MXPA04003594A - Azaindoles e indolinas tetraciclicas que tienen actividad en serotonina 5-ht-2. - Google Patents

Azaindoles e indolinas tetraciclicas que tienen actividad en serotonina 5-ht-2.

Info

Publication number
MXPA04003594A
MXPA04003594A MXPA04003594A MXPA04003594A MXPA04003594A MX PA04003594 A MXPA04003594 A MX PA04003594A MX PA04003594 A MXPA04003594 A MX PA04003594A MX PA04003594 A MXPA04003594 A MX PA04003594A MX PA04003594 A MXPA04003594 A MX PA04003594A
Authority
MX
Mexico
Prior art keywords
compounds
azaindoles
indolines
tetracyclic
serotonin
Prior art date
Application number
MXPA04003594A
Other languages
English (en)
Inventor
Fu Jian-Min
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of MXPA04003594A publication Critical patent/MXPA04003594A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente invencion proporciona compuestos de la Formula (I):(ver formula I),en donde R1, R2, R3, R4, R5 y R6, tienen cualquiera de los valores definidos en la especificacion, asi como tambien las composiciones farmaceuticas que comprenden los compuestos. La invencion tambien proporciona los metodos terapeuticos, asi como tambien los procesos e intermediarios utiles para preparar los compuestos de la Formula (I). Los compuestos son ligandos 5-HT y son utiles para tratar enfermedades en donde se desea la modulacion de la actividad 5-HT2c.
MXPA04003594A 2001-10-18 2002-10-15 Azaindoles e indolinas tetraciclicas que tienen actividad en serotonina 5-ht-2. MXPA04003594A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33508101P 2001-10-18 2001-10-18
PCT/US2002/033176 WO2003033497A1 (en) 2001-10-18 2002-10-15 Tetracyclic azaindoles and -indolines having serotonin 5-ht2c activity

Publications (1)

Publication Number Publication Date
MXPA04003594A true MXPA04003594A (es) 2004-07-30

Family

ID=23310182

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04003594A MXPA04003594A (es) 2001-10-18 2002-10-15 Azaindoles e indolinas tetraciclicas que tienen actividad en serotonina 5-ht-2.

Country Status (7)

Country Link
US (1) US6930105B2 (es)
EP (1) EP1436294A1 (es)
JP (1) JP2005508969A (es)
BR (1) BR0213417A (es)
CA (1) CA2464412A1 (es)
MX (1) MXPA04003594A (es)
WO (1) WO2003033497A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CL2004000826A1 (es) 2003-04-25 2005-03-04 Pfizer Uso de un agonista para el receptor 5-ht2c para preparar un medicamento util en el tratamiento de la incontinencia urinaria provocada por estres, con la condicion de que el agonista no sea 1-[6-cloro-5-(trifluorometil)-2-piridinil]piperazina (org-129
US20050052815A1 (en) * 2003-09-09 2005-03-10 Smc Corporation Static eliminating method and apparatus therefor
EP1792629A4 (en) 2004-08-25 2010-08-25 Takeda Pharmaceutical PREVENTIVE / REMEDY AGENTS FOR INCONTINENCE OF STRESS AND SELECETING METHOD THEREOF
GT200500317A (es) * 2004-11-05 2006-10-27 Proceso para preparar compuestos de quinolina y productos obtenidos de los mismos
WO2006117218A2 (en) * 2005-05-04 2006-11-09 Charite Universitätsmedizin - Berlin Serotonin-transport-protein binding radiopharmaceutical for the production of a diagnostic medicament for the diagnosis of headache
EP1728520A1 (de) * 2005-05-04 2006-12-06 Charité - Universitätsmedizin Berlin Verwendung von spezifisch an das Serotonin-Transport-Protein (SERT) bindenden Radiopharmaka zur Herstellung eines Diagnostikums zur Untersuchung von Kopfschmerzerkrankungen
AR054849A1 (es) * 2005-07-26 2007-07-18 Wyeth Corp Diazepinoquinolinas, sintesis de las mismas, e intermediarios para obtenerlas
TW200734334A (en) * 2006-01-13 2007-09-16 Wyeth Corp Treatment of substance abuse
AR060088A1 (es) * 2006-03-24 2008-05-21 Wyeth Corp Metodos para tratar trastornos cognitivos y otros afines
CA2644662A1 (en) * 2006-03-24 2007-10-04 Wyeth New therapeutic combinations for the treatment of depression
EP1998781A2 (en) * 2006-03-24 2008-12-10 Wyeth a Corporation of the State of Delaware Treatment of pain
EP2742936A1 (en) 2006-05-16 2014-06-18 Takeda Pharmaceutical Company Limited Fused heterocyclic compound and use thereof
CL2008002777A1 (es) * 2007-09-21 2010-01-22 Wyeth Corp Metodo de preparacion de compuestos diazepinoquinolinicos quirales por recristalizacion en un sistema de solvente ternario.
JP5520051B2 (ja) 2007-11-15 2014-06-11 武田薬品工業株式会社 縮合ピリジン誘導体およびその用途
TW201024302A (en) * 2008-11-27 2010-07-01 Boehringer Ingelheim Int 6,7,8,9-tetrahydro-5H-1,4,7,10a-tetraaza-cyclohept[f]indene derivatives, pharmaceutical compositions containing these compounds, their use and processes for preparing them
US20120253036A1 (en) 2009-12-11 2012-10-04 Yukinori Nagakura Agent for treating fibromyalgia
JPWO2019131902A1 (ja) 2017-12-27 2020-12-10 武田薬品工業株式会社 腹圧性尿失禁および便失禁の治療薬

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20010052A1 (es) * 1999-04-23 2001-01-27 Upjohn Co Compuestos de azepinindol tetraciclico como agonistas o antagonistas del receptor de 5-ht
CA2373920A1 (en) * 1999-06-15 2000-12-21 Wei Deng Substituted heterocycle fused gamma-carbolines

Also Published As

Publication number Publication date
US6930105B2 (en) 2005-08-16
US20030091505A1 (en) 2003-05-15
EP1436294A1 (en) 2004-07-14
WO2003033497A1 (en) 2003-04-24
BR0213417A (pt) 2004-11-03
JP2005508969A (ja) 2005-04-07
CA2464412A1 (en) 2003-04-24

Similar Documents

Publication Publication Date Title
MXPA04001203A (es) 1-h-pirido[4,3-b] indoles terapeuticos.
MXPA04003594A (es) Azaindoles e indolinas tetraciclicas que tienen actividad en serotonina 5-ht-2.
AP1822A (en) Substituted pyridinones as modulators of P38 MAP kinase.
TW200517109A (en) Substituted pyridinones
WO2001017963A3 (en) Aminoalkoxy carbazoles and their use as 5-ht ligands
DE60204452D1 (de) Pyrazolo[1,5]pyridinderivate
MXPA02012425A (es) Compuestos nuevos.
SE0104140D0 (sv) Novel Compounds
MXPA05009359A (es) Tetrahidroisoquinolinas 2,5- y 2,6 substituidas para uso como moduladores 5-ht6.
GB9813540D0 (en) Chemical compounds
IL175819A0 (en) Tricyclic indole hydroxyethylamine derivatives and their use in the treatment of alzheimer's disease
EP1633740A4 (en) CHEMICAL COMPOUNDS
HK1069169A1 (en) Substituted tetracyclic pyrroloquinolone derivatives useful as phosphodiesterase inhibitors
MXPA04005886A (es) Derivados de azaindolilalquilamina como ligandos de 5-hidroxitirptamina-6.
HUP0303254A2 (hu) Új pirimidinvegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
WO2003024976A3 (en) Tricyclic indole derivatives as 5-ht ligands
IL147149A0 (en) Novel diphenyl-piperidine derivate
MXPA06000701A (es) Compuestos de sulfonildihidrobencimidazolona como ligandos de 5-hidroxitriptamina-6.
MY138466A (en) Aminoalkoxyndoles as 5-ht6-receptor ligands for the treatment of cns-disorders
MXPA04000358A (es) Hexahidroazepino (4,5-g) indoles e indolinas como ligandos del receptor 5-ht.
UA83821C2 (ru) Производные бензолсульфонамидов, способ их получения и их применение для лечения воспалительных заболеваний и утоления боли
MXPA04000036A (es) Benzofuranos sustituidos con (hetero) arilo como ligandos 5-ht.
SE9902551D0 (sv) Novel compounds
MXPA02012426A (es) Compuestos nuevos.
MXPA04001201A (es) Derivados tetraciclicos de indol como ligandos del receptor de 5-ht.