MXPA97006453A - Compositions containing useful benzoyl peroxide in the topical treatment of scaled tissue and reaction to tissue trauma relationship - Google Patents

Abstract

The present invention relates to topical application to scar tissue regions of a composition comprising various ingredients commonly used in cosmetic products, such as benzoyl peroxide, leading to a reduction and a softening of the scar tissue

Description

METHOD FOR TOPICAL TREATMENT OF CICATRIZED AND REACTION TO THE TRAUMA OF THE RELATED TISSUE BACKGROUND OF THE INVENTION The present invention relates to a method for softening and reducing cutaneous and subcutaneous scar tissue. More specifically, the present invention relates to a method of treating scar tissue by the topical application of a specific composition directly to the areas of the body where healing has occurred, for example, as a result of the trauma accompanying the surgery. Plastic surgery advances have diminished the problem of scarring, both in the layers of the skin (cutaneously) and in the region under the skin (subcutaneously) due to the trauma associated with injury or surgical intervention. However, there is therefore little that can be done to normalize the appearance of specific scar tissue after enough time has elapsed to have stopped the significant natural reduction of scar mass. It has been discovered in Schweiger, U.S. Patent. 4,694,021 ("the '021 patent"), that a composition having a consistency that allows it to form a cake in the region where the healing occurred, advantageously led to a softening and reduction of the scar tissue. In the '021 patent, the preferable composition contained enough water, inter alia, to achieve the desired "cake" consistency, i.e., until the cake has dried and hardened in the composition. In fact, the commercially preferred product of the '021 patent was MUDD®, therefore, the composition preferably had the texture of a compress or face mask. That method for treating scar tissue by the topical application of this specific compound, therefore has been proven to be somewhat impractical and not popular in view of the inconvenience to apply the therapeutic preparation in the form of a voluminous facial mask. Therefore, there is a need to develop a method for treating scar tissue that is (1) easy and convenient to use and (2) produces superiorly effective results. SUMMARY OF THE INVENTION Therefore, it is an object of the present invention to provide a therapeutic method for treating scar tissue which is effective in normalizing the appearance of said tissue, even after the process of natural reduction of healed mass has ceased. It is also an object of the present invention to provide a simple, non-invasive and relatively inexpensive method for smoothing and reducing both cutaneous and subcutaneous scar tissue. It is a further object of the present invention to provide a compound with a practical and comfortable consistency to be used in a method in order to soften and reduce both scar tissue and both subcutaneous and cutaneous tissue.

