MY170949A - A peptide capable of binding with a human leukocyte antigen (hla) molecule, a cancer vaccine derived from said peptide and use of said cancer vaccine - Google Patents

A peptide capable of binding with a human leukocyte antigen (hla) molecule, a cancer vaccine derived from said peptide and use of said cancer vaccine

Info

Publication number
MY170949A
MY170949A MYPI2011003259A MYPI2011003259A MY170949A MY 170949 A MY170949 A MY 170949A MY PI2011003259 A MYPI2011003259 A MY PI2011003259A MY PI2011003259 A MYPI2011003259 A MY PI2011003259A MY 170949 A MY170949 A MY 170949A
Authority
MY
Malaysia
Prior art keywords
peptide
cancer vaccine
hla
binding
molecule
Prior art date
Application number
MYPI2011003259A
Inventor
Sok Ching Cheong
Soo Hwang Teo
Kue Peng Lim
Mohd Zain Rosnah
Ariff Abdul Rahman Zainal
Ponniah Sathibalan
Original Assignee
Cancer Res Initiatives Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Res Initiatives Foundation filed Critical Cancer Res Initiatives Foundation
Priority to MYPI2011003259A priority Critical patent/MY170949A/en
Priority to PCT/MY2012/000198 priority patent/WO2013009165A1/en
Priority to TW101124710A priority patent/TWI567088B/en
Publication of MY170949A publication Critical patent/MY170949A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001184—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • A61K39/001186—MAGE
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to a peptide comprising at least an amino acid sequence selected from at least a portion of MAGE-D4b protein, which the peptide is capable of binding with at least a human leukocyte antigen (HLA) molecule. The binding of the peptide with the human leukocyte antigen (HLA) molecule described herein, is capable of inducing the immune system of a subject to recognize oral cancer cells as being foreign. Upon being recognized as foreign particles, these cells are targeted and destroyed by the CD8+ cytotoxic T cells. Further disclosed in the present invention is a cancer vaccine derived from the MAGE-D4b peptides and the use of said cancer vaccine. Most illustrative drawing: Figure 1
MYPI2011003259A 2011-07-11 2011-07-11 A peptide capable of binding with a human leukocyte antigen (hla) molecule, a cancer vaccine derived from said peptide and use of said cancer vaccine MY170949A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
MYPI2011003259A MY170949A (en) 2011-07-11 2011-07-11 A peptide capable of binding with a human leukocyte antigen (hla) molecule, a cancer vaccine derived from said peptide and use of said cancer vaccine
PCT/MY2012/000198 WO2013009165A1 (en) 2011-07-11 2012-07-05 A peptide capable of binding with a human leukocyte antigen (hla) molecule, a cancer vaccine derived from said peptide and use of said cancer vaccine
TW101124710A TWI567088B (en) 2011-07-11 2012-07-10 Peptide capable of binding with a human leukocyte antigen (hla) molecule, cancer vaccine derived from said peptide, and use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MYPI2011003259A MY170949A (en) 2011-07-11 2011-07-11 A peptide capable of binding with a human leukocyte antigen (hla) molecule, a cancer vaccine derived from said peptide and use of said cancer vaccine

Publications (1)

Publication Number Publication Date
MY170949A true MY170949A (en) 2019-09-20

Family

ID=47506273

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI2011003259A MY170949A (en) 2011-07-11 2011-07-11 A peptide capable of binding with a human leukocyte antigen (hla) molecule, a cancer vaccine derived from said peptide and use of said cancer vaccine

Country Status (3)

Country Link
MY (1) MY170949A (en)
TW (1) TWI567088B (en)
WO (1) WO2013009165A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY192920A (en) * 2017-03-15 2022-09-15 Cancer Res Malaysia Immunogenic peptide composition
WO2018225732A1 (en) * 2017-06-05 2018-12-13 国立大学法人三重大学 Antigen-binding protein recognizing mage-a4-derived peptide

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004026135A1 (en) * 2004-05-25 2006-01-05 Immatics Biotechnologies Gmbh Tumor-associated peptides binding to MHC molecules
ATE440107T1 (en) * 2005-09-05 2009-09-15 Immatics Biotechnologies Gmbh TUMOR-ASSOCIATED PEPTIDES THAT BIND HLA CLASS I OR II MOLECULES AND ANTI-TUMOR VACCINES
US20110236314A1 (en) * 2008-09-12 2011-09-29 Cancer Research Initiatives Foundation Method of detection and diagnosis of oral and nasopharyngeal cancers

Also Published As

Publication number Publication date
TWI567088B (en) 2017-01-21
WO2013009165A1 (en) 2013-01-17
TW201302801A (en) 2013-01-16

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