MXPA06004586A - Insecticide formulation - Google Patents

Abstract

The present invention provides a new insecticide formulation based on cyclodextrin characterised in that the active substance (insecticide and/or insect growth regulator), and a compound synergistic with the active substance, are complexed simultaneously with cyclodextrin. The formulation presents as a solid or as a solid/oil composition, and is soluble or completely emulsifiable in water or in aqueous mixtures of water miscible solvents. The activity of the present formulations was found to be greater than that of a mixture of the two active components each complexed separately with cyclodextrin, for the same dose. The preparation process of said formulation and its use as an insecticide in agriculture, for veterinary use or to eliminate household insects, are further aspects of the present invention.

Description

FORMULATION OF AN INSECTICIDAL SYNERGISTIC COMPOSITION AS A COMPLEX OF CICLODEXTRIN FIELD OF THE INVENTION The present invention is related to the field of insecticide compositions, in particular, to those in which the insecticidal agent is mixed with substances inhibiting the mechanisms of elimination of the toxicity of insects. New compositions are described in which the effect of the insecticide and the synergistic substance is further improved by simultaneous complexing with cyclodextrin.

HISTORY OF THE TECHNIQUE The problem of tolerance and resistance to the activity of pesticides is particularly serious, which leads to the increasingly difficult control and eradication of harmful insects in agriculture, veterinary and domestic hygiene applications. Many insects have reinforced their natural defenses and their immune and enzymatic systems against toxins with which they have contact so that, in order to destroy them, it is necessary to increase the dose or continuously use insecticides or inhibitors of new insect growth, with the resulting risk and greater damage to the entire ecosystem and the food chain to man, and consequent growing costs. The use of substances such as piperonillo butoxide and its analogues that are capable, in synergistic combination with insecticides, of inhibiting the activity of certain metabolic enzymes of insects that are involved in the processes of elimination of toxicity and resistance to pesticides, as well as able to increase in vitro efficacy, it is known in the literature [see for example, Gunning, et al, "Piperonyl Butoxide", pp. 215-225, Academic Press (1998)], having already suggested its use in vivo. In order to better demonstrate the synergistic activities particularly in cases where the insect is more resistant, treatment with the synergistic product was proposed at intervals before the insecticide or a repeated treatment with insecticide; The pre-treatment with synergistic compounds is especially beneficial because the subsequent exposure to the insecticide is carried out in an already sensitized insect, thus being more effective. Separate administrations are not so practical and are economically unfavorable when compared to unique applications of the two components. Also disclosed in the literature and patents are formulations of insect growth regulating insecticides in cyclodextrins (CD) [see, for example, L. Szente, et al, "Cyclodextrins in Pesticides" in "Comprehensive Suprmolecular Chemistry", p. 503-514, Elsevier (1996), USA 3,846,551]. There are many main reasons for using such inclusion complexes: modification of the physicochemical properties of pesticides, improved stability, improved wettability and bioavailability of pesticides with poor solubility and poor absorption, for example. The cyclodextrins a, ß, and? they are natural or semi-synthetic cyclic oligosaccharides, generally non-toxic and biodegradable; ß-CD and some of its derivatives, such as hydroxypropyl (HP-ß-CD) and sulfobutyl ether (SBE- ß-CD) are particularly preferred for applications.

U.S. Pat. 3,846,551 states that the activity of insecticides complexed with CD is better than that of non-complexed insecticides. However, formulations that simultaneously contain a synergistic compound have never been described. PBO has also been prepared as a complex with CD (US 4,524,068), which has proven to be more effective as an insecticide synergist than non-complexed PBO; again in this case, however, the tests were carried out in mixtures of non-complexed insecticides and PBO / CD and not in a single formulation. The present invention proposes to overcome the disadvantages of the known art and to significantly improve the performance of commercially known insect growth regulators or insecticides; Another aspect of the invention is to obtain a process for the preparation of said formula that is economically industrial, with low or no toxicity for the user.

BRIEF DESCRIPTION OF THE INVENTION The present invention is related to a new formulation characterized by the simultaneous presence, as a complex together with cyclodextrin, of (i) an active principle that is a compound with insecticidal activity and / or a compound with growth regulating activity for insects and (ii) a compound capable of synergistically improving the activity of the active principle. The invention also relates to a preparation of said formulation and its use in agriculture, in veterinary practices and for the elimination of insects in the home. The formulation is obtained by holding both the insecticide and the synergistic composition together for CD complexation. The aforementioned formulation is also effective in cases where an insect is tolerant and resistant to the activity of insecticides or growth regulation with the same active substance, leading to an insecticide and for the same dose, to an insect mortality substantially greater than that demonstrated with the same active compounds used in mixtures alone or complexed separately with cyclodextrin.

