NI201800130A - Moduladores del receptor beta-3 adrenérgico de utilidad para el tratamiento o la prevención de trastornos relacionados con ellos - Google Patents
Moduladores del receptor beta-3 adrenérgico de utilidad para el tratamiento o la prevención de trastornos relacionados con ellosInfo
- Publication number
- NI201800130A NI201800130A NI201800130A NI201800130A NI201800130A NI 201800130 A NI201800130 A NI 201800130A NI 201800130 A NI201800130 A NI 201800130A NI 201800130 A NI201800130 A NI 201800130A NI 201800130 A NI201800130 A NI 201800130A
- Authority
- NI
- Nicaragua
- Prior art keywords
- heart failure
- heart
- failure
- left ventricular
- nyha
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invención se refiere a compuestos de fórmula (Ia) y a sus composiciones farmacéuticas que modulan la actividad del receptor beta-3 adrenérgico. Los compuestos de la presente invención y sus composiciones farmacéuticas están orientados a métodos útiles en el tratamiento de un trastorno mediado por el receptor beta-3 adrenérgico, tal como, insuficiencia cardíaca; rendimiento cardiaco en insuficiencia cardíaca; mortalidad, reinfarto y/u hospitalización en relación con la insuficiencia cardíaca; insuficiencia cardiaca aguda; insuficiencia cardiaca descompensada aguda; insuficiencia cardíaca congestiva; insuficiencia cardíaca congestiva severa; daño en los órganos asociado con la insuficiencia cardíaca (por ejemplo, daño o insuficiencia renal, problemas de las válvulas cardíacas, problemas del ritmo cardíaco y/o daño hepátco); insuficiencia cardíaca debida a disfunción ventricular izquierda; insuficiencia cardíaca con fracción de eyección normal; mortalidad cardiovascular después de un infarto de miocardio; mortalidad cardiovascular en pacientes con insuficiencia ventricular izquierda o con disfunción ventricular izquierda; insuficiencia ventricular izquierda; disfunción ventricular izquierda; insuficiencia cardíaca de clase II en base al sistema de clasificación de la New York Heart Association (NYHA); insuficiencia cardíaca clase III en base al sistema de clasificación de la New York Heart Association (NYHA); insuficiencia cardiaca clase IV en base al sistema de clasificación de la New York Heart Association (NYHA); fracción de eyección del ventrículo izquierdo (LVEF) <40% mediante ventriculografía con radionúclidos; LVEF ?35% por ecocardiografía o angiografía de contraste ventricular; y condiciones relacionadas a ellas.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662346293P | 2016-06-06 | 2016-06-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NI201800130A true NI201800130A (es) | 2019-06-13 |
Family
ID=59067920
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NI201800130A NI201800130A (es) | 2016-06-06 | 2018-12-05 | Moduladores del receptor beta-3 adrenérgico de utilidad para el tratamiento o la prevención de trastornos relacionados con ellos |
Country Status (30)
| Country | Link |
|---|---|
| US (5) | US20190284200A1 (es) |
| EP (1) | EP3464292B8 (es) |
| JP (3) | JP6771246B2 (es) |
| KR (2) | KR102408272B1 (es) |
| CN (1) | CN109563103B (es) |
| AR (1) | AR108772A1 (es) |
| AU (2) | AU2017278102B2 (es) |
| BR (1) | BR112018075201A2 (es) |
| CA (1) | CA3026024A1 (es) |
| CL (1) | CL2018003451A1 (es) |
| CO (1) | CO2019000041A2 (es) |
| CR (1) | CR20180595A (es) |
| DK (1) | DK3464292T3 (es) |
| EA (1) | EA201892817A1 (es) |
| EC (1) | ECSP19001018A (es) |
| ES (1) | ES2929737T3 (es) |
| IL (2) | IL289378B (es) |
| MA (2) | MA44037B1 (es) |
| MX (2) | MX2018015124A (es) |
| MY (1) | MY195982A (es) |
| NI (1) | NI201800130A (es) |
| NZ (1) | NZ749202A (es) |
| PE (1) | PE20190445A1 (es) |
| PH (1) | PH12018502550A1 (es) |
| PT (1) | PT3464292T (es) |
| SG (1) | SG11201810788QA (es) |
| TN (1) | TN2018000391A1 (es) |
| TW (2) | TWI784840B (es) |
| UA (1) | UA125120C2 (es) |
