MXPA98010247A - Dental paste compounds containing fluidified carboximetilcelul polymer suspensions - Google Patents

Abstract

The present invention relates to toothpaste compositions as well as a process for the preparation of such compositions comprising dental abrasive, humectant, fluidized polymer suspension and a suitable vehicle for the humectant, wherein the fluidized polymer suspension comprises: polyethylene glycol, carboxymethylcellulose and hydrated silica of espesamien

Description

DENTAL PASTE COMPOUNDS CONTAINING FLUIDIFIED CARBOX POLYMER SUSPENSIONS IMETILCELLULOSA FIELD OF THE INVENTION This. invention relates to toothpaste compounds containing fluidized suspensions of carbohydrate, and the methods for preparing said toothpaste compounds. BACKGROUND OF THE INVENTION Toothpaste formulations generally contain a dentally acceptable abrasive, a humectant, water and a water soluble polymer which serves as a thickener and co-binder for the ingredients. A variety of other ingredients such as sabarizante 5 sweeteners, conservatives? Fluoride are also used at low levels. Glycerin and sarbital are the most commonly used moisturizers for toothpaste, and depending on the characteristics desired in the product, polyethylene glycol or polypropylene glycol can also be incorporated. Some types of toothpaste are produced: i) cream or opaque; and 2) transparent or translucent gel, the most common thickeners or lickers used for toothpaste san carba: imetilcelulase (CMC) and hydraxyethylcellulose (HEC). Carrageenan, antahna, and paryacrilata are also used, but in a very frequent way.

In the toothpaste manufacturing process, the incorporation of the dry water-soluble polymer binder within the composition often presents difficulties for the tendency to lump when the dry polymer is added and dispersed in aqueous systems. Attempts to avoid this problem have resulted in several typical procedures for the manufacture of toothpaste. In the first, the binder is pre-dispersed in a non-solvent (glycerin is preferred to wet the binder), and then a mixture of sorbital / water with vigorous stirring is added. If there is no glycerin (only a low level) or another organic fluid mixable in water in the formulation, then all the available sarbital is used with so much free water that can be released with vigorous agitation. In the second method, the binder is dry mixed with other dry materials of the formulation, for example, abrasives, and the resulting mixture is dispersed in the liquid ingredients with vigorous stirring. To obtain a good dispersion the binder must be about 20% ores of the total dry mixture. It was this method it is important to avoid mixing the binder with competing materials such as water, for example, salts or sweeteners. These dispersion techniques require a lot of time. Accordingly, there is a need in the industry for methods for incorporating water-soluble polymers that provide lump-free products, rapid viscosity development, and reduced batch preparation time and that allow for convenient handling of the binder. U.S. Patent 3,574,824 discloses an anhydrous toothpaste base having the following ingredients: an oil, such as mineral or vegetable oil, with a viscosity of 100 to 300 cps; a combination of polyethylene glycols with a viscosity comprised between 2,200 and 3,400 cps with molecular weight between 550 and 6,000; a non-toxic nonionic emulsifier; at least one agglomerating agent and one compound that has negative hydrating calender. The binder agents presented are: palivinylpyrralidane, colloidal aluminum magnesia silicate, Acacia gum. , sodium alginate, Irish musga extract, carbaximeti Icelulosa and methylcellulase. Hexahydric alcohols, in particular annitol and inosital, are present as compounds that have negative heat of hydration. U.S. Patent 5,192,529 shows a toothpaste composition containing a pantilly humectant, an abrasive and a thickener system consisting of low viscosity sodium carboxymethylcellulose and low viscosity hydroxyethylcellulase. The patent of the United Kingdom Na. 1,363,182 discloses a clear toothpaste compound or translucent gel comprising polyethylene glycol having a molecular weight below 700 and a hydrous silica polishing agent having a specific surface area below 600 ^ / 'g. The composition can be thickened with carboxymethylcellulose.

