MY170949A - A peptide capable of binding with a human leukocyte antigen (hla) molecule, a cancer vaccine derived from said peptide and use of said cancer vaccine - Google Patents
A peptide capable of binding with a human leukocyte antigen (hla) molecule, a cancer vaccine derived from said peptide and use of said cancer vaccineInfo
- Publication number
- MY170949A MY170949A MYPI2011003259A MYPI2011003259A MY170949A MY 170949 A MY170949 A MY 170949A MY PI2011003259 A MYPI2011003259 A MY PI2011003259A MY PI2011003259 A MYPI2011003259 A MY PI2011003259A MY 170949 A MY170949 A MY 170949A
- Authority
- MY
- Malaysia
- Prior art keywords
- peptide
- cancer vaccine
- hla
- binding
- molecule
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 6
- 229940022399 cancer vaccine Drugs 0.000 title abstract 4
- 238000009566 cancer vaccine Methods 0.000 title abstract 4
- 239000000427 antigen Substances 0.000 title abstract 3
- 102000036639 antigens Human genes 0.000 title abstract 3
- 108091007433 antigens Proteins 0.000 title abstract 3
- 210000000265 leukocyte Anatomy 0.000 title abstract 3
- 210000004027 cell Anatomy 0.000 abstract 2
- 208000003445 Mouth Neoplasms Diseases 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001184—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
- A61K39/001186—MAGE
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The present invention relates to a peptide comprising at least an amino acid sequence selected from at least a portion of MAGE-D4b protein, which the peptide is capable of binding with at least a human leukocyte antigen (HLA) molecule. The binding of the peptide with the human leukocyte antigen (HLA) molecule described herein, is capable of inducing the immune system of a subject to recognize oral cancer cells as being foreign. Upon being recognized as foreign particles, these cells are targeted and destroyed by the CD8+ cytotoxic T cells. Further disclosed in the present invention is a cancer vaccine derived from the MAGE-D4b peptides and the use of said cancer vaccine. Most illustrative drawing: Figure 1
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MYPI2011003259A MY170949A (en) | 2011-07-11 | 2011-07-11 | A peptide capable of binding with a human leukocyte antigen (hla) molecule, a cancer vaccine derived from said peptide and use of said cancer vaccine |
PCT/MY2012/000198 WO2013009165A1 (en) | 2011-07-11 | 2012-07-05 | A peptide capable of binding with a human leukocyte antigen (hla) molecule, a cancer vaccine derived from said peptide and use of said cancer vaccine |
TW101124710A TWI567088B (en) | 2011-07-11 | 2012-07-10 | Peptide capable of binding with a human leukocyte antigen (hla) molecule, cancer vaccine derived from said peptide, and use thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MYPI2011003259A MY170949A (en) | 2011-07-11 | 2011-07-11 | A peptide capable of binding with a human leukocyte antigen (hla) molecule, a cancer vaccine derived from said peptide and use of said cancer vaccine |
Publications (1)
Publication Number | Publication Date |
---|---|
MY170949A true MY170949A (en) | 2019-09-20 |
Family
ID=47506273
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MYPI2011003259A MY170949A (en) | 2011-07-11 | 2011-07-11 | A peptide capable of binding with a human leukocyte antigen (hla) molecule, a cancer vaccine derived from said peptide and use of said cancer vaccine |
Country Status (3)
Country | Link |
---|---|
MY (1) | MY170949A (en) |
TW (1) | TWI567088B (en) |
WO (1) | WO2013009165A1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY192920A (en) * | 2017-03-15 | 2022-09-15 | Cancer Res Malaysia | Immunogenic peptide composition |
WO2018225732A1 (en) * | 2017-06-05 | 2018-12-13 | 国立大学法人三重大学 | Antigen-binding protein recognizing mage-a4-derived peptide |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102004026135A1 (en) * | 2004-05-25 | 2006-01-05 | Immatics Biotechnologies Gmbh | Tumor-associated peptides binding to MHC molecules |
ATE440107T1 (en) * | 2005-09-05 | 2009-09-15 | Immatics Biotechnologies Gmbh | TUMOR-ASSOCIATED PEPTIDES THAT BIND HLA CLASS I OR II MOLECULES AND ANTI-TUMOR VACCINES |
US20110236314A1 (en) * | 2008-09-12 | 2011-09-29 | Cancer Research Initiatives Foundation | Method of detection and diagnosis of oral and nasopharyngeal cancers |
-
2011
- 2011-07-11 MY MYPI2011003259A patent/MY170949A/en unknown
-
2012
- 2012-07-05 WO PCT/MY2012/000198 patent/WO2013009165A1/en active Application Filing
- 2012-07-10 TW TW101124710A patent/TWI567088B/en active
Also Published As
Publication number | Publication date |
---|---|
TWI567088B (en) | 2017-01-21 |
WO2013009165A1 (en) | 2013-01-17 |
TW201302801A (en) | 2013-01-16 |
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