MXPA02011376A - Benzofenonas como inhibidores de il-1beta y tnf-alfa. - Google Patents
Benzofenonas como inhibidores de il-1beta y tnf-alfa.Info
- Publication number
- MXPA02011376A MXPA02011376A MXPA02011376A MXPA02011376A MXPA02011376A MX PA02011376 A MXPA02011376 A MX PA02011376A MX PA02011376 A MXPA02011376 A MX PA02011376A MX PA02011376 A MXPA02011376 A MX PA02011376A MX PA02011376 A MXPA02011376 A MX PA02011376A
- Authority
- MX
- Mexico
- Prior art keywords
- 1bgr
- agr
- tnf
- benzophenones
- inhibitors
- Prior art date
Links
- 239000012965 benzophenone Substances 0.000 title 1
- 150000008366 benzophenones Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- -1 Heteroaryl aminobenzophenones Chemical class 0.000 abstract 1
- 102000015696 Interleukins Human genes 0.000 abstract 1
- 108010063738 Interleukins Proteins 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
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- A—HUMAN NECESSITIES
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- A61K31/13—Amines
- A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/47—Quinolines; Isoquinolines
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- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
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- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
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- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
Abstract
La presente invencion se refiere a heteroaril-aminobenzofrenonas de la Formula General (I) que inhiben la interleucina -1¦ y TNF-a y, por lo tanto, son utiles en la terapia de enfermedades y trastornos inflamatorios. (ver formula).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US20557900P | 2000-05-22 | 2000-05-22 | |
PCT/DK2001/000346 WO2001090074A2 (en) | 2000-05-22 | 2001-05-18 | BENZOPHENONES AS INHIBITORS OF IL-1β AND TNF-$g(a) |
Publications (1)
Publication Number | Publication Date |
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MXPA02011376A true MXPA02011376A (es) | 2004-02-26 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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MXPA02011376A MXPA02011376A (es) | 2000-05-22 | 2001-05-18 | Benzofenonas como inhibidores de il-1beta y tnf-alfa. |
Country Status (14)
Country | Link |
---|---|
US (1) | US6432962B2 (es) |
EP (1) | EP1289958A2 (es) |
JP (1) | JP2003534327A (es) |
KR (1) | KR20030001551A (es) |
CN (1) | CN1239485C (es) |
AU (2) | AU2001260081B2 (es) |
BR (1) | BR0111034A (es) |
CA (1) | CA2408727A1 (es) |
HK (1) | HK1055949A1 (es) |
HU (1) | HUP0301932A3 (es) |
MX (1) | MXPA02011376A (es) |
PL (1) | PL359862A1 (es) |
RU (1) | RU2270194C2 (es) |
WO (1) | WO2001090074A2 (es) |
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AU7895601A (en) * | 2000-07-18 | 2002-01-30 | Bone Care Int Inc | Stabilized 1alpha-hydroxy vitamin d |
US20020165286A1 (en) * | 2000-12-08 | 2002-11-07 | Hanne Hedeman | Dermal anti-inflammatory composition |
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US20090149453A1 (en) * | 2002-05-23 | 2009-06-11 | Activbiotics Pharma Llc | Methods and compositions for treating bacterial infections and diseases associated therewith |
JP2005538066A (ja) * | 2002-07-09 | 2005-12-15 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | 新規な抗コリン作用薬及びp38キナーゼ阻害剤を用いた新規な医薬組成物 |
ES2363914T3 (es) * | 2002-11-21 | 2011-08-19 | Genzyme Corporation | Utilización de un derivado de diamida para inhibir el rechazo crónico de un transplante. |
DK1562571T3 (da) * | 2002-11-21 | 2011-12-05 | Genzyme Corp | Kombination af et diamidderivat og immunsuppressive midler til hæmning af transplantatafstødning |
US20040127519A1 (en) * | 2002-12-12 | 2004-07-01 | Pharmacia Corporation | Method of using aminocyanopyridine compounds as mitogen activated protein kinase-activated protein kinase-2 inhibitors |
US20040176404A1 (en) * | 2002-12-12 | 2004-09-09 | Sayada Chalom B. | Methods and reagents for treating or preventing atherosclerosis and diseases associated therewith |
US6909001B2 (en) * | 2002-12-12 | 2005-06-21 | Pharmacia Corporation | Method of making tricyclic aminocyanopyridine compounds |
US20040127511A1 (en) * | 2002-12-12 | 2004-07-01 | Pharmacia Corporation | Tricyclic aminocyanopyridine inhibitors of mitogen activated protein kinase-activated protein kinase-2 |
US20040142978A1 (en) * | 2002-12-12 | 2004-07-22 | Pharmacia Corporation | Aminocyanopyridine inhibitors of mitogen activated protein kinase-activated protein kinase-2 |
EP1572693A1 (en) * | 2002-12-20 | 2005-09-14 | Pharmacia Corporation | Mitogen activated protein kinase-activated protein kinase-2 inhibiting compounds |
EP1471057B1 (en) * | 2003-04-25 | 2006-01-18 | Actimis Pharmaceuticals, Inc. | Pyrimidinylacetic acid derivatives useful for the treatment of diseases mediated by CRTH2 |
CN101039957A (zh) | 2003-05-16 | 2007-09-19 | 因特缪恩公司 | 合成的趋化因子受体配体及其使用方法 |
WO2005037214A2 (en) | 2003-10-14 | 2005-04-28 | Intermune, Inc. | Macrocyclic carboxylic acids and acylsulfonamides as inhibitors of hcv replication |
US7597884B2 (en) | 2004-08-09 | 2009-10-06 | Alios Biopharma, Inc. | Hyperglycosylated polypeptide variants and methods of use |
KR101318012B1 (ko) | 2004-10-20 | 2013-10-14 | 메르크 세로노 에스.에이. | 3-아릴아미노 피리딘 유도체 |
ATE455768T1 (de) | 2004-12-13 | 2010-02-15 | Leo Pharma As | Triazolsubstituierte aminobenzophenonverbindungen |
WO2008026704A1 (fr) * | 2006-08-31 | 2008-03-06 | Kyowa Hakko Kogyo Co., Ltd. | Dérivé d'isoquinoline |
DE102007005580A1 (de) * | 2007-01-23 | 2008-07-24 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Arzneimittel zur Behandlung von Sepsis |
ES2429592T3 (es) * | 2008-04-22 | 2013-11-15 | Toyama Chemical Co., Ltd. | Combinación de un derivado de benzofenona o de una sal del mismo y de un agente inmunosupresor y composición farmacéutica que contiene estos componentes |
US8410126B2 (en) * | 2009-05-29 | 2013-04-02 | Boehringer Ingelheim International Gmbh | Pyrimidine inhibitors of PKTK2 |
US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
US9394285B2 (en) | 2013-03-15 | 2016-07-19 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
WO2017151409A1 (en) | 2016-02-29 | 2017-09-08 | University Of Florida Research Foundation, Incorporated | Chemotherapeutic methods |
CN114230513A (zh) * | 2022-01-07 | 2022-03-25 | 大连九信精细化工有限公司 | 一种3-氯-2-甲基-5-三氟甲基吡啶的合成方法 |
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JPS57177058A (en) | 1981-04-24 | 1982-10-30 | Hodogaya Chem Co Ltd | Novel fluoran compound |
JPH03179059A (ja) * | 1989-12-08 | 1991-08-05 | Hodogaya Chem Co Ltd | 2―アニリノ―3―メチル―6―n―エチル―n―テトラヒドロフルフリルアミノフルオランの結晶変態 |
GB9701453D0 (en) * | 1997-01-24 | 1997-03-12 | Leo Pharm Prod Ltd | Aminobenzophenones |
AU768878B2 (en) | 1999-07-16 | 2004-01-08 | Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) | Aminobenzophenones as inhibitors of IL-1beta and TNF-alpha |
DE60014394T2 (de) | 1999-07-16 | 2005-12-22 | Leo Pharma A/S | Aminobenzophenone als inhibitoren von il-1beta und tnf-alpha |
PL353645A1 (en) | 1999-07-16 | 2003-12-01 | Leo Pharma A/Sleo Pharma A/S | Novel aminobenzophenones |
JP2003505360A (ja) | 1999-07-16 | 2003-02-12 | レオ・ファーマ・アクティーゼルスカブ | IL−1βおよびTNF−αの抑制剤としてのアミノベンゾフェノン |
DK1210320T3 (da) | 1999-07-16 | 2005-01-31 | Leo Pharma As | Aminobenzofenoner som inhibitorer for IL-1beta og TNF-alfa |
AU776395B2 (en) | 1999-12-06 | 2004-09-09 | Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) | Aminobenzophenones as inhibitors of IL-1beta and TNF-alpha |
-
2001
- 2001-05-18 EP EP01933642A patent/EP1289958A2/en not_active Withdrawn
- 2001-05-18 HU HU0301932A patent/HUP0301932A3/hu unknown
- 2001-05-18 AU AU2001260081A patent/AU2001260081B2/en not_active Ceased
- 2001-05-18 KR KR1020027015832A patent/KR20030001551A/ko not_active Application Discontinuation
- 2001-05-18 AU AU6008101A patent/AU6008101A/xx active Pending
- 2001-05-18 CN CNB018098657A patent/CN1239485C/zh not_active Expired - Fee Related
- 2001-05-18 WO PCT/DK2001/000346 patent/WO2001090074A2/en not_active Application Discontinuation
- 2001-05-18 CA CA002408727A patent/CA2408727A1/en not_active Abandoned
- 2001-05-18 JP JP2001586263A patent/JP2003534327A/ja active Pending
- 2001-05-18 RU RU2002134487/04A patent/RU2270194C2/ru not_active IP Right Cessation
- 2001-05-18 MX MXPA02011376A patent/MXPA02011376A/es active IP Right Grant
- 2001-05-18 PL PL35986201A patent/PL359862A1/xx not_active Application Discontinuation
- 2001-05-18 BR BR0111034-9A patent/BR0111034A/pt not_active IP Right Cessation
- 2001-05-21 US US09/860,492 patent/US6432962B2/en not_active Expired - Fee Related
-
2003
- 2003-11-12 HK HK03108182A patent/HK1055949A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2408727A1 (en) | 2001-11-29 |
HUP0301932A3 (en) | 2007-09-28 |
HK1055949A1 (en) | 2004-01-30 |
CN1430607A (zh) | 2003-07-16 |
WO2001090074A3 (en) | 2002-05-02 |
KR20030001551A (ko) | 2003-01-06 |
CN1239485C (zh) | 2006-02-01 |
US20020016347A1 (en) | 2002-02-07 |
RU2270194C2 (ru) | 2006-02-20 |
PL359862A1 (en) | 2004-09-06 |
AU2001260081B2 (en) | 2005-07-28 |
HUP0301932A2 (hu) | 2003-09-29 |
BR0111034A (pt) | 2003-06-17 |
AU6008101A (en) | 2001-12-03 |
EP1289958A2 (en) | 2003-03-12 |
WO2001090074A2 (en) | 2001-11-29 |
JP2003534327A (ja) | 2003-11-18 |
US6432962B2 (en) | 2002-08-13 |
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