None of the aforementioned references discloses the use of fluidized suspensions of polymers in toothpastes. SUMMARY OF THE INVENTION This invention relates to toothpaste compositions comprising a dental abrasive, a humectant and a fluidized polymer suspension, wherein the composition of the present invention relates to toothpaste compositions. Fluidized polymeric suspension comprises paliethylene glycol, carboxymethylcellulase and hydrous thickened silica. In preferred compositions the humectant is glycerin, sorbitol, polyethylene glycol, prapilenglical to mixtures thereof. In another embodiment, the invention relates to an improved process for preparing a toothpaste composition comprising dry carbaxymethylcellulase, the improvement comprising replacing the dry carbaxymethylcellulase with a fluidized suspension of polymer comprising polyethylene glycol, carbaximethylcellulase and hydrous thickened silica, wherein the Carboxymethylcellulase present in the fluidized polymer slurry dissolves in the composition in a shorter time than the dried carboxymethyl cellulose «DETAILED DESCRIPTION OF THE INVENTION The present invention relates to toothpaste compositions containing, abrasive, humectant and a fluidized polymer suspension . The fluidized polymer suspension comprises polyethylene glycol, carboxymethylcellulose and hydrated thickener silica. The toothpaste compositions may also contain water or other carriers for the humectant, and comprise clear or translucent compositions, both opaque to crem. The use of carbaxy ethyl cellulose as a fluidized polymer suspension in the toothpastes of the present invention provides a substantial advantage over the use of dry polymer, because the suspension eliminates the problem of lumps and slow dispersion when a dry polymer That is, the water-soluble polymer dissolves in the composition in less time when it is in the form of a fluidized polymer suspension than in the form of a dry polymer. The fluidized polymer suspensions of the present invention comprise suspensions of carbaximeti Icelulose in pharma of its sodium salt. Technical and purified grades of carboxymethyl cellulose can be used in the toothpaste of the present invention, Although water soluble liquid pallet can be used in fluidized polymer suspensions, those whose molecular weight is less than 1,000 are preferred. . More preferred are those whose molecular weight is less than 700, and preferably those whose molecular weight is between 200 and 400. Hydrated thickener silica is incorporated into the fluidized polymer suspensions of the present invention as a suspending agent. for the water soluble dispersed palmer. Hydrous thickened silicas include calcined silicas, amorphous precipitated silicas and silica gel. Preferred san silica Aerasil (mr) 200, available from Degusa AT, Fran furt, Germany, and silica Syloblanc (mr), available from 6 Davisce, S.A., Epernon, France. The most preferred is silica Aerosil (mr) 20. In the fluidized polymer suspensions used in the present invention it is preferred that the carboxymethyl cellulose be present at a minimum level of about 20% based on the total weight of the fluidized polymer suspension. It is preferred that the maximum level of carbaxymethyl cellulose is about 80%, and more preferably about 60% and preferably even greater than about 55%.

Preferably the level of polyethylene 1 used in the fluidized polymer suspension is about 80% by weight based on the total weight of the fluidized polymer suspension. More preferably, the maximum level is approximately 60%, preferably even higher, of approximately 55%. A minimum level of polyethylene glycol is approximately 20%, with a preference of approximately 40% and with even greater preference of approximately 45%. The maximum level of hydrous thickened silica which is used in the fluidized polymer suspension is about 3% by weight based on the total weight of the fluidized polymer suspension. Preferably the maximum is about 2%. The minimum level of hydrated silica is approximately 0.5%. The level of hydrated silica is selected for use in the fluidized polymer suspension depending on the particular viscosity balance, fluidity and stability that is desired. At lower levels, an area of approximately 0.5%, high fluidity and low viscosity are obtained, but the stability, qualified, for phase separation, is not as good as that obtained at the highest levels, close to 2%. A good balance of fluidity, viscosity and stability has been achieved at intermediate levels of approximately 1.5%. A fluidized polymer suspension for use in the present invention comprises between about 45% and about 55% by weight of carboxymethylcellulose, between about 55% and about 45% by weight of polyethylene glycol having a molecular weight of about 400 and about 0.5% and approximately 2.0% of Aerasil (mr) 200 hydrated silica as thickener. Another class of ingredients present in the toothpaste of the present invention are humectants, which are used to retain moisture, particularly in the tuba mouthpiece of the toothpaste where the toothpaste may be in prolonged contact with air. Typical humectants for use in the toothpaste of the present invention include glycerin, sorbitol, ethylene glycol, praline glycol, or mixtures thereof, which are mixed with a suitable humectant carrier such as water. The dental abrasives for use in the toothpaste of the present invention are typically the silicas and the insoluble inorganic salts. Preferred inorganic salts are calcium carbonate, dibasic calcium phosphate, tribasic calcium phosphate, calcium sulfate, insalutable sodium ethanophate, hydrous aluminum oxide and magnesia phosphates and carbonates. Silicas and silica xerogels are particularly useful for transparent and translucent toothpaste.