To achieve the above objectives, a method for treating scar tissue comprising the step of applying topically to a region of the body where cutaneous or subcutaneous scarring has been presented, has been provided in accordance with one aspect of the present invention. Therapeutically effective amount of a composition comprising benzoyl peroxide, an argillaceous absorbent and at least one ester of hydroxybenzoic acid In a preferred embodiment, the composition mentioned above is applied to the region of the body where the healing occurred, in a sufficient amount such as a light to moderate bed of the composition that covers substantially the entire region of the body affected by the scar. Additionally, in a preferred embodiment, the aforementioned composition is applied to the region of the body where healing has occurred by the repeated application of light to moderate applications of a compos tion having an active ingredient of benzoyl peroxide lotion (hereinafter sometimes referred to as the "preferred composition") The preferred composition is applied in this form, leaving from half a minute to a minute for the medicine to be fixed before gently applying the next portion of the composition on the previous layer Each of said applications of the preferred composition overlaps with the region of the body affected by the underlying scar for maximizing effectiveness With respect to subcutaneous healing at the tip of the nose, the preferred composition is similarly applied in a series of layers on the mucosal membrane on the upper portion of each nostril. Other objects, aspects and advantages of the present invention will be apparent from the following detailed description. However, it should be understood that the detailed description and specific examples, while indicating preferred embodiments of the invention, are given by way of illustration only, since various changes and modifications within the spirit and scope of the invention will be apparent to the experts in the art. technique of this detailed description. DETAILED DESCRIPTION OF THE PREFERRED MODALITIES It has been found that a substance having a known use in cosmetic products, but not a well-defined therapeutic effect for treating scar masses, can be used via topical application to effect a reduction and softening of scar tissue , even years after the trauma that caused the healing. Although the physiological basis for this therapeutic effect is not clear, it is thought that the topical application of the substance described above induces (or increases) the natural mechanisms for decalcification and rupture of fibrous material in the masses of scar tissue. Such activity could be in accordance with the observation, described in greater detail below, that topical applications of a composition according to the present invention leads to a reduction of cutaneous and subcutaneous scar tissue and overgrowth of calcified bone after rhinoplasty surgery. A composition useful for treating scar tissue according to the present invention preferably comprises an argillaceous material, such as an aluminum silicate solid, which can act as both an absorbent and a base for the composition. Specifically, an aluminum silicate preferably used as an absorbent and a base for the composition is aluminum magnesium silicate. The composition described above also comprises benzoyl peroxide. Benzoyl peroxide has been used as a bleaching agent for flours, fats, oils and waxes, as well as a drying agent for unsaturated oils. According to Hawley, THE CONDENSED CHEMICAL DICTIONARY 120 (Van Nostrand Co. 1981), benzoyl peroxide has application as "a drying agent for unsaturated oils for pharmaceutical and cosmetic purposes". However, it is not known that any role that affects scar tissue that has been ascribed to topical applications of benzoyl peroxide. A third constituent of a composition employed in the present invention is an ester of p-hydroxybenzoic acid, such as methyl p-hydroxybenzoate ("methyl paraben") propyl p-hydroxybenzoate ("propylparaben"). Such esters are widely used in cold creams, eyeliners and liquid make-up products as preservatives, antimicrobial agents, but there is no known therapeutic activity that has been attributed to them. In the present invention, it is preferable that methyl p-hydroxybenzoate as propyl, they are present in the topically applied composition. A composition used in accordance with the present invention should also contain normal ingredients found in skin cleansers, such as emulsifiers, surfactants, stabilizers, solvents, etc., including, but not limited to. glyceryl ester, isopropyl palmitate, polyethylene glycol stearate (PEG-20), propylene glycol, stearic acid, water, xanthan gum and zinc stearate In any case, it is preferred that the primary benzoyl peroxide-containing composition be substantially applied to the entire region of the scar tissue, preferably in an amount sufficient to form an effective layer "Substantially" in this context denotes that the therapy of the present invention does not require, for effectiveness, a full coverage of the scarred region. However, it is preferred that the area of the body affected by scarring be completely covered with a slight overlap and decreasing the layer in the surrounding regions that are or are thus affected It is also preferable that the composition used to soften and reduce the cutaneous and subcutaneous scar tissue have a light to moderate consistency in weight and texture, thus providing an effective yet comfortable vehicle for topically delivering a pharmaceutically effective amount of the preferred composition. For this purpose, a composition that is particularly preferred to be used for the purpose of treating scar tissue in accordance with the present invention includes 10% BENZOYL PEROXIDE LOTION (manufactured by KMart Corporation, Troy Michigan), an acne medication that it has a formulation comprising 10% benzoyl peroxide, glyceryl monostearate, isopropyl palmitate, aluminum magnesium silicate, methylparaben, propylparaben, PEG-20 stearate, propylene glycol, stearic acid, water, xanthan gum and stearate of zinc, which falls within the preceding description. The periodic topical applications of the 10% BENZOYL PEROXIDE LOTION, to a region of the nose that has been healed, both cutaneously and subcutaneously, by major rhinoplasty surgery or in some way associated with a reduction in the mass of scar tissue, a concomitant softening of remaining scar tissue and a recession in tracing overgrowth which has caused an apparent thickness of the nasal bone. The present invention was made when a LOTION OF % BENZOYL PEROXIDE, marketed to help cure acne, was applied in order to alleviate bacterial infection in the right nasal window. The scar tissue from a surgical rhinoplasty procedure many years before was located at the nasal tip at the time of this treatment for bacterial infection. After four days of treatment of infection with 10% BENZOYL PEROXIDE LOTION, not only did it alleviate the discomfort of the infection, as expected, but it also reduced the scar tissue and also presented a more normal appearance of the nasal tip. , the result of which was very unexpected. The continuous application of 10% BENZOYL PEROXIDE LOTION resulted in the continuous reduction of scar tissue in the following months. Additionally, the scar tissue softened as it was reduced in size. These effects of the therapy, after the present invention, were particularly unexpected since the surgery that caused the healing that was treated, was performed approximately from seventeen to eighteen years before, that is, the treatment was effective after it ceased well from the treatment. significant postoperative normalization of damaged tissue. The maximum benefit of the present invention was realized about one to one hour and one quarter of the time that the 10% BENZOYL PEROXIDE LOTION was applied. It is thought that the maximum benefit occurs while the lotion is wet, thus corresponding to the time frame mentioned above for the application of the preferred composition. The formation of layers of the composition helps to ensure that the lotion will not dry very quickly and therefore shortens the benefit period. After the treatment, the dry residue was washed with water. A light application of hydrocortisone cream and / or nonprescription moisturizer can be used to help avoid or mitigate red coloring and scale formation. A multiplier effect can be shown when two to three topical treatments of the BENZOYL PEROXIDE LOTION The 10% are carried out in close proximity to one another, generally one to fifteen minutes apart. The results of said effect may offer increased scarring and / or accelerated scarring on the results caused by the same number of treatments spaced by a day. Another improvement technique, which may lengthen and / or reinforce the therapeutic effect of the preferred composition of In accordance with the present invention, a moderate to severe application of the 10% BENZOYL PEROXIDE LOTION is added from twenty-five to thirty-five minutes after the application of the original layers and while the first application is still wet. In any case, if two or more treatments are performed with several minutes of separation in order to help achieve accelerated, augmented, elongated or reinforced results, it is preferable that the applications of the preferred composition, particularly the latter, be preceded with a light application of hydrocortisone cream without prescription and / or a light application of moisturizing lotion. Additionally, the last layer treatment should preferably be followed by the application of the hydrocortisone cream and possibly a moisturizing lotion (as opposed to a moisturizing cream, since in one example the cream tended to promote bacterial inflammation), in order to avoid irritation to the area being treated In view of the present invention, it is thought that benzoyl peroxide is an agent that generally helps the body repair itself of excess tissue formations and fluids caused by the tissue damaged Such damage could be presented from the outside of the trauma, that is, the burned tissue, or also from events that occur naturally such as arthritis. Consequently, it is ensured that large quantities of BENZOYL PEROXIDE LOTION AT 10% could reduce the time of cure and the degree of "permanence" of the damage and can help disqualification and reduce arthritic malformations in the hand Additional, it is understood that an appropriately acceptable solution of benzoyl peroxide could be injected into a smovin 'tissue of the joint in order to help alleviate arthritic problems In this vein, a permissible solution of benzoyl peroxide could be effective for related surgical uses. However, according to the dermatological consultation, approximately 2% of the population is allergic to 10% benzoyl peroxide Therefore, it is conceivable that a person with the need to use said composition to soften and reduce scar tissue cutaneous or subcutaneous , could develop an immediate allergic reaction or after the continuous application of said composition The consequences could result in a simple urticaria or swelling (normal) and / or moderate asthma (the dermatological consultation indicates that this type of reaction is unusual) Additionally, in this regard, the literature of the PEROXIDE LOTION OF B 10% ENZOYL, marketed by KMart Corporation, set under "WARNINGS", For external use only. The use of other topical acne medications at the same time or immediately after using this product may increase skin dryness or irritation. If you have very sensitive skin or if you are sensitive to benzoyl peroxide, this product may cause irritation, characterized by redness, burning, itching, detachment, a medication should be used unless directed by a doctor. Skin, or possibly swelling Moderate irritation may be reduced by using the product less frequently or in a lower concentration If irritation becomes very severe, discontinue use, if irritation persists, consult a doctor. Keep away from eyes, lips and mouth In case of accidental ingestion, get professional help or contact immediately to a Poison Control Center Avoid contact with hair, fabrics or carpets since benzoyl peroxide will cause bleaching It is possible, with those with traditionally sensitive skin, that the application of the BENZOYL PEROXIDE LOTION AT 10% is routinely preceded with a 1% hydrocortisone cream application without prescription and after treating with the same cream to mitigate reddish coloration and dryness. With or without 1% hydrocortisone cream, softening and reduction of scar tissue would occur. The above invention has been described with reference to the particularly preferred embodiments. Those skilled in the art recognize that various modifications can be made to the invention without departing from the spirit and scope thereof.

