MXPA06003498A - High alcohol content gel-like and foaming compositions - Google Patents
High alcohol content gel-like and foaming compositionsInfo
- Publication number
- MXPA06003498A MXPA06003498A MXPA/A/2006/003498A MXPA06003498A MXPA06003498A MX PA06003498 A MXPA06003498 A MX PA06003498A MX PA06003498 A MXPA06003498 A MX PA06003498A MX PA06003498 A MXPA06003498 A MX PA06003498A
- Authority
- MX
- Mexico
- Prior art keywords
- alcohol
- further characterized
- composition
- composition according
- amount
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 440
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title claims abstract description 236
- 238000005187 foaming Methods 0.000 title claims description 15
- 239000004094 surface-active agent Substances 0.000 claims abstract description 141
- 239000006260 foam Substances 0.000 claims abstract description 121
- 239000004615 ingredient Substances 0.000 claims abstract description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 27
- 239000004599 antimicrobial Substances 0.000 claims abstract description 25
- 239000003380 propellant Substances 0.000 claims abstract description 25
- 239000003974 emollient agent Substances 0.000 claims abstract description 22
- 239000004872 foam stabilizing agent Substances 0.000 claims abstract description 21
- 239000000443 aerosol Substances 0.000 claims abstract description 13
- 239000003205 fragrance Substances 0.000 claims abstract description 7
- 239000002537 cosmetic Substances 0.000 claims abstract description 6
- 239000003814 drug Substances 0.000 claims abstract description 3
- 230000000249 desinfective Effects 0.000 claims description 80
- 230000001476 alcoholic Effects 0.000 claims description 61
- -1 beiaines Chemical class 0.000 claims description 61
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 40
- 239000003795 chemical substances by application Substances 0.000 claims description 36
- 150000002148 esters Chemical class 0.000 claims description 35
- 239000003995 emulsifying agent Substances 0.000 claims description 28
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 24
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 22
- 239000000194 fatty acid Substances 0.000 claims description 22
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 21
- BDERNNFJNOPAEC-UHFFFAOYSA-N propanol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 21
- GLDOVTGHNKAZLK-UHFFFAOYSA-N Stearyl alcohol Polymers CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 20
- 239000002253 acid Substances 0.000 claims description 20
- 125000000129 anionic group Chemical group 0.000 claims description 20
- 150000002191 fatty alcohols Chemical class 0.000 claims description 20
- 235000021317 phosphate Nutrition 0.000 claims description 20
- 125000004432 carbon atoms Chemical group C* 0.000 claims description 18
- KFZMGEQAYNKOFK-UHFFFAOYSA-N iso-propanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 18
- DNIAPMSPPWPWGF-UHFFFAOYSA-N propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 17
- IAYPIBMASNFSPL-UHFFFAOYSA-N oxane Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 16
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 15
- 239000010452 phosphate Substances 0.000 claims description 14
- PUPZLCDOIYMWBV-UHFFFAOYSA-N butylene glycol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 13
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 12
- 150000001298 alcohols Chemical class 0.000 claims description 12
- 125000004005 formimidoyl group Chemical group [H]\N=C(/[H])* 0.000 claims description 12
- MHAJPDPJQMAIIY-UHFFFAOYSA-N hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 12
- 239000011630 iodine Substances 0.000 claims description 12
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims description 12
- 229910052740 iodine Inorganic materials 0.000 claims description 12
- 239000002736 nonionic surfactant Substances 0.000 claims description 12
- NBIIXXVUZAFLBC-UHFFFAOYSA-N phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 12
- BXWNKGSJHAJOGX-UHFFFAOYSA-N Cetyl alcohol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims description 11
- NBIIXXVUZAFLBC-UHFFFAOYSA-K [O-]P([O-])([O-])=O Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 11
- 229960003237 betaine Drugs 0.000 claims description 11
- 229960000541 cetyl alcohol Drugs 0.000 claims description 11
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical group OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 claims description 11
- 229960003333 chlorhexidine gluconate Drugs 0.000 claims description 11
- NDVLTYZPCACLMA-UHFFFAOYSA-N Silver oxide Chemical compound [O-2].[Ag+].[Ag+] NDVLTYZPCACLMA-UHFFFAOYSA-N 0.000 claims description 10
- 229920001296 polysiloxane Polymers 0.000 claims description 10
- WPYMKLBDIGXBTP-UHFFFAOYSA-N Benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 9
- 235000011187 glycerol Nutrition 0.000 claims description 9
- 229960005150 glycerol Drugs 0.000 claims description 9
- 239000003906 humectant Substances 0.000 claims description 9
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 9
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 9
- JNYAEWCLZODPBN-CTQIIAAMSA-N Sorbitan Chemical compound OCC(O)C1OCC(O)[C@@H]1O JNYAEWCLZODPBN-CTQIIAAMSA-N 0.000 claims description 8
- 125000005233 alkylalcohol group Chemical group 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 8
- RZRNAYUHWVFMIP-KTKRTIGZSA-N 1-oleoylglycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-KTKRTIGZSA-N 0.000 claims description 7
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Exidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims description 7
- 239000004166 Lanolin Substances 0.000 claims description 7
- 229940039717 Lanolin Drugs 0.000 claims description 7
- 230000003750 conditioning Effects 0.000 claims description 7
- 150000004665 fatty acids Chemical class 0.000 claims description 7
- 150000002430 hydrocarbons Chemical class 0.000 claims description 7
- 235000019388 lanolin Nutrition 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 7
- 239000003921 oil Substances 0.000 claims description 7
- 239000002904 solvent Substances 0.000 claims description 7
- HLZKNKRTKFSKGZ-UHFFFAOYSA-N 1-Tetradecanol Chemical compound CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 claims description 6
- 229940080421 COCO GLUCOSIDE Drugs 0.000 claims description 6
- 239000004215 Carbon black (E152) Substances 0.000 claims description 6
- LQZZUXJYWNFBMV-UHFFFAOYSA-N Dodecanol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 claims description 6
- 239000004952 Polyamide Substances 0.000 claims description 6
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 6
- 150000001412 amines Chemical class 0.000 claims description 6
- 230000000844 anti-bacterial Effects 0.000 claims description 6
- FLNKWZNWHZDGRT-UHFFFAOYSA-N azane;dihydrochloride Chemical compound [NH4+].[NH4+].[Cl-].[Cl-] FLNKWZNWHZDGRT-UHFFFAOYSA-N 0.000 claims description 6
- 150000001719 carbohydrate derivatives Chemical class 0.000 claims description 6
- 239000012141 concentrate Substances 0.000 claims description 6
- 239000000470 constituent Substances 0.000 claims description 6
- IMROMDMJAWUWLK-UHFFFAOYSA-N ethenol Chemical compound OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 claims description 6
- LYCAIKOWRPUZTN-UHFFFAOYSA-N glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- ACGUYXCXAPNIKK-UHFFFAOYSA-N hexachlorophene Chemical compound OC1=C(Cl)C=C(Cl)C(Cl)=C1CC1=C(O)C(Cl)=CC(Cl)=C1Cl ACGUYXCXAPNIKK-UHFFFAOYSA-N 0.000 claims description 6
- 229960004068 hexachlorophene Drugs 0.000 claims description 6
- 125000001165 hydrophobic group Chemical group 0.000 claims description 6
- 229940043348 myristyl alcohol Drugs 0.000 claims description 6
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 6
- 150000003013 phosphoric acid derivatives Chemical class 0.000 claims description 6
- 229920002647 polyamide Polymers 0.000 claims description 6
- 229920005862 polyol Polymers 0.000 claims description 6
- 150000003077 polyols Chemical class 0.000 claims description 6
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 6
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 6
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 6
- 239000004332 silver Substances 0.000 claims description 6
- 229910052709 silver Inorganic materials 0.000 claims description 6
- 239000003381 stabilizer Substances 0.000 claims description 6
- 239000001993 wax Substances 0.000 claims description 6
- 238000009736 wetting Methods 0.000 claims description 6
- 229960004424 Carbon Dioxide Drugs 0.000 claims description 5
- CBFCDTFDPHXCNY-UHFFFAOYSA-N Icosane Chemical group CCCCCCCCCCCCCCCCCCCC CBFCDTFDPHXCNY-UHFFFAOYSA-N 0.000 claims description 5
- 229940069338 Potassium Sorbate Drugs 0.000 claims description 5
- CHHHXKFHOYLYRE-STWYSWDKSA-M Potassium sorbate Chemical compound [K+].C\C=C\C=C\C([O-])=O CHHHXKFHOYLYRE-STWYSWDKSA-M 0.000 claims description 5
- GGCZERPQGJTIQP-UHFFFAOYSA-M Sodium 2-anthraquinonesulfonate Chemical compound [Na+].C1=CC=C2C(=O)C3=CC(S(=O)(=O)[O-])=CC=C3C(=O)C2=C1 GGCZERPQGJTIQP-UHFFFAOYSA-M 0.000 claims description 5
- 229940075582 Sorbic Acid Drugs 0.000 claims description 5
- 239000003899 bactericide agent Substances 0.000 claims description 5
- CURLTUGMZLYLDI-UHFFFAOYSA-N carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 5
- 239000001569 carbon dioxide Substances 0.000 claims description 5
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 5
- 150000007942 carboxylates Chemical class 0.000 claims description 5
- 239000000084 colloidal system Substances 0.000 claims description 5
- 238000005260 corrosion Methods 0.000 claims description 5
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims description 5
- 150000002009 diols Chemical class 0.000 claims description 5
- 150000002314 glycerols Chemical class 0.000 claims description 5
- 239000003112 inhibitor Substances 0.000 claims description 5
- 230000002401 inhibitory effect Effects 0.000 claims description 5
- 239000004302 potassium sorbate Substances 0.000 claims description 5
- 235000010241 potassium sorbate Nutrition 0.000 claims description 5
- 230000002335 preservative Effects 0.000 claims description 5
- 239000003755 preservative agent Substances 0.000 claims description 5
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 claims description 5
- 239000001294 propane Substances 0.000 claims description 5
- 229910001923 silver oxide Inorganic materials 0.000 claims description 5
- 239000004334 sorbic acid Substances 0.000 claims description 5
- 235000010199 sorbic acid Nutrition 0.000 claims description 5
- 239000000375 suspending agent Substances 0.000 claims description 5
- ZQBJRVYLUFBBEQ-UHFFFAOYSA-N 2-[diamino(3-formamidopropyl)azaniumyl]acetate Chemical group [O-]C(=O)C[N+](N)(N)CCCNC=O ZQBJRVYLUFBBEQ-UHFFFAOYSA-N 0.000 claims description 4
- 239000005711 Benzoic acid Substances 0.000 claims description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 4
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 4
- PXBRQCKWGAHEHS-UHFFFAOYSA-N Dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims description 4
- 239000004338 Dichlorodifluoromethane Substances 0.000 claims description 4
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 claims description 4
- 239000006096 absorbing agent Substances 0.000 claims description 4
- 239000004480 active ingredient Substances 0.000 claims description 4
- 150000003862 amino acid derivatives Chemical class 0.000 claims description 4
- 230000000111 anti-oxidant Effects 0.000 claims description 4
- 239000003963 antioxidant agent Substances 0.000 claims description 4
- 235000010233 benzoic acid Nutrition 0.000 claims description 4
- 229960004365 benzoic acid Drugs 0.000 claims description 4
- IJDNQMDRQITEOD-UHFFFAOYSA-N butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 claims description 4
- 239000001273 butane Substances 0.000 claims description 4
- 125000002091 cationic group Chemical group 0.000 claims description 4
- 238000004040 coloring Methods 0.000 claims description 4
- 229940042935 dichlorodifluoromethane Drugs 0.000 claims description 4
- 235000019404 dichlorodifluoromethane Nutrition 0.000 claims description 4
- 230000001804 emulsifying Effects 0.000 claims description 4
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 claims description 4
- 239000004088 foaming agent Substances 0.000 claims description 4
- 235000003084 food emulsifier Nutrition 0.000 claims description 4
- 150000002462 imidazolines Chemical class 0.000 claims description 4
- 150000003903 lactic acid esters Chemical class 0.000 claims description 4
- 239000000787 lecithin Substances 0.000 claims description 4
- 235000010445 lecithin Nutrition 0.000 claims description 4
- 239000003094 microcapsule Substances 0.000 claims description 4
- 239000002480 mineral oil Substances 0.000 claims description 4
- 235000010446 mineral oil Nutrition 0.000 claims description 4
- 150000003904 phospholipids Chemical class 0.000 claims description 4
- CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Chemical group [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 4
- 229910000031 sodium sesquicarbonate Inorganic materials 0.000 claims description 4
- 235000018341 sodium sesquicarbonate Nutrition 0.000 claims description 4
- WSWCOQWTEOXDQX-UHFFFAOYSA-N sorbic acid Chemical compound CC=CC=CC(O)=O WSWCOQWTEOXDQX-UHFFFAOYSA-N 0.000 claims description 4
- 239000000600 sorbitol Substances 0.000 claims description 4
- 150000003871 sulfonates Chemical class 0.000 claims description 4
- 150000003462 sulfoxides Chemical class 0.000 claims description 4
- 229960003500 triclosan Drugs 0.000 claims description 4
- 229940058015 1,3-butylene glycol Drugs 0.000 claims description 3
- POAOYUHQDCAZBD-UHFFFAOYSA-N 2-Butoxyethanol Chemical compound CCCCOCCO POAOYUHQDCAZBD-UHFFFAOYSA-N 0.000 claims description 3
- VYWRBUBXZALATG-UHFFFAOYSA-N 2-hydroxyoctadecanamide Chemical compound CCCCCCCCCCCCCCCCC(O)C(N)=O VYWRBUBXZALATG-UHFFFAOYSA-N 0.000 claims description 3
- 229940015001 Glycerin Drugs 0.000 claims description 3
- 229940080352 Sodium Stearoyl Lactylate Drugs 0.000 claims description 3
- 235000019437 butane-1,3-diol Nutrition 0.000 claims description 3
- 229940073507 cocamidopropyl betaine Drugs 0.000 claims description 3
- 229940075507 glyceryl monostearate Drugs 0.000 claims description 3
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 3
- 239000004310 lactic acid Substances 0.000 claims description 3
- 235000014655 lactic acid Nutrition 0.000 claims description 3
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 claims description 3
- VBICKXHEKHSIBG-UHFFFAOYSA-N rac-1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 3
- 150000004072 triols Chemical class 0.000 claims description 3
- PSBDWGZCVUAZQS-UHFFFAOYSA-N (dimethylsulfonio)acetate Chemical compound C[S+](C)CC([O-])=O PSBDWGZCVUAZQS-UHFFFAOYSA-N 0.000 claims description 2
- FKOKUHFZNIUSLW-UHFFFAOYSA-N 2-hydroxypropyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(C)O FKOKUHFZNIUSLW-UHFFFAOYSA-N 0.000 claims description 2
- MRUAUOIMASANKQ-UHFFFAOYSA-N Cocamidopropyl betaine Chemical group CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 2
- ODFAPIRLUPAQCQ-UHFFFAOYSA-M Sodium stearoyl lactylate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC(=O)OC(C)C(=O)OC(C)C([O-])=O ODFAPIRLUPAQCQ-UHFFFAOYSA-M 0.000 claims description 2
- 230000003213 activating Effects 0.000 claims description 2
- 229940081733 cetearyl alcohol Drugs 0.000 claims description 2
- 125000003963 dichloro group Chemical group Cl* 0.000 claims description 2
- UBHWBODXJBSFLH-UHFFFAOYSA-N hexadecan-1-ol;octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO.CCCCCCCCCCCCCCCCCCO UBHWBODXJBSFLH-UHFFFAOYSA-N 0.000 claims description 2
- 230000003020 moisturizing Effects 0.000 claims description 2
- 229920000728 polyester Polymers 0.000 claims description 2
- 229940093625 propylene glycol monostearate Drugs 0.000 claims description 2
- 229940117986 sulfobetaine Drugs 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims 7
- 239000011780 sodium chloride Substances 0.000 claims 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 6
- LRHPLDYGYMQRHN-UHFFFAOYSA-N n-butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims 6
- 229960003260 Chlorhexidine Drugs 0.000 claims 4
- 239000004341 Octafluorocyclobutane Substances 0.000 claims 4
- BCCOBQSFUDVTJQ-UHFFFAOYSA-N Octafluorocyclobutane Chemical compound FC1(F)C(F)(F)C(F)(F)C1(F)F BCCOBQSFUDVTJQ-UHFFFAOYSA-N 0.000 claims 4
- WXMKPNITSTVMEF-UHFFFAOYSA-M Sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims 4
- 235000019407 octafluorocyclobutane Nutrition 0.000 claims 4
- 239000004299 sodium benzoate Substances 0.000 claims 4
- 235000010234 sodium benzoate Nutrition 0.000 claims 4
- DDMOUSALMHHKOS-UHFFFAOYSA-N 1,2-dichloro-1,1,2,2-tetrafluoroethane Chemical compound FC(F)(Cl)C(F)(F)Cl DDMOUSALMHHKOS-UHFFFAOYSA-N 0.000 claims 3
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 claims 3
- 229940087091 Dichlorotetrafluoroethane Drugs 0.000 claims 3
- 229940067606 Lecithin Drugs 0.000 claims 3
- 229960003885 Sodium Benzoate Drugs 0.000 claims 3
- YFMFNYKEUDLDTL-UHFFFAOYSA-N 1,1,1,2,3,3,3-Heptafluoropropane Chemical compound FC(F)(F)C(F)C(F)(F)F YFMFNYKEUDLDTL-UHFFFAOYSA-N 0.000 claims 2
- TYIOVYZMKITKRO-UHFFFAOYSA-N 2-[hexadecyl(dimethyl)azaniumyl]acetate Chemical compound CCCCCCCCCCCCCCCC[N+](C)(C)CC([O-])=O TYIOVYZMKITKRO-UHFFFAOYSA-N 0.000 claims 2
- 229940057971 Butane Drugs 0.000 claims 2
- 239000003945 anionic surfactant Substances 0.000 claims 2
- 150000002170 ethers Chemical class 0.000 claims 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 2
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 2
- 239000011734 sodium Substances 0.000 claims 2
- 229910052708 sodium Inorganic materials 0.000 claims 2
- 125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 claims 2
- LVGUZGTVOIAKKC-UHFFFAOYSA-N 1,1,1,2-Tetrafluoroethane Chemical compound FCC(F)(F)F LVGUZGTVOIAKKC-UHFFFAOYSA-N 0.000 claims 1
- NSGXIBWMJZWTPY-UHFFFAOYSA-N 1,1,1,3,3,3-Hexafluoropropane Chemical compound FC(F)(F)CC(F)(F)F NSGXIBWMJZWTPY-UHFFFAOYSA-N 0.000 claims 1
- QSMUFXXTSUEZJA-UHFFFAOYSA-N 1,3-dibenzyl-2-oxoimidazolidine-4,5-dicarboxylic acid Chemical compound O=C1N(CC=2C=CC=CC=2)C(C(=O)O)C(C(O)=O)N1CC1=CC=CC=C1 QSMUFXXTSUEZJA-UHFFFAOYSA-N 0.000 claims 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N 2-Pyrrolidone Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims 1
- FQHODMBKDHIWRL-UHFFFAOYSA-N CCCCCCCCCCCCCCCCCC([Na])=O Chemical compound CCCCCCCCCCCCCCCCCC([Na])=O FQHODMBKDHIWRL-UHFFFAOYSA-N 0.000 claims 1
- OSDLLIBGSJNGJE-UHFFFAOYSA-N Chloroxylenol Chemical compound CC1=CC(O)=CC(C)=C1Cl OSDLLIBGSJNGJE-UHFFFAOYSA-N 0.000 claims 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical group OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 claims 1
- UMNKXPULIDJLSU-UHFFFAOYSA-N Dichlorofluoromethane Chemical compound FC(Cl)Cl UMNKXPULIDJLSU-UHFFFAOYSA-N 0.000 claims 1
- 229940067631 Phospholipids Drugs 0.000 claims 1
- 239000004698 Polyethylene (PE) Substances 0.000 claims 1
- QLGLKGKYKXRALK-UHFFFAOYSA-N [Na].CC=C Chemical compound [Na].CC=C QLGLKGKYKXRALK-UHFFFAOYSA-N 0.000 claims 1
- 239000002250 absorbent Substances 0.000 claims 1
- 230000002745 absorbent Effects 0.000 claims 1
- 150000000475 acetylene derivatives Chemical class 0.000 claims 1
- 229940073669 ceteareth 20 Drugs 0.000 claims 1
- 239000003086 colorant Substances 0.000 claims 1
- 229940099364 dichlorofluoromethane Drugs 0.000 claims 1
- OTMSDBZUPAUEDD-UHFFFAOYSA-N ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 claims 1
- 229940050410 gluconate Drugs 0.000 claims 1
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 claims 1
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- 238000004519 manufacturing process Methods 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 229920001888 polyacrylic acid Polymers 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- FDCJDKXCCYFOCV-UHFFFAOYSA-N 1-hexadecoxyhexadecane Chemical class CCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCC FDCJDKXCCYFOCV-UHFFFAOYSA-N 0.000 description 1
- 229960001631 Carbomer Drugs 0.000 description 1
- 229940103091 Potassium Benzoate Drugs 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M Potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
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- 239000006265 aqueous foam Substances 0.000 description 1
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- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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Abstract
This invention relates to a"high lower alcohol content"(>40%v/v of a C1-4 alcohol) liquid composition able to be either dispensed as a stable foam with the use of non-propellant foam dispensing devices from non-pressurized containers or as an alcohol gel composition which does not use thickener and gelling agents that leave undesirable deposits or a sticky after-feel and that has a final viscosity less than 4,000cps. The liquid compositions comprise an alcohol, C1-4 (>40%v/v), a fluorosurfactant of at least 0.001%by weight to prepare a foamable composition or from 0-2.0%to prepare a gel-like composition of a final viscosity less than 4,000cps, 0-10%w/w of additional minor components added to obtain the desired performance (a foamable composition or a gel-like composition with a viscosity less than 4,000 cps), and the balance being purified water. The compositions may include emulsifier-emollients and mosturizers, secondary surfactants, foam stabilizers, fragrances, antimicrobial agents, other type of medicinal ingredients, and the like ingredients or additives or combinations thereof commonly added to alcohol gels or foams, aerosol compositions or to toiletries, cosmetics, pharmaceuticals and the like.
Description
FOAMING AND SIMILAR COMPOSITIONS TO GEL WITH HIGH ALCOHOL CONTENT
CROSS REFERENCE TO RELATED REQUESTS U.S.
This patent application concerns, and claims the benefit of, the priority of the United States Provisional Patent Application Serial No. 60 / 506,172 filed on September 29, 2003, and the United States Provisional Patents Application. with Serial No. 60/591, 601 filed on July 28, 2004.
FIELD OF THE INVENTION
The present invention concerns compositions with high lower alcohol contents (C? .4) which could be a gel-like composition or a solution capable of being distributed as a foam. The compositions to be distributed as foams contain a fluorinated surfactant and when mixed with air provide a stable alcoholic foam that can be used for personal cleansing or for disinfection purposes. The gel-like compositions may or may not contain a fluorinated surfactant.
BACKGROUND OF THE INVENTION
The compositions with ethanol and / or isopropyl alcohol with at least 60% v / v (approximately 52% by weight) are well-known to be antibacterial, therefore, they can be used as an antibacterial agent. Widely accepted for disinfection purposes. However, due to the inherent characteristics of the alcohol, it was perceived that the more the conenido is, the better the product is and a more alcohol-friendly solution with more than 60% by volume is more desirable. Alcoholic disinfectant solutions are usually thickened in order to eliminate the waste and facilitate the spread of the composition throughout the desired area. It is also known that from different gelling agents one can use paraffin or waxes to thicken a solution with high alcohol concentration. It is described in U.S. Patent No. 2,054,989, which tol composition added with lanolin can reduce the melting point closest to the body temperature. One of the disadvantages of compositions containing gels and this type of thick alcohol is that if it does not leave a sticky feeling on the hands after use (although some do), the effect increases after repeated use during the day, making it necessary to remove the thickeners eventually by washing before continuing the use of an alcoholic antiseptic solution. The present invention if formulated for said type of product does not leave such a feeling,
and I do not need to be re-irritated by washing after having been used repeatedly. Another way to thicken solutions with high alcohol content was disclosed in U.S. Patent No. 6,090,395 and 6,623,744 where emulsifiers and surfactants were used as the thickener system to produce a hydroalcoholic lotion with a viscosity of at least 4,000 cps. Also US Pat. No. 4,956,170 discloses polyethoxylated nonionic surfactants / emulsifiers to stabilize added emollient oils in addition to a fatty alcohol although with the addition of a polymeric thickening agent to prepare a skin conditioning / moisturizing antimicrobial gel. hydroalcoholic The disinfectant compositions of the present invention which are in gel form have a viscosity of less than 4,000 cps and no polymeric thickening agent is added. Generally speaking, a disinfecting solution with alcohol conenido disinfects but not clean. In order to make it disinfect and clean, it would take too much soap to make the skin feel soapy and unpleasant, unacceptable for rubbing alcohol purposes. However, a formulation with high content of lower alcohols that disinfects the skin, non-irritant for use as an agent for washing the skin is successfully achieved by combining emulsifiers, skin sensitizers and emollients of the skin to be used as a gel or
ointment as described in U.S. Patent No. 5,629,006. Surfactants other than those for cleaning are also used to spread an aqueous composition containing one or more active substances rapidly and uniformly on a surface due to its wetting properties. The use of good wetting agents definitely improves the efficient use of active substances in different compositions as described in the Patent of the States
United No. 5,928,993. Accordingly, the composition described in the present invention includes the addition of surfactants, specifically fluorinated surfactants which are well known for their unparalleled wetting power and which are also surfactants in the lower alcohols used as a disinfectant and solvent system at levels which they also make it acceptable for rubbing alcohol purposes, which provides cleaning, moisture and wetting properties to the composition. Although a disinfectant solution with high alcohol content has good disinfecting characteristics, it has an acute odor and is generally perceived to cause dryness of the skin, characteristics that can be decreased to a desirable level in the present invention. A foaming product of more than 40% v / v of alcohol, easy and safe to use, is desirable over the products of conventional ointment or gel compositions. The concentration of alcohol already has a
danger by themselves, and there are many applications in which the perceived risk can be diminished could be distributed as a foam without the use of pressurized aerosol containers. A foam intended to be useful as a skin disinfecting agent should have a uniform consistency, stretchability, cleanliness ability, and have a pleasant feel, i.e. have rapid disintegration power when pressure is applied; all of which present a challenge for a lower alcohol content composition. The description of a foaming, aqueous disinfectant composition which uses 15% w / w alcohol as a co-solvent, which does not require pressurized container or addition of propellant to produce the foam, is described in the Patent of the Sides United No. 3,962,150. The foam forming agents used now have been unable to form stable foams when the liquid phase has high alcohol content without using other ingredients. In addition, it has been considered that lower alcohols are defoamers, preferably, to foam-producing chemicals. According to Klausner, in U.S. Patent No. 3,131, 153, if more than 64% alcohol is used, inhomogeneous compositions are obtained. The compositions in the patent required propellant for foaming and the foams produced were of limited stability. Prior to this invention, when an alcohol concentration of more than 40% v / v was required in a product, it is generally
accepted that the product will be either liquid or gel, and that if it is desired that the concentration of alcohol is necessarily reduced or it would be required to use a propellant and a pressurized system. Surprisingly, in the low-foamable, high-alcohol products described, the types of foam obtained were not similar to those expected from the aqueous solutions. The foams obtained are described as fast or aerated foams, of rapid disintegration, with low or limited stability, which would not last for more than a minute, usually disappearing in seconds. It was disclosed that fluorinated surfactants and alcohol can be combined to produce a "stable" foam by means of a process using high pressurization means to generate the foam.
Very stable pressurized foams containing high lower alcohol contents and methods of forming and using said pressurized foams in the oil industry using a nonionic surfactant or mixture of nonionic surfactants of a specific group of fluorinated surfactants, are provided in the United States 4,440,653. The compositions of this patent require the use of a pressurized gas system to generate the foam. Several examples of compositions with a high content of lower alcohols which are dissipated as a foam have been described, although for the purpose of the present invention the characteristics of the foam are not of the desired result, since they are of disintegration
fast, low stability and the foam is produced by means of propellants and aerosol containers only, such as that described in U.S. Patent No. 5,906,808, which describes a product using an emulsifying wax NF, and a combination of alcohol cetyl and stearyl, or other combinations of waxes that improve the foaming results of the composition, in combination with cetyl lactate, to produce an alcoholic product of chlorhexidine gluconate at 0.8%. U.S. Patent No. 5,167,950 issued to Lins discloses a foam product that requires a propellant and no surfactant is added as a cleaning agent. The composition described in this patent is based on the use of an emulsifier system (fatty alcohol ROH of 16 to 22 carbon atoms) in combination with the use of a thickening agent (carbomer, klucel, etc.). U.S. Patent No. 5,167,950 to Lins discloses an antimicrobial aerosol foam having a high alcohol content. The foam comprises alcohol, water, and a polymeric gelling agent and a surfactant system comprising an alcohol of 16 to 22 carbon atoms, propellant of aerosol and a non-ionic polyethoxylated surfactant. Despite the work done, it was currently shown that there is little specific knowledge about how foam is reacted and formed, and surprisingly the formulations that do not seem foamable result in the best foam produced by some, while other formulations that seem to have been producing of uniform foam
While they are prepared they do not turn out well at all in some non-aerosol foam dispensers. The behavior of aqueous foams is not the same as that of an alcoholic foam. Traditional ways of forming a gel using pojimeric thickeners have undesirable characteristics and similarly little has been done in the formation of thick gels as emulsions. It is very advantageous to have disinfecting formulations based on alcohol that can be distributed either as a gel or as a foam. In addition, it would be very advantageous and desirable to find a foaming agent that could be used in concentrations that could be used in products that can remain in the area in which they have been applied and do not need to be rinsed or removed by rubbing due to small amounts of waste. remnants after evaporation.
It would also be very advantageous to provide foams or gels that do not leave a sticky or unpleasant after-feel as most alcoholic products similar to commercial gels are known for, or which obstruct the dispensing equipment used to distribute the foams and gels.
BRIEF DESCRIPTION OF THE INVENTION
It is an object of this invention to provide liquid compositions with high alcohol content, containing an anti-surfactant agent.
cleaner as well as a disinfectant / cleaner / solvent / carrier and that causes very little dryness to the user's skin or hands and is capable of being distributed either as a gel or as a foam from both pressurized and non-pressurized systems. The present invention provides compositions with high alcohol content which are either gels or capable of being distributed as a foam, which are easily extendable on the desired surface. Among the different applications where said compositions can be used, it is another object also to provide an antimicrobial alcohol foam and an antimicrobial alcohol gel. The foamable composition when distributed from a suitable distributor is stable and does not require the use of propellants and pressurized containers. The gels described in the present with a viscosity of less than 4,000 cps do not use the thickening or gelling agents typically used in commercial gels and after a single application or multiple gel applications there is no subsequent feeling of usual adhesion or stickiness. and the gel does not obstruct the distributors from which the gels are distributed. These and other objects and services will be obvious from the following description of the invention. All percentages provided herein are based on total weight unless otherwise indicated. Accordingly, the present invention provides compositions for personal hygiene, as follows.
Foamable Compositions The present invention provides a foamable composition, comprising: a) an alcohol of 1 to 4 carbon atoms, or mixture thereof, present in a quantity greater than about 40% v / v of the total composition. b) an effective fluoridated surfactant for moistening and foaming, present in a quantity of at least 0.001% by weight of the total composition; and c) water, present in an amount to balance the total composition to 100% by weight. In this aspect of the nvención, ageníe -fluorado surfactant is present in an effective amount from about 0.001% to about 10.0% by weight of the total composition -es physiologically acceptable so that can be used in product type for personal care. In a preferred embodiment of the invention el- surfactant may be an amphoteric fluorinated acetoxypropyl politetrafluoroetilen beíaína of the following formula CF3CF2 (CF2CF2) p CH2CH2 (OAc) CH2N + (CH3) 2CH2COO-) where n = 2 to 4, a fluorinated surfactant not ethoxylated ion of the following structure: RfCH2CH2 (CH2CH2O) xH where Rf = F (CF2CF2) y, x = 0 to about 15 y = 1 to about 7; or an anionic fluorinated surfactant phosphate of the following structure: (RfCH2CH20) xP (O) (ONH4) and where
Rf = F (CF2CF2) Z, x = 1 or 2, y = 2 or 1 and z = 1 to about 7, or mixtures thereof. In another aspect of the invention there is provided an alcoholic disinfectant composition, comprising: a) ethanol, present in an amount of between about
60% to 70% v / v of the tolal composition; b) a physiologically acceptable fluorinated ionenside in an amount from about 0.01% to about 2.0% by weight of the total composition; c) at least one nonionic non-ionic agent selected from the group consisting of polyethoxylated fatty alcohols present in an amount from about 0.01 to about 10.9 weight percent. d) a foaming foam agent; e) water in an amount to balance the total composition to 100% by weight. The present invention also provides an alcoholic disinfectant composition: a) ethanol, present in an amount of between about 60% to 70% v / v of the total composition; b) an acceptable anionic fluorinated surfactant phosphate in an amount from about 0.01% to about 2.0% by weight of the total composition; c) n-propanol at least 1%;
d) foam stabilizing agents including at least 1,3-buylene glycol at 2%, buxoxyieolol at 0.001% - 3% ea; e) an enhancer of the lipid layer as a mixture of alkyl glucoside and glyceryl oleate; and f) water, in an amount to balance the total composition to
100% by weight
Gel-like compositions In this aspect of the invention there is provided a gel-like alcohol composition, comprising: a) an alcohol of 1 to 4 carbon atoms, or mixtures of same, present in an amount greater than about 40% v / v of the total composition; b) at least one nonionic surfactant selected from the group consisting of: a poly alcohol (ethoxylated and / or propoxylated) a poii esier (eíoxilado and / or propoxylated derivative of a poly alcohol (ethoxylated and / or propoxylated) a derivative of a poly ester (ethoxylated and / or propoxylated), an alkyl alcohol, an alkenyl alcohol, an ester of a polyhydric alcohol, an ether of a polyhydric alcohol, an ester of a polyalkoxylated derivative of a polyhydric alcohol, an ether a polyalkoxylated of a polyhydric alcohol derivative, a fatty acid ester of sorbiían, a polyalkoxylated derivative of a fatty acid ester of sorbitan, and mixtures thereof, present in an amount of from about 0.10% to about 5% by weight.
c) an emulsifier, present in an amount of between about 0.10% to about 3.0% by weight; and d) water in an amount sufficient to form a stable gel-like disinfectant composition. The compositions described herein provide a wide variety and range of high alcohol content disinfectants. In accordance with the percentage of alcohol used in the compositions and varying the proportions of the other constituents in the formulation, foams with different properties can be achieved thus allowing the production of foams that are either thick or wet that quickly crush, or foams that are soft that contain fine bubbles and that are relatively dry that have prolonged foam stability, or thick foams creamy that are in gel.
Also, the compositions may or may not be disinfectants in accordance with the percentage of alcohol. Surprisingly it was found that by varying the percentages of the ingredients an alcoholic composition similar to gel was obtained which did not dry the hands or left a posterior feeling of adhesion and did not obstruct the gel distributors, which have the desired consistency and which show a viscosity of less than 4,000 cps. Some of the compositions can be conveniently manufactured in a two-step process so that the alcohol can be added at a later time and / or location making it
First part a suitable concentrate to ship less dangerous items and weights. Heating the first part from 30 to 80 degrees Celsius), depending on the particular composition) before adding the main portion of alcohol improves the long-term stability of the compositions. This heating may take place either on the same day in the same location where the finished composition was prepared or the first part of the concentrate may be stored or shipped elsewhere and the heating may take place either when the first part is mixed or before to add the main portion of alcohol. It is evident that the described modality can be subjected to adjustment and / or improvement for specific applications either as a gel or a foam or as a desired active ingredient, without departing from the scope of the present invention. Different materials and / or ingredients will then be necessary to compensate for the disruption of the stability of the foam and / or composition that must be generated by the change (ie, to produce a uniform primary or secondary comparative surfactant), to adjust the compatible stabilizing percentage. of foam and / or vary the relative amount of emulsifier and / or alcohol and / or water) or compensate for displacement at the desired viscosity and characteristics of the foam to obtain the desired gel (i.e., reduce the amount of fluorinated surfactant or increase the polyexylated surfactants, or add an emulsifier and / or increase p decrease alcohol and / or water). These and other changes in the standards can be made with the spirit and spirit of the invention, which is widely
constructed and not limited except by the nature of the appended claims hereto. For example, alcohol-based compositions may contain up to 10% by weight of other ingredients or active additives or combinations thereof commonly added to aerosol compositions or to toilets, cosmetics, pharmaceuticals, etc. Materials that may be added may include organic gums and colloids, lower alkanolamides of higher fatty acids, short chain diols and triols, alkyl glucoside, fragrance, coloring matter, additional emollients, UV absorber, solvents, emulsifiers, stabilizer foam or mixture of said stabilizers, suspending agents, regulators, conditioning agents, antioxidants, bactericides, medicinal acive ingredient and the like. The present invention provides a composition, comprising: a) an alcohol of 1 to 4 carbon atoms, or mixtures thereof, present in an amount greater than about 40% v / v of the ionic composition; b) at least one nonionic surfactant selected from the group consisting of a poly (ethoxylated and / or propoxylated) alcohol, a ester (ethoxylated and / or propoxylated, a derivative of a poly (ethoxylated and / or propoxylated) alcohol, a derivative of a poly (ethoxylated and / or propoxylated) ester, an alkyl alcohol, an alkenyl alcohol, an ester of a polyhydric alcohol, an ether of an alcohol
polyhydric, an ester of a polyalkoxylated derivative of a polyhydric alcohol, an ether of a polyalkoxylated derivative of a polyhydric alcohol, a fatty acid ester of sorbitan, a poiialkoxylated derivative of a fatty acid ester of sorbitan, and mixtures thereof, present in an amount of between about 0.10% to about 5% by weight. c) an emulsifier present in an amount of between about 0.10% to about 3.0% by weight; and d) water in an amount sufficient to form a stable gel-like composition with a viscosity of less than 4,000 cps. The invention will be described in relation to several specific examples, which are intended to be illustrative, preferably limiting. However, the present invention itself leads to the preparation of a wide variety of products, and it will be understood that other embodiments may be used and that changes may be made without departing from the scope of the invention.
DETAILED DESCRIPTION OF THE INVENTION
Definitions The term "emollient" as used herein refers broadly to materials that are capable of maintaining or improving the moisture level, compliance, or appearance of the skin when used repeatedly. The term "emulsifier" as used herein refers to
to surfactants or other materials added in small amounts to a mixture of two miscible liquids to aid in the formation and stabilization of an emulsion. The phrase "emulsifying ingredients", as used herein, is synonymous with emulsifier defined above. The term "emulsion" as used herein refers to a colloidal dispersion of one liquid in another. The term "surfactant" is the widely employed contraction for surface active agents "which is the descriptive generic term for materials that preferably adsorb on interfaces as a result of the presence of both lyophilic and lyophobic structural units, adsorption usually results in the alteration of the surface or interfacial properties of the system The term "fluorinated surfactant" as used herein, refers to active agents with a fluorinated surface that facilitate the composition in which the contents are clean, wet and foam. The phrase "foam stabilizer" as used herein, refers to an additive that increases the amount or persistence of the foam produced by an ion-resistive system. The phrase "gel composition", as used herein, refers to a hydroalcoholic solution with at least 40% v / v of alcohol content, which is thickened by the use of emulsifiers and surfactants to provide a higher viscosity than water and less than 4,000
cps. The term "disinfect" as used herein means destroying or reducing harmful microorganisms. The present invention provides compositions with high contents of lower alcohols (from 1 to 4 carbon atoms capable of being distred as a gel or as a foam.) Foamable compositions when mixed with air release a stable foam to provide an alcoholic liquid solution which can be used for personal cleaning or disinfection purposes and which are disintegrated by application of pressure such as when a user rubs their hands or when it is applied on a surface.The gel-like composition releases a liquid of appropriate consistency to be smeared on the hands, still not dripping.This gel-like composition with at least 60% by volume of alcohol provides an effective disinfectant that does not leave a sticky feeling once the alcohol has evaporated and is common to the said alcoholic gels. they use thickening and gelling agents that have been commonly used in pasta during single or multiple The gel-like composition does not easily obstruct the dispenser as common gel products do. The alcohol used in the present invention is a lower hydrocarbon chain alcohol such as an alcohol of 1 to 4 carbon atoms. The preferred alcohol is selected from ethanol, 2-propanol, or n-propanol, more preferably hydrogen, well accepted by the health personnel
as an adequate disinfection in the correct porcenlajes. The invention suggests that a single alcohol or a mixture of two or more alcohols can be used to contain the alcohol content of the composition either for a foamable or gel product.