The amounts of the various ingredients present in the toothpaste of the present invention are quite variable and depend on the exact properties desired in the final product. In particular, the amounts of the ingredients can vary widely depending on whether. the toothpaste is cream or gel type. The amount of abrasive is limited only by the amount that safely provides a polishing and cleaning when combined with the other ingredients gives a toothpaste which is smooth and fluent with nice ends and with a minimum of grit »The minimum amount of The abrasive used is approximately 5% by weight based on the total weight of the toothpaste. Preferably the amount is about 7% and more preferably about 10%. The maximum amount of abrasive used is about 45%, preferably about 30% and more preferably about 25%. The maximum level of humectant present in the toothpaste of the present invention is about 85% by weight based on the total weight of the toothpaste. Preferably, the maximum level is about 80%, and preferably about 75%. The minimum level present in the toothpaste is approximately 15%. Preferably the minimum level is about 20%, and more preferably is about 25%.

The amount of water used is preferably between about 5% and about 45% by weight based on the total weight of the toothpaste, and more preferably between about 5% and about 40%. The toothpaste will contain the fluidized polymer suspension in an amount sufficient to provide carboxymethylcellulose at a minimum preferred level of about 0.1% by weight based on the total weight of the toothpaste formulation. A more preferred minimum level is about 0.2% torque and the most preferred minimum level is about 0.3% by weight. The maximum level of carbamaxymethyl cellulase provided by the fluidized polymer suspension is preferably about 5% by weight based on the total weight of the toothpaste formulation. A most preferred maximum level is approximately 3% by weight and the most preferred maximum level is approximately 2% by weight. The toothpaste formulations of the present invention may contain additional ingredients, for example, anionic, cathiopic, nonionic and ampholytic surfactants, especially anionic surfactants with detergent and foaming properties; lethal agents; bleaching agents; conservatives and agen is antibacterial. Any of these additives may be present in the toothpaste of the present invention in an amount up to about 5%. Typical anionic surfactants include sodium lauryl sulfate and n-laurayl sodium sarcosinate, and nonionic surfactants include ethylene oxide block copolymers and prapilene oxide where the ratio of ethylene oxide units to the units of Propylene oxide is 2: 1. Suitable savory agents include the oils of peppermint, spearmint and cinnamon. Sweetening agents such as sodium saccharin, preservatives such as p-chlorafeni biguanide, 4-palebenzydril biguanide and 5,6-diclara-2-guanidinebenzimidazole can also be included in the compounds of the present invention, in addition to those composed of present invention can sing a compound containing fluoride in an amount sufficient to provide a content of 1,000 ppm of ionic fluoride. Typical compounds that contain fluoride include sodium fluoride to sodium monofluorophosphate. In the preparation process of the toothpaste of the present invention the first pass is the preparation of the fluidized polymer suspension of carbaximeti 1 cellulose. In the preparation of the fluidized polymer suspensions, the palethylene glycol is added to a high shear mixing device., and the appropriate hydrated silica is added. The mixture is stirred for a sufficient time to fight the yeast, and then the carbaxy eti Icelulosa is added. Further agitation is carried out