DETAILED DESCRIPTION OF THE INVENTION For the purposes of the present invention, any cyclodextrin can be used. For example, the cyclodextrin can be a cyclodextrin a, β, or? as it is or, if appropriate, derivatized in order to increase the hydrophilic or hydrophobic nature thereof. Particularly preferred are β-Cd, β-CD and HP-β-CD, with β-Cd being the most preferred due to its lower cost. The insecticides that can be used in the present invention preferably contain within their structure at least one carbocycle or aromatic heterocycle. Particularly preferred are those with a pyrethroid structure, such as Alletrin, Bioallethrin, Tetramethrin, Parallethrin, Cypermethrin (α-Cypermethrin, β-cypermethrin, β-Cypermethrin), Esbiothrin, Permethrin, Fenpropathrin, Transfluthrin, Bifenthrin, Resmethrin, Bioremetrin, Fenvalereate, Esfenvalerate , Tetramethrin, Imiprotrin, Phenothrin, β-Ciflutrin, Deltamethrin, Cihalotrine, Etofenprox, Silafluofen, etc., and their enatiomeric and / or diastereomeric mixtures. Cypermeatarin, fenvalerate, deltamethrin and β-cyfluthrin and their enatiomeric and / or diastereomeric mixtures are most preferred. The amount of insecticide in relation to the cyclodextrin is preferably between 5% and 40% (w / w) and more preferably between 10% and 25%. Suitable growth regulators for insects include, for example, Brevioxim, Buprofezin, Ketoconazole, Teflubenzuron. The amount of growth regulator in relation to the cyclodextrin, Brevioxima, Buprofezina, Ketoconazole, Teflubenzuron, Brevioxima, Buprofezina, Ketoconazole, Teflubenzuron is preferably between 0.01% and 5% (w / w) and still more preferred between 0.5 % and 3%. The components capable of synergistically increasing the activity of the active principle (hereinafter referred to as "synergistic compounds") are known per se and are already in use. Such products are inhibitors of enzymes for eliminating insect toxicity, for example, stereoses or oxidases. Preferred examples of synergistic compounds are piperonylbutoxide and sesamol. Piperonylbutoxide is particularly preferred. The synergistic compounds can be used as they are or already pre-formulated with additives; an example of a commercially available pre-formulation is known as PB80EC-NF; It contains 88% PBO and 12% emulsifier (dodecylbenzene sulfate, also known as SOITEM). The amount of synergistic compound relative to cyclodextrin is preferably between 10% and 100% (weight / weight) and of still greater preference between 25% and 95%; these percentages refer to the amount of pure synergistic compound, therefore, exclude additives that may be present in the pre-formulation.

The amount of insecticide relative to the synergistic compound is preferably between 5% and 50% (w / w) and still more preferred between 10% and 30%. They can also be present in the aforementioned formulation emulsifiers, UV stabilizers, antioxidants and other additives that are not specific to the insecticidal activity. The amounts of said additives relative to the cyclodextrin are preferably between 0 and 30% (w / w) and of still greater preference between 5% and 15%. These percentages refer to all present additives, including those already present in the pre-formulations of the active principle used. The emulsifiers which can be used are, for example, those already mentioned, dodecylbenzene sulfate, lignosulfonates, phospholipids and polyethylene glycols. UV stabilizers which can be used are for example 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-octoxy-benzophenone and sebacate of 4-hydroxy-2,2,6,6-tetramethylpiperdine. Antioxidants that can be used are for example 2,6-diterbutyl-l-hiroxy-toluene. The composition of the invention is preferably formulated as a solid or as a solid / oil composition; said formulations may be used as they come, or previously dissolved / emulsified in water or in aqueous solutions of water miscible solvents, such as alcohol Cl-4; said aqueous solutions contain between 1% and 99% by weight, preferably between 5% and 60% by weight, of the solvent miscible with water.

The process of preparing the above-mentioned formulations is characterized by a simultaneous cyclodextrin complexing of the synergistic compound and the insecticide and / or the growth regulator. More specifically, the process consists of the following steps: a) the preparation of a solution or suspension of the synergistic and insecticidal compound and / or the growth regulator in an appropriate solvent; the solvent is preferably alcohol, for example ethanol or 2-propanol. b) the preparation of a cyclodextrin solution in water or in mixtures of water / water miscible organic solvent; the dissolution of the CD can be conveniently facilitated by heating (for example by keeping it at 70 ° C-90 ° C for 30-90 minutes). c) Add the solution / suspension obtained in (a) to the solution obtained in (b); preferably the solution / suspension (a) is added slowly, for example, to 2-10 hours (more preferably 4-8 hours); at a temperature of 20 ° C-90 ° C, (most preferably 30 ° C-70 ° C). After adding the active components, the complex reaction is finally carried out within a period generally between 12 and 36 hours (preferably 18-24 hours), keeping the mixture under stirring, at a temperature between 20 ° C and 90 ° C. ° C (preferably 30 ° C-70 ° C). The final CD complex, which includes both the synergistic compound and the insecticide and / or growth regulator, is recovered from the reaction mixture by means of known methods, such as filtration, drying or lyophilization.

Another aspect of the invention is the use of the aforementioned formulations as insecticides in agriculture, for veterinary use or for the elimination of household insects. The joint complexation of the insecticide and / or the growth regulator and the synergistic compound with cyclodextrin has surprisingly resulted in a significant increase in the efficacy of the compound compared to a mixture of the two complex components individually. By means of the invention an improvement in the interaction between the insecticide and the synergistic compound is achieved; in comparative tests carried out by the inventors, this improvement has always been above 50%; the effect is then of substantial proportions. The improvement in activity leads to several industrially significant advantages: For example, by using equal amounts of the active substance, synergistic compositions of higher activity can be achieved; or insecticide compositions can be obtained with an efficacy equal to known compositions but with the use of fewer active substances; the use of fewer active substances results in a lower production cost, reduced environmental impact of the production process, as well as a lower volume / weight of the final composition, of practical advantage for the crop fumigator. Therefore, highly effective insecticide formulations, at lower cost than known formulations, were obtained in a surprising manner with the current invention.

EXPERIMENTAL SECTION Example 1 The procedure for the preparation of the formulation and stability measures. ßCD (2g) is introduced in distilled water (20 ml) at 80 ° C in a double neck flask, equipped with a cooler and nitrogen outlet. The solution is left for 1 hour at 80 ° C with stirring. After this period, a solution of 96% ethanol (25 ml) containing the synergistic composition and the insecticide and / or growth regulator in the required proportions is added in portions over a period of 6 hours at 65 ° C. . The mixture is left at 70 ° C with stirring for a further 21 hours, then the mixture is left at room temperature to cool with stirring and finally allowed to drip for 4 hours. The solid is filtered and the solution is dried in vacuo. By means of the aforementioned procedure, the following products were prepared: inclusion complex of ßCD-fenvalerate and PBO (*) (a soluble solid of white water) inclusion complexes of ßCD-cypermethrin and PBO (*) (a water soluble solid) white). (*): the PBO was used starting from the commercial composition known as PB80EC-NF, which contains 88% PBO and 12% SOITEM. The inclusion complexes were stable in the solid phase for at least 30 days at 23 ° C.

EXAMPLE 2 Preparation of a fenvalerate-based formulation Operate as in Example 1, a formulation was prepared starting from 1.9 g ßCD, 0.35 g fenvalerate and 1.6 g PB80EC-NF.

Example 3 Preparation of a formulation based on cypermethrin To operate as in example 1, a formulation was prepared starting from 1.9 g ßCD, 0.35 g acipermethrin and 1.6 g PB80EC-NF.

Example 4 Mortality test In the mortality test, carried out as reported in the literature [Gurining R.V. et al., J. Econ. Entomol 77, 1283-1287 (1984)], a cotton aphid specimen was used to show a resistance to cipeirnetrin at least 7,000 times greater than the lethal dose (LD50). Complete mortality of the insect was obtained using the formulation prepared according to Example 3 at a concentration of active ingredient lower than LD50, while with traditional formulations containing the same dose of cypermethrin or with mixtures of cypermethrin and PBO encapsulated separately and at equal doses , mortality was always < 50% or nothing.