| WO (1) | WO2017214002A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA44037B1 (fr) * | 2016-06-06 | 2020-03-31 | Arena Pharm Inc | Modulateurs du récepteur adrénergique bêta 3 utile dans le traitement ou la prévention de troubles associés à ceux-ci |
| AU2018240172C1 (en) | 2017-03-20 | 2019-10-24 | Novo Nordisk Health Care Ag | Pyrrolopyrrole compositions as pyruvate kinase (PKR) activators |
| CN111699189A (zh) * | 2017-12-06 | 2020-09-22 | 艾尼纳制药公司 | 可用于治疗或预防与其相关的心力衰竭和障碍的β-3肾上腺素能受体的调节剂 |
| CN113226356A (zh) | 2018-09-19 | 2021-08-06 | 福马治疗股份有限公司 | 活化丙酮酸激酶r |
| US10675274B2 (en) | 2018-09-19 | 2020-06-09 | Forma Therapeutics, Inc. | Activating pyruvate kinase R |
| EP4384169A1 (en) * | 2021-08-09 | 2024-06-19 | Arena Pharmaceuticals, Inc. | Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of heart failure |
| CA3230339A1 (en) * | 2021-08-26 | 2023-03-02 | Arena Pharmaceuticals, Inc. | Modulators of the beta-3 adrenergic receptor for the treatment or prevention of renal cystic disease and cardiorenal syndrome |
| WO2023057896A1 (en) * | 2021-10-06 | 2023-04-13 | Arena Pharmaceuticals, Inc. | Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of disorders related thereto |
| WO2023154499A1 (en) * | 2022-02-14 | 2023-08-17 | Biogen Ma Inc. | Emopamil-binding protein inhibitors and uses thereof |
| CN114539103B (zh) * | 2022-03-21 | 2023-04-07 | 佳木斯黑龙农药有限公司 | 2-二氟乙氧基-6-三氟甲基苯磺酰氯的合成方法 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3028340C2 (de) * | 1980-07-25 | 1987-02-05 | Dr. Willmar Schwabe GmbH & Co, 7500 Karlsruhe | Amino-desoxy-1.4;3.6-dianhydro-hexit-nitrate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen |
| US5254595A (en) | 1988-12-23 | 1993-10-19 | Elf Sanofi | Aryloxypropanolaminotetralins, a process for their preparation and pharmaceutical compositions containing them |
| FR2751646B1 (fr) | 1996-07-23 | 1999-01-22 | Sanofi Sa | Phenoxypropanolamine a action antagoniste beta3-adrenergique |
| WO1998027080A1 (en) | 1996-12-19 | 1998-06-25 | Agrevo Uk Limited | Chromones useful as fungicides |
| FR2780057B1 (fr) * | 1998-06-18 | 2002-09-13 | Sanofi Sa | Phenoxypropanolamines, procede pour leur preparation et compositions pharmaceutiques les contenant |
| ATE356624T1 (de) * | 1999-12-17 | 2007-04-15 | Sanofi Aventis | Phenoxypropanolamin-derivate, ihre herstellung und therapeutische verwendung |
| DE20204129U1 (de) | 2002-03-15 | 2002-07-25 | Wella Ag, 64295 Darmstadt | Mittel zur Färbung von Keratinfasern mit Chinolinium-Farbstoffen |
| WO2005092860A1 (en) * | 2004-03-23 | 2005-10-06 | Pfizer Limited | Compounds for the treatment of diseases |
| US20080255134A1 (en) * | 2004-11-30 | 2008-10-16 | Artesian Therapeutics, Inc. | Cardiotonic Compounds With Inhibitory Activity Against Beta-Adrenergic Receptors And Phosphodiesterase |
| US8697674B2 (en) | 2004-12-29 | 2014-04-15 | Naturon, Inc. | Xanthurenic acid derivative pharmaceutical compositions and methods related thereto |
| WO2008094507A2 (en) | 2007-01-26 | 2008-08-07 | Cellicon Biotechnologies, Inc. | Novel fusion compounds |
| US8039505B2 (en) | 2007-04-11 | 2011-10-18 | University Of Utah Research Foundation | Compounds for modulating T-cells |
| US8722851B2 (en) | 2007-11-02 | 2014-05-13 | Pain Therapeutics, Inc. | Analgesia with minimal tolerance and dependence by a mu opioid receptor agonist that also binds filamin A |
| AU2009308769B2 (en) | 2008-10-31 | 2015-03-12 | Pain Therapeutics, Inc. | Filamin A-binding anti-inflammatory analgesic |
| CA2779261C (en) | 2008-10-31 | 2015-03-24 | Pain Therapeutics, Inc. | Filamin a binding anti-inflammatory and analgesic |
| US20100279997A1 (en) | 2009-05-04 | 2010-11-04 | Lindsay Burns Barbier | Analgesic that binds filamin a |
| JP2012509309A (ja) * | 2008-11-21 | 2012-04-19 | ファイザー・インク | Ｆａａｈ阻害剤としての１−オキサ−８−アザスピロ［４．５］デカン−８−カルボキサミド化合物 |
| EP2563764B1 (en) * | 2010-04-26 | 2015-02-25 | Merck Sharp & Dohme Corp. | Novel spiropiperidine prolylcarboxypeptidase inhibitors |
