MXPA05013526A - Secuencias de acido nucleico que codifican y composiciones que comprenden el peptido de senal de ige y/o il-15 y metodos para uso de los mismos. - Google Patents
Secuencias de acido nucleico que codifican y composiciones que comprenden el peptido de senal de ige y/o il-15 y metodos para uso de los mismos.Info
- Publication number
- MXPA05013526A MXPA05013526A MXPA05013526A MXPA05013526A MXPA05013526A MX PA05013526 A MXPA05013526 A MX PA05013526A MX PA05013526 A MXPA05013526 A MX PA05013526A MX PA05013526 A MXPA05013526 A MX PA05013526A MX PA05013526 A MXPA05013526 A MX PA05013526A
- Authority
- MX
- Mexico
- Prior art keywords
- nucleic acid
- compositions
- disclosed
- methods
- signal peptide
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5443—IL-15
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
- A61K2039/55527—Interleukins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Se describen las proteinas de fusion y las moleculas de acido nucleico que codifican para las proteinas de fusion. Las proteinas de fusion comprende el peptido de senal no IL15 enlazado a las secuencias de la proteina IL-15, y las proteinas de fusion que comprenden un peptido de senal de IgE enlazado a las secuencias proteicas no IgE son tambien descritas. Se describen tambien los vectores que comprenden las moleculas de acido nucleico, y a las celulas hospederas que comprenden tales vectores, asi como las vacunas recombinantes y los patogenos atenuados vivos que codifican para las proteinas de fusion, y los metodos para utilizar las mismas. Se describe tambien el efecto inmunomodulador despues de la administracion de IL-15 y CD40L, con o si inmunogenos, como se describen tambien las diversas moleculas de acido nucleico y las composiciones de las mismas, utilizadas para la distribucion de tales proteinas, y los metodos para utilizar tales composiciones.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47821003P | 2003-06-13 | 2003-06-13 | |
US47820503P | 2003-06-13 | 2003-06-13 | |
PCT/US2004/018962 WO2005000235A2 (en) | 2003-06-13 | 2004-06-14 | NUCLEIC ACID SEQUENCES ENCODING AND COMPOSITIONS COMPRISING IgE SIGNAL PEPTIDE AND/OR IL-15 AND METHODS FOR USING THE SAME |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA05013526A true MXPA05013526A (es) | 2006-03-09 |
Family
ID=33555491
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA05013526A MXPA05013526A (es) | 2003-06-13 | 2004-06-14 | Secuencias de acido nucleico que codifican y composiciones que comprenden el peptido de senal de ige y/o il-15 y metodos para uso de los mismos. |
Country Status (12)
Country | Link |
---|---|
US (2) | US8173786B2 (es) |
EP (2) | EP1638987B1 (es) |
JP (2) | JP2007516696A (es) |
KR (2) | KR101225473B1 (es) |
CN (1) | CN1832956B (es) |
AU (2) | AU2004251070B2 (es) |
BR (1) | BRPI0411363A (es) |
CA (1) | CA2529145C (es) |
IL (1) | IL172496A (es) |
MX (1) | MXPA05013526A (es) |
NZ (2) | NZ570709A (es) |
WO (1) | WO2005000235A2 (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ570709A (en) * | 2003-06-13 | 2010-04-30 | Univ Pennsylvania | Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the same |
ATE533782T1 (de) * | 2006-01-13 | 2011-12-15 | Univ Pennsylvania | Impfstoffe und immuntherapeutika mit codon- optimiertem il-15 und verwendungsverfahren dafür |
EP2049559B1 (en) | 2006-07-28 | 2012-12-19 | The Trustees of the University of Pennsylvania | Improved hpv vaccines |
US10426827B1 (en) * | 2006-11-06 | 2019-10-01 | Microvax, Llc | Dengue hemorrhagic fever virus vaccine |
KR101686942B1 (ko) * | 2008-01-11 | 2016-12-28 | 이노비오 파마수티컬즈, 인크. | 뎅기 바이러스 다중 서브타입에 대항하는 신규한 백신 |
CN102016023A (zh) | 2008-04-04 | 2011-04-13 | 宾夕法尼亚州立大学托管会 | 使用il-28和组合物的疫苗和免疫治疗及其使用方法 |
KR101589511B1 (ko) * | 2008-04-04 | 2016-02-01 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 치쿤구니야 바이러스 단백질의 공통 서열, 이를 인코딩하는 핵산 분자, 조성물 및 이를 이용하는 방법 |
KR20120093163A (ko) | 2009-09-14 | 2012-08-22 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | Il-15 수용체 알파 및/또는 이를 인코딩하는 핵산 분자를 포함하는 백신 및 면역 치료제, 및 이를 이용하는 방법 |
KR101784177B1 (ko) | 2010-02-08 | 2017-10-11 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | Rantes를 암호화하는 핵산 분자, 그리고 이를 포함하는 조성물 및 이의 사용 방법 |
US9238679B2 (en) | 2011-02-11 | 2016-01-19 | The Trustees Of The University Of Pennslyvania | Nucleic acid molecule encoding hepatitis B virus core protein and surface antigen protein and vaccine comprising the same |
MX343830B (es) | 2011-02-11 | 2016-11-24 | Univ Pennsylvania | Molecula de acido nucleico que codifica la proteina nuclear del virus de la hepatitis b y vacuna que comprende la misma. |
JP6407028B2 (ja) * | 2011-12-12 | 2018-10-17 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | MRSAのPBP2a及びその断片を含むタンパク質、それをコードする核酸、並びにMRSA感染を予防する及び治療するための組成物及びそれらの使用 |
WO2013155205A1 (en) | 2012-04-10 | 2013-10-17 | The Trustees Of The University Of Pennsylvania | Human respiratory syncytial virus concensus antigens, nucleic acid constructs and vaccines made thereform, and methods of using same |
JP6389163B2 (ja) | 2012-04-12 | 2018-09-12 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | フィロウイルスコンセンサス抗原、核酸構築物、およびそれから作製されるワクチン、ならびにその使用方法 |
JP6463577B2 (ja) | 2013-05-14 | 2019-02-06 | ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム | 改変キメラ抗原受容体(car)t細胞のヒト応用 |
KR20230145241A (ko) * | 2014-10-01 | 2023-10-17 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 항원 및 어쥬번트로서 인터류킨-21을 갖는 백신 |
MA46317A (fr) * | 2015-10-22 | 2019-08-07 | Modernatx Inc | Vaccin contre le virus respiratoire syncytial |
EA201892124A1 (ru) | 2016-12-02 | 2019-04-30 | Дэвид Б. Уэйнер | Днк-конструкции антител и способы их применения |
CU24546B1 (es) * | 2016-12-30 | 2021-09-07 | Ct Ingenieria Genetica Biotecnologia | Composición vacunal que comprende un mutante de la interleucina-15 humana |
IL267865B2 (en) | 2017-01-10 | 2024-07-01 | Intrexon Corp | Modulation of expression of polypeptides through a new system for changing gene expression |
US12036257B2 (en) | 2017-10-31 | 2024-07-16 | Kalivir Immunotherapeutics, Inc. | Platform oncolytic vector for systemic delivery |
US11154602B2 (en) | 2017-12-13 | 2021-10-26 | Inovio Pharmaceuticals, Inc. | Cancer vaccines targeting mesothelin and uses thereof |
AU2020345943A1 (en) | 2019-09-10 | 2022-03-31 | Obsidian Therapeutics, Inc. | CA2-IL15 fusion proteins for tunable regulation |
US20220133885A1 (en) * | 2020-11-02 | 2022-05-05 | Drexel University | Compositions and methods employing adenosine deaminase-1 (ada-1) as an adjuvant |
BR112023022681A2 (pt) | 2021-04-30 | 2024-01-23 | Kalivir Immunotherapeutics Inc | Vírus oncolíticos para expressão modificada de mhc |
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US5240703A (en) * | 1991-03-01 | 1993-08-31 | Syntro Corporation | Attenuated, genetically-engineered pseudorabies virus s-prv-155 and uses thereof |
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CA2456648C (en) | 2001-08-23 | 2011-08-16 | Genmab A/S | Human antibodies specific for interleukin 15 (il-15) |
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NZ570709A (en) * | 2003-06-13 | 2010-04-30 | Univ Pennsylvania | Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the same |
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2004
- 2004-06-13 NZ NZ570709A patent/NZ570709A/en not_active IP Right Cessation
- 2004-06-14 CA CA2529145A patent/CA2529145C/en not_active Expired - Fee Related
- 2004-06-14 NZ NZ544077A patent/NZ544077A/en not_active IP Right Cessation
- 2004-06-14 EP EP04776577.1A patent/EP1638987B1/en not_active Expired - Lifetime
- 2004-06-14 AU AU2004251070A patent/AU2004251070B2/en not_active Ceased
- 2004-06-14 KR KR1020117023822A patent/KR101225473B1/ko active IP Right Grant
- 2004-06-14 MX MXPA05013526A patent/MXPA05013526A/es active IP Right Grant
- 2004-06-14 WO PCT/US2004/018962 patent/WO2005000235A2/en active Application Filing
- 2004-06-14 US US10/560,650 patent/US8173786B2/en not_active Expired - Fee Related
- 2004-06-14 CN CN2004800228915A patent/CN1832956B/zh not_active Expired - Fee Related
- 2004-06-14 KR KR1020057023994A patent/KR101269548B1/ko active IP Right Grant
- 2004-06-14 JP JP2006533791A patent/JP2007516696A/ja active Pending
- 2004-06-14 BR BRPI0411363-2A patent/BRPI0411363A/pt not_active Application Discontinuation
- 2004-06-14 EP EP10191165A patent/EP2292634A3/en not_active Withdrawn
-
2005
- 2005-12-11 IL IL172496A patent/IL172496A/en active IP Right Grant
-
2012
- 2012-02-14 JP JP2012029973A patent/JP5623444B2/ja not_active Expired - Fee Related
- 2012-05-07 US US13/466,015 patent/US20120276142A1/en not_active Abandoned
- 2012-05-16 AU AU2012202867A patent/AU2012202867B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
AU2012202867A1 (en) | 2012-06-07 |
EP2292634A2 (en) | 2011-03-09 |
BRPI0411363A (pt) | 2006-07-25 |
AU2004251070B2 (en) | 2012-02-23 |
CN1832956B (zh) | 2013-11-20 |
US8173786B2 (en) | 2012-05-08 |
IL172496A (en) | 2013-02-28 |
EP2292634A3 (en) | 2012-08-08 |
KR101225473B1 (ko) | 2013-01-24 |
NZ544077A (en) | 2009-01-31 |
EP1638987B1 (en) | 2014-11-19 |
AU2004251070A1 (en) | 2005-01-06 |
NZ570709A (en) | 2010-04-30 |
KR101269548B1 (ko) | 2013-06-21 |
EP1638987A2 (en) | 2006-03-29 |
JP2012110345A (ja) | 2012-06-14 |
WO2005000235A3 (en) | 2005-06-16 |
IL172496A0 (en) | 2006-04-10 |
JP5623444B2 (ja) | 2014-11-12 |
US20120276142A1 (en) | 2012-11-01 |
KR20110129945A (ko) | 2011-12-02 |
CN1832956A (zh) | 2006-09-13 |
WO2005000235A2 (en) | 2005-01-06 |
KR20060030041A (ko) | 2006-04-07 |
US20070041941A1 (en) | 2007-02-22 |
CA2529145A1 (en) | 2005-01-06 |
AU2012202867B2 (en) | 2015-01-29 |
EP1638987A4 (en) | 2007-12-26 |
CA2529145C (en) | 2017-07-11 |
JP2007516696A (ja) | 2007-06-28 |
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