Example 5 Preparation of a formulation based on cypermethrin ßCD (50 g) in distilled water (630 ml) was introduced at 75 ° C in a double neck flask fitted with a cooler and nitrogen outlet. The solution was maintained with stirring at 75 ° C for 1 hour. Then a solution of 2-propanol (790 ml) containing PBO / SOITEM (98/2, 13.4 g) and acipermethrin (5.4 g) was added in portions at the temperature of 70-75 ° C for 6 hours. The mixture was kept under stirring at 75 ° C for another 18 hours, then the mixture was allowed to cool to room temperature for 90 minutes and was finally left undisturbed for 3 hours. The solution was dried under vacuum obtaining, as dry residue, a formulation based on cypermethrin. In said dry residue, which contains 8.6% water and 2% 2-propanol, the PBO / cypermethrin ratio consisted of between 2.7 and 3 [as GC-FID and 1H NMR (DMSO-d6), respectively] while the amount (weight / weight) of ßCD was around 72% [1 H NMR (DMSO-d6)].

Example 6 Preparation of a bifenthrin-based formulation ßCD (2 g) was introduced into distilled water (20 ml) at 75 ° C in a double neck flask fitted with a cooler and nitrogen outlet. The solution was maintained with stirring at 75 ° C for 1 hour. Then a solution of 2-propanol (25 ml) containing PBO / SOITEM (98/2, 0.52 g) and bifenthrin (0.22 g) was added in portions at the temperature of 75 ° C for 6 hours. The mixture was kept under stirring at 75 ° C for another 18 hours, then the mixture was allowed to cool to room temperature for 2 hours and was finally left undisturbed for 3 hours. The solution was dried in vacuo to obtain, as a dry residue, a formulation based on bifenthrin.

Example 7 Preparation of a formulation based on cyfluthrin The formulation was prepared according to example 6, starting from 2 g ßCD, 0.53g PBO / SOITEM (98/2) and 0.22g ßciflutrin.

Example 8 Preparation of a formulation based on cyhalothrin The formulation was prepared according to example 6, starting from 5 g ßCD, 1.33g PBO / SOITEM (98/2) and 0.58g? Cihalorrin.

Example 9 Preparation of a formulation based on deltamethrin The formulation was prepared according to example 6, starting from 5 g ßCD, 1.33g PBO / SOITEM (98/2) and 0.65g deltamethrin.

Example 10 Preparation of an enfenvalerate-based formulation The formulation was prepared according to Example 6, starting from 5 g ßCD, 1.33g PBO / SOITEM (98/2) and 0.54g fenvalerate. In the dry residue thus obtained, the proportion of PGO / fenvalerate was around 4.2 [as in 1H NMR analysis (DMSO-d6)], while the ßCD (weight / weight) content was around 76% [1H NMR ( DMSO-d6)].

Example 11 Preparation of a formulation based on cypermethrin ßCD (2 g) in distilled water (20 ml) was introduced at 75 ° C into a double neck flask fitted with a cooler and nitrogen outlet. The solution was maintained with stirring at 75 ° C for 1 hour. A solution of 2-propanol (25 ml) containing PBO / SOITEM (96/4) was added, 0.93 g) and acepermethrin (0.36 g) in portions at the temperature of 70-75 ° C for 6 hours. The mixture was kept under stirring at 75 ° C for another 18 hours, then the mixture was allowed to cool to room temperature for 2 hours and finally was left unmoved for 3 hours. Thus, the oily phase was removed and the remaining solution was dried under vacuum obtaining, as dry residue, a formulation based on cypermethrin.

Example 12 Preparation of a formulation based on cypermethrin ßCD (1 g) in distilled water (20 ml) was introduced at 75 ° C into a double neck flask fitted with a cooler and nitrogen outlet. The solution was maintained with stirring at 75 ° C for 1 hour. Then the solution was cooled to 50 ° C, then at this temperature a solution of 2-propanol (25 ml) containing PBO / SOITEM (98/2, 0.26 g) and acepermethrin (0.11 g) was added in portions for 6 hours . The mixture was kept under stirring at 50 ° C for another 18 hours, then the mixture was allowed to cool to room temperature for 2 hours and finally was left unmoved for 3 hours. The solid was filtered (4%) and the solution containing the inclusion complex was dried under vacuum obtaining, as a dry residue, a formulation based on cypermethrin. In the dry residue thus obtained the proportion of PBO / cypermethrin was around 4/1 [as in 1H NMR analysis (DMSO-d6)], while the ßCD (weight / weight) content was around 73% [1H NMR (DMSO-d6)].

