NI200300025A - Derivados de nicotinamida utiles como inhibidores de pde4. - Google Patents

Derivados de nicotinamida utiles como inhibidores de pde4.

Info

Publication number
NI200300025A
NI200300025A NI200300025A NI200300025A NI200300025A NI 200300025 A NI200300025 A NI 200300025A NI 200300025 A NI200300025 A NI 200300025A NI 200300025 A NI200300025 A NI 200300025A NI 200300025 A NI200300025 A NI 200300025A
Authority
NI
Nicaragua
Prior art keywords
useful
nicotinamide derivatives
pde inhibitors
derivatives
nicotinamide
Prior art date
Application number
NI200300025A
Other languages
English (en)
Inventor
Simon Bailey
Elisabeth Colette Louise Gauti
Alan John Henderson
Thomas Victor Magee
Anthony Marfaf
John Paul Mathias
Dale Gordon Mcloud
Sandra Marina Monaghan
Blanda Luzia Christa Stammen
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0203196A external-priority patent/GB0203196D0/en
Priority claimed from GB0220999A external-priority patent/GB0220999D0/en
Priority claimed from GB0224453A external-priority patent/GB0224453D0/en
Priority claimed from GB0227139A external-priority patent/GB0227139D0/en
Application filed by Pfizer filed Critical Pfizer
Publication of NI200300025A publication Critical patent/NI200300025A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
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    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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Abstract

LA INVENCION SE REFIERE A DERIVADOS DE NICOTINAMIDA Y A PROCEDIMIENTOS PARA SU PREPARACION , A INTERMEDIOS UTILIZADOS EN SU PREPARACION , A COMPOSICIONES QUE LOS CONTIENEN Y A LOS USOS DE DICHOS DERIVADOS. LOS DERIVADOS DE NICOTINAMIDA DE ACUERDO CON LA PRESENTE INVENCION SON UTILES EN NUMEROSAS ENFERMEDADES, TRASTORNOS Y DOLENCIAS, EN PARTICULAR ENFERMEDADES, TRASTORNOS Y DOLENCIAS INFLAMATORIOS, ALERGICOS , RESPIRATORIOS, ASI COMO EN HERIDAS.
NI200300025A 2002-02-11 2003-02-10 Derivados de nicotinamida utiles como inhibidores de pde4. NI200300025A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0203196A GB0203196D0 (en) 2002-02-11 2002-02-11 Nicotinamide derivatives useful as pde4 inhibitors
GB0220999A GB0220999D0 (en) 2002-09-10 2002-09-10 Nicotinamide derivatives useful as pde4 inhibitors
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RS70104A (en) 2007-02-05
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