MY136639A - New process for the synthesis of (2s, 3as, 7as)-perhydroindole-2-carboxylic acid and esters thereof, and application in the synthesis of perindopril - Google Patents

New process for the synthesis of (2s, 3as, 7as)-perhydroindole-2-carboxylic acid and esters thereof, and application in the synthesis of perindopril

Info

Publication number
MY136639A
MY136639A MYPI20041884A MYPI20041884A MY136639A MY 136639 A MY136639 A MY 136639A MY PI20041884 A MYPI20041884 A MY PI20041884A MY PI20041884 A MYPI20041884 A MY PI20041884A MY 136639 A MY136639 A MY 136639A
Authority
MY
Malaysia
Prior art keywords
synthesis
perindopril
application
perhydroindole
esters
Prior art date
Application number
MYPI20041884A
Inventor
Thierry Dubuffet
Jean-Pierre Lecouve
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of MY136639A publication Critical patent/MY136639A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCESS FOR THE SYNTHESIS OF COMPOUNDS OF FORMULA (I) :(I)WHEREIN R WHEREIN R REPRESENTS A HYDROGEN ATOM OR A BENZYL OR LINEAR OR BRANCHED (C1-C6)ALKYL GROUP, AND ADDITION SALTS THEREOF WITH A MINERAL OR ORGANIC ACID OR BASE.APPLICATION IN THE SYNTHESIS OF PERINDOPRIL AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF.
MYPI20041884A 2003-05-19 2004-05-19 New process for the synthesis of (2s, 3as, 7as)-perhydroindole-2-carboxylic acid and esters thereof, and application in the synthesis of perindopril MY136639A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03291157A EP1354875B1 (en) 2003-05-19 2003-05-19 Method for synthesis of (2S,3aS,7aS)-perhydroindole-2-carboxylic acid and esters thereof; and use in the synthesis of perindopril

Publications (1)

Publication Number Publication Date
MY136639A true MY136639A (en) 2008-11-28

Family

ID=28459641

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI20041884A MY136639A (en) 2003-05-19 2004-05-19 New process for the synthesis of (2s, 3as, 7as)-perhydroindole-2-carboxylic acid and esters thereof, and application in the synthesis of perindopril

Country Status (10)

Country Link
EP (1) EP1354875B1 (en)
AR (1) AR044392A1 (en)
AT (1) ATE283258T1 (en)
DE (1) DE60300168T2 (en)
DK (1) DK1354875T3 (en)
ES (1) ES2233914T3 (en)
MY (1) MY136639A (en)
PT (1) PT1354875E (en)
SI (1) SI1354875T1 (en)
WO (1) WO2004103969A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100391945C (en) * 2005-05-31 2008-06-04 浙江大学 S-(-)-indolyl-2-carboxylic acid synthesizing method
PE20150184A1 (en) 2012-07-17 2015-02-13 Hoffmann La Roche ARYLETINYL DERIVATIVES

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1341296C (en) * 1981-12-29 2001-09-25 Hansjorg Urbach 2-azabicycloalkane-3-carboxylic acid derivatives, processes for their preparation, agents containing these compounds and their use
FR2620703B1 (en) * 1987-09-17 1991-10-04 Adir PROCESS FOR THE INDUSTRIAL SYNTHESIS OF PERHYDROINDOLE CARBOXYLIC ACID - 2 (2S, 3AS, 7AS). APPLICATION TO THE SYNTHESIS OF CARBOXYALKYL DIPEPTIDES

Also Published As

Publication number Publication date
DE60300168D1 (en) 2004-12-30
DK1354875T3 (en) 2005-03-14
SI1354875T1 (en) 2005-02-28
EP1354875B1 (en) 2004-11-24
DE60300168T2 (en) 2005-12-01
PT1354875E (en) 2005-03-31
ES2233914T3 (en) 2005-06-16
AR044392A1 (en) 2005-09-14
ATE283258T1 (en) 2004-12-15
WO2004103969A1 (en) 2004-12-02
EP1354875A1 (en) 2003-10-22

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