MY140507A - Quinazoline derivatives, pharmaceutical compositions containing them, processes for their preparation and their use in the production of an antiangiogenic and/or vascular permeability reducing effect - Google Patents

Abstract

THE INVENTION RELATES TO THE USE OF COMPOUNDS OF THE FORMULA 1:WHEREIN RING C IS AN 8, 9, 10, 12 OR 13-MEMBERED BICYCLIC OR TRICYCLIC MOIETY WHICH OPTIONALLY MAY CONTAIN 1-3 HETEROATOMS SELECTED INDEPENDENTLY FROM O, N AND S; Z IS -O-, -NH-, -S-, -CH()- OR A DIRECT BOND; N IS 0-5; M IS 0-3; R2 REPRESENTS HYDROGEN, HYDROXY, HALOGENO, CYANO, NITRO, TRIFLUOROMETHYL, C()ALKYL, C()ALKOXY, C()ALKYLSULPHANYL, -NR3R4 (WHEREIN R3 AND R4, WHICH MAY BE THE SAME OR DIFFERENT, EACH REPRESENTS HYDROGEN OR C()ALKYL), OR R5X1- (WHEREIN X1 AND R5 ARE AS DEFINED HEREIN; R1 REPRESENTS HYDROGEN, OXO, HALOGENO, HYDROXY, C()ALKOXY, C()ALKYL, C()ALKOXYMETHYL, C()ALKANOYL, C()HALOALKYL, CYANO, AMINO, C()ALKENYL, C()ALKYNYL, C()ALKANOYLOXY, NITRO, C()ALKANOYLAMINO, C()ALKOXYCARBONYL, C()ALKYLSULPHANYL, C()ALKYLSULPHINYL, C()ALKYLSULPHONYL, CARBAMOYL, N-C()ALKYLCARBAMOYL, N, N-DI(C()ALKYL)CARBAMOYL, AMINOSULPHONYL, N-C()ALKYLAMINOSULPHONYL, N, N-DI(C()ALKYL)AMINOSULPHONYL, N-(C()ALKYLSULPHONYL)AMINO, N-(C()ALKYLSULPHONYL)-N-(C()ALKYL)AMINO, N, N-DI(C()ALKYLSULPHONYL)AMINO, A C()ALKYLENE CHAIN JOINED TO TWO RING C CARBON ATOMS, C()ALKANOYLAMINOC()ALKYL, CARBOXY OR A GROUP R56X10 (WHEREIN X10 AND R56 ARE AS DEFINED HEREIN); AND SALTS THEREOF, IN THE MANUFACTURE OF A MEDICAMENT FOR USE IN THE PRODUCTION OF AN ANTIANGGIOGENIC AND/OR VASCULAR PERMEABILITY REDUCING EFFECT IN WARM-BLOODED ANIMALS, PROCESSES FOR THE PRAPARATION OF SUCH COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING A COMPOUND OF FORMULA 1 OR A PHARMACEUTICALLY ACCEPTABLE SALT TEHREOF AS ACTIVE INGREDIENT AND COMPOUNDS OF FORMULA 1. THE COMPOUNDS OF FORMULA 1AND THE PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF INHIBIT THE EFFECTS OF VEGF, A PROPERTY OF VALUE IN THE TREATMENT OF A NUMBER OF DISEASES STATES INCLUDING CANCER AND RHEUMATOID ARTHRITIS.