Foamable compositions One of the main achievements of the present invention is to prepare compositions with an alcohol content greater than 40% v / v able to be dispersed as a cosmetic foam cosmetically. The other important achievement is to obtain an alcoholic gel without using the typical gelling agents known to those skilled in the art that do not obstruct the dispenser or leave a sticky feeling. The use of a fluorinated surfactant is the key ingredient as the primary foaming agent in the composition designed for foaming described herein. Fluorinated surfactants have several interesting properties, such as leaving little residue, which are capable of functioning in discordant and thermal chemical environments.; They have an unparalleled wetting power, etc. Unlike traditional surfactants, they show properties of activating unusual surfaces in organic solvents that are known to those skilled in the art, and which have made them widely used for applications in coatings, in the field of oils, finishing materials, cleaning, paintings, etc. The fluorinated surfactants suitable for these types of
The compositions may include, but not be limited to, ethyloxylates, glycerol esters, amine oxides, alcoholic acetylenic derivatives, carboxylates, phosphates, carbohydrate derivatives, sulfonates, betaines, esters, polyamides, silicones, and hydrocarbon surfactants which have been fluorinated and which they are compatible with the other components that are used for a particular formulation. A fluorinated surfactant is polytetrafluoroethylene aceyoxypropyl beiraine CF3CF2 (CF2CF2) nCH2CH2 (OAc) CH2N + (CH3) 2CH2COO- where n = 2-4.
However, it was contemplated that other fluorinated surfactants may be used which include as non-limiting examples for use in the present invention an ethoxylated non-ionic fluorinated surfactant of the following structure:
RfCH2CH2O (CH2CH2O) xH where Rf = F (CF2CF2) y, x = 0 to approximately
e y = 1 to approximately 7; an anionic fluorinated surfactant phosphate of the following structure: (RfCH2CH20) xP (O) (ONH) and where Rf = F (CF2CF2) z, x = 1 or 2, y = 2 or 1, x + y = 3, and z = 1 to about 7 or mixtures thereof. Surprisingly it was found that despite the characteristics of the fluorinated surfactants there is little or no information about their use to produce a foamable product with high alcohol content other than one that uses non-ionic fluorinated surfactants and pressurized gas as a foam former as disclosed in United States Patent No. 4,440,653. In addition, in order to obtain a product with a high content of
alcohol able to produce a foam even if propellant or pressurized containers are not used would require values of surface tension as low as possible so that the pressure required to produce said foam by means of manual pumps and mechanical means would be sufficient. Consequently, surface tension values of less than 20 dynes / cm (0.01% DW at 25 ° C) achievable with these ionosurfactants make them suitable for application. During the development of the present invention it was unexpectedly found that an aerated foam of rapid disintegration could still be obtained when only ethanol and the fluorinated surfactant are used, while using the traditional surfactants in still twice the percentage give results that could not be even slightly similar and no foam could be obtained. In order to achieve a commercially suitable formulation, reduce the amount of fluorinated surfactant used while using the aid of other ingredients such as secondary surfactants, emulsifiers, foam stabilizers, fragrances, and similar ingredients used in cosmetics, aerosols, products. of toilet, personal care products, etc., is one of the procedures followed. One of the commercial products obtained uses emulsifiers and polyethoxylated fatty acid surfactants described in USPatent Nos. 5,167,950 and 6,090,395, while other examples use a combination of different foam stabilizers to achieve a
similar result. Examples of secondary surfactants which may be used in the compositions herein include alkyl glucosides, a poly (ethoxylated and / or propoxylated) alcohol, a poly (ethoxylated and / or propoxylated) ester, a derivative of a poly (ethoxylated and or propoxylated), a derivative of a poly (eioxylated and / or propoxylated ester, an alkyl alcohol, an alkenyl alcohol, an ester of a polyhydric alcohol, an ether of a polyhydric alcohol, an ester of a polyalkoxylated derivative of a polyhydric alcohol , an ether of a polyalkoxylated derivative of a polyhydric alcohol, an ester of a sorbitan fatty acid, a polyalkoxylated derivative of a sorbitan fatty acid ester, a betaine, a sulfobetaine, imidazoline derivatives, amino acid derivatives, lecithins, phosphatides , some amine oxides and sulfoxides and mixtures thereof, present in a range of from about 0.10% to about 5% by weight. amidopropyl betaine A preferred alkyl glucoside is cocoglucoside. Preferred polyethoxylated fatty alcohols are polyethoxylated stearyl alcohol (21 moles of ethylene oxide) and polyaryoxylated stearyl alcohol (2 moles of ethylene oxide), and a combination of these two. The compositions may include an antimicrobial agent. The following antimicrobials are offered as non-limiting examples of antimicrobials suitable for use in the present invention and may include the chlorhexidine salt, iodine, a complexed form of iodine,
parachloromethaxyleneol, triclosan, hexachlorophene, a phenol, a surfactant having a long chain hydrophobic group and a quaternary group, hydrogen peroxide, silver, a silver salt, silver oxide, and mixtures thereof. A preferred antimicrobial agent in the compositions herein is chlorhexidine gluconate (CHG) present in a volume of about 0.50% to about 4.0% by weight. Another preferred antimicrobial agent is didecyldimethyl diammonium chloride in a volume of about 0.05% to 5% by weight. If the quantity of ingredients used is insufficient to not leave a sticky feeling after the composition evaporates after a single use or multiple uses, and this is achieved provided that at least the concentration of 60% v / v is maintained of ethanol or of n-propanol or 70% v / v of isopropanol, then the composition would be ideal for use as a foamable disinfectant / alcoholic hand sanitizer composition. The addition of water to alcohol produces a more stable foam while reducing the amount of fluorinated surfactant required to foam the product. For example, using 0.5 to 1.0% fluorinated surfactant with 50 to 60% v / v water alcohol solution produces a stable foam that does not easily collapse and that produces a stable discharge that does not fall even when reversed and does not It collapses until pressure is applied (such as when rubbed on hands or on a surface) to provide an alcoholic liquid solution.
The use of a non-irritating mild surfactant widely used in the cosmetics industry such as cocoamidopropyl betaine as a secondary surfactant is more suitable for preparing the foamable hydroalcoholic composition of the present invention depending on the fluorinated surfactant being used. In order to stabilize the foam, foam stabilizers as well as emulsifying ingredients have been tried with good results by allowing the product to be distributed as a foam when pressurized and / or propellant container systems are not used. Examples of compatible foam stabilizers which may be optionally employed include lactic acid esters of monoglycerides, cationic emulsifiers, tricquaternized stearic phospholipid complex, propyltriamine hydroxystearamide salts, lactic acid monoglycerides, food emulsifiers such as glyceryl monostearate, propylene glycol monostearate , sodium stearoyl lactylate, silicone wax, an encapsulated oil, Microcapsule Mineral Oil®. A preferred foam stabilizer used in the foamable compositions herein is cetyl beiraine. A preferred combination of foam stabilizers is that of butylene glycol, buioxyethanol and n-propanol. Examples of humectants and / or emollients that can be used in the formulations herein include lanolin, vinyl alcohol, polyvinyl pyrrolidone and polyols selected from the group consisting of glycerol,
propylene glycol, glyceryl oleate and sorbitol, cocoglucoside or a fatty alcohol selected from the group consisting of cetyl alcohol, esarylic alcohol, lauryl alcohol, myristyl alcohol and palmityl alcohol, cetyl alcohol, ceyarethyl 20, and combinations thereof, present in a amount up to about 5%. Examples of emulsifier that can be used in the compositions of the present invention include a mixture of cetyl ethers of polyethylene oxide having an average of about 20 oxide units. The compositions may include an acid or a base to adjust the pH of the composition to a pre-selected pH. The acid or base may be present in an amount from about 0.05 to about 0.5% by weight of the total composition. Non-limiting examples of the acid used to adjust the pH include hydrochloric acid, citric acid and phosphoric acid, and a non-limiting example of the base used to adjust the pH include sodium sesquicarbonate. The compositions may also include a preservative in an amount from about 0.01 to about 5% by weight of the total composition. Compositions formulated to be distributed as a foam may be stored in a non-pressurized dispenser having a distributor pump for mixing the composition with air and distributing the foam therefrom. The composition may include an aerosol propellant in
an amount from about 3 to about 20 weight percent of the total composition for pressurized discharge of the foam. The aerosol propellant may include propane, carbon dioxide, butane, dichloro difluoro methane, dichloro tephra fluoro ethane, octafluoro buffalo; 1,1,1,1-tetrafluoroethane; 1, 1, 1, 2,3,3,3 hepiafluoropropane, and 1,1,1,3,3-hexafluoropropane. When stored in a metallic container with propellant, the formulation may include a corrosion inhibitor such as sorbic acid, benzoic acid, potassium sorbate and potassium benzoate, in an amount from about 0.1 to about 5 weight percent of the composition total.
Gel-like compositions Some of the compositions studied had some gel-like properties. These characteristics led to the second most important achievement of the present invention; this is an alcohol gel with viscosities less than 4,000 cps that do not use conventional polymeric thickeners (ie, cellulose derivatives, carbomers, etc.) that are known to leave a sticky residue on the surface in multiple or unique applications that increase. This discourages users and tends to obstruct distributors. In order to prepare a gel-like composition, a fluorinated surfactant is not required to form a gel, however, using a small amount improves the subsequent feel, it also allows one
reduce the use of other required surfactants, therefore improving the results of the composition. The use of the fluorinated surfactant also significantly improves the exteridability of the disinfectious gel composition on the hands or a surface. The following is a basic formulation of the gel-like composition, an alcohol of 1 to 4 carbon atoms or mixtures thereof, present in an amount greater than about 40% v / v, one or more surfactants present in an amount of range from about 0.10% to about 5% by weight, an emulsifier present in a quantity of from about 0.10% to about 3.0% by weight, and water in an amount sufficient to form a stable gel-like composition. Non-limiting examples of nonionic surfactants include poly (ethoxylated and / or propoxylated) alcohol, a poly (ethoxylated and / or propoxylated) ester, a derivative of a poly (ethoxylated and / or propoxylated) alcohol, a derivative of a poly ( ethoxylated and / or propoxylated), an alkyl alcohol, an alkenyl alcohol, an ester of a polyhydric alcohol, an ether of a polyhydric alcohol, an ester of a polyalkoxylated derivative of a polyhydric alcohol, an ether of a polyalkoxylated derivative of a polyhydric alcohol , a fatty acid ester of sorbitan, a polyalkoxylated derivative of a sorbitan fatty acid ester, and mixtures thereof. A preferred nonionic nonionic agent includes polyethoxylated fatty alcohols such as polyethoxylated stearyl alcohol (21 moles of ethylene oxide) and polyethoxylated stearyl alcohol (2 moles of ethylene oxide), and / or
a combination of polyethoxylated fatty alcohols. To make gel-like compositions for personal care applications, the compositions may include a physiologically acceptable fluorinated surfactant to about 2.5%. A preferred fluororesensory agent is used in gel-like compositions, ie polytetrafluoroethylene acetoxypropyl betaine CF3CF2 (CF2CF2) nCH2CH2 (OAc) CH2N + (CH2) 2CH2COO-, where n = 2-4. Another fluorinated surfactant agent also preferred is a ethoxylated non-ionic fluorinated surfactant of the following structure: RfCH2CH2O (CH2CH2O) xH where Rf = F (CF2CF2) y, x = 0 to about 15 y = 1 to about 7 and yet another is an anionic fluorinated surfactant phosphate of the following structure: (RfCH2CH20)? P (O) (ONH4) and where Rf =
F (CF2CF2) Z, x = 1 or 2, y = 2 or 1, x + y = 3, and z = 1 to approximately 7 or mixtures thereof. The following non-limiting examples are set forth to illustrate the various preferred embodiments and in no way limit the scope of the present invention.
EXAMPLES
Examples 1 to 12 were prepared to illustrate the ability to produce alcohol-based formulations that can be distributed as foams using different surfactants and a 50% water solution.
of ethanol. Examples 13 through 18 show increasing concentrations of ethanol and of fluorinated surfactant to produce foam. Examples 19 to 30 illustrate the ability to produce foam using different surfactants and a 70% v / v solution of isopropanol. All parts and percentages are expressed by weight unless otherwise indicated.
(1) Amphoteric, (2) Non-ionic, (3) Anionic
(1) Amphoteric, (2) Non-ionic, (3) Anionic
(1) Amphoteric, (2) Non-ionic, (3) Anionic
The solutions prepared were evaluated to know if foam was produced or not, and if so, then the foam produced was as described below: Example Foam produced foam evaluation / Description / Characteristics Ex. 1 Yes Very good, stable, creamy, spongy, rigid and soft, lasted minutes Ex. 2 Not just very wet, the bubbles produced lasted < 10 seconds
Ex. 3 No Ex. 4 No Ex. 5 No Ex. 6 No Just very wet, the bubbles produced lasted < 7 seconds Ex. 7 No Just very wet, the bubbles produced lasted < 10 seconds
Ex. 8 No Ex. 9 No Just very wet, the bubbles produced lasted < 10 seconds
Ex. 10 No Ex. 11 No Ex. 2 No Ex. 13 Yes Very good, stable, creamy, fluffy, rigid and soft, lasted minutiae
Ex. 14 Yes Very good, creamy and soft, lasted minutes Ex. 15 Yes Very good, creamy, and soft, lasted minutes Ex. 16 Yes Very good, creamy, fluffy, and soft, lasted more than a minute Ex. 17 Yes Quick disintegrating foam lasted more than 15 seconds Ex. 18 Yes Rapid disintegrating foam lasted more than 10 seconds Ex. 19 Yes Rapid disintegrating foam lasted more than 20 seconds Ex. 20 No Ex. 21 No Ex. 22 No Ex. 23 No Ex. 24 No Ex. 25 No Ex. 26 No Ex. 27 No Ex. 28 No Ex. 29 No Ex. 30 No
In a comparative manner, it was also found that for example cocamidopropyl, betaine (CAPB) only still only 40% ethanol and 3% CAPB, was unable to produce as good results as those with 60% by volume of ethanol and fluorinated surfactants using much less percentage (less than 1.0%). Cocamidopropyl betaine does not give any acceptable foam above that percentage of alcohol and less than 60% v / v of the alcohol content makes it unsuitable for a sanitizing solution. Also the solution leaves an unacceptable feeling on the skin after the alcohol evaporates (ie a soapy sticky feeling) indicating high levels of lensing agent. Very interestingly, the fluorinated surfactants appeared to have a similar way of achieving a foaming composition that contains more than 40% v / v alcohol. The fact that the foam can be achieved even when no water was added was not used other than 95% v / v alcohol ingredients and the fluorinated surfactant as shown in Example 18 makes the present invention suitable for many different applications.
EXAMPLE 31 Alcoholic hand sanitizer sanitizing disinfectant composition
0. 01-1.0% * of anionic or nonionic fluorinated surfactant
amphoteric (primary surfactant) 0.01-1.0% cocamidopropyl betaine (secondary surfactant) 0.05-1.0% ceylal beiraine (foam foam agent) 0.10-1.5% alcohol ROH from 16 to 22 fatty carbon atoms 5 emulsifier or combination thereof work well in a final formulation containing 60-70% v / v ethanol cbp of water * Preferably polytetrafluoroethylene acefoxipropyl Beiraine
CF3CF2 (CF2CF2) nCH2CH2 (OAc) CH2N + (CH3) 2CH2COO-, where n = 2-4 or a
, schedule ethoxylated non-ionic fluorinated surfactant of the following structure:
RfCH2CH2O (CH2CH20) xH where Rf = F (CF2CF2) y, x = 0 to approximately
e y = 1 to approximately 7; or an anionic fluorinated surfactant phosphate of the following structure: (RfCH2CH2O) xP (0) (ONH4) and where Rf = h 15 F (CF2CF2) Z. x = 1 or 2, y = 2 or 1, x + y = 3, and z = 1 to about 7, or mixtures thereof.
EXAMPLE 32 Concentrated alcoholic composition foamable disinfectant 20 hand sanitizer
0. 01-1.0% * of anionic or nonionic fluorinated surfactant, amphoteric (primary surfactant)
0. 01-12.0% of 1,3-butylene glycol, 2-butoxyethanol, n-propanol (foam stabilizing agent) 0.05-5.0% cocoglucoside, glycerin, glyceryl oleate (humectants, emollients and the like) 60-70% by volume of efanol, n-propanol, isopropanol or a combination thereof cbp of water * Preferably an anionic fluorinated surfactant phosphate of the following structure: (RfCH2CH2O) xP (0) (ONH4) and where Rf = F (CF2CF2) z, x = 1 or 2, y = 2 or 1, x + y = 3, and z = 1 to approximately 7 or an agent
, anionic fluorinated ethoxylated surfactant of the following structure:
RfCH2CH2O (CH2CH2O) xH where Rf = F (CF2CF2) y, x = 0 to approximately
e y = 1 to approximately 7; or polytearyfluoroethylene acetoxypropyl beiraine
CF3CF2 (CF2CF2) nCH2CH2 (OAc) CH2N + (CH3) 2CH2-COO-, where n = 2-4, or mixtures thereof.
EXAMPLE 33 Alcoholic composition sanitizing foaming hand sanitizer
a) olhanol present in amounts of about 60% to 70% v / v of the total composition; b) a phosphate agent anionic fluorinated surfactant acceptable
physiologically in an amount from about 0.01% to about 2.0% by weight of the total composition; c) at least 1% n-propanol d) foam stabilizing agents that include at least 1, 3-butylene glycol, butoxyethanol at 0.001 - 3% ea. e) an enhancer of the lipid layer such as a mixture of alkyl glycoside and glyceryl oleate f) water in an amount to balance the total composition to 100% by weight.
EXAMPLE 34 Alcoholic composition sanitizing foaming hand sanitizer & Chlorhexidine gluconate (CHG)
Formulations 31 or 32 added with 0.50-4.0% chlorhexidine gluconate (CHG)
EXAMPLE 35
Formulations 31 or 32 added with 0.01-5.0% didecyl dimethyl diammonium chloride
EXAMPLE 36 Alcoholic disinfectant composition similar to sanitizing gel for hands with a viscosity less than 4,000 cps
0. 0-1.0% * of anionic or non-ionic fluorinated surfactant, amphoteric (primary surfactant) 0.10-2.0% of a wetting and / or emollient emulsifier preferably a nonionic surfactant and / or a combination of cetearyl alcohol and Cerealis 20 or a combination thereof to give a composition with a viscosity of less than 4,000 cps; s 0.50-4.0% of a combination of tensioactive agents not
Specifically from the group of polyethoxylated fatty alcohols 60-70% v / v ethanol c.b.p. of water * Preferably polytetrafluoroethylene acetoxypropyl betaine
CF3CF2 (CF2CF2) nCH2CH2 (OAc) CH2N + (CH3) 2CH2COO-, where n = 2-4 or an ethoxylated non-ionic fluorinated surfactant of the following structure: RfCH2CH2O (CH2CH2O) xH where Rf = F (CF2CF2) y, x = 0 at about 15 ey = 1 to about 7; or an anionic fluorinated surfactant phosphate of the following structure: (RfCH2CH2O) xP (O) (ONH4) and where Rf = F (CF2CF2) z, x = 1 or 2, y = 2 or 1, x + y = 3, yz = 1 to about 7, or mixtures thereof. The process for preparing the compositions herein
The invention described here is straightforward since most of the ingredients are liquid. When wax-like ingredients are used, they can be incorporated by heating to 40-45 ° C, preferably in the alcoholic portion while mixing and then allowing it to cool or they could be added in "cold", at room temperature to the alcohol before any other ingredients. and mixed hasíacorporación complemented anís to add the rest of the ingredients according to the composition. Whether or not all the ingredients are liquid or not, heating from 30 to 80 degrees Celsius, (depending on the particular composition) increases the long-term stability of the compositions. The active ingredients could be pre-dissolved in the water first. A procedure that someone with sufficient knowledge in the art would have no problem in implementing. If you can not adjust a specific formulation for the foamable composition in the percentages of the ingredients, there is still the option of modifying the characteristics of the foam forming pump, such as changing pressures, sieve size, etc. The compositions described in the present invention improve on the prior art products commercially available in high concentrations of alcohol, as well as in the fact of being able to "foam even without propellants or pressurized containers (the use of propellants could considerably improve the foam quality) and be able to produce alcohol-like gel compositions that do not leave a subsequent feeling of stickiness that increases and does not obtrude
distributors after a single application or multiple applications. Depending on the concentration of alcohol and the application of the particular composition, the foam produced can vary widely, being at the upper end of a variety of relatively fast disintegration sufficiently stable to be smeared perfectly on the skin without waste in a unique manner and the viscosity of the gel-like composition varies with the concentration of alcohol. The gel-like composition obtained is a unique process that does not follow the traditional ways of making alcoholic gels. In summary it could be said that the established invention has exceeded expectations. Due to the nature of the base composition with respect to the concentration of alcohol and the quality of the ingredients, one of the first logical applications for the present invention would be as an alcoholic hand sanitizer composition either for a foamable product or for a gel-like alcohol product, examples of which were described above. However, the present invention itself leads to the preparation of a wide variety of products, and it is understood that other embodiments may be used and changes may be made without departing from the scope of the invention. Accordingly, it is intended that the claims be interpreted to cover said modifications and equivalents. As a brief observation, the following may be mentioned: medicated foams and gels, foams and sunscreen gels, cream foams for
hands, cream foams for shaving without a brush, oily foams for bath or shower, foams for dry shampoo for hair, makeup foams, gels and rubs in analgesic foams, foams for hair care and foams for hair cleaning and antiperspirants, antiperspirant foam, hair conditioning foams. As used herein, the terms "comprises", "comprising", "includes" and "including" were constructed as being of an open and inclusive, and not exclusive, purpose, specifically when used in this specification including the claims, the terms "comprises", "comprising", "includes" and "including" and variations thereof mean that the specific aspects, steps or components are included. These terms are not interpreted to exclude the presence of other aspects, stages or components. The above description of the preferred embodiments of the invention has been presented to illustrate the principles and not to limit the invention to the particular embodiment illustrated. It is intended that the scope of the invention is defined by all of the embodiments encompassed by the following claims and their equivalents.
References Cited U.S. Patent Documents 2, 054, 9899/1936 Moore 167/58
3, 131, 1534/1964 Klausner 252/305 3, 962, 1506/1976 Leonard et al. 252/542 4, 440, 6534/1984 James et al. 252/8. 55 5, 167, 950 12/1992 Lins 424/47 4, 956, 170 09/1990 Lee 514 / 772.1 5, 629, 0065/1997 Minh et al. 424/405 5, 906, 8085/1999 Osborne, et al 424 / 43 5, 928, 9937/1999 Ingegárd 504/116 5, 951, 993 09/1999 Scholz et al. 424/405 6, 090, 395 07/2000 Asmus et al. 424/401 6, 610, 315 08/2003 Scholz and collaborators 424/415 6, 623, 744 09/2003 Asmus et al. 424/401 6, 562, 360 05/2003 Scholz et al. 424/405
Other publications Myers, Drew; "Surfactant Science and Technology", second edition, Drew Myers, VCH Publishers, New York, 1992 Reduces Tension Dupont Zonyl® Fluorosurfactants Field Manual published by Dupont Co. in May 2001.
Claims (147)
- NOVELTY OF THE INVENTION CLAIMS i 1. - An alcoholic composition foamable under low pressure when mixed with air at low pressure, characterized in that it comprises: a) an alcohol of 1 to 4 carbon atoms or mixtures thereof, present in an amount greater than about 40% v / v of the total composition; b) an effective fluorinated surfactant for wetting and foaming present in an amount of at least 0.001 percent by weight of the total composition; and c) water present in an amount to balance the total composition to 100% by weight.
- 2. The composition according to claim 1, including air, further characterized in that when the composition is mixed with air, the mixture of the composition and air forms a foam.
- 3. The composition according to claim 1 or 2, further characterized in that the effective fluorinated surface active agent is a fluorinated surfactant present in an amount from about 0.001% to about 10.0% by weight of the total composition.
- 4. The composition according to claim 1, 2 or 3, further characterized in that the effective fluorinated surface active agent is a physiologically acceptable fluorinated surfactant, and wherein the Fluorinated surfactant is selected from the group consisting of fluorinated ethoxylates, glycerol esters, aminated oxides, acetylenic alcohol derivatives, carboxylates, phosphates, carbohydrate derivatives, sulphonates, beiaines, esters, polyamides, silicones, and hydrocarbon surfactants.
- 5. The composition according to claim 1, 2, 3 or 4, further characterized in that the alcohol of 1 to 4 carbon atoms is an aliphatic alcohol selected from the group consisting of methanol, ethanol, isopropanol, n-propanol, butanol and combinations thereof.
- 6. The composition according to claim 1, 2, 3, 4 , or 5, further characterized in that the fluorinated surfactant is an amphoteric polytetrafluoroethylene acetoxypropyl betaine (CF3CF2 (CF2CF2) nCH2CH2 (OAc) CH2N + (CH3) 2CH2COO-) where n = 2 to 4.
- 7. The composition according to claim 1, 2, 3, 4 or 5, also characterized in that the fluoridated fluorescent agent is an ethoxylated nonionic fluorinated surfactant agent of the following structure: RfCH2CH2O (CH2CH2O) xH where Rf = F (CF2CF2) y, x = 0 to approximately 15, e y = 1 to approximately 7.
- 8. The composition according to claim 1, 2, 3, 4 or 5, further characterized in that the fluorinated surfactant is a phosphate anionic surfactant of the following structure: (RfCH2CH2O) xP (O) (ONH4) and where Rf = F (CF2CF2) Z, x = 1 or 2, y = 2 or 1, x + y = 3, and z = 1 to about 7 or mixtures thereof. 9. - The composition according to claim 1, 2, 3, 4 or 5, further characterized in that the fluorinated surfactant is a mixture of two or more of the fluorinated agents in claims 6,7 and ß. 10. The composition according to claim 1, 2, 3, 4, 5, 6, 7, 8 or 9, further characterized in that the alcohol is present in a range from about 40% to about 90% v / v. 11. The composition according to claim 1, 2, 3, 4, 5, 6, 7, 8 or 9, further characterized in that the alcohol is ethanol present in an amount of at least 60% v / v, and in where the composition is for use as an alcoholic foam for personal hygiene. 12. The composition according to claim 1, 2, 3, 4, 5, 6, 7, 8 or 9, further characterized in that the alcohol is a mixture of n-propanol and ethanol present in a combined amount of at least 60% v / v, and wherein the composition is for use as a Alcoholic foam for personal hygiene. 13. The composition according to claim 1, 2, 3, 4, 5, 6, 7, 8 or 9, further characterized in that the alcohol is a mixture of isopropanol and ethanol present in a combined amount of at least 60% v / v, and wherein the composition is for use as an alcoholic foam for personal hygiene. 14. The composition according to claim 1, 2, 3, 4, 5, 6, 7, 8 or 9, further characterized in that the alcohol is isopropanol present in an amount of at least 70% v / v, and wherein the composition is for use as an alcoholic foam for personal hygiene. 15. The composition according to claim 1, 2, 3, 4, 5, 6, 7, 8 or 9, further characterized in that the alcohol is n-propanol present in an amount of at least 60% v / v, and wherein the composition is for use as an alcoholic foam for personal hygiene. 16. The composition according to claim 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 or 15, further characterized in that it includes at least one additional surfactant to adjust the properties of the foam produced from the composition. 17.- The composition according to claim 16, further characterized in that the additional tensioacíivo agent is selected from the group consisting of poly alcohol (eíoxilado and / or propoxylated), polyethylene, ester derivative (ethoxylated and / or propoxylated) a poly alcohol (ethoxylated and / or propoxylated), a derivative of a poly ester (ethoxylated and / or propoxylated), an alkyl alcohol, an alkenyl alcohol, an esier of a polyhydric alcohol, an ether of a polyhydric alcohol, an ester of a polyalkoxylated of a polyhydric alcohol derivative, an ether of a polyalkoxylated derivative of a polyhydric alcohol, a fatty acid ester of sorbitan, a polyalkoxylated derivative of a esier fatty acid sorbiían an alkylglycoside a beíaína a sulfobeíaína, a derivative of imidazoline, an amino acid derivative, a lecithin, a phosphatide, an amine oxide, a sulfoxide and mixtures thereof, present in an amount of between about 0.10% a about 5% by weight. 18. The composition according to claim 17, further characterized in that the betaine is cocamidopropyl betaine. 19. The composition according to claim 17, further characterized in that the alkylglucoside is cocoglucoside. 20. The composition according to claim 17, further characterized in that the polyethoxylated fatty alcohol is polyethoxylated stearyl alcohol (21 moles of ethylene oxide). 21. The composition according to claim 17, further characterized in that the polyethoxylated fatty alcohol is polyethoxylated stearyl alcohol (2 moles of ethylene oxide). 22.- The composition according to claim 17, further caracíerizada because the polyethoxylated fatty alcohol is a combination of polyethoxylated stearyl alcohol (21 moles ethylene oxide) and polyethoxylated stearyl alcohol (2 moles ethylene oxide). 23. The composition according to claim 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21 or 22, further characterized in that it includes a foam stabilizing agent present in a quantity of up to 5%. 24.- The composition according to claim 22, further characterized in that the foam stabilizing agent is selected from the group consisting of lactic acid esters of monoglycerides, cationic emulsifiers, phospholipid complexes íricuaíemizados stearic, salts propiltriamina hydroxystearamide, monoglycerides lácíico acid, food emulsifiers selected from the group of monoesíearaío consisíe glyceryl monoestearaío glyco !, propylene sodium stearoyl lactylate and cetyl betaine, glycol ether, n-propanol, butylene glycol, wax of silicone, an encapsulated oil, Microcapsule Mineral Oil®, and combinations thereof. 25. The composition according to claim 23, further characterized in that the foam stabilizing agent is selected from the group consisting of glycol ether, n-propanol, butylene glycol, and combinations thereof. 26. The composition according to any one of claims 1 to 25, characterized in that it includes any one of a humectant, emollient and combinations thereof selected from the group consisting of lanolin, vinyl alcohol, polyvinyl pyrrolidone and polyols selected from the group consisting of glycerol, propylene glycol, buleyylene glycol and sorbiol, and a fatty alcohol, selected from the group consisting of cetyl alcohol, stearyl alcohol, lauryl alcohol, myristyl alcohol and palmityl alcohol, ceilic alcohol, celerare 20, an alkyl glucoside and combinations thereof, present in a hasia of 5%. 27. The composition according to any one of claims 1 to 26, further characterized in that it comprises an acid or base for adjusting a pH of the composition to a preselected pH present in an amount from about 0.05 to about 0.5% in weight of the total composition. 28. The composition according to claim 27, further characterized in that when an acid is used to adjust the pH, the acid is selected from the group consisting of hydrochloric acid, citric acid and phosphoric acid, and that when a base is used To adjust the pH, the base is sodium sesquicarbonate. 29. The composition according to any one of claims 1 to 28, further characterized in that it includes a preservative in an amount from about 0.01 to about 5% by weight of the total composition. 30. The composition according to any one of claims 1 to 29, further characterized in that it includes an antimicrobial agent. 31. The composition according to claim 30, further characterized in that the antimicrobial agent is chlorhexidine gluconate present in an amount of between about 0.50% to about 4.0% by weight. 32. The composition according to claim 30, further characterized in that the antimicrobial agent is didecyl dimethyl diammonium chloride present in an amount of between about 0.05% to about 5.0% by weight. 33. The composition according to claim 30, characterized in that the antimicrobial agent is selected from the group of a salt of chlorhexidine, iodine, a complexed form of iodine, for chloromethaxylenol, iriclosane, hexachlorophene, a phenol, an isoensive agent having a long chain hydrophobic group and a quaternary group, hydrogen peroxide, silver, a silver salt, silver oxide, and mixtures thereof. 34. The composition according to any one of claims 1 to 33, further characterized in that it comprises constituents selected from the group consisting of gums and organic colloids, lower alkanolamides of higher fatty acids, diols and / or short-chain friol, fragrance. , colorant matter, ultraviolet absorbers, solvents, suspending agents, pH regulators, conditioning agents, antioxidants, bactericides and medicinally active ingredients, and combinations thereof. The composition according to any one of claims 1 to 34, further characterized in that it is stored in a non-pressurized distributor having a distributor pump to mix the composition with air and distribute foam therefrom. 36.- The composition according to any one of claims 1 to 34, further characterized in that it is stored in a pressurized distributor having a distributor pump for mixing the composition with air or a propellant and distributing therefrom the composition including a propellant of aerosol in an amount from about 3 to about 20 weight percent of the total composition. 37.- The composition according to claim 36, further characterized in that the aerosol propellant is selected from the group consisting of propane, carbon dioxide, butane, dichloro difluoro methane, dichloro teraphthalene ethane, octafluorocyclobutane, 1, 1, 1. , 2-pyrrolidone, 1, 1, 1, 2, 3,3,3-heptafluoropropane, and 1,1,1,3,3-hexafluoropropane. 38.- The composition according to claim 36 or 37, further characterized in that it includes a corrosion inhibitor which is selected from the group consisting of sorbic acid, benzoic acid, potassium sorbate and sodium benzoate, in an amount from about 0.1 to about 5 weight percent of the total composition. 39. A concentrated foamable alcoholic composition under low pressure when mixed with low pressure air, characterized in that it comprises: a) an anionic or nonionic, amphoteric fluorinated surfactant present in an amount from about 0.01 to about 1.0%; b) a foam scouring agent that includes at least about 0.01 to about 12.0% n-propanol; c) one of the humecides, emollients and combinations thereof present in a range from about 0.05% to about 5.0%; and d) water. 40.- The concentrated composition according to claim 39, further characterized in that the fluorinated anionic or nonionic surfactant agent, amphoteric is phosphate fluorinated surfactant anionic of the following structure: (RfCH2CH20) xP (0) (ONH) and where Rf = F (CF2CF2) Z, x = 1 or 2, y = 2 or 1, x + y = 3, and z = 1 to approximately 7 or a non-ionic fluorinated ethoxylated surfactant of the following structure: RfCH2CH2O (CH2CH2?) xH where Rf = F (CF2CF2) y, x = 0 to about 15 ey = 1 to about 7; or polytetrafluoroethylene acetoxypropyl betaine CF3CF2 (CF2CF2) nCH2CH2 (OAc) CH2N + (CH3) 2CH2COO-, where n = 2-4, or mixtures thereof. 41. The concentrated composition according to claim 39 or 40, further characterized in that the foam stabilizing agent includes 1,3-butylene glycol and 2-butoxyanol. 42. The composition according to claim 39, 40 or 41, further characterized in that the humecells and emollients include glycoloside, glycerin and glyceryl oleate. 43.- The concentrated composition according to claim 39, 40, 41 or 42, further characterized in that it is -constituted as an alcoholic disinfectant composition by addition of: a) an alcohol of 1 to 4 carbon atoms or mixtures thereof , present in an amount of between about 60 to about 80% v / v of the total composition; c) water present in an amount to balance the total composition to 100% by weight. 44. The concentrated composition according to claim 43, further characterized in that the alcohol of 1 to 4 carbon atoms is selected from the group consisting of eneol, n-propanol, isopropanol, and combinations thereof. 45. The composition according to any one of claims 39 to 44, further characterized in that it is prepared by means of a process of mixing the consfifuyeníes and then heating the concentrate at a temperature of between approximately 30 to approximately 80 degrees Celsius before shipping the concentrate. 46.- An alcoholic disinfectant composition foamable under low pressure when mixed with air at low pressure, characterized in that it comprises; a) an alcohol of 1 to 4 carbon atoms or mixtures thereof, present in an amount of about 60% to about 80% v / v of the total composition; b) a physiologically acceptable fluororesensitive agent present in an amount of at least 0.01% to about 2.0% by weight of the ionic composition; c) a foam stabilizing agent present in an amount from about 0.01 to about 12.0% by weight; d) any one of the humectants, emollients and combinations thereof present in an amount from about 0.05 to about 5.0%) by weight; and e) water in an amount to balance the total composition to 100% by weight. 47. The alcoholic disinfectant composition according to claim 46, further characterized in that it includes air, because when the disinfecting composition is mixed with air, the mixture of the composition disinfects and the air forms the foam. 48.- The disinfecting alcoholic composition in accordance with claims 46 or 47, further characterized in that the fluorinated surfactant is a polytetrafluoroethylene acetoxypropyl betaine (CF3CF2 (CF2CF2) n CH2CH2 (OAc) CH2N + (CH3) 2CH2COO-) where n = 2 to 4. 49.- The alcoholic disinfectant composition of according to claim 46 or 47, further characterized in that the fluorinated surfactant is an ethoxylated non-ionic fluorinated surfactant of the following structure: RfCH2CH2O (CH2CH2O) xH where Rf = F (CF2CF2) y, x = 0 to about 15 ey = 1 to about 7. 50.- The alcohol disinfectant composition according to claim 46 or 47, further characterized in that the fluorinated surfactant agent is an anionic fluorinated ionosurfactant phosphate of the following structure: (RfCH2CH2O) xP (O) (ONH4) and where Rf = F (CF2CF2) Z, x = 1 or 2, y = 2 or 1, x + y = 3, and z = 1 to about 7. 51.- The alcohol disinfectant composition according to claim 46 or 47, further characterized in that the fluorinated surfactant is selected from the group consisting of fluorinated efoxylaminos, glycerol esters, amine oxides, acetylenic alcohol derivatives, carboxylates, phosphates, carbohydrate derivatives, sulfonates, beiaines, esters, polyamides, silicones, surfactants of hydrocarbon, and a mixture of two or more of the fluorinated surfactants of claims 47, 48 and 49. 52. The alcoholic disinfectant composition according to claim 46, 47, 48, 49, 50 or 51, further characterized because the foam stabilizing agent is selected from the group consisting of lactic acid esters of monoglycerides, cationic emulsifiers, tricuaternized stearic phospholipid complex, hydroxystearide propyltriamine salts, monoglycerides of lactic acid, food emulsifiers selected from the group consisting of glyceryl monostearate, monostearate of propylene glycol and sodium stearoyl lactylate, silicone wax, an encapsulated oil, Microcapsule Mineral Oil®, butylene glycol, butoxiefanol and n-propanol, and mixtures thereof. 53. The alcohol composition disinfects according to any one of claims 46, 47, 48, 49, 50 or 51, further characterized in that the foam stabilizing agent is selected from the group consisting of butoxyethanol, glycolic acid, n-propanol , butylene glycol, and combinations thereof. 54.- The disinfecting alcohol composition according to claims 46, 47, 48, 49, 50, 51, 52, or 53, also characterized in that it includes any one of a humectant, emollient and combinations thereof selected from the group consisting of of lanolin, vinyl alcohol, polyvinyl pyrrolidone and polyols selected from the group consisting of glycerol, propylene glycol, butylene glycol and sorbitol, and a fatty alcohol selected from the group consisting of cetyl alcohol, stearyl alcohol, lauryl alcohol, myristyl alcohol and palmiyl alcohol , ceilyl alcohol, cephearel 20, an alkyl glucoside and combinations thereof, present in an amount of up to 5%. 55. - The alcohol disinfectant composition according to claim 46, 47, 48, 49, 50, 51, 52 or 53, further characterized in that it includes a humectant and an emollient selected from the group consisting of glyceryl oleate, glycerin, cocoglucoside and combinations thereof. 56.- The disinfecting alcohol composition according to claim 46, 47, 48, 49, 50, 51, 52, 53, 54 or 55, further characterized in that it includes an animicrobial agent. 57. The disinfecting alcohol composition according to claim 56, further characterized in that the antimicrobial agent is chlorhexidine gluconate present in a volume of about 0.50 to about 4.0% by weight. 58.- The alcohol disinfectant composition according to claim 56, further characterized in that the antimicrobial agent is Didecyl Dimethyl Diammonium Chloride present in an amount of between about 0.50% to about 5.0% by weight. 59.- The alcohol disinfectant composition according to claim 56, further characterized in that the antimicrobial agent is selected from the group consisting of a salt of chlorhexidine, iodine, a complex form of iodine, parachloromethaxylenol, triclosan, hexachlorophene, a phenol, a surfactant agent having a long chain hydrophobic group and a quaternary group, hydrogen peroxide, silver, a silver salt, silver oxide, and mixtures thereof. 60. - The alcohol disinfectant composition according to any one of claims 46 to 59, further characterized in that it includes a preservative in an amount from about 0.01 to about 5% by weight of the total composition. 61.- The alcohol disinfectant composition according to any one of claims 46 to 60, further characterized in that it comprises an acid or a base for adjusting a pH of the disinfectant composition to a pre-selected pH present in a quantity from about 0.05. to approximately 0.5% by weight of the total composition. 62.- The disinfectant alcohol composition according to claim 61, further characterized in that the acid is selected from the group consisting of hydrochloric acid, citric acid and phosphoric acid, and the base is sodium sesquicarbonaio. 63.- The disinfecting alcoholic composition according to any one of claims 46 to 62, characterized in that it is stored in a non-pressurized dispenser that has a dissipative pump to mix the disinfectant composition with air and distribute foam from it. 64.- The disinfectant alcohol composition according to any one of claims 46 to 62, further characterized in that it is stored in a pressurized dispenser which has a distributor pump for mixing the disinfectant composition with air or with a propellant and distributing the foam therefrom, the disinfectant composition including an aerosol propellant in a quantity from about 3 to about 20 weight percent of the total composition. The alcoholic disinfectant composition according to claim 64, further characterized in that the aerosol propellant is selected from the group consisting of propane, carbon dioxide, butane, dichloro fluoro methane, dichloro tetra fluoroethane, octafluorocyclobutane; 1, 1, 1, 2- teirafluoroean; 1, 1, 1, 2,3, 3,3-heptafluoropropane, and 1,1,1,3,3-hexafluoropropane. 66.- The alcoholic disinfectant composition in accordance with , claim 64 or 65, further characterized in that it includes a corrosion inhibitor that is selected from the group consisting of sorbic acid, benzoic acid, potassium sorbate and sodium benzoate, in a quantity from about 0.1 to about 5 weight percent. of the ioíal composition. 67.- the disinfectant alcohol composition according to any of claims 46 to 66, further characterized in that it includes any one of a humectant, emollient and combinations thereof selected from the group consisting of lanolin, vinyl alcohol, polyvinyl pyrrolidone and polyols selected from the group consisting of glycerol, propylene glycol, butylene glycol and sorbitol, and a fatty alcohol selected from the group consisting of cefyl alcohol, stearyl alcohol, lauryl alcohol, myristyl alcohol and palmityl alcohol, cefearethyl 20, an alkyl glucoside and combinations thereof, present in an amount of up to 5%. 68.- The disinfectant alcohol composition according to any of claims 46 to 67, further characterized in that it comprises other constituents or materials that include organic gums or colloids, lower alkanolamides of higher fatty acids, short chain diols and / or triols, fragrance, coloring matter, additional emollients, ultraviolet ray absorbers, solvents, emulsifiers, foam stabilizers or mixtures of said stabilizers, suspension agents, pH regulators, conditioning agents, antioxidants, bactericides, and medicinal acid ingredients for aerosol compositions, toilet, cosmetics and pharmaceutical products. 69.- An alcoholic composition foamable disinfectant under low pressure when mixed with air at low pressure, characterized in that it comprises: a) ethanol present in an amount of about 60% to about 80% v / v of the total composition; b) a physiologically acceptable fluorinated surfactant or mixtures thereof, present in an amount of at least 0.01% to about 2.0% by weight of the total composition; c) at least one secondary surfactant is present in a range from about 0.01 to about 10.0%. in weigh; d) a foaming foam agent; and e) water in an amount to balance the total composition to 100% by weight. 70.- The alcoholic disinfectant composition according to claim 69, further characterized in that the surfactant fluorinated is a polytearyfluoroethylene aceyloxypropyl amphiphilic acid (CF3CF2 (CF2CF2) n CH2CH2 (OAc) CH2N + (CH3) 2CH2COO-) where n = 2 to 4. 71. The alcoholic composition disinfects according to claim 69, further characterized in that the agent Fluorinated surfactant is an ethoxylated nonionic fluorinated surfactant of the following structure: RfCH2CH2O (CH2CH2O) xH where Rf = F (CF2CF2) y, x = 0 to about 15 ey = 1 to approximately 7. 72.- The disinfecting alcoholic composition of according to claim 69, further characterized in that the fluorinated surfactant is phosphate anionic fluorinated surfactant. following structure: (RfCH2CH2O) xP (0) (ONH4) and where Rf = F (CF2CF2) z, x = 1 or 2, y = 2 or 1, x + y = 3, and z = 1 to approximately 7. «73 .- The alcoholic disinfectant composition according to claim 69, further characterized in that the fluorinated surfactant is selected from the group consisting of fluorinated ethoxylates, glycerol esters, amine oxides, acetylenic alcohol derivatives, carboxylates, phosphates, carbohydrate derivatives, sulfonates, betaines, esters, polyamides, silicones, and insensitivity agents of hydrocarbon, and mixtures of two or more of the fluorinated surfactants in claims 70, 71 or 72. 74.- The disinfectant alcohol composition according to claim 69, 70, 71, 72 or 73, further characterized in that the agent secondary surfactant is at least one selected from the group consisting of a poly (ethoxylated and / or propoxylated) alcohol, a poly (ethoxylated and / or propoxylated) ester, a derivative of a poly (eioxylated and / or propoxylated) alcohol, a derivative of a poly (ethoxylated and / or propoxylated) ester, an alkyl alcohol, an alkenyl alcohol, an ester of a polyhydric alcohol, an ether of a polyhydric alcohol, an ester of a polyalkoxylated derivative of a polyhydric alcohol, an ether of a polyalkoxylated derivative of a polyhydric alcohol, a fatty acid ester of a sorbitan, a polyalkoxylated derivative of a fatty acid ester of sorbifan, a beyain, a sulfobeiaine, an imidazoline derivative, an amino acid derivative, a lecithin, a phosphaide, an aminated oxide, a sulfoxide and mixtures thereof, present in an amount of between * about 0.10% to about 5% by weight. 75.- The alcoholic disinfectant composition according to claim 69, 70, 71, 72 or 73, further characterized in that the secondary surfactant agent is cocoamidopropyl beiraine. 76.- The disinfecting alcohol composition according to claim 69, 70, 71, 72, 73, 74 or 75, further characterized in that it includes an emulsifier or mixture of emulsifiers present in an amount of between about 0.10% to about 1.5% in weight. 77.- The disinfectant alcohol composition according to claim 76, further characterized in that the emulsifier is a mixture of ceyl ethers and polyethylene oxide esaryaric ethers having an average of about 20 oxide units. 78.- The alcoholic composition desinfectenle in accordance with claim 69, 70, 71, 72, 73, 74, 75, 76 or 77, further characterized in that the foaming agent is foam-beinated. 79. The alcohol disinfectant composition according to claim 69, 70, 71, 72, 73, 74, 75, 76, 77 or 78, further characterized in that it includes an animicrobial agent. 80.- The alcohol disinfectant composition according to claim 79, further characterized in that the antimicrobial agent is chlorhexidine gluconate present in an amount of between about 0.50% to about 4.0% by weight. 81. The alcohol disinfectant composition according to claim 79, further characterized in that the antimicrobial agent is didecyl dimethyl diammonium chloride present in a range of from about 0.50% to about 5.0% by weight. 82.- The disinfecting alcohol composition according to claim 81, further characterized in that the antimicrobial agent is selected from the group consisting of chlorhexidine salt, iodine, a complex formed of iodine, parachloromethylenol, triclosan, hexachlorophene, a phenol, an agent surfactant having a long chain hydrophobic group and a quaternary group, hydrogen peroxide, silver, a silver salt, silver oxide, and mixtures thereof. 83.- The alcoholic disinfectant composition according to any of claims 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81 or 82, characterized in that it includes a conservative in a amount from about 0.01 to about 5% by weight of the total composition. 84. The alcohol disinfectant composition according to any one of claims 69 to 83, further characterized in that it comprises an acid or a base for adjusting a pH of the disinfecting composition to a pre-selected pH, present in an amount from about 0.05. to about 0.5% by weight of the total composition. The alcoholic disinfectant composition according to claim 84, further characterized in that the acid is selected from the group consisting of hydrochloric acid, citric acid and phosphoric acid, and the base is sodium sesquicarbonate. 86.- The disinfectant alcohol composition according to any one of claims 69 to 85, further characterized in that it is stored in a non-pressurized dispenser having a distributor pump for mixing the disinfectant composition with air and distributing foam therefrom. 87.- The disinfecting alcohol composition according to any one of claims 69 to 85, characterized in that it is stored in a pressurized distributor that has a distributor pump to mix the disinfecting composition with air or propellant and dissipate foam from it, the disinfecting composition that includes a propellant - of aerosol in an amount from about 3 to about 20 percent by weight of the total composition. 88. The alcohol composition disinfect according to claim 87, further characterized in that the aerosol propelenle is selected from the group consisting of propane, carbon dioxide, buffalo, dichloro difluoro methane, dichloro tetra fluoro ethane, octafluorocyclobutane; 1, 1, 1, 2-teirafluoroean; 1, 1, 1, 2, 3, 3, 3, -heptafluoropropane, and 1, 1, 1, 3,3,3, -hexafluoropropane. 89. The disinfecting alcohol composition according to claim 87 or 88, further characterized in that it includes a corrosion inhibitor selected from the group consisting of sorbic acid, acid , benzoic, potassium sorbate and sodium benzoate, in an amount from about 0.1 to about 5 percent by weight of the ionic composition. 90.- The disinfecting alcohol composition according to any one of claims 69 to 89, further characterized in that it includes a humectant and / or emollient of the group consisting of lanolin, alkyl glucoside, vinyl alcohol, polyvinyl pyrrolidone and polyols selected from the group consisting of of glyceroi, propylene glycol, glyceryl oleate and sorbitol, and a fatty alcohol selected from the group consisting of cetyl alcohol, stearyl alcohol, lauryl alcohol, myristyl alcohol and palmityl alcohol, etheareth 20, and combinations thereof, present in an amount up to 5% by weight. 91.- The alcoholic disinfectant composition in accordance with any of claims 69 to 90, further characterized by comprising other constituents or materials including organic gums and colloids, lower alkanolamides of higher fatty acids, short chain diols and / or triols, fragrance, coloring matter, additional emollients, absorbents of ultraviolet rays, solvents, emulsifiers, foam stabilizers or mixtures of said stabilizers, suspending agents, pH regulators, conditioning agents, anlioxidanis, bactericides, and medicinal acid ingredients for aerosol compositions, toiletries, cosmetics and pharmaceuticals. 92. The alcohol composition disinfects concentrated in accordance with claim 43 or 44, also characterized because it is prepared by means of a procedure of mixing the constituents and then loading the concentrate, and just in time to reconstitute the concentrate with alcohol, Concentrated at an hour of between 30 to about 80 degrees. 93. An alcoholic composition similar to gel, characterized in that it comprises: a) an alcohol of 1 to 4 carbon atoms, or mixtures thereof, present in an amount greater than about 40% v / v of the total composition; b) at least one nonionic surfactant selected from the group consisting of a poly (ethoxylated and / or propoxylated) alcohol, a poly (ethoxylated and / or propoxylated) ester, a derivative of a poly (ethoxylated and / or propoxylated) alcohol , a derivative of a poly (ethoxylated and / or propoxylated) ester, an alkyl alcohol, an alkenyl alcohol, an ester of a polyhydric alcohol, an ether of a polyhydric alcohol, an ester of a. polyalkoxylated derivative of a polyhydric alcohol, an ether of a polyalkoxylated derivative of a polyhydric alcohol, a fatty acid ester of sorbitan, a polyalkoxylated derivative of a sorbitan fatty acid ester, and mixtures thereof, present in an amount of about 0.10% to about 5% by weight; c) an emulsifier, present in a volume of about 0.10% to about 3.0% by weight; d) an effective fluoridated agent for moisturizing; and e) water in an amount sufficient to form a stable gel composition with a viscosity of less than 4,000 cps. 94. The gel-like alcohol composition according to claim 93, further characterized in that the effective fluorinated surfactant is a fluorinated surfactant selected from the group consisting of fluorinated eioxylates., esters of glycerol, aminated oxides, alcoholic acetylene derivatives, carboxylates, phosphates, carbohydrate derivatives, sulfonates, betaines, esters, polyamides, silicones, and hydrocarbon surfactants. 95. The gel-like alcohol composition according to claim 93, further characterized in that the effective fluorinated surfactant is an amphoteric polytetrafluoroethylene acetoxypropyl betaine of the following formula, CF3CF2 (CF2CF2) nCH2CH2 (OAc) CH2N + (CH3) 2CH2COO-) where n = 2 to 4, present in an amount from about 0.001% by weight to about 2.5. 96. - The gel-like alcohol composition according to claim 93, further characterized in that the effective fluorinated surfactant is an ethoxylated nonionic fluorinated surfactant of the following structure: RfCH2CH2O (CH2CH2O) xH where Rf = F (CF2CF2) y, x = 0 to about 15 y = 1 to about 7, present in an amount from about 0.001 wt% to about 2.5. 97. The gel-like alcohol composition according to claim 93, further characterized in that the effective fluorinated surfactant is an anionic fluorinated surfactant phosphate of the following structure: (RfCH2CH2O) xP (O) (ONH4) and where Rf = F (CF2CF2) z, x = 1 or 2, y = 2 or 1, x + y = 3 and z = 1 to about 7, present in an amount from about 0.001 wt% to about 2.5. 98. The gel-like alcoholic composition according to claim 93, further characterized in that the effective fluorinated lensioactive agent is a mixture of two or more of the fluorinated surfactants of claims 93, 94 or 95, present in an amount from about 0.001% by weight to about 2.5. 99.- The gel-like alcohol composition according to any one of claims 93 to 98, further characterized in that the alcohol of 1 to 4 carbon atoms is an aliphatic alcohol selected from the group consisting of methanol, ethanol, 2-propanol and butanol. 100.- The gel-like alcoholic composition according to any one of claims 93 to 98, further characterized in that at least one nonionic surfactant is a polyethoxylated fatty alcohol which is polyethoxylated stearyl alcohol (21 moles of ethylene oxide) in an amount from 0.1% to about 5% so that the final disinfectant composition has a final viscosity of less than 4,000 cps. 101. The gel-like alcohol composition according to any one of claims 93 to 98, further characterized in that the at least one nonionic surfactant is a polyethoxylated fatty alcohol which is polyethoxylated stearyl alcohol (2 moles of ethylene oxide) ) present in an amount from 0.1% to about 5% so that the final disinfectant composition has a final viscosity of less than 4,000 cps. 102. The gel-like alcohol composition according to any one of claims 93 to 98, further characterized in that the at least one nonionic surfactant is a combination of polyaryoxylated esarylene alcohol (21 moles of ethylene oxide) and stearyl alcohol polyethoxylated (2 moles of ethylene oxide) present in an amount of 0.1% to about 5% so that the disinfectant composition has a final viscosity of less than 4,000 cps. 103. - the gel-like alcohol composition according to any one of claims 93 to 102, further characterized in that it includes an ingredient or mixture of emulsifying and emollient humectant ingredients, present in an amount from about 0.10 to about 2.0% by weight of so that the disinfectant composition final has a final viscosity of less than 4,000 cps. 104.- The gel-like alcohol composition according to claim 103, further characterized in that the emollient and emollient ingredient or mixture of emulsifying ingredients comprises a mixture of cetearyl alcohol and ceteareth 20. 105.- The alcohol-like gel composition in accordance with any one of claims 93 to 104, further characterized in that it includes an antimicrobial agent. 106. The gel-like alcohol composition according to claim 105, further characterized in that the antimicrobial agent is chlorhexidine gluconate present in an amount between about 0.50 to about 4.0% by weight. 107.- The gel-like alcoholic composition according to claim 105, characterized in that the antimicrobial agent is selected from the group consisting of chlorhexidine salt, iodine, a complex form of iodine, parachlorometaxylenol, triclosan, hexachlorophene, a phenol, a surfactant having a long chain hydrophobic group and a quaternary group, hydrogen peroxide, silver, a plate salt, piafa oxide, and mixtures thereof. 108. The gel-like alcohol composition according to any one of claims 93 to -107, further characterized in that it includes a preservative in an amount from about 0.01 to about 5% by weight of the total composition. 109. - The gel-like alcohol composition according to any one of claims 93 to 108, further characterized in that it comprises an acid or a base for adjusting the pH of the composition to a pre-selected pH present in an amount of about 0.05. to about 0.5% by weight of the total composition. 110. The gel-like alcohol composition according to claim 109, further characterized in that the acid is selected from the group consisting of hydrochloric acid, cyclic acid and phosphoric acid, and the base is sesquicarbonaio sodium. 111. The gel-like alcohol composition according to any one of claims 93 to 110, further characterized in that it is stored in a non-pressurized dispenser having a dissipative pump to dissolve the composition therefrom in a gel-like manner. 112. The gel-like alcohol composition according to any one of claims 93 to 110, further characterized in that it is stored in a pressurized dispenser having a distributor pump for distributing the disinfectant composition therefrom, which includes an aerosol propellant in a density from about 3. to about 20 per cent by weight of the ionic composition. 113. The alcohol-like gel composition according to claim 112, further characterized in that the aerosol propellant ß is selected from the group consisting of propane, carbon dioxide, butane, dichloro difluoro methane, dichloro tetra fluoro ethane, octafluorocyclobutane, 1,1, 1,2-tetrafluoroethane, 1,1,1,3,3,3-heptafluoropropane, and 1, 1, 1, 3,3 , 3-hexafluoropropane. 114. The gel-like alcohol composition according to claim 112 or 113, further characterized in that it includes a corrosion inhibitor is selected from the group consisting of sorbic acid, benzoic acid, potassium sorbate and sodium benzoate, in an amount from about 0.1 to about 5 weight percent of the total composition. 115. A method of forming a foam containing alcohol, characterized in that it comprises the steps of: combining an alcohol of 1 to 4 carbon atoms or mixtures thereof, present in an amount greater than about 40% v / v of the composition Ionic with an effecive fluoridated foaming agent for moistening and foaming, present in an amount of at least 0.001 weight percent of the total composition, and water present in an amount to balance the tofal composition to 100 weight% to form an alcoholic mixture of fluorinated surfactant and storing said composition in a non-pressurized dispenser having a distributor pump; and activating the distributor pump to combine the alcoholic mixture of fluorinated surfactant with low pressure air to form a low pressure foam containing alcohol, which is distributed from said distributor. 116.- The method according to claim 115, further characterized in that the effective fluorinated surfactant is a fluorinated surfactant present in a quantity from about 0.001% to about 10.0% by weight of the ionic composition. 117. The method according to claim 115 or 116, further characterized in that the effective fluorinated surfactant is a physiologically acceptable fluorinated surfactant, and that the fluorinated surfactant is selected from the group consisting of fluorinated ethoxylates, glycerol esters, amine oxides, acetylenic alcohol derivatives, carboxylairs, phosphates, carbohydrate derivatives, sulphonates, betaines, esters, polyamides, silicones, and hydrocarbon surfactants. 118.- The method according to claim 115, 116 or 117, further characterized in that the alcohol of 1 to 4 carbon atoms is an aliphatic alcohol selected from the group consisting of methanol, ethanol, isopropanol, n-propanol, butanol and combinations thereof. . 119.- The method according to claim 115, 116, 117 or 118, further characterized in that the fluorinated surfactant is a polytetrafluoroethylene aceyloxypropyl beylan-amphoteric (CF3CF2 (CF2CF2) nCH2CH2 (OAc) CH2N + (CH3) 2CH2COO-) where n = 2 to 4. 120.- The method according to claim 115, 116, 117 or 118, characterized in that the fluorinated surfactant agent is an ethoxylated non-ionic fluorinated surfactant of the following structure: RfCH2CH20 (CH2CH20) xH where Rf = F (CF2CF2) y, x = 0 to about 15, and y = 1 to about 7. 121. The method according to claim 115, 116, 117 or 118, further characterized in that the fluorinated surfactant is a phosphate anionic surfactant of the following structure: (RfCH2CH2O) xP (O) (ONH) and where Rf = F (CF2CF2) z, x = 1 or 2, y = 2 or 1, x + y = 3, and z = 1 to about 7 or mixtures thereof. 122. The method according to claim 115, 116, 117 or 118, further characterized in that the fluorinated surfactant is a mixture of two or more of the fluorinated surfactants of claims 6, 7 and 8. 123.- The method according to any one of claims 115 to 122, further characterized in that the alcohol is present in a range from about 40% to about 90% v / v. 124. The method according to any one of claims 115 to 122, further characterized in that the alcohol is ethanol present in an amount of at least 60% v / v, and wherein the composition is for use as an alcoholic foam for personal hygiene. 125. The method according to any one of claims 115 to 122, further characterized in that the alcohol is a mixture of n-propanol and ethanol present in a combined amount of at least 60% v / v, and wherein the composition It is for use as a foam Alcoholic for personal hygiene. 126. The method according to any one of claims 115 to 122, further characterized in that the alcohol is a mixture of isopropanol and ethanol present in a combined amount of at least 60% v / v, and wherein the composition is for Use as an alcoholic foam for personal hygiene. 127.- The method according to any one of claims 115 to 122, further characterized in that the alcohol is isopropanol present in an amount of at least 70% v / v, and wherein the composition is for use as an alcoholic foam for personal hygiene. 128. The method according to any one of claims 115 to 122, further characterized in that the alcohol is n-propanol present in an amount of at least 60% v / v, and wherein the composition is for use as a foam. Alcoholic for personal hygiene. 129.- The method according to any one of claims 118 to 128, further characterized in that it includes at least one additional sensory agent to adjust the properties of the foam produced from the composition. 130. The method according to claim 129, further characterized in that the additional surfactant is selected from the group consisting of poly (ethoxylated and / or propoxylated) alcohol, a poly (e-butylated and / or propoxylated) ester, a derived from a poly (eioxylated and / or propoxylated) alcohol, a derivative of a poly (eioxylated and / or propoxylated ester), a alkyl alcohol, an alkenyl alcohol, an ester of a polyhydric alcohol, an ether of a polyhydric alcohol, an ester of a polyalkoxylated derivative of a polyhydric alcohol, an ether of a polyalkoxylated derivative of a polyhydric alcohol, a fatty acid ester of sorbitan , a polyalkoxylated derivative of a sorbitan fatty acid ester, an alkyl glucoside, a betaine, a sulfobetaine, an imidazoline derivative, an amino acid derivative, a lecithin, a phosphatide, an aminated oxide, a sulfoxide and mixtures thereof, present in a volume of about 0.10% to about 5% by weight. 131. The method according to claim 130, , further characterized in that the beiaine is cocamidopropyl beiraine. 132. The method according to claim 130, further characterized in that the alkylglucoside is cocoglucoside. 133. The method according to claim 130, further characterized in that the polyethoxylated fatty alcohol is polyaryoxylated stearyl alcohol (21 moles of ethylene oxide). 134. The method according to claim 130, further characterized in that the polyethoxylated fatty alcohol is polyoxylated stearyl alcohol (2 moles of ethylene oxide). The method according to claim 130, further characterized in that the polyethoxylated fatty alcohol is a combination of polyethoxylated stearyl alcohol (21 moles of ethylene oxide) and polyethoxylated stearyl alcohol (2 moles of ethylene oxide). 136. - The method according to any one of claims 115 to 135, further characterized in that it includes a foam stabilizing agent present in a quantity of 5% hasia. 137. The method according to claim 136, further characterized in that the foam stabilizing agent is selected from the group consisting of lactic acid esters of monoglycerides, cationic emulsifiers, complexes of hydrolyzed stearic phospholipids, salts of hydroxystearamide propyltriamine, monoglycerides of lactic acid, food emulsifiers selected from the group consisting of glyceryl monostearate, propylene glycol monostearate, stearoyl sodium lactylate and cetyl betaine, glycol ether, n-propanol, butylene glycol, silicone wax, an encapsulated oil, Microcapsule Mineral Oil® , and combinations thereof. 138. The method according to claim 136, further characterized in that the foam stabilizing agent is selected from the group consisting of glycol ether, n-propanol, butylene glycol, and combinations thereof. 139. The method according to any one of claims 115 to 138, further characterized in that it includes any one of a humeciole, emollient and combinations thereof selected from the group consisting of lanolin, vinyl alcohol, polyvinyl pyrrolidone and polyols selected from group consisting of glycerol, propylene glycol, butylene glycol and sorbiol, and a fatty alcohol, selected from the group consisting of cetyl alcohol, stearyl alcohol, lauryl alcohol, myristyl alcohol and palmiyl alcohol, cetyl alcohol, cefeareth 20, an alkyl glucoside and combinations thereof, present in an amount of up to 5%. The method according to any one of claims 115 to 139, further characterized in that it comprises an acid or base for adjusting a pH of the composition to a preselected pH present in an amount from about 0.05 to about 0.5% by weight of the total composition. 141. The method according to claim 140, further characterized in that when an acid is used to adjust the pH, the acid is selected from the group consisting of hydrochloric acid, citric acid and phosphoric acid, and that when a base is used To adjust the pH, the base is sodium sesquicarbonate. 142. The method according to any one of claims 115 to 141, further characterized in that it includes a preservative in an amount from about 0.01 to about 5% by weight of the total composition. 143. The method according to any one of claims 115 to 142, further characterized in that it includes an animicrobial agent. 144. The method according to claim 143, further characterized in that the antimicrobial agent is gluconate of chlorhexidine present in an amount of about 0.50% to about 4.0% by weight. 145. The method according to claim 143, further characterized in that the antimicrobial agent is didecyl dimethyl diammonium chloride present in an amount of between about 0.05% to about 5.0% by weight. 146. The method according to claim 143, further characterized in that the antimicrobial agent is selected from the group of a salt of chlorhexidine, iodine, a complex form of iodine, parachloromethaxyleneol, friclosane, hexachlorophene, a phenol, a "surfactant" agent. have a long chain hydrophobic group and a quaternary group, hydrogen peroxide, silver, a silver salt, silver oxide, and mixtures thereof. 147. The method according to any one of claims 115 to 146, further characterized in that it comprises constituents selected from the group consisting of organic gums and colloids, lower alkanolamides of higher fatty acids, short-chain diols and / or idols, fragrance. , coloring matter, ultraviolet ray absorbers, solvents, suspension agents, pH regulators, conditioning agents, antioxidants, bactericides and medicinally active ingredients, and combinations thereof.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60/506,172 | 2003-09-29 | ||
| US60/591,601 | 2004-07-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA06003498A true MXPA06003498A (en) | 2007-04-20 |
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