MY162345A - Chromone derivatives, a process for their ppreparation and their therapeutic applications - Google Patents
Chromone derivatives, a process for their ppreparation and their therapeutic applicationsInfo
- Publication number
- MY162345A MY162345A MYPI2012000354A MYPI2012000354A MY162345A MY 162345 A MY162345 A MY 162345A MY PI2012000354 A MYPI2012000354 A MY PI2012000354A MY PI2012000354 A MYPI2012000354 A MY PI2012000354A MY 162345 A MY162345 A MY 162345A
- Authority
- MY
- Malaysia
- Prior art keywords
- ppreparation
- therapeutic applications
- chromone derivatives
- chromone
- derivatives
- Prior art date
Links
- 150000004777 chromones Chemical class 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- OTAFHZMPRISVEM-UHFFFAOYSA-N chromone Chemical class C1=CC=C2C(=O)C=COC2=C1 OTAFHZMPRISVEM-UHFFFAOYSA-N 0.000 abstract 1
- 230000003291 dopaminomimetic effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Reproductive Health (AREA)
- Psychology (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Gynecology & Obstetrics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pyrane Compounds (AREA)
Abstract
THE PRESENT INVENTION RELATES TO CHROMONE DERIVATIVES, THEIR PREPARATION, THEIR PHARMACEUTICAL COMPOSITIONS AND THEIR APPLICATION AS D3 DOPAMINERGIC LIGANDS AS A MEDICAMENT FOR DISORDERS OF THE CENTRAL NERVOUS SYSTEM.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0955944A FR2949465B1 (en) | 2009-09-01 | 2009-09-01 | CHROMIUM DERIVATIVES, PROCESS FOR PREPARING THEM AND THERAPEUTIC APPLICATIONS THEREOF |
| US33699210P | 2010-01-29 | 2010-01-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY162345A true MY162345A (en) | 2017-06-15 |
Family
ID=41403421
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI2012000354A MY162345A (en) | 2009-09-01 | 2010-08-31 | Chromone derivatives, a process for their ppreparation and their therapeutic applications |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US8546402B2 (en) |
| EP (1) | EP2470520B1 (en) |
| JP (1) | JP5786229B2 (en) |
| KR (1) | KR101663635B1 (en) |
| CN (1) | CN102482251B (en) |
| AR (1) | AR078114A1 (en) |
| AU (1) | AU2010290871B2 (en) |
| BR (1) | BR112012003741B1 (en) |
| CA (1) | CA2771061C (en) |
| CL (1) | CL2012000516A1 (en) |
| CO (1) | CO6491096A2 (en) |
| DK (1) | DK2470520T3 (en) |
| ES (1) | ES2428751T3 (en) |
| FR (1) | FR2949465B1 (en) |
| GE (1) | GEP20146080B (en) |
| HK (1) | HK1170724A1 (en) |
| HR (1) | HRP20130832T1 (en) |
| IL (1) | IL217729A (en) |
| MA (1) | MA35674B1 (en) |
| MX (1) | MX2012002543A (en) |
| MY (1) | MY162345A (en) |
| NZ (1) | NZ597930A (en) |
| PL (1) | PL2470520T3 (en) |
| PT (1) | PT2470520E (en) |
| RU (1) | RU2545214C2 (en) |
| SG (1) | SG178198A1 (en) |
| SI (1) | SI2470520T1 (en) |
| TN (1) | TN2012000049A1 (en) |
| TW (1) | TWI510483B (en) |
| UA (1) | UA109260C2 (en) |
| WO (1) | WO2011027289A1 (en) |
| ZA (1) | ZA201200770B (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010015518A2 (en) | 2008-08-05 | 2010-02-11 | Boehringer Ingelheim Interntional Gmbh | 4-dimethylamino-phenyl-substituted naphthyridines, and use thereof as medicaments |
| AP3622A (en) | 2009-05-13 | 2016-03-02 | Gilead Sciences Inc | Antiviral compounds |
| BR112012018865A2 (en) | 2010-01-29 | 2016-04-12 | Boehringer Ingelheim Int | substituted naphthyridines and their use as syk kinase inhibitors |
| CN103827090B (en) | 2011-07-26 | 2016-04-20 | 勃林格殷格翰国际有限公司 | The quinoline replaced and the purposes as medicine thereof |
| JP6073897B2 (en) | 2011-09-16 | 2017-02-01 | ギリアド ファーマセット エルエルシー | Methods for treating HCV |
| ES2771458T3 (en) | 2013-01-31 | 2020-07-06 | Gilead Pharmasset Llc | Combination formulation of two antiviral compounds |
| PL3650014T3 (en) | 2013-08-27 | 2022-01-31 | Gilead Pharmasset Llc | Combination formulation of two antiviral compounds |