Example 13 Preparation of a formulation based on ketoconazole The formulation was prepared according to example 6, starting from 2 g ßCD, 0. 53 g PBO / SOITEM (98/2) and 0.06 g ketoconazole.

Example 14 Preparation of a cypermethrin-based formulation ßCD (1 g) in distilled water (20 ml) was introduced at 75 ° C in a double neck flask fitted with a cooler and nitrogen outlet. The solution was maintained with stirring at 75 ° C for 1 hour. Then the solution was cooled to 50 ° C, then at this temperature was added a solution of 2-propanol (50 ml) containing PBO / SOITEM (98/2, 0.26 g) and acepermethrin (0.11 g) in portions for 6 hours. The mixture was kept under stirring at 50 ° C for another 90 minutes, then the mixture was allowed to cool to room temperature for 90 minutes and was finally left unmoved for 1 hour. The separated solution was dried under vacuum obtaining, as dry residue, a formulation based on cypermethrin.

Example 15 Preparation of a formulation based on pyrethrum extracts ßCD (2 g) in distilled water (20 ml) was introduced at 75 ° C in a double neck flask fitted with a cooler and nitrogen outlet. The solution was maintained with stirring at 75 ° C for 1 hour. Then a solution of 2-propanol (25 ml) containing PBO / SOITEM (98/2, 0.53 g) and extracts of piretrum at 25% w / w (0.70 g) in portions at a temperature of 70- was added. 75 ° C for 6 hours. The mixture was kept under stirring at 75 ° C for another 18 hours, then the mixture was allowed to cool to room temperature for 2 hours and was finally left undisturbed for 3 hours. The solid was filtered, and the remaining solution was dried under vacuum, obtaining, as a dry residue, a formulation based on pyrethrum extracts.

EXAMPLE 16 Preparation of a formulation based on cypermethrin ßCD (5 g) in distilled water (50 ml) was introduced at 75 ° C into a double neck flask fitted with a cooler and nitrogen outlet. The solution was maintained with stirring at 80 ° C for 1 hour. Then a solution of 2-propanol (63 ml) containing PBO / SOITEM (98/2, 2.24 g) and acepermethrin (0.91 g) was added in portions at the temperature of 75 ° C for 6 hours. The mixture was kept under stirring at 75 ° C for another 18 hours, then the mixture was allowed to cool to room temperature for 2 hours with stirring and was finally left undisturbed for 3 hours. The oily phase was removed and the remaining solution was dried under vacuum, obtaining, as a dry residue, a formulation based on cypermethrin. In the dry residue thus obtained the proportion of PBO / cypermethrin was about 11 [as from 1 H NMR analysis (DMSO-d6)], while the ßCD (weight / weight) content was about 75% [1HNMR (DMSO -d6)].

Example 17 Preparation of a formulation based on cypermethrin ßCD (50 g) in distilled water (500 ml) was introduced at 75 ° C in a double neck flask fitted with a cooler and nitrogen outlet. The solution was maintained with stirring at 75 ° C for 1 hour. Then a solution of 96% ethanol (625 ml) containing PB80EC-NF (42.7 g) and acepermethrin (9.15 g) was added in portions at the temperature of 70-75 ° C for 6 hours. The mixture was maintained with stirring at 70 ° C for another 18 hours, then the mixture was allowed to cool to room temperature for 2 hours and was finally left unmoved for 3 hours. The oily phase was removed and the remaining solution was dried under vacuum, obtaining, as a dry residue, a formulation based on cypermethrin. In the dry residue thus obtained, the PBO / cypermethrin ratio was 2.8 (as in 1 H NMR analysis (DMSO-d6)], while the ßCD (w / w) content was around 60% [1 HNMR (DMSO -d6)].

EXAMPLE 18 Mortality test A mortality assay was carried out as in example 4 on a strain of Bemisia Tabaci (B-Biotype) (Whitefly of lead malice) using the formulation described in example 16, dissolved in 10 ml. Agral 90. The results are shown in table 1. The data obtained with acepermethrin dissolved in 10 ml Agral 90, and with a placebo (10 ml Agral 90) are shown as reference. In all tests, the concentration values refer to the quantity of the active principle.

Table 1. Product Concentration No. live insects / no. total% of (% w / v) insects after 48 hours Mortality Formulation eg. 16 0.1 0/60 100 Formulation eg 16 0.01 0/14 100 Formulation eg 16 0.001 0/16 100 Formulation eg 16 0.0001 20/22 9 Placebo 31/31 0 acepermethrin 0.1 4/12 67 acepepnetrine 0.01 22/27 19 Example 19 Mortality test A mortality test was carried out as reported in the example 4 in a cotton aphid strain (Aphis Gossypii) using the formulation described in example 10, dissolved in 10 ml Agral 90. The results are shown in table 2. The data obtained with fenvalerate dissolved in 10 ml are shown as reference. Agral 90, and with placebo (10 mi Agral 90). In all tests, the concentration values refer to the quantity of the active principle.

Table 2. Concentration No. live insects / no. % Product total (% w / v insects after 24 hours Mortality Formulation eg 10 0.2 0/10 100 Formulation eg 10 0.067 0/10 100 Formulation eg 10 0.02 2/10 80 Formulation eg 10 0.002 3 / 10 70 Placebo 10/10 0 fenvalerate 0.2 6/10 40 fenvalerate 0.02 8/10 20 fenvalerate 0.002 10/10 0 Example 20 Mortality test A mortality test was carried out as reported in Example 4 on a Heicoverpa strain Armigera (cotton bollworm) using the formulation described in example 17, dissolved in 10 ml Agral 90. The results are shown in table 3. The data obtained with acepermethrin dissolved in 10 ml Agral 90 are shown as reference, and a mixture of acepermethrin / PBO dissolved in 10 ml Agral 90 (the PBO content being 0.2% with respect to acepermethrin.) In all tests, the concentration values refer to the amount of the active ingredient.

Table 3. Concentration No. live insects / no. total% Product (% w / v) insects after 24 hours Mortality Formulation eg. 17 0.001 0/10 100 Formulation ex. 17 0.0005 0/10 100 acepermethrin 0.001 6/10 60 acepermethrin 0.0005 4/10 40 acepermethrin / PBO 0.001 9/10 90 acepepnetrine / PBO 0.0005 7/10 70

Claims (13)

RE I V I N D I C A C I O N S

1. An insecticidal composition consisting of (i) an active ingredient being a component with insecticidal activity that belongs to the pyrethroid class and / or a component with insect growth regulating activity, (ii) a component capable of synergistically improving the activity of the active ingredient, said composition is obtainable by subjecting both components (i) and (ii) to simultaneous complexation with cyclodextrin.

2. The composition according to claim 1, wherein the cyclodextrin is chosen from a, β,? Cyclodextrin, HP-β-cyclodextrin and SBE-β-cyclodextrin.

3. The composition according to claims 1 to 2, wherein the amount of insecticide relative to cyclodextrin is between 5% and 40% (w / w).

4. The composition according to claims 1 to 3, wherein the amount of growth regulator in relation to the cyclodextrin is between 0.01% and 5% (w / w).

5. The composition according to claims 1 to 3, wherein the compound capable of synergistically improving the activity of the active principle is chosen from piperonyl butoxide and sesamol.

6. The composition according to claims 1 to 4, wherein the amount of synergistic compound in relation to the cyclodextrin is between 10 and 100% (w / w).

7. The composition according to claims 1 to 5, wherein the amount of insecticide in relation to the synergistic compound is between 5% and 50% (weight / weight).

8. The composition according to claims 1 to 6, which consists of emulsifiers, UV stabilizers, antioxidants and other additives in an amount of between 0 and 30% (w / w).

9. The composition according to claims 1 to 7, formulated for use in solid form or as a solid / oil composition, possibly dissolved / emulsified in water or in aqueous solutions of water miscible solvents.

10. A process for the preparation of compositions according to those described in claims 1 to 9, characterized by the simultaneous complexation of the synergistic composition and the insecticide and / or growth regulator in cyclodextrin.

11. The process according to claim 10, comprising the following steps: a) Preparation of a solution or suspension of the synergistic composition and the insecticide and / or growth regulator in a suitable solvent; b) Preparation of a solution of cyclodextrin in water or in an aqueous mixture of organic solvents miscible in water; c) Add a composition / suspension obtained in (a) to the solution obtained in (b).

12. The use of a composition according to claims 1 to 9, as an insecticide in agriculture, or for the elimination of household insects.

13. The use of a composition according to claims 1 to 9, in the preparation of a veterinary formulation to be used as an insecticide.