until the suspension is complete. It is preferred that the temperature of the reaction mixture be maintained below 40 ° C during the preparation. For the preparation of the toothpaste, the fluidized polymer suspension is agitated can: a) a humectant or a mixture of humectants; b a humectant vehicle, typically water; c) salts d) an abrasive and e) sabsrizantes, dyes and surfactants to obtain a complete toothpaste formulation. In a preferred method of preparation, the fluidized polymer suspension is added directly to the mixture of humectants and the wetting vehicle and agitated until the polymer particles are completely dissolved; then the salts are added and then the abrasive. The abrasive is added after the complete dissolution of the salts. The mixture is stirred until the abrasive particles are wet; then the flavorings are added, continuing with the surfactant. The invention is illustrated in the following examples, which are for illustration and are not limiting. All percentages, parts, etc. They are by weight unless the opposite is specified. Examples 1-5 33 These examples illustrate the preparation of fluidized polymer slurry using carboxymethylcellulose (CMC 9H4XF, available from Hercules Incorporated, Wilmington, Dela.), Palleti leng 1 icol 400 (PEG 400, available from Dow Benelux NV, Edegem, Belgium) and two different types of silica hydrated thickener, Aerosil (mr) 200. { Degussa AS, Frankfurt, Germany) and Sylablanc (mr) (Grace Davison S.A., Epernan, France). The PEG 400 was added to a high-cut mixing device (Waring Blender / Mixer) and the appropriate amount of silica hydrous thickener was added. The resulting mixture was stirred vigorously for a sufficient time, such as 10 minutes, to make the silica, and the carbaxymethylcellulase was added. Agitation continued for an additional 10 minutes. The temperature during the preparation was kept below 40 ° C. The composition of the fluidized polymer suspensions of Examples 1-5 are summarized in Table 1. The suspensions are characterized by the Braakfield viscosity (LVF spindle 4 and 30 rpm), the fluidity and the stability for a period of 3 months « The data are in Table 2. The fluidity was evaluated by measuring the time required for a free flow of 50 ml. of the suspension through an orifice using a modification of ASTM D1200, but using a slightly different cup (AFNOR cup No. 6). In the test, the hole in the layer is closed holding a rubber stopper against it. Then the cup is filled with the prepared fluid, the preferred method is to overfill the cup and remove excess with a knife, the stopper is removed, and the time required to fill a graduated cylinder is measured. The shorter the time, the better the fluency. To simulate stability at room temperature, the suspension was aged for 3 months at 40 ° C, and stability was characterized for the extent of phase separation. After three months at age (at room temperature and at 40 ° C) the stability was characterized by weighing the amount of the clear syneresis layer, if any, on the suspension and expressing it as the percentage of the total weight of the suspension sample. These data are presented as "Syneresis Layer (% weight" in Table 2. In another method for measuring syneresis, glass bottles (100 ml.) Were filled to 50 mm in height with the fluidized polymer suspension and stored at ambient temperature and at 40 ° C. After i day, 7 days, 30 days and three months, the height of the clear coat, if any, was measured.The results are reported in Table 2. They are expressed as: height of syneresis (mm) / original height (50 mm) For example, 0.5 / 50 means O.5 mm of syneresis, 50 mm original height The term "Film" means a clear measurable layer.