| CA2805427A1 (en) * | 2010-07-23 | 2012-01-26 | Merck Sharp & Dohme Corp. | Novel pyrrolidine derived beta 3 adrenergic receptor agonists |
| JP2012092038A (ja) | 2010-10-26 | 2012-05-17 | F Hoffmann La Roche Ag | 糖尿病、糖尿病関連疾患又は糖尿病性合併症の予防又は治療剤 |
| EP2882428B1 (en) | 2012-07-13 | 2019-01-16 | Pain Therapeutics, Inc. | A method of inhibiting tau phosphorylation |
| JP6566867B2 (ja) | 2012-07-13 | 2019-08-28 | ペイン セラピューティクス インコーポレイテッド | 生きている患者でのアルツハイマー病アッセイ |
| GB201405359D0 (en) | 2014-03-25 | 2014-05-07 | Univ Liverpool | Synthetic process |
| MA44037B1 (fr) | 2016-06-06 | 2020-03-31 | Arena Pharm Inc | Modulateurs du récepteur adrénergique bêta 3 utile dans le traitement ou la prévention de troubles associés à ceux-ci |
| CN111699189A (zh) * | 2017-12-06 | 2020-09-22 | 艾尼纳制药公司 | 可用于治疗或预防与其相关的心力衰竭和障碍的β-3肾上腺素能受体的调节剂 |
-
2017
- 2017-06-04 MA MA44037A patent/MA44037B1/fr unknown
- 2017-06-05 CR CR20180595A patent/CR20180595A/es unknown
- 2017-06-05 EA EA201892817A patent/EA201892817A1/ru unknown
- 2017-06-05 US US16/307,830 patent/US20190284200A1/en not_active Abandoned
- 2017-06-05 AU AU2017278102A patent/AU2017278102B2/en active Active
- 2017-06-05 IL IL289378A patent/IL289378B/en unknown
- 2017-06-05 ES ES17730638T patent/ES2929737T3/es active Active
- 2017-06-05 EP EP17730638.8A patent/EP3464292B8/en active Active
- 2017-06-05 UA UAA201900139A patent/UA125120C2/uk unknown
- 2017-06-05 MA MA045150A patent/MA45150A/fr unknown
- 2017-06-05 PT PT177306388T patent/PT3464292T/pt unknown
- 2017-06-05 KR KR1020227004041A patent/KR102408272B1/ko active IP Right Grant
- 2017-06-05 CA CA3026024A patent/CA3026024A1/en active Pending
- 2017-06-05 JP JP2019516084A patent/JP6771246B2/ja active Active
- 2017-06-05 NZ NZ749202A patent/NZ749202A/en not_active IP Right Cessation
- 2017-06-05 WO PCT/US2017/035867 patent/WO2017214002A1/en active Search and Examination
- 2017-06-05 MX MX2018015124A patent/MX2018015124A/es unknown
- 2017-06-05 MY MYPI2018002257A patent/MY195982A/en unknown
- 2017-06-05 CN CN201780047870.6A patent/CN109563103B/zh active Active
- 2017-06-05 BR BR112018075201-0A patent/BR112018075201A2/pt active IP Right Grant
- 2017-06-05 PE PE2018003180A patent/PE20190445A1/es unknown
- 2017-06-05 KR KR1020197000005A patent/KR20190026731A/ko not_active IP Right Cessation
- 2017-06-05 SG SG11201810788QA patent/SG11201810788QA/en unknown
- 2017-06-05 DK DK17730638.8T patent/DK3464292T3/da active
- 2017-06-05 TN TNP/2018/000391A patent/TN2018000391A1/en unknown
- 2017-06-06 TW TW110147004A patent/TWI784840B/zh active
- 2017-06-06 AR ARP170101546A patent/AR108772A1/es active IP Right Grant
- 2017-06-06 TW TW106118610A patent/TWI752963B/zh active
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2018
- 2018-11-20 IL IL263148A patent/IL263148B/en unknown
- 2018-12-03 PH PH12018502550A patent/PH12018502550A1/en unknown
- 2018-12-03 CL CL2018003451A patent/CL2018003451A1/es unknown
- 2018-12-05 MX MX2021014043A patent/MX2021014043A/es unknown
- 2018-12-05 NI NI201800130A patent/NI201800130A/es unknown
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2019
- 2019-01-04 CO CONC2019/0000041A patent/CO2019000041A2/es unknown
- 2019-01-07 EC ECSENADI20191018A patent/ECSP19001018A/es unknown
- 2019-06-04 US US16/431,209 patent/US10479797B2/en active Active
- 2019-09-06 US US16/563,353 patent/US10662200B2/en active Active
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2020
- 2020-05-12 US US16/872,812 patent/US10927123B2/en active Active
- 2020-09-18 JP JP2020157196A patent/JP7083087B2/ja active Active
- 2020-12-14 US US17/120,759 patent/US11560386B2/en active Active
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2021
- 2021-07-20 AU AU2021206809A patent/AU2021206809B2/en active Active
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2022
- 2022-04-21 JP JP2022069821A patent/JP7449329B2/ja active Active
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