MXPA04001287A - Ensayo de receptor unido a proteina g. - Google Patents
Ensayo de receptor unido a proteina g.Info
- Publication number
- MXPA04001287A MXPA04001287A MXPA04001287A MXPA04001287A MXPA04001287A MX PA04001287 A MXPA04001287 A MX PA04001287A MX PA04001287 A MXPA04001287 A MX PA04001287A MX PA04001287 A MXPA04001287 A MX PA04001287A MX PA04001287 A MXPA04001287 A MX PA04001287A
- Authority
- MX
- Mexico
- Prior art keywords
- protein
- gpcr
- coupled receptor
- methods
- relates
- Prior art date
Links
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 title abstract 5
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 title abstract 5
- 238000003556 assay Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 3
- 108091006027 G proteins Proteins 0.000 abstract 1
- 102000030782 GTP binding Human genes 0.000 abstract 1
- 108091000058 GTP-Binding Proteins 0.000 abstract 1
- 230000002612 cardiopulmonary effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 238000004393 prognosis Methods 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 230000019491 signal transduction Effects 0.000 abstract 1
- 230000011664 signaling Effects 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
- G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Endocrinology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invencion se refiere a metodos y composiciones novedosas para el diagnostico, tratamiento y pronostico de los trastornos relacionados con el receptor unido a la proteina G (GPCR) por medio de la inhibicion de reguladores de las proteinas de senalizacion de la proteina G (RGS). La presente invencion se refiere a metodos de separacion por exclusion y evaluacion de los compuestos de prueba utiles en la intervencion y prevencion de los trastornos relacionados con GPCR incluyendo los trastornos neuropsiquiatricos y cardiopulmonares. La invencion se refiere ademas a metodos para identificar los inhibidores para la expresion o actividad de RGS los cuales son utiles en la modulacion de las rutas de senalizacion de GPCR.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31168401P | 2001-08-10 | 2001-08-10 | |
PCT/US2002/025213 WO2003013551A1 (en) | 2001-08-10 | 2002-08-08 | G protein-coupled receptor assay |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA04001287A true MXPA04001287A (es) | 2004-05-27 |
Family
ID=23207985
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA04001287A MXPA04001287A (es) | 2001-08-10 | 2002-08-08 | Ensayo de receptor unido a proteina g. |
Country Status (7)
Country | Link |
---|---|
US (1) | US20030119716A1 (es) |
EP (1) | EP1425023A1 (es) |
CN (1) | CN1592625A (es) |
BR (1) | BR0211835A (es) |
CA (1) | CA2455962A1 (es) |
MX (1) | MXPA04001287A (es) |
WO (1) | WO2003013551A1 (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1594986B1 (de) * | 2003-02-19 | 2011-07-13 | Universität Duisburg-Essen | Verwendung einer genveränderung im humanen gnas-gen zur vorhersage von erkrankungsrisiken, krankheitsverläufen und zur vorhersage des ansprechens auf krankheitstherapien |
JP2007530015A (ja) * | 2004-01-05 | 2007-11-01 | バイオテック・スタジオ・リミテッド・ライアビリティ・カンパニー | 生物治療学的、診断および研究試薬 |
DE102004026330A1 (de) * | 2004-05-26 | 2005-12-15 | Universität Duisburg-Essen | Verwendung einer Genveränderung im Humanen GNAQ-Gen zur Vorhersage von Erkrankungsrisiken, Krankheitsverläufen und zur Vorhersage des Ansprechens auf Krankheitstherapien |
GB0421693D0 (en) | 2004-09-30 | 2004-11-03 | Amersham Biosciences Uk Ltd | Method for measuring binding of a test compound to a G-protein coupled receptor |
US20060157318A1 (en) * | 2005-01-18 | 2006-07-20 | Gao Guang R | Money box |
WO2008024128A2 (en) * | 2005-12-05 | 2008-02-28 | Simon Delagrave | Loop-variant pdz domains as biotherapeutics, diagnostics and research reagents |
US20100021891A1 (en) * | 2006-06-12 | 2010-01-28 | Bernard Lerer | Rgs2 genotypes associated with extrapyramidal symptoms induced by antipsychotic medication |
US20110009475A1 (en) * | 2007-07-13 | 2011-01-13 | Massachusetts Institute Of Technology | Methods for treating stress induced emotional disorders |
CN102272307A (zh) * | 2008-11-21 | 2011-12-07 | 利莱恩斯生命科学有限公司 | siNA介导的VEGF-C和RhoA的敲低对VEGF-A分泌、血管生成和/或新血管生成的抑制 |
EP2382470B1 (en) * | 2009-01-29 | 2014-12-10 | Commonwealth Scientific and Industrial Research Organisation | Measuring g protein coupled receptor activation |
ES2351492B2 (es) * | 2009-05-28 | 2011-09-15 | Universidad De Málaga | Uso de la proteína rgs-14 para potenciar la memoria. |
US8791100B2 (en) | 2010-02-02 | 2014-07-29 | Novartis Ag | Aryl benzylamine compounds |
ES2374471B2 (es) * | 2010-08-07 | 2012-09-13 | Universidad De Málaga | Uso de la proteína rgs-14 para fabricar un potenciador de la memoria. |
ES2352931B1 (es) * | 2010-12-02 | 2011-12-30 | Universidad De Málaga | Uso de la proteína rgs-14 para la prevención y/o tratamiento de un desorden cognitivo y/o un desorden de la memoria. |
CN102839193A (zh) * | 2012-08-22 | 2012-12-26 | 海狸(广州)生物科技有限公司 | 一种g蛋白偶联受体对化合物特异性的检测方法 |
KR20160043948A (ko) * | 2013-08-20 | 2016-04-22 | 메이지 세이카 파루마 가부시키가이샤 | S1p1 수용체 아고니스트의 평가방법 및 스크리닝 방법 |
CN105106936B (zh) * | 2015-09-29 | 2018-05-15 | 武汉大学 | G蛋白信号转导调节蛋白10(rgs10)在治疗心肌肥厚中的功能及应用 |
CN105126079B (zh) * | 2015-09-29 | 2019-03-01 | 武汉大学 | G蛋白信号转导调节蛋白14(rgs14)在治疗心肌肥厚中的功能及应用 |
EP3327134A1 (en) * | 2016-11-28 | 2018-05-30 | Carsten Korth | Method and biomarkers for in vitro diagnosis of mental disorders |
EP3392656A1 (en) * | 2017-04-20 | 2018-10-24 | Euroimmun Medizinische Labordiagnostika AG | Diagnosis of a neuroautoimmune disease |
CN108241054B (zh) * | 2017-12-26 | 2021-03-12 | 天津市中西医结合医院(天津市南开医院) | 检测g蛋白偶联受体18的试剂在制备败血症诊断及病程监测和预后判断试剂中表达的应用 |
-
2002
- 2002-08-08 MX MXPA04001287A patent/MXPA04001287A/es not_active Application Discontinuation
- 2002-08-08 CN CN02819874.3A patent/CN1592625A/zh active Pending
- 2002-08-08 WO PCT/US2002/025213 patent/WO2003013551A1/en not_active Application Discontinuation
- 2002-08-08 CA CA002455962A patent/CA2455962A1/en not_active Abandoned
- 2002-08-08 BR BRPI0211835-1A patent/BR0211835A/pt unknown
- 2002-08-08 EP EP02757038A patent/EP1425023A1/en not_active Withdrawn
- 2002-08-09 US US10/215,776 patent/US20030119716A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
BR0211835A (pt) | 2006-04-04 |
US20030119716A1 (en) | 2003-06-26 |
EP1425023A1 (en) | 2004-06-09 |
CN1592625A (zh) | 2005-03-09 |
CA2455962A1 (en) | 2003-02-20 |
WO2003013551A1 (en) | 2003-02-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |