MXPA98004789A - Stabilized hydroxylamine solutions - Google Patents
Stabilized hydroxylamine solutionsInfo
- Publication number
- MXPA98004789A MXPA98004789A MXPA/A/1998/004789A MX9804789A MXPA98004789A MX PA98004789 A MXPA98004789 A MX PA98004789A MX 9804789 A MX9804789 A MX 9804789A MX PA98004789 A MXPA98004789 A MX PA98004789A
- Authority
- MX
- Mexico
- Prior art keywords
- stabilizer
- compound
- formula
- alkyl
- salt
- Prior art date
Links
- AVXURJPOCDRRFD-UHFFFAOYSA-N hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 title claims abstract description 47
- 150000001875 compounds Chemical class 0.000 claims abstract description 23
- 239000003381 stabilizer Substances 0.000 claims abstract description 22
- 229910052757 nitrogen Inorganic materials 0.000 claims description 25
- 229920002873 Polyethylenimine Polymers 0.000 claims description 21
- 239000011780 sodium chloride Substances 0.000 claims description 21
- 150000003839 salts Chemical class 0.000 claims description 20
- 125000000217 alkyl group Chemical group 0.000 claims description 16
- 239000002253 acid Substances 0.000 claims description 12
- 125000002947 alkylene group Chemical group 0.000 claims description 11
- -1 N-hydroxyethylene diamino Chemical group 0.000 claims description 7
- 125000002993 cycloalkylene group Chemical group 0.000 claims description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 6
- 229920000333 poly(propyleneimine) Polymers 0.000 claims description 6
- 125000002252 acyl group Chemical group 0.000 claims description 5
- 125000003545 alkoxy group Chemical group 0.000 claims description 5
- 125000000732 arylene group Chemical group 0.000 claims description 5
- 125000004450 alkenylene group Chemical group 0.000 claims description 4
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims description 3
- 239000005977 Ethylene Substances 0.000 claims description 3
- 125000004419 alkynylene group Chemical group 0.000 claims description 3
- 125000005724 cycloalkenylene group Chemical group 0.000 claims description 3
- 125000004956 cyclohexylene group Chemical group 0.000 claims description 3
- VGGSQFUCUMXWEO-UHFFFAOYSA-N ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims description 3
- 125000000623 heterocyclic group Chemical group 0.000 claims description 3
- 150000002466 imines Chemical group 0.000 claims description 3
- 230000000087 stabilizing Effects 0.000 claims description 3
- IFQUWYZCAGRUJN-UHFFFAOYSA-N 2-[2-(carboxymethylamino)ethylamino]acetic acid Chemical compound OC(=O)CNCCNCC(O)=O IFQUWYZCAGRUJN-UHFFFAOYSA-N 0.000 claims description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- NRNFFDZCBYOZJY-UHFFFAOYSA-N p-quinodimethane Chemical group C=C1C=CC(=C)C=C1 NRNFFDZCBYOZJY-UHFFFAOYSA-N 0.000 claims description 2
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 claims description 2
- 125000001424 substituent group Chemical group 0.000 claims description 2
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 4
- 150000002829 nitrogen Chemical group 0.000 claims 2
- PIICEJLVQHRZGT-UHFFFAOYSA-N 1,2-ethanediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims 1
- 125000006290 2-hydroxybenzyl group Chemical group [H]OC1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 241000711969 Chandipura virus Species 0.000 claims 1
- KSPMJHKUXSQDSZ-UHFFFAOYSA-N [N].[N] Chemical group [N].[N] KSPMJHKUXSQDSZ-UHFFFAOYSA-N 0.000 claims 1
- 230000002378 acidificating Effects 0.000 claims 1
- 239000000243 solution Substances 0.000 description 27
- 125000004432 carbon atoms Chemical group C* 0.000 description 9
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 8
- KCXVZYZYPLLWCC-UHFFFAOYSA-N edta Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 7
- RBLWMQWAHONKNC-UHFFFAOYSA-N hydroxyazanium Chemical class O[NH3+] RBLWMQWAHONKNC-UHFFFAOYSA-N 0.000 description 7
- 238000006467 substitution reaction Methods 0.000 description 7
- 229920000642 polymer Polymers 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 125000004433 nitrogen atoms Chemical group N* 0.000 description 5
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
- 239000002585 base Substances 0.000 description 4
- 230000001264 neutralization Effects 0.000 description 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 3
- 230000005591 charge neutralization Effects 0.000 description 3
- 238000000354 decomposition reaction Methods 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 150000002443 hydroxylamines Chemical class 0.000 description 3
- 238000006386 neutralization reaction Methods 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- JFDZBHWFFUWGJE-UHFFFAOYSA-N Benzonitrile Chemical compound N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 description 2
- WCYJQVALWQMJGE-UHFFFAOYSA-M Hydroxylammonium chloride Chemical compound [Cl-].O[NH3+] WCYJQVALWQMJGE-UHFFFAOYSA-M 0.000 description 2
- VGYYSIDKAKXZEE-UHFFFAOYSA-L Hydroxylammonium sulfate Chemical compound O[NH3+].O[NH3+].[O-]S([O-])(=O)=O VGYYSIDKAKXZEE-UHFFFAOYSA-L 0.000 description 2
- 239000004721 Polyphenylene oxide Substances 0.000 description 2
- 150000001450 anions Chemical class 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 230000000875 corresponding Effects 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000012458 free base Substances 0.000 description 2
- WTDHULULXKLSOZ-UHFFFAOYSA-N hydroxylamine hydrochloride Substances Cl.ON WTDHULULXKLSOZ-UHFFFAOYSA-N 0.000 description 2
- 229910000378 hydroxylammonium sulfate Inorganic materials 0.000 description 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 229920000570 polyether Polymers 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- 238000011105 stabilization Methods 0.000 description 2
- 238000004448 titration Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- KPPVNWGJXFMGAM-UUILKARUSA-N (E)-2-methyl-1-(6-methyl-3,4-dihydro-2H-quinolin-1-yl)but-2-en-1-one Chemical compound CC1=CC=C2N(C(=O)C(/C)=C/C)CCCC2=C1 KPPVNWGJXFMGAM-UUILKARUSA-N 0.000 description 1
- YXIWHUQXZSMYRE-UHFFFAOYSA-N 1,3-benzothiazole-2-thiol Chemical class C1=CC=C2SC(S)=NC2=C1 YXIWHUQXZSMYRE-UHFFFAOYSA-N 0.000 description 1
- WGJCBBASTRWVJL-UHFFFAOYSA-N 1,3-thiazolidine-2-thione Chemical compound SC1=NCCS1 WGJCBBASTRWVJL-UHFFFAOYSA-N 0.000 description 1
- LVPSKWMJXFMIHR-UHFFFAOYSA-N 1-hydroxy-1-phenylthiourea Chemical compound NC(=S)N(O)C1=CC=CC=C1 LVPSKWMJXFMIHR-UHFFFAOYSA-N 0.000 description 1
- ROFVEXUMMXZLPA-UHFFFAOYSA-N 2,2'-bipyridyl Chemical group N1=CC=CC=C1C1=CC=CC=N1 ROFVEXUMMXZLPA-UHFFFAOYSA-N 0.000 description 1
- CPPWUTNKPOSOOF-UHFFFAOYSA-N 3-ethenyl-5-ethyl-1,3-oxazolidin-2-one Chemical compound CCC1CN(C=C)C(=O)O1 CPPWUTNKPOSOOF-UHFFFAOYSA-N 0.000 description 1
- 125000003143 4-hydroxybenzyl group Chemical group [H]C([*])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H] 0.000 description 1
- 229940058934 Aminoquinoline antimalarials Drugs 0.000 description 1
- NJMVHBQEIKOPIT-UHFFFAOYSA-N CC(O)=O.CC(O)=O.CC(O)=O.CC(O)=O.NCCNCCO Chemical compound CC(O)=O.CC(O)=O.CC(O)=O.CC(O)=O.NCCNCCO NJMVHBQEIKOPIT-UHFFFAOYSA-N 0.000 description 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L Calcium hydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
- QOLIPNRNLBQTAU-UHFFFAOYSA-N Flavan Chemical compound C1CC2=CC=CC=C2OC1C1=CC=CC=C1 QOLIPNRNLBQTAU-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- CWERGRDVMFNCDR-UHFFFAOYSA-N Thioglycolic acid Chemical compound OC(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-N 0.000 description 1
- DGEZNRSVGBDHLK-UHFFFAOYSA-N [1,10]phenanthroline Chemical compound C1=CN=C2C3=NC=CC=C3C=CC2=C1 DGEZNRSVGBDHLK-UHFFFAOYSA-N 0.000 description 1
- NYIWQJCNXCTWOB-UHFFFAOYSA-N [N].[N+][O-] Chemical class [N].[N+][O-] NYIWQJCNXCTWOB-UHFFFAOYSA-N 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 230000002152 alkylating Effects 0.000 description 1
- 150000005010 aminoquinolines Chemical class 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 239000004410 anthocyanin Substances 0.000 description 1
- 235000010208 anthocyanin Nutrition 0.000 description 1
- 150000004636 anthocyanins Chemical class 0.000 description 1
- 229930002877 anthocyanins Natural products 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- KAKZBPTYRLMSJV-UHFFFAOYSA-N butadiene Chemical group C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 238000005039 chemical industry Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 125000005725 cyclohexenylene group Chemical group 0.000 description 1
- 125000004979 cyclopentylene group Chemical group 0.000 description 1
- 230000003247 decreasing Effects 0.000 description 1