Claims (1)

1. CLAIMS 1 The use of a therapeutically effective amount of a composition comprising, in combination (a) benzoyl peroxide as an active ingredient, and (b) an argillaceous absorbent and at least one p-hydroxybenzoic acid ester, in the preparation of an agent for use in a method for treating scar tissue, wherein said composition is applied topically to a body region where subcutaneous scarring or overgrowth of calcified bone occurred. The use according to claim 1, wherein said absorbent consists essentially of an aluminum silicate 3 The use according to claim 2, wherein said aluminum silicate absorbent consists essentially of magnesium aluminum silicate 4 The use according to claim 2 wherein said ester of p-acid hydroxybenzoic acid is, at least, the ester selected from the group consisting of methyl p-hydroxybenzoate and p-hydroxybenzoate Propyl 5 The use according to claim 1 wherein said composition further comprises one or more cleaning helpers selected from a group consisting of emulsifiers, surfactants, stabilizers and solvents. The use according to claim 1 wherein said amount of said The composition applied to such region of the body is sufficient to form a layer of said composition that substantially covers the aforementioned region. The use according to claim 6, wherein a layer of such a therapeutically effective amount of a composition is applied in a light to moderate thickness. The use according to claim 7, further comprising, prior to said topical application of such a layer of the aforementioned composition, the step of applying to said region of the body an amount of a second composition that is sufficient to form a layer of said second composition covering substantially all of said region, said second composition consisting essentially of a hypoallergenic cream. The use according to claim 7, further comprising, following said topical application of such a layer of the aforementioned composition, the step of applying to said region of the body an amount of a second composition that is sufficient to form a layer of such a composition. second composition substantially covering all said region, said second composition consisting essentially of said hypoallergenic cream. The use according to claim 8, wherein said second composition consists essentially of 1% hydrocortisone cream and / or a moisturizing lotion. 11. The use according to claim 9, wherein said second composition consists essentially of 1% hydrocortisone cream and / or a moisturizing lotion. 12. The use according to claim 1, wherein the natural reduction of healed mass in such region of the body has been stopped prior to the application of said composition. The use according to claim 1, wherein said composition comprises benzoyl peroxide, an argillaceous absorbent, at least one p-hydroxybenzoic acid ester and one or more skin cleansing aids selected from a group consisting of emulsifiers, surfactants, stabilizers and solvents.