MXPA03007261A - Moduladores del receptor de glucocorticoides. - Google Patents

Moduladores del receptor de glucocorticoides.

Info

Publication number
MXPA03007261A
MXPA03007261A MXPA03007261A MXPA03007261A MXPA03007261A MX PA03007261 A MXPA03007261 A MX PA03007261A MX PA03007261 A MXPA03007261 A MX PA03007261A MX PA03007261 A MXPA03007261 A MX PA03007261A MX PA03007261 A MXPA03007261 A MX PA03007261A
Authority
MX
Mexico
Prior art keywords
receptor modulators
glucocorticoid receptor
diabetes
mammal
compounds
Prior art date
Application number
MXPA03007261A
Other languages
English (en)
Inventor
Gaoquan Li
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/072,548 external-priority patent/US6583180B2/en
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of MXPA03007261A publication Critical patent/MXPA03007261A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C307/04—Diamides of sulfuric acids
    • C07C307/10—Diamides of sulfuric acids having nitrogen atoms of the sulfamide groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered

Abstract

Los compuestos de la formula (I): (ver formula) o sales farmaceuticamente aceptables de los mismos, son novedosos moduladores del receptor de glucocorticoides, y son utiles para el tratamiento de diabetes tipo II en un mamifero.
MXPA03007261A 2001-02-14 2002-02-12 Moduladores del receptor de glucocorticoides. MXPA03007261A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78363601A 2001-02-14 2001-02-14
US10/072,548 US6583180B2 (en) 2001-02-14 2002-02-08 Glucocorticoid receptor modulators
PCT/US2002/004501 WO2002064550A1 (en) 2001-02-14 2002-02-12 Glucocorticoid receptor modulators

Publications (1)

Publication Number Publication Date
MXPA03007261A true MXPA03007261A (es) 2006-03-09

Family

ID=26753481

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03007261A MXPA03007261A (es) 2001-02-14 2002-02-12 Moduladores del receptor de glucocorticoides.

Country Status (9)

Country Link
EP (1) EP1363876B1 (es)
JP (1) JP4499357B2 (es)
AT (1) ATE437853T1 (es)
CA (1) CA2438480C (es)
DE (1) DE60233111D1 (es)
DK (1) DK1363876T3 (es)
ES (1) ES2328795T3 (es)
MX (1) MXPA03007261A (es)
WO (1) WO2002064550A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL160845A0 (en) 2001-09-14 2004-08-31 Tularik Inc Linked biaryl compounds
ES2276038T3 (es) 2002-01-14 2007-06-16 Boehringer Ingelheim Pharmaceuticals Inc. Mimeticos de glucocorticoides, metodos para su obtencion, formulaciones farmaceuticas que los contienen y usos de los mismos.
EP1490317A1 (en) 2002-03-26 2004-12-29 Boehringer Ingelheim Pharmaceuticals Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
UA80120C2 (en) 2002-03-26 2007-08-27 Boehringer Ingelheim Pharma Glucocorticoid mimetics, pharmaceutical composition based thereon
US7186864B2 (en) 2002-05-29 2007-03-06 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
US7074806B2 (en) 2002-06-06 2006-07-11 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
WO2004018429A2 (en) 2002-08-21 2004-03-04 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted hihydroquinolines as glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
KR20050109922A (ko) 2003-01-03 2005-11-22 베링거 인겔하임 파마슈티칼즈, 인코포레이티드 1-프로판올과 1-프로필아민 유도체 및 글루코코르티코이드리간드로서의 이들의 용도
US8097606B2 (en) 2003-07-23 2012-01-17 Corcept Therapeutics, Inc. Antiglucocorticoids for the treatment of catatonia
JP4468369B2 (ja) 2003-10-16 2010-05-26 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド ある種のトリフルオロメチル置換アルコールの立体選択的合成
US20070082907A1 (en) * 2003-11-25 2007-04-12 Eli Lilly And Company Peroxisome proliferator activated receptor modulators
JP2008525525A (ja) 2004-12-27 2008-07-17 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド グルココルチコイドミメティクス、その製法、医薬組成物及び使用
EP1887005B1 (en) * 2005-05-31 2010-04-21 Kowa Co., Ltd. Processes for production of optically active ppar-activating compounds and intermediates for production thereof
TWI410422B (zh) 2007-01-15 2013-10-01 Mitsubishi Tanabe Pharma Corp 縮合四氫喹啉衍生物及其醫藥用途
TWI490214B (zh) * 2008-05-30 2015-07-01 艾德克 上野股份有限公司 苯或噻吩衍生物及該等作為ｖａｐ－１抑制劑之用途
AU2014274536B2 (en) * 2008-05-30 2016-07-28 R-Tech Ueno, Ltd. Benzene or thiophene derivative and use thereof as vap-1 inhibitor
JP2013500962A (ja) 2009-07-31 2013-01-10 カディラ ヘルスケア リミティド グルココルチコイド受容体のモジュレーターとしての新規化合物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3763141A (en) * 1968-05-13 1973-10-02 Eastman Kodak Co Substituted azobenzene compounds
US4954490A (en) * 1988-06-23 1990-09-04 Research Triangle Institute 11 β-substituted progesterone analogs
JP2873745B2 (ja) * 1991-04-05 1999-03-24 コニカ株式会社 ビススチリル化合物及び電子写真感光体
IL118974A (en) * 1995-08-17 2001-09-13 Akzo Nobel Nv History 11 - (Transformed Phenyl) - Astra - 4, 9 - Diane, their preparation and pharmaceutical preparations containing them
JPH1063021A (ja) * 1996-08-23 1998-03-06 Ricoh Co Ltd 電子写真感光体
WO1998023690A1 (en) * 1996-11-27 1998-06-04 Eastman Chemical Company Method for preparing light-absorbing polymeric compositions
WO1998027986A1 (en) * 1996-12-24 1998-07-02 Zymogenetics, Inc. Treatment agents and methods for treating type ii diabetes and symptoms of type ii diabetes
ZA9811842B (en) * 1997-12-24 2000-06-23 Ortho Mcneil Pharm Inc 4-[aryl(piperidin-4-yl)]aminobenzamides.
IL139865A0 (en) * 1998-06-08 2002-02-10 Karobio Ab A liver selective glucocorticoid antagonist and pharmaceutical compositions containing the same
US6166013A (en) * 1998-07-30 2000-12-26 Abbott Laboratories Glucocortiocoid-selective agents
YU57603A (sh) * 2001-01-22 2006-08-17 Memory Pharmaceuticals Corporation Inhibitori fosfodiesteraze 4

