MXPA02005562A - Superdesintegrante farmaceutico. - Google Patents
Superdesintegrante farmaceutico.Info
- Publication number
- MXPA02005562A MXPA02005562A MXPA02005562A MXPA02005562A MXPA02005562A MX PA02005562 A MXPA02005562 A MX PA02005562A MX PA02005562 A MXPA02005562 A MX PA02005562A MX PA02005562 A MXPA02005562 A MX PA02005562A MX PA02005562 A MXPA02005562 A MX PA02005562A
- Authority
- MX
- Mexico
- Prior art keywords
- superdisintegrant
- superdisintegrants
- dosage form
- solid dosage
- compactibility
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Medicinal Preparation (AREA)
Abstract
Se describen superdesintegrantes los cuales proporcionan compresabilidad mejorada en comparacion con los superdesintegrantes de la tecnica anterior que no tienen un impacto negativo sobre la compresabilidad de formulaciones que incluyen farmacos en altas dosis, y metodos para obtener los mismos. Los superdesintegrantes incluyen un aglomerado particulado de almidon o celulosa coprocesada y una cantidad suficiente de un agente aditivo para incrementar la compactabilidad del superdesintegrante. El superdesintegrante aumentado proporciona una desintegracion rapida de una forma de desintegracion solida cuando se incorpora en una cantidad suficiente homologa, sin afectar de manera adversa la compactabilidad de la forma de dosificacion solida (en relacion a una forma de dosificacion solida sin el superdesintegrante).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16917499P | 1999-12-06 | 1999-12-06 | |
PCT/US2000/032989 WO2001039746A1 (en) | 1999-12-06 | 2000-12-06 | Pharmaceutical superdisintegrant |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA02005562A true MXPA02005562A (es) | 2004-09-10 |
Family
ID=22614504
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA02005562A MXPA02005562A (es) | 1999-12-06 | 2000-12-06 | Superdesintegrante farmaceutico. |
Country Status (11)
Country | Link |
---|---|
US (2) | US6660303B2 (es) |
EP (1) | EP1244428A1 (es) |
KR (1) | KR20020062323A (es) |
AU (2) | AU771440B2 (es) |
BR (1) | BR0016482A (es) |
CA (1) | CA2393231A1 (es) |
HU (1) | HUP0301333A3 (es) |
IL (1) | IL150053A0 (es) |
MX (1) | MXPA02005562A (es) |
NO (1) | NO20022645L (es) |
WO (1) | WO2001039746A1 (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0204771D0 (en) * | 2002-02-28 | 2002-04-17 | Phoqus Ltd | Fast disintegrating tablets |
AU2003256284A1 (en) * | 2002-06-20 | 2004-01-06 | Orapharma, Inc. | Rapidly disintegrating formulations for treating or preventing mucositis |
SI21221A (sl) * | 2002-06-21 | 2003-12-31 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Hitro razpadljive tablete |
US20040265375A1 (en) * | 2003-04-16 | 2004-12-30 | Platteeuw Johannes J. | Orally disintegrating tablets |
US20050244490A1 (en) * | 2003-12-09 | 2005-11-03 | Michael Otto | Dosing methods for beta-D-2',3'-dideoxy-2',3'-didehydro-5-fluorocytidine antiviral therapy |
EP1725217B1 (en) * | 2004-03-10 | 2008-08-06 | Ranbaxy Laboratories, Ltd. | Processes for the preparation of solid dosage forms of amorphous valganciclovir hydrochloride |
US20050220865A1 (en) * | 2004-04-02 | 2005-10-06 | Koleng John J | Compressed composition comprising magnesium salt |
US8236349B2 (en) * | 2004-04-12 | 2012-08-07 | Bend Research Inc. | Taste-masked drugs in rupturing multiparticulates |
CA2784881C (en) * | 2005-02-25 | 2016-02-09 | Takeda Pharmaceutical Company Limited | Method for producing granules |
US20080020040A1 (en) * | 2006-07-18 | 2008-01-24 | Horizon Therapeutics, Inc. | Unit dose form for administration of ibuprofen |
US8067451B2 (en) * | 2006-07-18 | 2011-11-29 | Horizon Pharma Usa, Inc. | Methods and medicaments for administration of ibuprofen |
US20070043096A1 (en) * | 2005-07-18 | 2007-02-22 | Horizon Therapeutics, Inc. | Unit dose form with ibuprofen-famotidine admixture |
US8067033B2 (en) | 2007-11-30 | 2011-11-29 | Horizon Pharma Usa, Inc. | Stable compositions of famotidine and ibuprofen |
US10357462B2 (en) * | 2006-11-30 | 2019-07-23 | Ben Research, Inc. | Multiparticulates of spray-coated drug and polymer on a meltable core |
US11116728B2 (en) | 2006-11-30 | 2021-09-14 | Bend Research, Inc. | Multiparticulates of spray-coated drug and polymer on a meltable core |
US20100055179A1 (en) * | 2006-12-21 | 2010-03-04 | Mallinckrodt Inc. | Composition of and Method for Preparing Orally Disintegrating Tablets Containing a High Dose of Pharmaceutically Active Ingredients |
JP5637624B2 (ja) * | 2009-02-12 | 2014-12-10 | 富士化学工業株式会社 | 崩壊性粒子組成物及びそれを用いた速崩壊性圧縮成型物 |
EP3138603A1 (en) * | 2009-03-20 | 2017-03-08 | Incube Labs, Llc | Solid drug delivery apparatus, formulations and methods of use |
US20100285164A1 (en) * | 2009-05-11 | 2010-11-11 | Jrs Pharma | Orally Disintegrating Excipient |
US20160008310A1 (en) | 2014-07-11 | 2016-01-14 | Azanta A/S | Misoprostol dispersible tablet |
EA039069B1 (ru) * | 2014-07-11 | 2021-11-30 | Асанта Данмарк А/С | Способ обеспечения созревания шейки матки или стимулирования родов, включающий введение фармацевтической композиции мизопростола, и применение мизопростола для изготовления такой композиции |
EP4110263A4 (en) * | 2020-02-27 | 2024-04-17 | Henkel AG & Co. KGaA | PERSONAL CARE PRODUCT AND METHOD FOR PRODUCING A PERSONAL CARE PRODUCT BY A GENERATIVE PROCESS |
CN112618503B (zh) * | 2021-01-20 | 2022-04-15 | 天津市中央药业有限公司 | 头孢地尼分散片 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3141875A (en) | 1961-03-15 | 1964-07-21 | Fmc Corp | Crystallite aggregates disintegrated in acid medium |
GB2042888B (en) * | 1979-03-05 | 1983-09-28 | Teijin Ltd | Preparation for administration to the mucosa of the oral or nasal cavity |
US4772473A (en) | 1986-06-16 | 1988-09-20 | Norwich Eaton Pharmaceuticals, Inc. | Nitrofurantoin dosage form |
US4910023A (en) * | 1988-06-09 | 1990-03-20 | Warner-Lambert Company | Drug in combination with flavor masking agent and method for making same |
HU203041B (en) | 1989-03-14 | 1991-05-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing pharmaceutical compositions of controlled releasing factor containing nifedipin |
US5468286A (en) * | 1989-10-25 | 1995-11-21 | National Starch And Chemical Investment Holding Corporation | Enzymatically debranched starches as tablet excipients |
IT1241417B (it) * | 1990-03-06 | 1994-01-14 | Vectorpharma Int | Composizioni terapeutiche a rilascio controllato di farmaci supportatisu polimeri reticolati e rivestiti con film polimerici,e loro processodi preparazione |
