NL187746C - NŸ2-ARYLSULFONYL-L-ARGININE AMIDES, PROCESS FOR THEIR PREPARATION, AND PROCESS FOR PREPARING A PHARMACEUTICAL PREPARATION USING SUCH A COMPOUND AND/OR SALT THEREOF. - Google Patents

NŸ2-ARYLSULFONYL-L-ARGININE AMIDES, PROCESS FOR THEIR PREPARATION, AND PROCESS FOR PREPARING A PHARMACEUTICAL PREPARATION USING SUCH A COMPOUND AND/OR SALT THEREOF.

Info

Publication number
NL187746C
NL187746C NLAANVRAGE7800448,A NL7800448A NL187746C NL 187746 C NL187746 C NL 187746C NL 7800448 A NL7800448 A NL 7800448A NL 187746 C NL187746 C NL 187746C
Authority
NL
Netherlands
Prior art keywords
preparation
arylsulfonyl
salt
preparing
compound
Prior art date
Application number
NLAANVRAGE7800448,A
Other languages
Dutch (nl)
Other versions
NL187746B (en
NL7800448A (en
Original Assignee
Mitsubishi Chem Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/760,929 external-priority patent/US4101653A/en
Priority claimed from US05/760,676 external-priority patent/US4097472A/en
Priority claimed from US05/760,672 external-priority patent/US4093712A/en
Priority claimed from US05/760,668 external-priority patent/US4073913A/en
Priority claimed from US05/760,745 external-priority patent/US4066773A/en
Priority claimed from US05/776,195 external-priority patent/US4097591A/en
Priority claimed from JP6650877A external-priority patent/JPS6010028B2/en
Priority claimed from US05/804,331 external-priority patent/US4140681A/en
Priority claimed from US05/804,368 external-priority patent/US4131673A/en
Application filed by Mitsubishi Chem Ind filed Critical Mitsubishi Chem Ind
Publication of NL7800448A publication Critical patent/NL7800448A/en
Publication of NL187746B publication Critical patent/NL187746B/en
Publication of NL187746C publication Critical patent/NL187746C/en
Application granted granted Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/14—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 6 and unsubstituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/06—Six-membered rings
    • C07D327/08—[b,e]-condensed with two six-membered carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/76—Dibenzothiophenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C07K5/06095—Arg-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NLAANVRAGE7800448,A 1977-01-19 1978-01-13 NŸ2-ARYLSULFONYL-L-ARGININE AMIDES, PROCESS FOR THEIR PREPARATION, AND PROCESS FOR PREPARING A PHARMACEUTICAL PREPARATION USING SUCH A COMPOUND AND/OR SALT THEREOF. NL187746C (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US05/760,745 US4066773A (en) 1974-11-08 1977-01-19 N2 -arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof
US05/760,668 US4073913A (en) 1974-11-08 1977-01-19 N2 -arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof
US05/760,672 US4093712A (en) 1974-11-08 1977-01-19 N2 -arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof
US05/760,676 US4097472A (en) 1974-11-08 1977-01-19 N2 -arylsulfonyl-l-argininamides and the pharmaceutically acceptable salts thereof
US05/760,929 US4101653A (en) 1974-11-08 1977-01-19 N2 -arylsulfonyl-argininamides and the pharmaceutically acceptable salts thereof
US05/776,195 US4097591A (en) 1974-11-08 1977-03-10 N2 -arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof
JP6650877A JPS6010028B2 (en) 1977-06-06 1977-06-06 N↑2-arylsulfonyl-L-argininamides and pharmaceutically acceptable salts thereof
US05/804,331 US4140681A (en) 1974-11-08 1977-06-07 N2 -Arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof
US05/804,368 US4131673A (en) 1974-11-08 1977-06-07 N2 -arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof

Publications (3)

Publication Number Publication Date
NL7800448A NL7800448A (en) 1978-07-21
NL187746B NL187746B (en) 1991-08-01
NL187746C true NL187746C (en) 1992-01-02

Family

ID=27577127

Family Applications (1)

Application Number Title Priority Date Filing Date
NLAANVRAGE7800448,A NL187746C (en) 1977-01-19 1978-01-13 NŸ2-ARYLSULFONYL-L-ARGININE AMIDES, PROCESS FOR THEIR PREPARATION, AND PROCESS FOR PREPARING A PHARMACEUTICAL PREPARATION USING SUCH A COMPOUND AND/OR SALT THEREOF.

Country Status (17)

Country Link
CA (1) CA1131621A (en)
CH (2) CH648293A5 (en)
DD (1) DD137352A5 (en)
DE (1) DE2801478A1 (en)
DK (1) DK150521C (en)
FI (1) FI72316C (en)
GB (1) GB1596971A (en)
GR (1) GR60787B (en)
IL (1) IL53685A (en)
IT (1) IT1126229B (en)
NL (1) NL187746C (en)
NO (1) NO158681C (en)
NZ (1) NZ186198A (en)
PH (1) PH15913A (en)
SE (1) SE452624B (en)
SU (1) SU1181539A3 (en)
UA (1) UA8370A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE48623B1 (en) * 1978-08-31 1985-03-20 Mitsubishi Chem Ind Alpha-(n-arylsulfonyl-l-argininamides,processes for their preparation and pharmaceutical compositions containing these substances
JPS5533499A (en) * 1978-08-31 1980-03-08 Mitsubishi Chem Ind Ltd N2-arylsulfonyl-l-arginineamide and its pharmaceutically acceptable salt
GB9209032D0 (en) * 1992-04-25 1992-06-10 Ciba Geigy Ag New peptide derivatives
GB9426038D0 (en) 1994-12-22 1995-02-22 Iaf Biochem Int Low molecular weight bicyclic thrombin inhibitors
US6057314A (en) * 1995-12-21 2000-05-02 Biochem Pharma Inc. Low molecular weight bicyclic thrombin inhibitors
FR2761065B1 (en) * 1997-03-20 2000-03-03 Synthelabo N- (ARGINYL) BENZENESULFONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
CN111961114A (en) * 2020-08-03 2020-11-20 扬州中宝药业股份有限公司 Argatroban intermediate and preparation method and application thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3978045A (en) * 1973-08-13 1976-08-31 Mitsubishi Chemical Industries Ltd. N2 -dansyl-L-arginine derivatives, and the pharmaceutically acceptable acid addition salts thereof

Also Published As

Publication number Publication date
FI72316C (en) 1987-05-11
GR60787B (en) 1978-08-28
FI780073A (en) 1978-07-20
DE2801478A1 (en) 1978-07-20
IT1126229B (en) 1986-05-14
NL187746B (en) 1991-08-01
DK26378A (en) 1978-07-20
CH633773A5 (en) 1982-12-31
DK150521B (en) 1987-03-16
SE7800512L (en) 1978-07-20
CA1131621A (en) 1982-09-14
DD137352A5 (en) 1979-08-29
NO780191L (en) 1978-07-20
PH15913A (en) 1983-04-22
SU1181539A3 (en) 1985-09-23
DK150521C (en) 1987-10-19
UA8370A1 (en) 1996-03-29
DE2801478C2 (en) 1991-01-31
NZ186198A (en) 1980-12-19
IL53685A0 (en) 1978-03-10
CH648293A5 (en) 1985-03-15
GB1596971A (en) 1981-09-03
SE452624B (en) 1987-12-07
IL53685A (en) 1985-12-31
FI72316B (en) 1987-01-30
NO158681C (en) 1988-10-19
NO158681B (en) 1988-07-11
NL7800448A (en) 1978-07-21

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