Also Published As

Publication number Publication date
WO2002064550A8 (en) 2002-11-14
CA2438480A1 (en) 2002-08-22
ES2328795T3 (es) 2009-11-18
WO2002064550A1 (en) 2002-08-22
ATE437853T1 (de) 2009-08-15
CA2438480C (en) 2011-05-03
JP2005510450A (ja) 2005-04-21
JP4499357B2 (ja) 2010-07-07
EP1363876B1 (en) 2009-07-29
EP1363876A1 (en) 2003-11-26
DK1363876T3 (da) 2009-11-30
DE60233111D1 (de) 2009-09-10

Similar Documents

Publication Publication Date Title
MXPA03007261A (es) Moduladores del receptor de glucocorticoides.
IL157254A0 (en) N-substituted nonaryl-heterocyclic nmda/mr2b antagonists
MY134892A (en) Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines and their use
NO20025821L (no) 2-aminokarbonyl-9H-purinderivater
DE60112974D1 (en) Carbolinderivate
TR200102800T2 (tr) Yeni bileşikler.
AP2002002458A0 (en) Compounds for the treatment of ischemia.
MXPA03006093A (es) Derivados de n(fenilsulfonil)glicina y su uso terapeutico.
UA83620C2 (ru) Замещенные бензоксазолы и их аналоги как эстрогенные агенты
MXPA03000136A (es) Derivados anticonvulsivos utiles para prevenir el desarrollo de la diabetes mellitus de tipo ii o del sindromex.
GB9929552D0 (en) Compounds
DE60216233D1 (en) Carbolinderivate
PH12009500610A1 (en) 4-imidazolin-2-one compounds
AU2001266575A1 (en) Chemical compounds
MXPA03008215A (es) Inhibidores de integrina alfa v beta 6.
DK1063995T3 (da) Kombination til behandling af alkoholafhængighed indeholdende en opiod-antagonist og en NMDA-receptorkompleks-modulator
MXPA04005784A (es) 2-fenilbenzofuranos sustituidos como agentes estrogenitos.
WO2002070469A3 (en) Selective pde3b inhibitors and use of the same in therapy
TW200508199A (en) Novel compound
IL157540A0 (en) N-(aryl)-2-arylethenesulphonamides and therapeutic uses thereof
TR200201128T2 (tr) PDE4 inhibitörleri olarak tetrahidrotiyopiranfitalazinon türevleri.
MXPA01008993A (es) Tratamiento de combinacion para depresion y ansiedad.
AU2001263278A1 (en) Cyclic gmp-specific phosphodiesterase inhibitors
AUPR118000A0 (en) Therapeutic molecules and methods
UA92500C2 (ru) Цианопирролсульфонамидные модуляторы прогестеронового рецептора и их применение