TABLE i FLUIDIFIED POLYMER SUSPENSIONS Ingredien en Example Example Example Example Example 1 2 3 4 5 PET 400 53% 53% 54% 54.5% 53.5% Aerasil 200 2 - 1 0.5 1.5 Sylablanc 34 - 2 - - - 9H4XF CMC 45 45 45 45 45 TABLE 2 CHARACTERIZATION OF FLUIDIFIED POLYMER SUSPENSIONS Example Example Example Example Example Flow of 50 ml (sec.Cop 6) 0 Poor 102 116 62 82 24 hours 106 64 83 51 73 i week 97 54 65 42 73 1 month 102 50 59 45 84 3 months 95 58 66 - - Viscosity Brookfield LVF Spindle 4, 30 rpm (cps) 7400 6600 4600 3040 4000 24 hours 4800 3500 3400 2300 3500 1 week 4300 3000 3380 2300 3400 1 month 4500 2820 3100 2100 2900 3 months 4300 3060 3360 _ Sinérssis layer (% weight) 3 months at temp. 1.5 9.7 3.7 - - ambient 3 months to 2.5 11.0 5.8 40 ° C Syneresis (m) 24 hours at 0 0 0 0 0 temp. ambient 24 hours 0 0 0 Film 0 at 40 ° C 1 week 0 0.5 / 50 0 O temp. environment i week 0 2/50 Film 5/50 0 to 40 ° C 1 month O 4/50 0 5/50 Film temp. ambient 1 month Film 4/50 2/50 6/50 0.5 / 50 to 40 ° C 3 months 0.5 / 50 4/50 2/50 - - temp. Environment 3 months 0.5 / 50 5/50 2/50 at 40 ° C The data indicate that incorporating 2% silica hydrate thickener within the systems (Examples i and 2) gives. very viscous suspensions at the time of preparation. However, decreasing the amount of silica hydrous thickener of 2% to between 1% and 0.5% (Examples 3 and 4) provides more fluid suspensions; however, its stability was not good (phase separation after 1 week at 40 ° C. Aerosil (mr) 200 thickener silica gave coarser and stable suspensions than Syloblanc (mr) Example 6 and Comparative Example A Exemplary 6 illustrates the preparation of a toothpaste in cream using a fluidized polymer suspension. of 9M31XF CMC, available from Hercules Ipcarporated, Wilmingtan, DE, by the method used in Example 5. Comparative Example A illustrates the preparation of the same toothpaste using dry carboxymethylcellulose in place of the fluidized polymer suspension, at an equivalent level of carboxy ethylcellulose present in the fluidized polymer suspension in Example 6. The ingredients used are in Table 3. In Comparative Example A, dry carbaxymethyl cellulase (CMC) was added to the glycerin in a glass mixer and sealed. for 5 minutes. This is known as the "dispersion step". The water and sorbitol were then added, continuing the mixture for 30 minutes at 600 rpm. The viscosity was measured every 10 minutes. This is known as "premix". Caustics and salts were added and mixing was continued for 10 minutes. The mixture was transferred to a Ras mixer, the silica and Ti02 were added, and the resulting mixture was stirred briefly until the particles were integrated. Vacuum was applied and the mixture was continued at 60 rpm for 15 minutes. The flavor was added following the mixture for 5 minutes at 60 rpm, and then the surfactant was added by continuing the mixture for 10 minutes at 15 rpm under vacuum. In Example 6, the dispersion step was eliminated by adding the fluidized polymer suspension (FPS) directly to the mixture of glycerin, sorbitol and water, and the viscosity was measured every 5 minutes. The rest of the ingredients were added bed described above for the Axis Comparative.

Table 3 - Toothpaste Formulations Dental Toothpaste Incredibles Example 6 Comparative Example A Glycerin 8.30% .10.00% CMC, dry - - (9M31XF) Water 39.15 39.15 Sorbitol 25.00 25.00 FPS 3.1 (45% 9M31XF CMC ) manof luorafosfata 0.85 0.85 of Sodia Saccharinata of 0.20 0.20 Sodium NaOH (50%) O.40 0.40 S loblanc 81 20.00 20.00 Hydrated silica abrasive Ti02 0.50 0.50 Flavor 1.00 1.00 Lauryl sulfate 1.50 1.50 sodium, dry powder U The products of toothpaste compositions were evaluated in terms of their appearance, viscosity and strip stiffness. The data are in Table 4. The liquid stiffness is a measure of the anti-fall behavior of the toothpaste when it is squeezed out of the tube. Characterizes the ability of the paste to maintain a circular strip shape on the brush.

