceutische preparaten, 20,21-dinoreburnamenineverbindingen daarvoor en werkwijze voor hun bereiding.
FR2342724A1 (fr) Derives de 16,16-spirocycloalkylprostaglandines, leur preparation et leurs utilisations therapeutiques
NL174345C (nl) Zuur alkalicitraat, werkwijze ter bereiding daarvan en therapeutisch preparaat.
IT7825106A0 (it) Acetilenprostaglandine eprocedimento per la loro preparazione.
NL7803409A (nl) Werkwijze voor de bereiding van 4-hydroxy-5- -alkyl- en 4-hydroxy-2,5-dialkyl-3-oxo-2h- -furanen.
BE857576A (fr) Derives de la phenothiazine, leur preparation et leurs utilisations therapeutiques
NL7802525A (nl) Vast farmaceutisch preparaat en werkwijze ter bereiding daarvan.
BE868569A (fr) Derives du diphenyle, leur preparation et leurs utilisations therapeutiques
NL7610067A (nl) Derivaten van 1,2,4-oxadiazin-5-onen en werkwij- zen voor hun bereiding en toepassing.
IT7823392A0 (it) 17 beta-idrossi-4-androsten-3-oni e procedimento per la loro preparazione.
NL7601670A (nl) Aminopyrrool derivaten en werkwijzen voor de bereiding en toepassing daarvan.
NL7806321A (nl) Piperazinecarbodithiozuurderivaten, werkwijze voor de bereiding daarvan en geneesmiddelen daaruit.

Legal Events

Date Code Title Description
A85 Still pending on 85-01-01
BA A request for search or an international-type search has been filed
BB A search report has been drawn up
BC A request for examination has been filed
DNT Communications of changes of names of applicants whose applications have been laid open to public inspection

Free format text: BRISTOL-MYERS SQUIBB COMPANY

V1 Lapsed because of non-payment of the annual fee