- BRLQWZUYTZBJKN-UHFFFAOYSA-N epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 description 1
- 238000007046 ethoxylation reaction Methods 0.000 description 1
- CWYNVVGOOAEACU-UHFFFAOYSA-N fe2+ Chemical class [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 description 1
- 150000002213 flavones Chemical class 0.000 description 1
- 229930003944 flavones Natural products 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 229910000042 hydrogen bromide Inorganic materials 0.000 description 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 1
- 150000004338 hydroxy anthraquinones Chemical class 0.000 description 1
- 125000006289 hydroxybenzyl group Chemical group 0.000 description 1
- XBUFCZMOAHHGMX-UHFFFAOYSA-N hydroxylamine;phosphoric acid Chemical compound ON.ON.ON.OP(O)(O)=O XBUFCZMOAHHGMX-UHFFFAOYSA-N 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- KFZMGEQAYNKOFK-UHFFFAOYSA-N iso-propanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- QNXIYXGRPXRGOB-UHFFFAOYSA-N oxolane;propan-2-one Chemical compound CC(C)=O.C1CCOC1 QNXIYXGRPXRGOB-UHFFFAOYSA-N 0.000 description 1
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 description 1
- 150000008442 polyphenolic compounds Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propanol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 125000005551 pyridylene group Chemical group 0.000 description 1
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2(1H)-one Chemical class C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 150000004764 thiosulfuric acid derivatives Chemical class 0.000 description 1
- 150000003585 thioureas Chemical class 0.000 description 1
- 229960002447 thiram Drugs 0.000 description 1
Abstract
The present invention relates to stabilized hydroxylamine solutions containing, as a stabilizer, at least one compound of the formula I. R1R2N-A-NR3R4, in which A and R1 to R4 are as defined in the description
Description
STABILIZED HYDROXYLAMINE SOLUTIONS
The present invention relates to stabilized hydroxylamine solutions. Hydroxylamine, especially in the form of its salt with sulfuric acid, is an important intermediate for the chemical industry, and is widely used in chemical synthesis. It is often necessary to use hydroxylamine in the form of a solution of the free base, which is generally freed from a hydroxylammonium salt, such as, for example, hydroxylammonium sulfate or hydroxylammonium chloride, by the action of a suitable base. as ammonia, sodium hydroxide solution or an alcoholat ?. The neutral and alkaline hydroxylamine solutions are unstable and decompose to form ammonia, nitrogen nitrogen oxides and water, so that their transport or storage is highly problematic. The rate of decomposition increases with increasing temperature, raising the pH and raising the concentration of catalytically active impurities. To prevent the decomposition of hydroxylamine, a stabilizer is added to the solutions. Various stabilizers for hydroxylamine are known. The following proposals have been made: thioglycolic acid (JP-A-58069843), glycerol monoethers in hydroxyanthraquinones (DE-A-33 43 600), hydroxyquinolines (DE-A-33 45 734), polyhydroxyhexane-1,4-lactone (DE-A-33 45 733), anthocyanin (DE-A-33 47 260), hydroxyquinodines, flavones, benzonitrile, N-phenyl-N-hydroxythiourea (DE-A-36 01 803), flavan (DE-A- 33 43 599), thiosulfates, mercapto benzothiazoles, mercapto alkanols, mercapto thiazoline, thiuram disulfides, thioureas (EP-A-516 933), the tetrasodium salt of ethylenediamine tetra acetic acid, the trisodic salt of N-hydroxyethylethylenediamine tetra acetic acid, polyvinyl pyrrolidone or poly-N-vinyl-5-ethyl-2-oxazolidinone (US-A-3, 145, 082), amide oximes (US-A-3,480,391), hydroxamic acids (US-3, 480, 391), hydroxyureas (US-3,544,270), dipyridyl compounds (JP-A-58069842), aminoquinolines (JP-A-58069844), phenanthroline (JP-A-58069841), and polyhydroxyphenols (JP-A-4878099). However, none of the stabilizers proposed to date has been able to provide hydroxylamine solutions with sufficient stabilization so that no noticeable decomposition of the hydroxylamine occurs, especially during storage. Therefore, an object of the present invention is to provide a better means for stabilizing hydroxylamine solutions.