Table 4 - Properties of Toothpaste Toothpaste in Cream Example 6 Run Comparative A Viscosity Pre-mix Hellpath, Spindle TA, 20 rpm 5 minutes 5850 10 minutes 5800 4000 15 minutes 5600 20 minutes 5450 4750 30 minutes 5200 4850 Viscosity Toothpaste (cps) Hel Ipath, Spindle E, 5 rpm! "• 35, 265 24 hours 480 J-l < - < i week 550 4 ^ 5 2 weeks - 545 1 month - - Stability (cp) Freeze / Thaw 1 cycle 415 375 2 candles 460 400 3 cycles 460 420 Appearance of the toothpaste 24 hours S.G. S.G, 1 week S.G. S.G. 2 weeks - S.G. 1 month - - Rigidity in Listón 24 hours Excellent Excellent i week Excellent Excellent 2 weeks - Excellent 1 month - - Inertial toothpaste stability 24 hours T-, W + T-, W + 1 week. T-, W + T-, W + 2 weeks T- "W + 1 month S = appearance of soft toothpaste G = appearance of bright toothpaste T- / T - + - = absence / presence of syneresis in the upper part of the storage bottle W- / W + = absence / presence of syneresis in the walls of the bottle storage The data indicate that the fluidized polymer suspension dissolves faster in the mixture, of sorbital / water that is dry powder, even when the latter is pre-dispersed in glycerin. Before the complete dissolution, the dried powder passes through several dispersion raisins during which the palmeric agglomerates. The agglomeration is characterized by partial to fully swollen polymer. In pursuing salvation, there is an increase in viscosity, and as the salvation continues, the gel begins to disintegrate, leading to a state of partial dispersion characterized by a sharp decrease in viscosity at a level equivalent to that observed in the fluidized palm. With this base, it is concluded that the fluidized polymer suspension dissolves rapidly, leading to a high viscosity within 5 minutes, while dry carbaxymethylcellulase requires 30 minutes to reach an equal state of hydration, as indicated by the viscosity. There are no significant differences in the properties of toothpastes made with dry carbaxy ethyl cellulose to fluidized polymer suspensions. Except for the viscosity, all the properties were the same: good stability (without syneresis), very good ribbon stiffness and smooth and shiny appearance. Exemplary 7 and Exemplary Comparative B Exemplary 7 illustrates the preparation of gel toothpaste using the fluidized polymer suspension prepared by the method of Example 5 of 9M31XF CMC, available from Hercules Incarparated, Wilmington, DE. Comparative Example B illustrates the preparation of the. same toothpaste using dry 9M31XF carboxymethylcellulose in place of the fluidized polymer suspension at a level equivalent to that of the carboxymethylcellulose present in the fluidized polymer suspension in Example 7. The ingredients used are in Table 5- In Comparative Example B , dry carbaxymethylcellulase (CMC) was added to the pal ietileng licol in a glass mixer and mixed for 5 minutes at 600 rpm. The remaining steps 74 were the same as those described above for Comparative Example A. In Example 7, the dispersion pass was omitted by adding the fluidized polymer suspension (FPS) directly to the mixture of ethylene glycol, sarbital and water. The remaining steps were described above for Exemplary 6. Agitation was continued until the silica particles were integrated. Vacuum was applied and mixing at 60 rpm was continued for 15 minutes. The heat was added followed by mixing for 15 minutes, then the sweetener and the surfactants were added, followed by mixing for 15 minutes and 10 minutes respectively at 5 rpm in vacuum. The data on evaluation of toothpastes are presented in Table 6.

Table 5 - Dental Paste Formulations Dental Gel Pastes Ingredients Example 7 Comparative Example B Po1 ieti 1en- 3.52% 4.00% g1 ica1 400 Water 8.15 8.15 Sorbitol1 68.00 68.00 CMC dry - - (9M31XF) FPS (457. 0.89 9M31XF CMC) Manaf luorophosphate 0.75 0.75 Sodium Saccharinate 0.20 0.20 sodium Benzaata 0.10 0.10 Sodium Sident 15 15.00 15.00 Hydrated silica Coloring 0.20 0.20 Sabarizante 0.70 0.70 Laurila sulfate 2.50 2.50 Sodium, liquid Table 6 - Properties of Toothpaste Toothpaste of Gel Example 7 Comparative Example B Viscosity Premix Hel lpath. TA spindle, 20 rpm 5 minutes 2050 10 minutes 2350 2300 15 minutes - - 20 minutes 2250 2200 minutes 20500 2150 Viscosity Toothpaste (cps) Hel 1 path, Spindle E, 5 rpm 0 345 365 24 hours 415 430 1 week 515 520 2 weeks 530 555 1 month 545 550 Stability (cps) Freeze / Thaw 1 cycle 360 380 2 cycles 385 385 3 cycles 380 385 Appearance of the toothpaste 24 hours Tr, S.G. Tr, S.G, 1 week Tr, S.G. Tr, S.G, 2 weeks Tr, S.G. Tr, S.G, 1 month Tr, S.G. - Rigidity in Batten 24 hours Excellent Excellent 1 week E celente E 2 weeks Excellent Excellent i month Excellent Excellent Stability of Pasta Dent l Syneresis 24 hours T-, W- T-, W- 1 week T-, W- T-, W ~ 2 weeks T-, W- T- "W- 1 month T-, W- T-, W- As in the case of the toothpaste in cream (Example 6 and Comparative Example A), the dried carbaxymethylcellulase was first dispersed in polyethylene glycol, and then the sorbitan / water mixture and the resulting mixed mixture were added for 30 minutes before add the remaining ingredients. When the fluidized polymer suspension was used, it was poured into the polyethylene glycol / sorbitol / water mixture without prior dispersion. In gel toothpastes, due to the low water content, the dispersion / disintegration of the aglamerant / thickener presents less risk of lumping. The data confirm this, demonstrating that fluidized polymer suspensions and dry carboxymethylcellulose develop? 8 similar viscosities. However, it was also observed that the fluidized polymer suspension gives a pre-mix, more transparent gel after only 10 minutes of mixing, while the dry powder requires 20 minutes to maintain similar transparency. The dried carboxymethylcellulose and fluidized polymer suspension produced toothpastes of similar viscosity, frozen / thawed stability, appearance, ribbon stiffness and lack of syneresis. The examples presented here are not intended to limit the invention, but are presented to illustrate some of the specific embodiments of the invention. invention. Various ramifications and variations of the invention may be made without departing from the scope of the appended claims.

Claims (29)

1. CLAIMS 1. A toothpaste composition comprising a dental abrasive, a humectant and a fluidized polymer suspension, wherein the fluidized polymer suspension comprises; pol ieti len licol, carboxymethylcellulose and silica hydrate thickener.
2. 2. The toothpaste composition of Claim 1 wherein the polyethylene glycol has a molecular weight of about 1000.
3. 3, The toothpaste composition of Claim 2 wherein the palieti tongue has a molecular weight of less than about 700.
4. 4. The toothpaste composition of Claim 3 wherein the polyethylene glycol has a molecular weight of from about 200 to about 400. 5. The toothpaste composition of Claim i in dap of the humectant is selected from the group consisting of of glycerin, sorbitol, prapilengl icol, polyethylene glycol and mixtures thereof. 6. The tooth paste paste of Claim 1 wherein the particle size distribution of the carboxymethyl cellulose in the fluidized polymer suspension is such that about 80% of the particles have a size less than about 75 μm. 7. The toothpaste campaign of Claim 1 3? which also comprises water. 8. The toothpaste composition of Claim 7 which has between about 5 and about 45% by weight of dental abrasive, between about 15 and about 85% by weight of humectant, between about 5 and about 45% by weight of water and an amount of fluidized polymer suspension sufficient to provide between about 0.1 and about 5% by weight of carbaximethyl cellulose. The toothpaste composition of Claim 8 which has between about 10 and about 25% by weight of dental abrasive, between about 25 and about 75% by weight of humectant, between about 5 and about 40% by weight of water and an amount of fluidized polymer suspension sufficient to provide between about 0.3 and about 2% by weight of carboxymethylcellulase. The toothpaste composition of any of the preceding claims wherein the fluidized polymer suspension comprises between about 20 and about 80% by weight of polyethylene glycol, between about 20 and about 80% by weight of carbaximethylcellulose and between about 0.5 and about 3% pair hydrated silica thickener. 11, The toothpaste composition of Claim 10 wherein the fluidized polymer suspension comprises between about 40 and about 60% by weight of polyethylene glycol, between about 40 and about 60% by weight of carboxymethylcellulase and between about 0.5 and 0.
5. 5. Approximately 2% by weight of hydrated thickened silica. 12. The toothpaste composition of Claim 11 wherein the fluidized polymer suspension comprises between about 45 and approximately 55% of ethylene glycol, between about 45 and about 55% by weight of carboxymethylcellulose and between about 0.5. and about 2% by weight of silica hydrous thickener. 13. The toothpaste composition of Claim 8 wherein the humectant is selected from the group consisting of sorbitol, glycerin, polyethylene glycol, prapylene glycol and mixtures thereof, 14. The toothpaste composition of Claim 1 which it further comprises selected ingredients within the group consisting of flavorings, sweeteners, preservatives, surfactants, antibacterials, fillers and fluoride. 15. In a process for preparing a toothpaste composition, comprising the use of dry carboxymethylcellulose, the improvement comprises the replacement of the dry carbaxymethylcellulase with a fluidized polymer suspension comprising polyethylene glycol., carboxj.metilcelulosa and silica hydrate thickener. 16. The process of Claim 15 wherein the carboxymethylcellulose present in the fluidized polymer suspension dissolves in the composition in less time than the dry carboxymethyl cellulose. The process of Claim 15 wherein the polyethylene glycol has a molecular weight less than about 1000, 18. The process of Claim 17 wherein the pallet has a molecular weight of less than about 700. The process of Claim 18 wherein the polyethylene glycol has a molecular weight between about 200. and approximately 400. 20. The process of the. Claim 15 wherein the toothpaste composition further comprises water and a humectant selected from the group consisting of glycerin, sarbital, prapilengl icol, palietileng 1 icol and mixtures thereof. 21. The process of Claim 15 wherein the particle size distribution of the. The carboxymethylcellulose in the fluidized polymer suspension is such that about 80% of the particles have a size of 75 μm. 22. The process of Claim 15 wherein the fluidized polymer suspension comprises between about 20 and about 80% by weight of polyethylene glycol, between about 20 and about 80% by weight of carboxymethyl cellulose and between about 0.5 and about 3% by weight of hydrated silica and pesapte. 23. The process of Claim 22 wherein the fluidized polymer suspension comprises between about 40 and about 60% by weight of polyethylene glycol, between about 40 and about 60% by weight of carboxymethylcellulose and between about 0.5 and about 2%. by weight of hydrated thickened silica, 24. The process of Claim 23 wherein the fluidized polymer suspension comprises between about 45 and about 55% polyethylene glycol weight couple, between about 45 and about 55% by weight of carbaximethyl cellulase and between about 0.5 and about 2% by weight of silica hydrous thickener. 25. The process of Claim 20 wherein the dsntal paste composition comprises between about 5 and about 45% by weight of dental abrasive, between about 15 and about 85% by weight of humectant, between about 5 and about 45% by weight of water and wherein the fluidized polymer suspension is used in an amount sufficient to provide between about 0.1 and about 5% by weight of carbaximeti Icellulose, 26. The process of Claim 25 wherein the composition of dental it ranges from about 10 to about 25% by weight of dental abrasive, from about 25 to about 75% by weight of humectant, from about 5 to about 40% by weight of water, and wherein the fluidized polymer suspension is used in a sufficient amount to provide between about 0.3 and about 2% by weight of carbaximethylcellulase. 27. The process of Claim 25 wherein the humectant is selected within the group consisting of sarbitol, glycerin, polyethylene glycol, propylene glycol, and the like. mixtures thereof. The process of Claim 15 wherein the toothpaste composition further comprises ingredients selected from within the group consisting of flavorings, sweeteners, preservatives, surfactants, antibacterials, calorants agents and fluoride. 29. The toothpaste made by the process of any of claims 15 to 28. PESUMFN OF THE INVENTION Compositions of toothpaste and a process for the preparation of such compositions comprising dental abrasive, humectant, fluidized suspension and polymer and a suitable vehicle for the humectant, wherein the fluidized suspension of pal -mero you understand pal íeti 3 eng 1 icol, carbo; imeti l cellulose and silica hydrated of espei-ißmienio.