| JP6419826B2 (en) * | 2013-12-13 | 2018-11-07 | ピエール、ファーブル、メディカマン | Chromone derivatives as dopamine D3 receptor antagonists for the treatment of autism spectrum disorders |
| CN111295191A (en) | 2017-11-03 | 2020-06-16 | 皮埃尔法布雷医药公司 | Treatment of schizophrenia |
| PT3762368T (en) | 2018-03-08 | 2022-05-06 | Incyte Corp | Aminopyrazine diol compounds as pi3k-y inhibitors |
| WO2020010003A1 (en) | 2018-07-02 | 2020-01-09 | Incyte Corporation | AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS |
| CN112220782B (en) * | 2020-11-11 | 2021-08-20 | 中国人民解放军军事科学院军事医学研究院 | Application of 1,2, 4-trimethoxy benzene in preventing and treating posttraumatic stress disorder |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5089497A (en) * | 1990-09-20 | 1992-02-18 | Warner-Lambert Company | Substituted piperazines as central nervous system agents |
| DE4233963A1 (en) * | 1992-10-08 | 1994-04-14 | Schwabe Willmar Gmbh & Co | New benzopyranone, process for its preparation and use |
| DK1519726T3 (en) * | 2002-07-04 | 2007-06-04 | Sanol Arznei Schwarz Gmbh | Heteroarenecarboxamides for use as dopamine D3 ligands in the treatment of CNS disorders |
| EP1683790A1 (en) * | 2005-01-24 | 2006-07-26 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | 3,4-dihydro-2-naphthamide derivatives as selective dopamine D3 ligands |
| AU2006215785A1 (en) * | 2005-02-18 | 2006-08-24 | Arpida Ag | Novel processes for the preparation of a benzofuran |
| FR2903986A1 (en) * | 2006-07-21 | 2008-01-25 | Pierre Fabre Medicament Sa | NOVEL CHROMENES OR THIOCHROMENES CARBOXAMIDE DERIVATIVES, PROCESS FOR PREPARING THEM AND THERAPEUTIC APPLICATIONS THEREOF |
-
2009
- 2009-09-01 FR FR0955944A patent/FR2949465B1/en not_active Expired - Fee Related
-
2010
- 2010-08-10 TW TW099126581A patent/TWI510483B/en not_active IP Right Cessation
- 2010-08-30 AR ARP100103170A patent/AR078114A1/en active IP Right Grant
- 2010-08-31 GE GEAP201012642A patent/GEP20146080B/en unknown
- 2010-08-31 ES ES10754594T patent/ES2428751T3/en active Active
- 2010-08-31 UA UAA201202432A patent/UA109260C2/en unknown
- 2010-08-31 KR KR1020127005385A patent/KR101663635B1/en active IP Right Grant
- 2010-08-31 MY MYPI2012000354A patent/MY162345A/en unknown
- 2010-08-31 RU RU2012106743/04A patent/RU2545214C2/en active
- 2010-08-31 BR BR112012003741-2A patent/BR112012003741B1/en not_active IP Right Cessation
- 2010-08-31 US US13/393,542 patent/US8546402B2/en active Active
- 2010-08-31 WO PCT/IB2010/053895 patent/WO2011027289A1/en active Application Filing
- 2010-08-31 DK DK10754594.9T patent/DK2470520T3/en active
- 2010-08-31 PL PL10754594T patent/PL2470520T3/en unknown
- 2010-08-31 CA CA2771061A patent/CA2771061C/en active Active
- 2010-08-31 CN CN201080038431.7A patent/CN102482251B/en not_active Expired - Fee Related
- 2010-08-31 NZ NZ597930A patent/NZ597930A/en not_active IP Right Cessation
- 2010-08-31 EP EP10754594.9A patent/EP2470520B1/en active Active
- 2010-08-31 JP JP2012527432A patent/JP5786229B2/en active Active
- 2010-08-31 SI SI201030323T patent/SI2470520T1/en unknown
- 2010-08-31 MX MX2012002543A patent/MX2012002543A/en active IP Right Grant
- 2010-08-31 AU AU2010290871A patent/AU2010290871B2/en not_active Ceased
- 2010-08-31 PT PT107545949T patent/PT2470520E/en unknown
- 2010-08-31 SG SG2012006870A patent/SG178198A1/en unknown
-
2012
- 2012-01-25 IL IL217729A patent/IL217729A/en active IP Right Grant
- 2012-01-27 CO CO12013015A patent/CO6491096A2/en active IP Right Grant
- 2012-01-31 TN TNP2012000049A patent/TN2012000049A1/en unknown
- 2012-01-31 ZA ZA2012/00770A patent/ZA201200770B/en unknown
- 2012-02-09 MA MA34616A patent/MA35674B1/en unknown
- 2012-02-28 CL CL2012000516A patent/CL2012000516A1/en unknown
- 2012-11-02 HK HK12111043.0A patent/HK1170724A1/en not_active IP Right Cessation
-
2013
- 2013-09-06 HR HRP20130832AT patent/HRP20130832T1/en unknown
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