We have now found that this objective is achieved, surprisingly, by the use as a stabilizer of at least one compound of formula I: RVN-A-NRV (I) in which A is alkylene, alkenylene, alkynylene, cycloalkylene, cycloalkenylene, arylene, o-, m- or p-xylylene, a saturated or unsaturated 5- or 6-membered heterocycle having a nitrogen atom, the radicals being capable of containing
1, 2 or 3 substituents that are independently selected from alkyl, alkoxy, and hydroxyl, or is -X- [-NR-B -] -:? wherein B and X are CH ^ CH-- or - CH ^ CH ^ CH; -, n is 10-50,000, R is H, alkylene, ethylene or propylene which is substituted by OH, NH_, NHCOR5, or COOH, or is CSSH, CH? CN or CH2P03H_, or is a bridge to a nitrogen atom of another polyethylene imine or polypropylene imine chain, the bridge is formed by -X- [-NR-B-] - or CH ^ CHOH CH; - [ -O CH CH] - CH.CHOH CH; - wherein independently o and p are 1-15, R 5 is H, Cι-Cis alkyl or CHR 5 COR 6 where R 6 is C 2 -C 8 alkyl; R R3, and R4 independent of each other are H CH2COOH, CH2PO3H2, alkyl, acyl, CH2CH2OH, CH2CH2NH2 O wherein R7 is OH, SH; NHt, CN, COOH, alkyl 1 alkoxy, or the salts thereof, with the exceptions of ethylenediaminetetraacetic acid and N-hydroxyethylene diamido tetra acetic acid and salts thereof. The present invention further relates to stabilized hydroxylamine solutions containing hydroxylamine and at least one compound of formula I. The novel solutions comprise hydroxylamine in the form of the free base or a hydroxylamine salt at least partially neutralized; in other words, free hydroxylamine is mixed with the hydroxylamine salt. The stabilizers that are used according to the invention can be used to stabilize all types of hydroxylamine solutions. These can be aqueous solutions or hydroxylamine solutions in an organic solvent such as methanol, ethanol, N-propanol, isopropanol, acetone tetrahydrofuran, etc., or they can be mixtures of water and organic solvents. The stabilizers which are used according to the invention are also soluble in the solvents in which the hydroxylamine is soluble. If appropriate, the solubility can be obtained by choosing the appropriate R1-R4 and A groups. Hydroxylamine solutions are generally obtained by reacting a hydroxylammonium salt, especially hydroxylammonium sulfate, hydroxylammonium chloride and hydroxylammonium phosphate, with a suitable base, such as ammonia, sodium hydroxide, potassium hydroxide or calcium hydroxide. In the case of completing the neutralization of the hydroxylammonium salt, a solution is obtained comprising the free hydroxylamine and the salt derived from the base cation and the acid anion which are present in the hydroxylammonium salt. The salt can be completely or partially separated. The hydroxylammonium salt can also be neutralized only partially with the base. In this case, a solution is obtained comprising not only free hydroxylamine and the aforementioned salt but also unreacted hydroxylammonium salt. All these solutions can be stabilized according to the invention, the nature of the anion in the hydroxylammonium salt being not crucial. In the context of the present invention, the alkyl is a straight or branched chain radical preferably of 1 to 18 carbon atoms, especially of 1 to 6 carbon atoms and, in particular, of 1 to 4 carbon atoms. The same comments apply to the alkyl group in alkoxy. The alkylene is a divalent radical having a straight or branched chain, preferably having from 2 to 6 carbon atoms, especially from 2 to 4 carbon atoms. Alkenylene and alkynylene are branched or straight chain divalent radicals, preferably having 3 to 6 carbon atoms and, in particular, 3 or 4 carbon atoms. The alkylene and cycloalkenylene rings are preferably cyclopentylene or cyclohexylene or, respectively, cyclopentenylene or cyclohexenylene. The arylene is preferably an aromatic hydrocarbon radical of Cr. To Ci or phenylene. The saturated or unsaturated heterocycle is preferably pyrrolidinylene, piperidinylene, pyrrolylene or pyridinylene. The helocycle is attached by carbon atoms to the two nitrogen atoms of the formula I. The acyl is straight or branched chain and preferably has