MXPA03005394A - Composiciones que contienen complejos de inclusion. - Google Patents
Composiciones que contienen complejos de inclusion.Info
- Publication number
- MXPA03005394A MXPA03005394A MXPA03005394A MXPA03005394A MXPA03005394A MX PA03005394 A MXPA03005394 A MX PA03005394A MX PA03005394 A MXPA03005394 A MX PA03005394A MX PA03005394 A MXPA03005394 A MX PA03005394A MX PA03005394 A MXPA03005394 A MX PA03005394A
- Authority
- MX
- Mexico
- Prior art keywords
- therapeutic
- composition
- polymer
- guest
- complexing agent
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
- A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/555—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound pre-targeting systems involving an organic compound, other than a peptide, protein or antibody, for targeting specific cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
- C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
- C08G65/33396—Polymers modified by chemical after-treatment with organic compounds containing nitrogen having oxygen in addition to nitrogen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
- C08G65/48—Polymers modified by chemical after-treatment
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y113/00—Oxidoreductases acting on single donors with incorporation of molecular oxygen (oxygenases) (1.13)
- C12Y113/12—Oxidoreductases acting on single donors with incorporation of molecular oxygen (oxygenases) (1.13) with incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)(1.13.12)
- C12Y113/12007—Photinus-luciferin 4-monooxygenase (ATP-hydrolysing) (1.13.12.7), i.e. firefly-luciferase
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G2650/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G2650/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterized by the type of post-polymerisation functionalisation
- C08G2650/04—End-capping
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G2650/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G2650/28—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type
- C08G2650/38—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type containing oxygen in addition to the ether group
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Polymers & Plastics (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Materials Engineering (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Neurology (AREA)
- Virology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Communicable Diseases (AREA)
- Orthopedic Medicine & Surgery (AREA)
Abstract
La invencion proporciona una composicion que contiene un compuesto en particulas de un polimero y un agente terapeutico. La composicion contiene tambien un agente acomplejante. El polimero interactua con el agente acomplejante en una interaccion anfitrion-huesped o huesped- anfitrion para formar un complejo de inclusion. Una composicion terapeutica de la invencion se puede usar para suministrar el agente terapeutico para tratar varios trastornos. Tanto el polimero del compuesto en particulas como el agente acomplejante se pueden usar para introducir funcionalidad en la composicion terapeutica. La invencion se refiere tambien a un metodo para preparar una composicion. El metodo combina un agente terapeutico, un polimero que tiene funcionalidad de anfitrion o huesped y un agente acomplejante que tiene funcionalidad de huesped o anfitrion para formar la composicion terapeutica. El agente acomplejante forma un complejo de inclusion con el polimero. La invencion se refiere tambien a un metodo para suministrar un agente terapeutico. De acuerdo con el metodo, una cantidad terapeuticamente efectiva de una composicion terapeutica de la invencion es administrada a un mamifero (por ejemplo una persona o animal) en necesidad del agente terapeutico.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25634400P | 2000-12-19 | 2000-12-19 | |
US25634100P | 2000-12-19 | 2000-12-19 | |
US29354301P | 2001-05-29 | 2001-05-29 | |
PCT/US2001/048620 WO2002049676A2 (en) | 2000-12-19 | 2001-12-19 | Compositions containing inclusion complexes |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA03005394A true MXPA03005394A (es) | 2004-05-31 |
Family
ID=27400946
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA03005394A MXPA03005394A (es) | 2000-12-19 | 2001-12-19 | Composiciones que contienen complejos de inclusion. |
Country Status (13)
Country | Link |
---|---|
US (11) | US7166302B2 (es) |
EP (1) | EP1351710A2 (es) |
JP (3) | JP4476545B2 (es) |
KR (1) | KR100894186B1 (es) |
CN (1) | CN100415296C (es) |
AU (2) | AU2906502A (es) |
BR (1) | BR0116346A (es) |
CA (1) | CA2431207C (es) |
HU (1) | HUP0400655A3 (es) |
IL (2) | IL156398A0 (es) |
MX (1) | MXPA03005394A (es) |
TW (1) | TWI321054B (es) |
WO (1) | WO2002049676A2 (es) |
Families Citing this family (94)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI321054B (en) * | 2000-12-19 | 2010-03-01 | California Inst Of Techn | Compositions containing inclusion complexes |
US20040063654A1 (en) * | 2001-11-02 | 2004-04-01 | Davis Mark E. | Methods and compositions for therapeutic use of RNA interference |
JP2005527639A (ja) * | 2001-11-02 | 2005-09-15 | インサート セラピューティクス インコーポレイテッド | Rna干渉の治療的利用のための方法及び組成物 |
CA2470524A1 (en) | 2001-12-21 | 2003-07-24 | David S. Soane | Use of oligomers and polymers for drug solublization, stabilization, and delivery |
PT1534340E (pt) | 2002-09-06 | 2012-03-13 | Cerulean Pharma Inc | Polímeros à base de ciclodextrina para a administração de medicamentos ligados por ligação covalente |
US20040220153A1 (en) * | 2002-09-24 | 2004-11-04 | Jost-Price Edward Roydon | Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines |
RU2005114007A (ru) * | 2002-10-09 | 2005-10-10 | Инсерт Терапьютикс, Инк. (Us) | Материалы на основе циклодекстринов, их композиции и применение |
EP1605978B1 (en) | 2003-03-07 | 2010-09-01 | Alnylam Pharmaceuticals Inc. | Therapeutic compositions |
US20070179100A1 (en) * | 2003-04-09 | 2007-08-02 | Muthiah Manoharan | Protected monomers |
EP2664672A1 (en) * | 2003-04-17 | 2013-11-20 | Alnylam Pharmaceuticals Inc. | Modified iRNA agents |
US8017762B2 (en) * | 2003-04-17 | 2011-09-13 | Alnylam Pharmaceuticals, Inc. | Modified iRNA agents |
US7851615B2 (en) * | 2003-04-17 | 2010-12-14 | Alnylam Pharmaceuticals, Inc. | Lipophilic conjugated iRNA agents |
US8796436B2 (en) | 2003-04-17 | 2014-08-05 | Alnylam Pharmaceuticals, Inc. | Modified iRNA agents |
AU2004232964B2 (en) | 2003-04-17 | 2011-09-22 | Alnylam Pharmaceuticals, Inc. | Protected monomers |
US7723509B2 (en) | 2003-04-17 | 2010-05-25 | Alnylam Pharmaceuticals | IRNA agents with biocleavable tethers |
JP4535229B2 (ja) * | 2003-05-08 | 2010-09-01 | 国立大学法人 東京大学 | ポリエチレングリコール−ポリカチオンブロック共重合体 |
EP2508608A1 (en) | 2003-06-09 | 2012-10-10 | Alnylam Pharmaceuticals Inc. | Method of treating neurodegenerative disease |
US7595306B2 (en) * | 2003-06-09 | 2009-09-29 | Alnylam Pharmaceuticals Inc | Method of treating neurodegenerative disease |
KR100554156B1 (ko) * | 2003-07-26 | 2006-02-22 | 학교법인 포항공과대학교 | 쿠커비투릴 유도체가 응집되어 형성된 나노 입자, 그 나노입자에 약물이 담지된 약제학적 조성물, 및 이들의 제조방법 |
KR100988321B1 (ko) * | 2003-07-26 | 2010-10-18 | 포항공과대학교 산학협력단 | 쿠커비투릴을 포함하는 고분자, 이를 이용한 정지상 및 컬럼 |
TW200517114A (en) | 2003-10-15 | 2005-06-01 | Combinatorx Inc | Methods and reagents for the treatment of immunoinflammatory disorders |
WO2005051174A2 (en) * | 2003-11-21 | 2005-06-09 | The Trustees Of Columbia University In The City Of New York | Nucleic acid aptamer-based compositions and methods |
JP4692983B2 (ja) * | 2004-07-12 | 2011-06-01 | 独立行政法人科学技術振興機構 | リポソーム封入物質がエンドソームから脱出可能なリポソーム |
TW200612993A (en) * | 2004-10-08 | 2006-05-01 | Alza Corp | Lipopolymer conjugates |
US7883688B2 (en) * | 2005-02-03 | 2011-02-08 | Agency For Science, Technology And Research | Polycationic polyrotaxanes capable of forming complexes with nucleic acids |
TW200640493A (en) * | 2005-02-16 | 2006-12-01 | Insert Therapeutics Inc | Cyclodextrin-based polymers for therapeutics delivery |
AU2006230436B2 (en) | 2005-03-31 | 2011-11-24 | Calando Pharmaceuticals, Inc. | Inhibitors of ribonucleotide reductase subunit 2 and uses thereof |
JP2007006849A (ja) * | 2005-07-04 | 2007-01-18 | Japan Science & Technology Agency | 6−アミノ−6−デオキシキトサン誘導体から成る核酸導入剤 |
EP1904526A4 (en) | 2005-07-07 | 2009-10-28 | Fulcrum Sp Ltd | SP1-POLYPEPTIDES, MODIFIED SP1-POLYPEPTIDES AND APPLICATIONS THEREOF |
KR100642220B1 (ko) * | 2005-07-12 | 2006-11-03 | 광주과학기술원 | 사이클로덱스트린과 폴리(옥시에틸렌)의 결합체 및 그제조방법 |
WO2007009265A1 (en) * | 2005-07-22 | 2007-01-25 | The Governors Of The University Of Alberta Tec Edmonton | NOVEL β-CYCLODEXTRIN-BASED MOLECULES AND DRUG DELIVERY COMPOSITIONS |
WO2007016757A1 (en) * | 2005-08-05 | 2007-02-15 | Orbus Pharma Inc. | Stabilized extended release pharmeceutical compositions comprising an hmg-coa reductase inhibitor |
AU2006308765B2 (en) | 2005-11-02 | 2013-09-05 | Arbutus Biopharma Corporation | Modified siRNA molecules and uses thereof |
US20090247603A1 (en) * | 2005-12-23 | 2009-10-01 | Orbus Pharma, Inc. | Stabilized pharmaceutical compositions comprising an HMG-CoA reductase inhibitor |
JP2007217376A (ja) * | 2006-02-17 | 2007-08-30 | Nagoya Institute Of Technology | 自己組織化ペプチド組成物 |
KR100751540B1 (ko) * | 2006-06-07 | 2007-08-22 | 재단법인서울대학교산학협력재단 | 카세란드, 카세로 착물 및 게스트 쌍 카세로 이성체와 이를이용한 전자소자 |
US9744137B2 (en) * | 2006-08-31 | 2017-08-29 | Supernus Pharmaceuticals, Inc. | Topiramate compositions and methods of enhancing its bioavailability |
ES2555066T3 (es) | 2006-11-17 | 2015-12-28 | Supernus Pharmaceuticals, Inc. | Formulaciones de liberación sostenida de topiramato |
CN102114002B (zh) * | 2006-12-04 | 2016-05-11 | 苏佩努斯制药公司 | 托吡酯的增强的立即释放制剂 |
CA2675014C (en) * | 2007-01-17 | 2016-03-29 | Immunomedics, Inc. | Polymeric carriers of therapeutic agents and recognition moieties for antibody-based targeting of disease sites |
JP2010516625A (ja) | 2007-01-24 | 2010-05-20 | インサート セラピューティクス, インコーポレイテッド | 制御された薬物送達のためのテザー基を有するポリマー−薬物コンジュゲート |
US8974814B2 (en) * | 2007-11-12 | 2015-03-10 | California Institute Of Technology | Layered drug delivery polymer monofilament fibers |
US20090176729A1 (en) * | 2007-12-14 | 2009-07-09 | Alnylam Pharmaceuticals, Inc. | Method of treating neurodegenerative disease |
JP5697988B2 (ja) | 2007-12-27 | 2015-04-08 | プロチバ バイオセラピューティクス インコーポレイティッド | 干渉rnaを使用したポロ様キナーゼ発現のサイレンシング方法 |
JP5250796B2 (ja) * | 2008-03-06 | 2013-07-31 | 株式会社不二製作所 | ゲル状研磨材の製造方法及びゲル状研磨材 |
CN102037123A (zh) | 2008-04-04 | 2011-04-27 | 卡兰多制药股份有限公司 | Epas1抑制剂的组合物和用途 |
WO2009129319A2 (en) | 2008-04-15 | 2009-10-22 | Protiva Biotherapeutics, Inc. | Silencing of csn5 gene expression using interfering rna |
IL192262A (en) | 2008-06-17 | 2016-05-31 | Z H T Eng Equipment And Tech Ltd | A polymer that releases drugs into the animal body, a medicinal product containing it and a method for its preparation |
US20110223665A1 (en) * | 2008-07-25 | 2011-09-15 | Alnylam Pharmaceuticals, Inc. | ENHANCEMENT OF siRNA SILENCING ACTIVITY USING UNIVERSAL BASES OR MISMATCHES IN THE SENSE STRAND |
EP2323628B1 (en) | 2008-08-13 | 2022-04-13 | California Institute of Technology | Carrier nanoparticles and related compositions, methods and systems |
US20100168044A1 (en) * | 2008-12-26 | 2010-07-01 | Devesh Kumar Misra | Superparamagnetic nanoparticle encapsulated with stimuli responsive polymer for drug delivery |
US8309530B2 (en) * | 2009-02-04 | 2012-11-13 | Washington State University | Compositions and methods for modulating ghrelin-mediated conditions |
US20120077774A1 (en) | 2009-05-28 | 2012-03-29 | Cornell University | Compositions and their use for removing cholesterol |
ES2337226B2 (es) * | 2009-12-16 | 2011-09-14 | Universidad De Granada | Sistemas lipidicos funcionalizados con vinilsulfonas. sintesis y usos. |
EP2515946B1 (en) | 2009-12-23 | 2019-05-22 | The Board of Trustees of the University of Illionis | Nanoconjugates and nanoconjugate formulations |
WO2011097138A1 (en) * | 2010-02-04 | 2011-08-11 | Rgo Bioscience Llc | Molecular entities for binding, stabilization and cellular delivery of negatively charged molecules |
RU2552927C2 (ru) * | 2010-03-13 | 2015-06-10 | Истпонд Лабораториз Лимитед | Жиросвязывающая композиция |
EP2553019A1 (en) | 2010-03-26 | 2013-02-06 | Mersana Therapeutics, Inc. | Modified polymers for delivery of polynucleotides, method of manufacture, and methods of use thereof |
WO2011160062A2 (en) | 2010-06-17 | 2011-12-22 | The Usa As Represented By The Secretary, National Institutes Of Health | Compositions and methods for treating inflammatory conditions |
HUE026520T2 (en) | 2010-07-08 | 2016-06-28 | Bonac Corp | Single chain nucleic acid molecule for gene expression control |
EP2674494B1 (en) | 2010-08-03 | 2014-12-17 | Bonac Corporation | Single-stranded RNA molecule having nitrogen-containing alicyclic skeleton |
AU2011287430A1 (en) | 2010-08-04 | 2013-03-21 | Cizzle Biotechnology Limited | Methods and compounds for the diagnosis and treatment of cancer |
EP2600900A4 (en) | 2010-08-06 | 2014-11-19 | Univ Illinois | SUPRAMOLECULAR MULTIPLEX AGGREGATES FOR THE NONVIRAL OUTPUT OF GENETIC MATERIALS |
CN101935365B (zh) * | 2010-08-25 | 2012-03-21 | 华东理工大学 | 一种脑靶向基头修饰性环糊精衍生物的合成方法 |
WO2012051413A1 (en) * | 2010-10-13 | 2012-04-19 | University Of Maryland, College Park | Reversal of drug-induced neuromuscular block using novel molecular containers |
US9566351B2 (en) | 2010-10-13 | 2017-02-14 | University Of Maryland, College Park | Molecular containers and methods of making and using same |
CN102443200B (zh) * | 2011-09-22 | 2013-10-16 | 四川大学 | pH敏感形状记忆材料及其制备方法 |
EP2780456A1 (en) | 2011-11-17 | 2014-09-24 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Therapeutic rna switches compositions and methods of use |
US9035039B2 (en) | 2011-12-22 | 2015-05-19 | Protiva Biotherapeutics, Inc. | Compositions and methods for silencing SMAD4 |
US9528111B2 (en) | 2012-01-07 | 2016-12-27 | Bonac Corporation | Single-stranded nucleic acid molecule having amino acid backbone |
US9827321B2 (en) | 2012-08-14 | 2017-11-28 | The Trustees Of The University Of Pennsylvania | Stabilizing shear-thinning hydrogels |
WO2014055493A1 (en) | 2012-10-02 | 2014-04-10 | Cerulean Pharma Inc. | Methods and systems for polymer precipitation and generation of particles |
US9468681B2 (en) | 2013-03-01 | 2016-10-18 | California Institute Of Technology | Targeted nanoparticles |
US9132097B2 (en) | 2013-03-01 | 2015-09-15 | California Institute Of Technology | Nanoparticles stabilized with nitrophenylboronic acid compositions |
WO2014148378A1 (ja) * | 2013-03-19 | 2014-09-25 | 公立大学法人首都大学東京 | 界面活性剤様化合物 |
JP6180241B2 (ja) * | 2013-08-29 | 2017-08-16 | 学校法人同志社 | シクロデキストリン誘導体及び医薬組成物 |
JP6468777B2 (ja) * | 2014-09-30 | 2019-02-13 | 株式会社リバネス | 改良型葉酸修飾シクロデキストリン誘導体 |
WO2016054421A1 (en) | 2014-10-02 | 2016-04-07 | Protiva Biotherapeutics, Inc | Compositions and methods for silencing hepatitis b virus gene expression |
CN104840975B (zh) * | 2015-04-24 | 2018-01-23 | 南开大学 | 一种靶向传递小干扰rna的超分子组装体及制备方法 |
WO2016197132A1 (en) | 2015-06-04 | 2016-12-08 | Protiva Biotherapeutics Inc. | Treating hepatitis b virus infection using crispr |
US10287401B2 (en) | 2015-07-01 | 2019-05-14 | California Institute Of Technology | Cationic mucic acid polymer-based delivery systems |
EP3329003A2 (en) | 2015-07-29 | 2018-06-06 | Arbutus Biopharma Corporation | Compositions and methods for silencing hepatitis b virus gene expression |
IL243839B (en) | 2016-01-28 | 2018-01-31 | Sp Nano Ltd | Conductive wires |
IL243838A (en) | 2016-01-28 | 2017-07-31 | Sp Nano Ltd | The composition containing sp1 protein and carbon nanoparticles and its uses |
EP3696269A4 (en) | 2017-10-13 | 2021-09-01 | Bonac Corporation | SINGLE STRAND NUCLEIC ACID MOLECULE AND ITS PRODUCTION PROCESS |
CN109134709B (zh) * | 2018-07-19 | 2020-08-25 | 昆明理工大学 | 胺基修饰环糊精键接开环葫芦脲的键接物及其制备方法和应用 |
CN109160995B (zh) * | 2018-08-19 | 2021-02-23 | 南京理工大学 | 一种柱[5]芳烃自组装弹性体材料及其制备方法 |
JPWO2020138421A1 (ja) * | 2018-12-27 | 2021-11-18 | 国立大学法人 熊本大学 | 脳移行性リガンド及び薬物担体 |
KR102286453B1 (ko) * | 2019-06-19 | 2021-08-09 | 한국과학기술연구원 | 베타-사이클로덱스트린을 통한 호스트-게스트 상호작용에 의해 온도감응성 폴리포스파젠에 결합된 생리활성 물질을 포함하는 하이드로젤 포접 복합체 및 이의 용도 |
WO2022132748A1 (en) * | 2020-12-14 | 2022-06-23 | Bps Just Energy Technology, Llc | Antimicrobial compositions with supramolecular structures |
CN115160454A (zh) * | 2021-04-01 | 2022-10-11 | 四川大学 | 一种基于聚-β-环糊精与金刚烷主客体作用的超分子多醛化合物及其制备方法 |
CN113234183B (zh) * | 2021-06-24 | 2022-07-22 | 西北民族大学 | 一种基于主客体识别的包合物单体及其制备方法、淀粉-苯丙抗菌乳液及其制备方法和应用 |
CN113603823B (zh) * | 2021-09-10 | 2022-05-03 | 广东电网有限责任公司 | 一种抗紫外修复材料及其制备方法与应用 |
CN114833336B (zh) * | 2022-04-21 | 2023-08-04 | 南开大学 | 一种可打印的液态金属乳液胶体及其制备方法和应用 |
Family Cites Families (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US667293A (en) * | 1900-09-11 | 1901-02-05 | Frank W Cherry | Holder for fly-paper. |
GB1390479A (en) * | 1973-09-05 | 1975-04-16 | I Orch Sinteza Akademii Nauk L | Pharmaceutical composition for treatment of parkinsonism |
GB2197720A (en) | 1986-11-20 | 1988-05-25 | Nat Res Dev | Immobilisation of polynucleotides |
EP0362290A4 (en) | 1987-06-17 | 1991-09-25 | Princess Margaret Children's Medical Research Foundation (Inc.) | Cloning of mite allergens |
US4877778A (en) * | 1987-07-01 | 1989-10-31 | The Children's Medical Center Corporation | Method of enhancing lipophile transport using cyclodextrin derivatives |
US4887778A (en) | 1988-06-01 | 1989-12-19 | Universal Instruments Corporation | Feeder drive assembly and replaceable section for tape supplying and cover peeling |
HU200913B (en) | 1988-07-28 | 1990-09-28 | Ciklodextrin Kutato Fejlesztoe | Process for producing infusion stock-solution containing pharmaceutically active components of bad water solubility |
US5139687A (en) | 1990-05-09 | 1992-08-18 | The Proctor & Gamble Company | Non-destructive carriers for cyclodextrin complexes |
JPH0425505A (ja) | 1990-05-21 | 1992-01-29 | Toppan Printing Co Ltd | シクロデキストリンポリマー及びシクロデキストリン膜の製造方法 |
CA2066633A1 (en) | 1990-11-30 | 1992-05-31 | Masanobu Yoshinaga | Processes for producing cyclodextrin derivatives and polymers containing immobilizing cyclodextrin therein |
HU213200B (en) * | 1993-05-12 | 1997-03-28 | Chinoin Gyogyszer Es Vegyeszet | The cyclodextrin or cyclodextrin derivative cluster complexes of taxol, taxotere, or taxus, pharmaceutical preparations containing them and process for their production |
HU210922B (en) | 1993-05-24 | 1995-09-28 | Europharmaceuticals Sa | Nimesulide alkali salt cyclodextrin inclusion complexes their preparation and pharmaceutical compositions containing them |
US5880154A (en) * | 1994-02-01 | 1999-03-09 | The Board Of Regents Of The University Of Nebraska | Polymeric adamantane analogues |
HU218280B (en) | 1994-04-26 | 2000-07-28 | Cyclodextrin inclusion complexes containing sin-1a which are stable intheir solid state, process for their preparation and pharmaceutical compositions containing the comlexes | |
US5691316A (en) | 1994-06-01 | 1997-11-25 | Hybridon, Inc. | Cyclodextrin cellular delivery system for oligonucleotides |
JP3699141B2 (ja) | 1994-09-24 | 2005-09-28 | 伸彦 由井 | 超分子構造の生体内分解性医薬高分子集合体及びその調製方法 |
US5728804A (en) * | 1995-06-02 | 1998-03-17 | Research Corporation Technologies, Inc. | Use of cyclodextrins for protein renaturation |
US6667293B1 (en) | 1995-09-12 | 2003-12-23 | Hybridon, Inc. | Use of cyclodextrins to modulate gene expression with reduced immunostimulatory response |
AU743204B2 (en) | 1997-04-23 | 2002-01-24 | University Of Otago | Controlled release of ophthalmic compositions |
US5990237A (en) | 1997-05-21 | 1999-11-23 | Shearwater Polymers, Inc. | Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines |
JPH11100401A (ja) | 1997-07-30 | 1999-04-13 | Kikkoman Corp | 環状オリゴ糖及びそれを含むレトロウイルス性疾患の予防または治療剤 |
KR100615117B1 (ko) | 1997-09-15 | 2006-08-22 | 제네틱 이뮤너티, 엘엘씨. | 피부의 항원제시 세포에 유전자를 전달하는 방법 |
IT1298732B1 (it) * | 1998-03-13 | 2000-02-02 | Recordati Chem Pharm | Composizioni farmaceutiche orali assumibili senza liquidi,contenenti complessi di inclusione |
US6048736A (en) * | 1998-04-29 | 2000-04-11 | Kosak; Kenneth M. | Cyclodextrin polymers for carrying and releasing drugs |
US6509323B1 (en) * | 1998-07-01 | 2003-01-21 | California Institute Of Technology | Linear cyclodextrin copolymers |
US6703381B1 (en) | 1998-08-14 | 2004-03-09 | Nobex Corporation | Methods for delivery therapeutic compounds across the blood-brain barrier |
CA2353552A1 (en) | 1998-12-04 | 2000-06-15 | California Institute Of Technology | Supramolecular complexes containing therapeutic agents |
WO2000040692A2 (en) | 1999-01-05 | 2000-07-13 | Valentis, Inc. | Methods and compositions for delivering nucleic acids |
US6740643B2 (en) | 1999-01-21 | 2004-05-25 | Mirus Corporation | Compositions and methods for drug delivery using amphiphile binding molecules |
US6309833B1 (en) * | 1999-04-12 | 2001-10-30 | Nanogen/Becton Dickinson Partnership | Multiplex amplification and separation of nucleic acid sequences on a bioelectronic microchip using asymmetric structures |
WO2000075162A1 (en) | 1999-06-07 | 2000-12-14 | Mirus Corporation | A compound containing a labile disulfide bond |
DK1102785T3 (da) | 1999-06-07 | 2013-05-13 | Arrowhead Res Corp | Sammensætninger til lægemiddeltilførsel ved anvendelse af pH-følsomme molekyler |
US6309633B1 (en) * | 1999-06-19 | 2001-10-30 | Nobex Corporation | Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same |
WO2001037665A1 (en) | 1999-11-29 | 2001-05-31 | Mirus Corporation | Compositions and methods for drug delivery using amphiphile binding molecules |
DE19961338A1 (de) | 1999-12-17 | 2001-06-21 | Nutrinova Gmbh | Feste Mischung von Lebensmittelinhalts- und Lebensmittelzusatzstoffen, Verfahren zu ihrer Herstellung und Verwendung derselben |
SK282717B6 (sk) | 2000-03-10 | 2002-11-06 | �Stav Experiment�Lnej Farmakol�Gie Sav | Spôsob prípravy ultravysokomolekulových hyalurónanov |
JP2005503101A (ja) * | 2000-08-01 | 2005-02-03 | オレゴン ヘルス アンド サイエンス ユニバーシティ | 哺乳動物のdnaを結合する膜結合タンパク質をコードする遺伝子およびその使用 |
TWI321054B (en) * | 2000-12-19 | 2010-03-01 | California Inst Of Techn | Compositions containing inclusion complexes |
-
2001
- 2001-12-18 TW TW090131376A patent/TWI321054B/zh not_active IP Right Cessation
- 2001-12-19 IL IL15639801A patent/IL156398A0/xx unknown
- 2001-12-19 US US10/021,294 patent/US7166302B2/en not_active Expired - Lifetime
- 2001-12-19 KR KR1020037008188A patent/KR100894186B1/ko not_active IP Right Cessation
- 2001-12-19 JP JP2002551013A patent/JP4476545B2/ja not_active Expired - Fee Related
- 2001-12-19 CA CA2431207A patent/CA2431207C/en not_active Expired - Fee Related
- 2001-12-19 CN CNB018227295A patent/CN100415296C/zh not_active Expired - Fee Related
- 2001-12-19 WO PCT/US2001/048620 patent/WO2002049676A2/en active IP Right Grant
- 2001-12-19 AU AU2906502A patent/AU2906502A/xx active Pending
- 2001-12-19 AU AU2002229065A patent/AU2002229065C1/en not_active Ceased
- 2001-12-19 EP EP01990201A patent/EP1351710A2/en not_active Ceased
- 2001-12-19 HU HU0400655A patent/HUP0400655A3/hu unknown
- 2001-12-19 BR BR0116346-9A patent/BR0116346A/pt not_active IP Right Cessation
- 2001-12-19 US US10/021,312 patent/US7018609B2/en not_active Expired - Lifetime
- 2001-12-19 MX MXPA03005394A patent/MXPA03005394A/es active IP Right Grant
-
2003
- 2003-06-11 IL IL156398A patent/IL156398A/en not_active IP Right Cessation
-
2005
- 2005-12-28 US US11/321,441 patent/US7807198B2/en not_active Expired - Fee Related
-
2006
- 2006-10-25 US US11/588,033 patent/US7968123B2/en not_active Expired - Fee Related
-
2009
- 2009-09-14 JP JP2009212206A patent/JP2010031284A/ja active Pending
-
2010
- 2010-07-29 US US12/846,344 patent/US8092833B2/en not_active Expired - Fee Related
-
2011
- 2011-05-13 US US13/107,024 patent/US8277846B2/en not_active Expired - Fee Related
- 2011-11-28 US US13/305,592 patent/US20120172525A1/en not_active Abandoned
-
2012
- 2012-08-15 US US13/586,328 patent/US20130197210A1/en not_active Abandoned
-
2014
- 2014-01-16 US US14/157,393 patent/US20150031753A1/en not_active Abandoned
- 2014-03-04 US US14/196,954 patent/US20150050233A1/en not_active Abandoned
- 2014-08-07 JP JP2014161842A patent/JP2014210810A/ja not_active Ceased
-
2016
- 2016-07-28 US US15/222,669 patent/US20170049903A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MXPA03005394A (es) | Composiciones que contienen complejos de inclusion. | |
IL267381A (en) | A pharmaceutical preparation containing dextromethorphan and quinidine for the treatment of nervous disorders | |
PL363218A1 (en) | Compositions for delivery of a cortisol antagonist | |
WO1996025947A3 (en) | Induction of e-selectin for targetting therapeutic agents | |
AU2002225772A1 (en) | Therapeutic agents and methods of use thereof for treating an amyloidogenic disease | |
IL151503A0 (en) | Therapeutic combinations of antihypertensive and antiagiogenic agents | |
TW200612987A (en) | Combination treatment for non-hematologic malignancies | |
BRPI0207700B8 (pt) | mistura de conjugados monodispersa, composição farmacêutica, e, uso de uma mistura substancialmente monodispersa de um conjugado de polipeptídeo de insulina-oligômero | |
WO2002026262A3 (en) | Compositions for reducing side effects in chemotherapeutic treatments | |
DE69816297T2 (de) | Verfahren und zusammensetzungen des gewebefaktors zur koagulation und behandlung von tumoren | |
MEP36608A (en) | Novel medicament compositions, based on anticholinergically effective compounds and beta-mimetics | |
WO2001030802A3 (en) | Therapeutic treatments comprising administration of certain steroids for blood cell deficiencies | |
ATE347361T1 (de) | Kombination eines pde4-inhibitors mit tiotropium zur behandlung obstruktiver atemwegserkrankungen | |
WO2005016234A3 (en) | Compositions, methods, apparatuses, and systems for singlet oxygen delivery | |
AU7226301A (en) | Pyridoxine and pyridoxal analogues: cardiovascular therapeutics | |
WO2003049694A3 (en) | Methods of therapy for non-hodgkin's lymphoma | |
AU4258101A (en) | Combination therapies with vascular damaging activity | |
BR0012175A (pt) | Antagonistas de receptor de igiur5, seletivos para o tratamento de enxaqueca | |
MXPA02010316A (es) | Terapia novedosa para los trastornos asociados con la hiperlipidemia. | |
MX2008001661A (es) | Metodos para tratar afecciones malignas de celulas b que utilizan una molecula de fusion del activador de transmembrana o interactor del ligando de ciclofilina de modulacion de calcio-ig. | |
IL141550A0 (en) | Methods and compositions for the prevention or treatment of cancer | |
AP1896A (en) | The method of treating cancer | |
MXPA05010804A (es) | Torio 227 para uso en radioterapia de enfermedades del tejido blando. | |
DE50212918D1 (de) | Polypeptid, dessen konjugat doxorubicin enthält, uetzung | |
EP1011672A4 (en) | CONNECTIONS WITH ANALGETIC EFFECT AND COMPILATIONS THAT CONTAIN THEM |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |