MXPA03003329A - Metodo para preparacion de bifenil-isoxazol-sulfonamidas. - Google Patents
Metodo para preparacion de bifenil-isoxazol-sulfonamidas.Info
- Publication number
- MXPA03003329A MXPA03003329A MXPA03003329A MXPA03003329A MXPA03003329A MX PA03003329 A MXPA03003329 A MX PA03003329A MX PA03003329 A MXPA03003329 A MX PA03003329A MX PA03003329 A MXPA03003329 A MX PA03003329A MX PA03003329 A MXPA03003329 A MX PA03003329A
- Authority
- MX
- Mexico
- Prior art keywords
- preparation
- methods
- isoxazole sulfonamides
- biphenyl isoxazole
- biphenyl
- Prior art date
Links
- KFJGHVOVYDCDOS-UHFFFAOYSA-N 1,1'-biphenyl;1,2-oxazole-3-sulfonamide Chemical class NS(=O)(=O)C=1C=CON=1.C1=CC=CC=C1C1=CC=CC=C1 KFJGHVOVYDCDOS-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/14—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/14—Nitrogen atoms
- C07D261/16—Benzene-sulfonamido isoxazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24090200P | 2000-10-17 | 2000-10-17 | |
| PCT/US2001/042741 WO2002032884A2 (en) | 2000-10-17 | 2001-10-12 | Methods for the preparation of biphenyl isoxazole sulfonamides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA03003329A true MXPA03003329A (es) | 2003-10-15 |
Family
ID=22908392
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA03003329A MXPA03003329A (es) | 2000-10-17 | 2001-10-12 | Metodo para preparacion de bifenil-isoxazol-sulfonamidas. |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US6639082B2 (es) |
| EP (1) | EP1328523A2 (es) |
| JP (1) | JP2004513098A (es) |
| KR (1) | KR20030041168A (es) |
| CN (1) | CN1501925A (es) |
| AU (1) | AU2002232382A1 (es) |
| BR (1) | BR0114709A (es) |
| CA (1) | CA2425911A1 (es) |
| CZ (1) | CZ20031369A3 (es) |
| HU (1) | HUP0600606A2 (es) |
| IL (1) | IL155318A0 (es) |
| MX (1) | MXPA03003329A (es) |
| PL (1) | PL365567A1 (es) |
| WO (1) | WO2002032884A2 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6872849B2 (en) | 2002-11-08 | 2005-03-29 | Novo Nordisk A/S | Halo sulfonyl aryl boronates |
| ATE343583T1 (de) * | 2002-11-08 | 2006-11-15 | Novo Nordisk As | Halogensulfonylarylboronate |
| CN101137412B (zh) | 2005-01-13 | 2012-11-07 | 布里斯托尔-迈尔斯·斯奎布公司 | 用作凝血因子XIa抑制剂的取代的二芳基化合物 |
| MX2022005063A (es) | 2019-10-30 | 2022-08-04 | Perfuse Therapeutics Inc | Tratamiento de enfermedades oculares con antagonistas de receptor de endotelina. |
| JP2023512763A (ja) | 2020-02-06 | 2023-03-29 | パフューズ セラピューティクス， インコーポレイテッド | 眼疾患の処置のための組成物 |
| KR20240004643A (ko) | 2021-04-30 | 2024-01-11 | 퍼퓨즈 세라퓨틱스, 인크. | 안구 질환의 치료를 위한 제약 조성물 및 유리체내 약물 전달 시스템 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2888455A (en) | 1956-09-04 | 1959-05-26 | Shionogi & Co | New sulfonamide and process for producing the same |
| DE1059459B (de) | 1956-09-04 | 1959-06-18 | Shionogi & Co | Verfahren zur Herstellung des therapeutisch wertvollen 3-Sulfanilamido-5-methylisoxazols |
| GB897440A (en) | 1960-02-08 | 1962-05-30 | Shionogi & Co | Improvements in or relating to sulfonamides |
| EP0194548A3 (de) | 1985-03-12 | 1988-08-17 | Dr. Karl Thomae GmbH | Neue Sulfonylaminoäthylverbindungen, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| US5571821A (en) | 1993-05-20 | 1996-11-05 | Texas Biotechnology Corporation | Sulfonamides and derivatives thereof that modulate the activity of endothelin |
| US5591761A (en) | 1993-05-20 | 1997-01-07 | Texas Biotechnology Corporation | Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
| US5464853A (en) | 1993-05-20 | 1995-11-07 | Immunopharmaceutics, Inc. | N-(5-isoxazolyl)biphenylsulfonamides, N-(3-isoxazolyl)biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin |
| US5594021A (en) | 1993-05-20 | 1997-01-14 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl sulfonamides and derivatives thereof that modulate the activity of endothelin |
| US5514691A (en) | 1993-05-20 | 1996-05-07 | Immunopharmaceutics, Inc. | N-(4-halo-isoxazolyl)-sulfonamides and derivatives thereof that modulate the activity of endothelin |
| CA2005741C (en) | 1988-12-26 | 1998-06-02 | Hiroyoshi Hidaka | Quinoline sulfonoamino compounds having vessel smooth muscle relaxation activity |
| DE122007000050I1 (de) | 1990-02-19 | 2007-11-08 | Novartis Ag | Acylverbindungen |
| US5236928A (en) | 1991-03-19 | 1993-08-17 | Merck & Co., Inc. | Imidazole derivatives bearing acidic functional groups at the 5-position, their compositions and methods of use as angiotensin II antagonists |
| TW270116B (es) | 1991-04-25 | 1996-02-11 | Hoffmann La Roche | |
| RU2086544C1 (ru) | 1991-06-13 | 1997-08-10 | Хоффманн-Ля Рош АГ | Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина |
| SE9103397D0 (sv) | 1991-11-18 | 1991-11-18 | Kabi Pharmacia Ab | Nya substituerade salicylsyror |
| TW224462B (es) | 1992-02-24 | 1994-06-01 | Squibb & Sons Inc | |
| US5378715A (en) | 1992-02-24 | 1995-01-03 | Bristol-Myers Squibb Co. | Sulfonamide endothelin antagonists |
| NZ247440A (en) | 1992-05-06 | 1995-04-27 | Squibb & Sons Inc | Phenyl sulphonamide derivatives, preparation and pharmaceutical compositions thereof |
| US5514696A (en) | 1992-05-06 | 1996-05-07 | Bristol-Myers Squibb Co. | Phenyl sulfonamide endothelin antagonists |
| TW287160B (es) | 1992-12-10 | 1996-10-01 | Hoffmann La Roche | |
| TW394761B (en) | 1993-06-28 | 2000-06-21 | Hoffmann La Roche | Novel Sulfonylamino Pyrimidines |
| US5965732A (en) | 1993-08-30 | 1999-10-12 | Bristol-Myers Squibb Co. | Sulfonamide endothelin antagonists |
| US5612359A (en) | 1994-08-26 | 1997-03-18 | Bristol-Myers Squibb Company | Substituted biphenyl isoxazole sulfonamides |
| CA2168154A1 (en) | 1995-02-06 | 1996-08-07 | Natesan Murugesan | Substituted biphenyl sulfonamide endothelin antagonists |
| US5760038A (en) | 1995-02-06 | 1998-06-02 | Bristol-Myers Squibb Company | Substituted biphenyl sulfonamide endothelin antagonists |
| US5780473A (en) | 1995-02-06 | 1998-07-14 | Bristol-Myers Squibb Company | Substituted biphenyl sulfonamide endothelin antagonists |
| CZ299246B6 (cs) | 1995-04-04 | 2008-05-28 | Encysive Pharmaceuticals Inc. | Sulfonamid, farmaceutická kompozice s jeho obsahem a jeho použití pro výrobu léciva |
| UA58494C2 (uk) | 1995-06-07 | 2003-08-15 | Зенека Лімітед | Похідні n-гетероарилпіридинсульфонаміду, фармацевтична композиція, спосіб одержання та спосіб протидії впливам ендотеліну |
| GB9512697D0 (en) | 1995-06-22 | 1995-08-23 | Zeneca Ltd | Heterocyclic compounds |
| US5846990A (en) | 1995-07-24 | 1998-12-08 | Bristol-Myers Squibb Co. | Substituted biphenyl isoxazole sulfonamides |
| SG87051A1 (en) | 1996-02-20 | 2002-03-19 | Bristol Myers Squibb Co | Process for preparing biphenyl isoxazole sulfonamide intermediates |
| US5856507A (en) | 1997-01-21 | 1999-01-05 | Bristol-Myers Squibb Co. | Methods for the preparation of biphenyl isoxazole sulfonamides |
| US5939446A (en) | 1996-04-09 | 1999-08-17 | Bristol-Myers Squibb Co. | Heteroaryl substituted phenyl isoxazole sulfonamide endothelin antagonists |
| TW536540B (en) * | 1997-01-30 | 2003-06-11 | Bristol Myers Squibb Co | Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe |
| JP2002540088A (ja) | 1999-03-19 | 2002-11-26 | ブリストル−マイヤーズ スクイブ カンパニー | ビフェニルイソキサゾール・スルホンアミド化合物の製造法 |
| CA2395088A1 (en) | 1999-12-15 | 2001-06-21 | Bristol-Myers Squibb Company | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists |
-
2001
- 2001-09-28 US US09/967,387 patent/US6639082B2/en not_active Expired - Fee Related
- 2001-10-12 MX MXPA03003329A patent/MXPA03003329A/es active IP Right Grant
- 2001-10-12 WO PCT/US2001/042741 patent/WO2002032884A2/en active Application Filing
- 2001-10-12 CA CA002425911A patent/CA2425911A1/en not_active Abandoned
- 2001-10-12 IL IL15531801A patent/IL155318A0/xx unknown
- 2001-10-12 EP EP01987748A patent/EP1328523A2/en not_active Withdrawn
- 2001-10-12 AU AU2002232382A patent/AU2002232382A1/en not_active Abandoned
- 2001-10-12 BR BR0114709-9A patent/BR0114709A/pt not_active IP Right Cessation
- 2001-10-12 KR KR10-2003-7005306A patent/KR20030041168A/ko not_active Application Discontinuation
- 2001-10-12 JP JP2002536267A patent/JP2004513098A/ja active Pending
- 2001-10-12 PL PL01365567A patent/PL365567A1/xx not_active Application Discontinuation
- 2001-10-12 CZ CZ20031369A patent/CZ20031369A3/cs unknown
- 2001-10-12 CN CNA01820659XA patent/CN1501925A/zh active Pending
- 2001-10-12 HU HU0600606A patent/HUP0600606A2/hu unknown
-
2003
- 2003-08-12 US US10/639,228 patent/US20040059123A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2004513098A (ja) | 2004-04-30 |
| CZ20031369A3 (cs) | 2003-08-13 |
| IL155318A0 (en) | 2003-11-23 |
| WO2002032884A3 (en) | 2002-10-17 |
| US20040059123A1 (en) | 2004-03-25 |
| PL365567A1 (en) | 2005-01-10 |
| US20020132838A1 (en) | 2002-09-19 |
| HUP0600606A2 (en) | 2006-11-28 |
| EP1328523A2 (en) | 2003-07-23 |
| WO2002032884A2 (en) | 2002-04-25 |
| US6639082B2 (en) | 2003-10-28 |
| AU2002232382A1 (en) | 2002-04-29 |
| CN1501925A (zh) | 2004-06-02 |
| CA2425911A1 (en) | 2002-04-25 |
| BR0114709A (pt) | 2004-06-15 |
| KR20030041168A (ko) | 2003-05-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |