MXPA04002530A - Oligonucleotidos de treitilenglicol colesteril terapeuticamente utiles. - Google Patents
Oligonucleotidos de treitilenglicol colesteril terapeuticamente utiles.Info
- Publication number
- MXPA04002530A MXPA04002530A MXPA04002530A MXPA04002530A MXPA04002530A MX PA04002530 A MXPA04002530 A MX PA04002530A MX PA04002530 A MXPA04002530 A MX PA04002530A MX PA04002530 A MXPA04002530 A MX PA04002530A MX PA04002530 A MXPA04002530 A MX PA04002530A
- Authority
- MX
- Mexico
- Prior art keywords
- seq
- induction
- composition
- triethyleneglycol
- therapeutically useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/547—Chelates, e.g. Gd-DOTA or Zinc-amino acid chelates; Chelate-forming compounds, e.g. DOTA or ethylenediamine being covalently linked or complexed to the pharmacologically- or therapeutically-active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/555—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound pre-targeting systems involving an organic compound, other than a peptide, protein or antibody, for targeting specific cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/18—Type of nucleic acid acting by a non-sequence specific mechanism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3515—Lipophilic moiety, e.g. cholesterol
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
La presente invencion proporciona la composicion que comprende una secuencia sintetica de colesteril 3'-TEG 5'-OR, en donde la secuencia es SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, y un portador farmaceuticamente aceptable La presente invencion tambien proporciona metodos para usar esta composicion en la preparacion de medicamentos y metodos para usar esta composicion para la induccion de una respuesta en una celula, incluyendo pero no limitandose a la inhibicion de la proliferacion celular, de la induccion del arresto de ciclo de celula, de la induccion de la activacion de caspasa, del desdoblamiento de poli (ADP-ribosa) polimerasa, de la induccion de apoptosis o de la modulacion de interacciones de celula-matriz extracelular o combinaciones de los mismos en celulas de cancer y/o celulas sinoviales.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32688401P | 2001-10-03 | 2001-10-03 | |
PCT/IB2002/004065 WO2003028764A1 (en) | 2001-10-03 | 2002-10-03 | Therapeutically useful triethyleneglycol cholesteryl oligonucleotides |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA04002530A true MXPA04002530A (es) | 2004-05-31 |
Family
ID=23274136
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA04002530A MXPA04002530A (es) | 2001-10-03 | 2002-10-03 | Oligonucleotidos de treitilenglicol colesteril terapeuticamente utiles. |
Country Status (16)
Country | Link |
---|---|
US (1) | US7635686B2 (es) |
EP (1) | EP1432450B1 (es) |
JP (1) | JP4405259B2 (es) |
KR (1) | KR100971571B1 (es) |
CN (1) | CN100352510C (es) |
AT (1) | ATE314096T1 (es) |
AU (1) | AU2002341264B2 (es) |
CA (1) | CA2462425A1 (es) |
DE (1) | DE60208400T2 (es) |
DK (1) | DK1432450T3 (es) |
ES (1) | ES2250713T3 (es) |
HK (1) | HK1067308A1 (es) |
IL (2) | IL161181A0 (es) |
MX (1) | MXPA04002530A (es) |
PT (1) | PT1432450E (es) |
WO (1) | WO2003028764A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100445380C (zh) * | 1999-12-13 | 2008-12-24 | 拜昂尼科生命科学有限公司 | 治疗用合成寡核苷酸 |
US7491805B2 (en) * | 2001-05-18 | 2009-02-17 | Sirna Therapeutics, Inc. | Conjugates and compositions for cellular delivery |
AU2003219383B2 (en) * | 2002-04-22 | 2010-08-26 | Bioniche Life Sciences Inc. | Oligonucleotide compositions and their use for the modulation of immune responses |
GB2443591B (en) * | 2005-09-07 | 2010-04-28 | Secr Defence | Adjuvanted vaccine |
US20090054366A1 (en) * | 2007-06-15 | 2009-02-26 | Reliance Life Sciences Pvt. Ltd. | RNAi MEDIATED KNOCKDOWN OF NUMA FOR CANCER THERAPY |
GB0906234D0 (en) | 2009-04-14 | 2009-05-20 | Secr Defence | Vaccine |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4958013A (en) * | 1989-06-06 | 1990-09-18 | Northwestern University | Cholesteryl modified oligonucleotides |
ES2256843T3 (es) * | 1993-11-30 | 2006-07-16 | Tanox, Inc. | Proteinas con que modulan la apoptosis, adn codante para estas proteinas, y su modo de utilizacion. |
US5756668A (en) * | 1994-11-15 | 1998-05-26 | The Johns Hopkins University School Of Medicine | Hypermethylated in cancer polypeptide, HIC-1 |
US5643890A (en) | 1995-01-31 | 1997-07-01 | The Board Of Regents Of The University Of Nebraska | Synthetic oligonucleotides which mimic telomeric sequences for use in treatment of cancer and other diseases |
AU7596496A (en) | 1995-10-19 | 1997-05-07 | Johnson & Johnson Interventional Systems | Conjugation of c-myc antisense oligonucleotides with cholesterol to significantly enhance their inhibitory effect on neointimal hyperplasia |
US5958780A (en) * | 1997-06-30 | 1999-09-28 | Boston Advanced Technologies, Inc. | Method for marking and identifying liquids |
EP1009852A2 (en) | 1997-09-04 | 2000-06-21 | Bayer Corporation | Oligonucleotide probes bearing quenchable fluorescent labels, and methods of use thereof |
EP0979869A1 (en) | 1998-08-07 | 2000-02-16 | Hoechst Marion Roussel Deutschland GmbH | Short oligonucleotides for the inhibition of VEGF expression |
US6703381B1 (en) * | 1998-08-14 | 2004-03-09 | Nobex Corporation | Methods for delivery therapeutic compounds across the blood-brain barrier |
CN100445380C (zh) | 1999-12-13 | 2008-12-24 | 拜昂尼科生命科学有限公司 | 治疗用合成寡核苷酸 |
US7087586B2 (en) * | 2001-04-24 | 2006-08-08 | Bioniche Life Sciences, Inc. | Oligonucleotide compositions and their use to induce differentiation of cells |
JP2005525991A (ja) * | 2001-05-16 | 2005-09-02 | マイジェニックス インコーポレイテッド | 核酸ベースの化合物およびその使用方法 |
-
2002
- 2002-10-03 EP EP02775055A patent/EP1432450B1/en not_active Expired - Lifetime
- 2002-10-03 ES ES02775055T patent/ES2250713T3/es not_active Expired - Lifetime
- 2002-10-03 DK DK02775055T patent/DK1432450T3/da active
- 2002-10-03 PT PT02775055T patent/PT1432450E/pt unknown
- 2002-10-03 CN CNB028241916A patent/CN100352510C/zh not_active Expired - Fee Related
- 2002-10-03 MX MXPA04002530A patent/MXPA04002530A/es active IP Right Grant
- 2002-10-03 AU AU2002341264A patent/AU2002341264B2/en not_active Ceased
- 2002-10-03 JP JP2003532094A patent/JP4405259B2/ja not_active Expired - Fee Related
- 2002-10-03 IL IL16118102A patent/IL161181A0/xx unknown
- 2002-10-03 KR KR1020047004837A patent/KR100971571B1/ko not_active IP Right Cessation
- 2002-10-03 DE DE60208400T patent/DE60208400T2/de not_active Expired - Lifetime
- 2002-10-03 US US10/264,280 patent/US7635686B2/en not_active Expired - Fee Related
- 2002-10-03 WO PCT/IB2002/004065 patent/WO2003028764A1/en active IP Right Grant
- 2002-10-03 AT AT02775055T patent/ATE314096T1/de active
- 2002-10-03 CA CA002462425A patent/CA2462425A1/en not_active Abandoned
-
2004
- 2004-03-30 IL IL161181A patent/IL161181A/en not_active IP Right Cessation
- 2004-12-29 HK HK04110291A patent/HK1067308A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2462425A1 (en) | 2003-04-10 |
ATE314096T1 (de) | 2006-01-15 |
IL161181A0 (en) | 2004-08-31 |
DK1432450T3 (da) | 2006-05-15 |
DE60208400T2 (de) | 2006-07-06 |
WO2003028764A1 (en) | 2003-04-10 |
JP2005509607A (ja) | 2005-04-14 |
IL161181A (en) | 2010-06-30 |
EP1432450A1 (en) | 2004-06-30 |
AU2002341264B2 (en) | 2007-07-12 |
US7635686B2 (en) | 2009-12-22 |
DE60208400D1 (de) | 2006-02-02 |
CN1599627A (zh) | 2005-03-23 |
EP1432450B1 (en) | 2005-12-28 |
ES2250713T3 (es) | 2006-04-16 |
CN100352510C (zh) | 2007-12-05 |
JP4405259B2 (ja) | 2010-01-27 |
HK1067308A1 (en) | 2005-04-08 |
US20030125290A1 (en) | 2003-07-03 |
PT1432450E (pt) | 2006-05-31 |
KR20040068114A (ko) | 2004-07-30 |
KR100971571B1 (ko) | 2010-07-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |