NL1039690C2 - Method of recovering hyperpolarization in hp-mri experiments. - Google Patents

Method of recovering hyperpolarization in hp-mri experiments. Download PDF

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Publication number
NL1039690C2
NL1039690C2 NL1039690A NL1039690A NL1039690C2 NL 1039690 C2 NL1039690 C2 NL 1039690C2 NL 1039690 A NL1039690 A NL 1039690A NL 1039690 A NL1039690 A NL 1039690A NL 1039690 C2 NL1039690 C2 NL 1039690C2
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Netherlands
Prior art keywords
magnetic field
pulse
plane
field gradient
magnetization
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NL1039690A
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English (en)
Inventor
Soemar Emid
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Soemar Emid
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Priority to NL1039690A priority Critical patent/NL1039690C2/en
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Publication of NL1039690C2 publication Critical patent/NL1039690C2/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/561—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution by reduction of the scanning time, i.e. fast acquiring systems, e.g. using echo-planar pulse sequences

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Signal Processing (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Claims (3)

1. Methode voor MRI-beeldvorming met hypergepolariseerde gassen of contrast media, met het kenmerk, dat een hoge graad van hyperpolarisatie uit het experiment wordt herwonnen, door 5 plaatscodering in het, door de vlak-selectieve 90° rf puls geselecteerde, vlak met een in het vlak roterend bipolair magneetveldgradiënt, door het magneetveldgradiënt bij de ene uitvoering een hele periode en bij de andere uitvoering een halve periode te doen roteren in een tijd die kort is ten opzichte van de vervaltijden van de magnetisaties in dat vlak, waarna de defasering van de magnetisatie door de inhomogeniteit van het hoofdmagneetveld wordt omgekeerd door een 10 vlak-selectieve 180° rf puls in quadratuur-fase met de selectieve 90° rf puls, bij uitgezet magneetveldgradiënt, na de 180° rf puls het magneetveldgradiënt, bij de ene uitvoering met dezelfde sterkte en rotatiesnelheid als voor de puls weer een hele periode roteert, zodat aan het einde van deze periode de transversale magnetisatie in een echo eindigt en bij de andere uitvoering het magneetveldgradiënt met dezelfde rotatiesnelheid en richting, doch met 15 tegengestelde polariteit de tweede helft van de periode roteert, zodat aan het einde van deze halve periode de transversale magnetisatie in een echo eindigt. In beide gevallen wordt de transversale magnetisatie herwonnen met een hoge mate van hyperpolarisatie, die met een selectieve 90° rf puls wordt omgezet in longitudinale magnetisatie.
2. Methode voor plaatscodering in MRI, gekenmerkt door fasecodering en refocusering van 20 de coherentie van de magnetisatie in een meer-dimensionaal vlak uit te voeren met een periodiek veranderlijk magneetveldgradiënt in dat vlak.
3. Methode van MRI-beeldvorming volgens conclusies 1 en 2, met het kenmerk, dat de fase van het roterende magneetveldgradiënt voor de opeenvolgende refocuseringen stapsgewijs wordt veranderd om een betere verdeling van de resolutie en signaalruisverhouding over het 25 vlak te bewerkstelligen. 1039690
NL1039690A 2012-06-21 2012-06-21 Method of recovering hyperpolarization in hp-mri experiments. NL1039690C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NL1039690A NL1039690C2 (en) 2012-06-21 2012-06-21 Method of recovering hyperpolarization in hp-mri experiments.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL1039690A NL1039690C2 (en) 2012-06-21 2012-06-21 Method of recovering hyperpolarization in hp-mri experiments.
NL1039690 2012-06-21

Publications (1)

Publication Number Publication Date
NL1039690C2 true NL1039690C2 (en) 2013-04-09

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Family Applications (1)

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NL1039690A NL1039690C2 (en) 2012-06-21 2012-06-21 Method of recovering hyperpolarization in hp-mri experiments.

Country Status (1)

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NL (1) NL1039690C2 (nl)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0366158A1 (en) * 1983-02-18 1990-05-02 Albert Macovski High speed NMR imaging system
EP1995604A1 (en) * 2007-05-21 2008-11-26 Soemar Emid High speed, high resolution, silent, real-time MRI method
US20090273344A1 (en) * 2008-04-22 2009-11-05 Fain Sean B Method for simultaneously measuring t2* and diffusion with magnetic resonance imaging

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0366158A1 (en) * 1983-02-18 1990-05-02 Albert Macovski High speed NMR imaging system
EP1995604A1 (en) * 2007-05-21 2008-11-26 Soemar Emid High speed, high resolution, silent, real-time MRI method
US20090273344A1 (en) * 2008-04-22 2009-11-05 Fain Sean B Method for simultaneously measuring t2* and diffusion with magnetic resonance imaging

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HOLMES J.H. ET AL.: "3D/2D Hybrid PR for Single Dose Acquisition of Dynamic and Breath-held Hyperpolarized He-3 Ventilation Imaging", ISMRM THIRTEENTH MEETING PROCEEDINGS, 7 May 2005 (2005-05-07), Miami, Florida, pages 1808, XP002689879 *
IMAI FUMITO ET AL: "Hyperpolarized 129Xe MR imaging with balanced steady-state free precession in spontaneously breathing mouse lungs.", MAGNETIC RESONANCE IN MEDICAL SCIENCES : MRMS : AN OFFICIAL JOURNAL OF JAPAN SOCIETY OF MAGNETIC RESONANCE IN MEDICINE 2011, vol. 10, no. 1, 2011, pages 33 - 40, XP002689878, ISSN: 1880-2206 *

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Legal Events

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MM Lapsed because of non-payment of the annual fee

Effective date: 20160701