from 1 to 19 carbon atoms. A is preferably alkylene, cycloalkylene, arylene or -X - [- NR-B -] - r and in particular is alkylene cycloalkylene or -X - [- NR-B-] -, in this case the independent radicals R1 to R4 preferably, they are CH2COOH, CH2CH: OH, CH2CH2NH2, and in particular they are CH2COOH or R "preferably in the ortho position and in particular is OH, COOH or a branched alkyl radical (bulky), such as isopropyl, ter -butyl, etc. The stabilizers according to the invention can also be used in the form of salts.The particularly suitable salts are alkali metal salts, such as sodium salts or potassium salts, or ammonium salts, if they are present. present acid functions and acid addition salts with inorganic acids such as HF, HCl, HBr, HrSO ^, H-.PO, etc., if basic functions are present.Another preferred embodiment is a stabilized solution containing as a stabilizer a compound of the formula I in which A is alkylene or cycloalkylene and R a R "independent of each other is CH 2 CH 2 OH or wherein R 7 is as defined above and in particular is OH, SH or NH 4. If A is -X - [- NR-B -] - n, the compounds of the formula I are the polymers polyethylene imine or polypropylene imine, which are generally weakly refolded. The repeating units of the formula can be identical or different. This applies in particular when units that are substituted on the nitrogen atom are present, ie, R is different from hydrogen in at least some of the units. The degree of substitution chosen can be found within a wide range and is generally in the range from 5 to 98%. The slight crosslinking, which is the result of the preparation of the polyethyleneimines and polypropyleneimines, can be increased by polyether bridges between the polymers. The polyether bridge is formed by alkylating some of the nitrogen atoms with epichlorohydrin followed by ethoxylation. In the case of the polyethylene imine or polypropylene imine polymers, the radicals R to R4 are preferably H or alkyl. The average molecular weight of the polymers can be chosen within a wide range, and is generally in the range from 800 to 2,000,000, in particular from 1,000 to 1,500,000 and, in the case of more highly crosslinked polymers, in the range from 50,000 to 2,000,000. According to another preferred embodiment, the stabilized hydroxylamine solution comprises at least one compound of the formula I in which A is -X _ - [- NR-B-] - r ,, B and X are CH2CH: -, R is CH ^ COOH, CH2CH: C00H, CHCH2OH, CH: CH ~ NH_, NHCOR 'or CSSH or is a bridge as defined above, R5 is as defined above and R1 to R4 are H or alkyl. Particularly preferred compounds in this context are: a weakly cross-linked polyethyleneimine with an average molecular weight in the range from 1,000 to 2,000,000; carboxymethylated polyethyleneimines with a degree of substitution from 25 to 98% and an average molecular weight in the range of 1,500 to 1,500,000; carboxylated polyethyleneimines with a degree of substitution of 5 to 50% and an average molecular weight in the range of 1,000 to 1,500,000; partially amidated polyethylene imines (one or two of the radicals R "to R4 are acyl of C? ~ CI?) with a degree of substitution of 5 to 50% and an average molecular weight in the range from 1,000 to 1,500,000; crosslinked polyetherimines polyetherimines with an average molecular weight in the range from 50,000 to 1,500,000; hydrophobically modified polyethyleneimines (R = -CH2CH2NCORr, wherein R5 is CHR'5COR6 and R6 is Ci2 to C3 alkyl, especially hexadecyl) with a degree of substitution of 1; at 7% and an average molecular weight in the range of 1,500 to 1,500,000.These polymers are obtained by reacting the corresponding ethylene (R = CH2CH: NH with the corresponding alkyldytetenes;
hydroxyethyl substituted polyethyleneimines with a degree of substitution from 80 to 100% a and ur average molecular weight in the range of 1 to 2,000,000; polyethylenimine dithiocarba atos (R = CSSH) with a degree of substitution from 30 to 60% and an average molecular weight from 2,000 to 1,000,000, and the sodium salts of these. Some of the above polyethyleneimines are commercially available and are marketed, for example, by BASF AG under the name LUPASOL®. According to another preferred embodiment, the stabilized hydroxylamine solution comprises as a stabilizer a compound of the formula I in which A is cyclohexylene or -CH 2 CH - and R 1 to R 4 are CH.COOH or wherein R-7 is OH, SH, NH_, or COOH Particularly preferably these compounds are: trans-1,2-diaminocyclohexan-N, N, N ', N'-tetraacetic acid and / or N, N'-di (2-) acid hydroxybenzyl) ethylenediamine-N, N'-diacetic and the salts thereof The compounds of the formula I are known and commercially available or can be prepared by analogy with the known methods. the compounds of formula I in an amount which is sufficient for stabilization, preferably containing from 0.001 to 20% by weight (from 10 to 2000,000 ppm), in particular from 0.001 to 10% by weight, particularly preferably from 0.01 to 5% by weight, very particularly preferably from 0.02 to 2% and n weight, of a compound of formula I, based on the hydroxylamine content. The concentration of hydroxylamine is, in general, 1-100% by weight, in particular 1-70% by weight, based on the total weight of the solution. The stabilizer can be added before or after the neutralization of the hydroxylamine salt, but preferably before neutralization. The compounds of the formula I are effective over a wide temperature range. For example, they stabilize hydroxylamine solutions from -20 ° C to 130 ° C, preferably at -10 ° C-100 ° C. However, these are also suitable as stabilizers at noticeably higher temperatures, under the pressures that are necessary to liquefy the solution. The following examples illustrate the invention without limiting it. The determination of the hydroxylamine concentrations that are carried out in the examples is done by redox titration.
Empies: 20 ml of an aqueous solution of hydroxylamine at 50% concentration were charged to a 50 ml round-bottom glass flask and 500 ppm (m / m) of the stabilizer of formula I, based on the mass of hydroxylamine, were added in each case. The flask was kept at room temperature or heated with an oil bath at 100 ° C and maintained at this temperature. The hydroxylamine contents of the solutions stabilized at ambient temperature and at 100 ° C were determined by redox titration after the defined periods. For this purpose, the defined amounts of the sample were removed from the solutions, boiled for 5 minutes with excess ammoniacal iron (III) salt solution in sulfuric acid and the iron (II) salt formed was titrated with Serious salt (IV), the end point was determined by potentiometer. Table 1 shows the results at room temperature while in Table 2 they are at 100 ° C. To demonstrate the outstanding stabilizing action of the compounds of the formula I in the hydroxylamine solutions, measurements with unstabilized hydroxylamine solutions and with hydroxylamine solutions stabilized using ethylene diamine tetra acetic acid (EDTA) are shown for comparison.
Table 1 room temperature
Compound Time [d] Hydroxylamine content [%] Polyethyleneimine (not 27 48.1 substituted, branched, MW ~ 800) Polyethylenimine 30 47.7
(carboxylated, branched PM-1000) Polyethylenimine (carboxy 30 48.4 ethylated, branched MW ~ 1 million) N, N'-di (2- 29 45.4 hydroxybenzyl) ethylenediamine-N, N'-diacetic acid Trans-1, 2- acid diamino 31 48.6 cyclohexan-N, N, N ', N' -tetraacetic acid Not stabilized 31 38.0
EDTA 30 17
MW = Molecular weight Table 2 100 ° C
Compound Time [h] Hydroxylamine content [%]
Polyethylenimine (not 6 47.8 substituted, branched, PM-800) Polyethylenimine (amidated, 47.0 branched MW ~ 4000) Polyethylenimine (carboxyl 49.5 ethylated, branched PM-1000) Polyethylenimine 48.5 (carboxylated, branched, (MW ~ 1 million) Transidic acid 1, 2-diamino 49.9 cyclohexan-N, N, N ', N'-tetraacetic acid Not stabilized 6 EDTA 6 20
It is evident that the concentration of hydroxylamine in the non-stabilized samples fell sharply. The concentration of the samples to which the known EDTA stabilizer had been added actually dropped even more than the non-stabilized samples. On the contrary, the concentration of the stabilized samples according to the invention only decreased slightly.
Claims (9)
1. A stabilized hydroxylamine solution comprising, as a stabilizer, at least one compound of the formula I RXR2N-A-NR3R4 (I) in which A is alkylene, alkenylene, alkynylene, cycloalkylene, cycloalkenylene, arylene, or-, m- or p-xylylene, a saturated or unsaturated 5- or 6-membered heterocycle having a nitrogen atom, the radicals being capable of containing 1, 2 or 3 substituents which are independently selected from alkyl, alkoxy, and hydroxyl, or is -X- [- NR-B-] -., in which B and X are CH2CH: - or - CH2CHCH -, n is 10-50,000, R is H, alkylene, ethylene or propylene which is substituted by OH , NH, CHCOR5, or COOH, or is CSSH, CH CN or CHP? 3H-, or is a bridge to a nitrogen-nitrogen atom of another polyethylene imine or polypropylene imine chain, the bridge is formed by -X- [-NR -B-] -. or CH 2 CHOH CH 2 - [- O CH 2 CH 2 -] - P CH 2 CHOH CH 2 - wherein o and p independently are 1-15, R 5 is H, C 1 or C 0 alkyl or CHR 6 COR 6 where R 6 is C 2 C alkyl ? 8 R ^ R ^ R3, and R4 independent of each other are H CH2COOH, CH2P03H2, alkyl, acyl, CH2CH2OH, CH: CH2NH or wherein R7 is OH, SH; NH :, CN, COOH, alkyl 1 alkoxy, or the salts thereof, with the exceptions of the acid ethylene diamine tetra acetic and the N-hydroxyethylene diamino tetra acetic acid and the salts thereof.
2. The stabilized hydroxylamine solution according to claim 1, wherein the stabilizer is at least one compound of the formula I or a salt thereof in which A is alkylene, alkenylene, cycloalkylene, arylene, or -X- [-NR-B -] -, B and X are -CH; -CH2- and n, R, and R * to R1 are as defined in claim 1.
3. The stabilized hydroxylamine solution according to claim 2 , wherein the stabilizer is at least one compound of the formula I or a salt thereof in which A is alkylene, cycloalkylene or -X - [- NR-E -] - r and B, X, n and R: a R "are as defined in claim 2.
4. The stabilized hydroxylamine solution according to claim 1, wherein the stabilizer is at least one compound of the formula I or a salt thereof in which A is alkylene, cycloalkylene and R 1 to R 4 independent of each other are CH 2 COOH, CHP03H2 or wherein R7 is as defined in claim 1.
5. The stabilized hydroxylamine solution according to claim 4, wherein the stabilizer is at least one compound of the formula I or a salt thereof in which A is cyclohexylene or -CHCH2- and R1 to R independent of each other are CH2COOH or wherein R1 is OH, SH, NH2, or COOH
6. The stabilized hydroxylamine solution according to claim 5, wherein the stabilizer is acidic trans-1, 2-diaminocyclohexan-N, N, N ', N' -tetraacetic acid and / or N, N '-di (2-hydroxybenzyl) ethylenediamine-N, N'-diacetic acid. The stabilized hydroxylamine solution according to claim 1, wherein the stabilizer is at least one compound of the formula I or a salt thereof, wherein A is -X - [- NR-B -] - r;, B and X are -CH2CH: -, n is from 10 to 50,000, R is CH2COOH, CH2CH2COOH, CH2CH2OH, CH2CH2NH2, NHCOR5 or CSSH or is a bridge as defined in claim 1 to a nitrogen atom of another polyethylene imine or polypropylene imine chain, R5 is as defined in claim 1, and R1 to R4 independent of each other are H, alkyl or acyl of Ci to C19 8. A stabilized hydroxylamine solution according to any of the preceding claims, containing 0.001-20% by weight, in particular 0.001-10% by weight preferably 0.01 to 5% by weight, particularly preferably 0.02-2% by weight of the stabilizer based on hydroxylamine. 9. The use of at least one compound as defined in any of claims 1 to 7 for stabilizing hydroxylamine solutions.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19547759A DE19547759A1 (en) | 1995-12-20 | 1995-12-20 | Stabilized hydroxylamine solutions |
DE19547759.6 | 1995-12-20 | ||
US08/684,910 US5783161A (en) | 1995-12-20 | 1996-07-25 | Stabilized hyroxylamine solutions |
Publications (2)
Publication Number | Publication Date |
---|---|
MX9804789A MX9804789A (en) | 1998-10-31 |
MXPA98004789A true MXPA98004789A (en) | 1999-01-11 |
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