CA2041774C (en) | 1990-11-27 | 1994-04-19 | Mircea A. Mateescu | Use of cross-linked amylose as a matrix for the slow release of biologically active compounds |
US5215757A (en) * | 1991-03-22 | 1993-06-01 | The Procter & Gamble Company | Encapsulated materials |
US5272191A (en) | 1991-08-21 | 1993-12-21 | Fmc Corporation | Cold water soluble films and film forming compositions |
CA2140032C (en) | 1992-07-24 | 1999-01-26 | Mircea A. Mateescu | Cross-linked amylose material for enzymatically controlled drug release |
US5616343A (en) | 1993-03-25 | 1997-04-01 | Labopharm, Inc. | Cross-linked amylose as a binder/disintegrant in tablets |
US5948438A (en) | 1995-01-09 | 1999-09-07 | Edward Mendell Co., Inc. | Pharmaceutical formulations having improved disintegration and/or absorptivity |
IL139728A (en) | 1995-01-09 | 2003-06-24 | Penwest Pharmaceuticals Compan | Aqueous slurry composition containing microcrystalline cellulose for preparing a pharmaceutical excipient |
US6106865A (en) | 1995-01-09 | 2000-08-22 | Edward Mendell Co., Inc. | Pharmaceutical excipient having improved compressibility |
US5585115A (en) | 1995-01-09 | 1996-12-17 | Edward H. Mendell Co., Inc. | Pharmaceutical excipient having improved compressability |
US5733578A (en) | 1995-11-15 | 1998-03-31 | Edward Mendell Co., Inc. | Directly compressible high load acetaminophen formulations |
TW430561B (en) * | 1995-12-20 | 2001-04-21 | Gea Farmaceutisk Fabrik As | Rapid release tablet composition comprising tolfenamic acid or a pharmaceutically acceptable salt thereof as active ingredient and a method of preparing such tablet |
US5989589A (en) | 1997-10-24 | 1999-11-23 | Cartilier; Louis | Cross-linked cellulose as a tablet excipient |
-
2000
- 2000-12-06 CA CA002393231A patent/CA2393231A1/en not_active Abandoned
- 2000-12-06 IL IL15005300A patent/IL150053A0/xx unknown
- 2000-12-06 US US09/731,238 patent/US6660303B2/en not_active Expired - Fee Related
- 2000-12-06 BR BR0016482-8A patent/BR0016482A/pt not_active Application Discontinuation
- 2000-12-06 AU AU20614/01A patent/AU771440B2/en not_active Ceased
- 2000-12-06 HU HU0301333A patent/HUP0301333A3/hu unknown
- 2000-12-06 KR KR1020027007259A patent/KR20020062323A/ko not_active IP Right Cessation
- 2000-12-06 MX MXPA02005562A patent/MXPA02005562A/es unknown
- 2000-12-06 WO PCT/US2000/032989 patent/WO2001039746A1/en not_active Application Discontinuation
- 2000-12-06 EP EP00983920A patent/EP1244428A1/en not_active Withdrawn
-
2002
- 2002-06-05 NO NO20022645A patent/NO20022645L/no not_active Application Discontinuation
-
2003
- 2003-10-02 US US10/677,847 patent/US20050100600A1/en not_active Abandoned
-
2004
- 2004-06-10 AU AU2004202515A patent/AU2004202515A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US6660303B2 (en) | 2003-12-09 |
KR20020062323A (ko) | 2002-07-25 |
CA2393231A1 (en) | 2001-06-07 |
US20020068084A1 (en) | 2002-06-06 |
BR0016482A (pt) | 2002-12-24 |
AU2004202515A1 (en) | 2004-07-01 |
IL150053A0 (en) | 2002-12-01 |
AU771440B2 (en) | 2004-03-25 |
HUP0301333A2 (hu) | 2004-05-28 |
AU2061401A (en) | 2001-06-12 |
NO20022645L (no) | 2002-08-01 |
WO2001039746A1 (en) | 2001-06-07 |
NO20022645D0 (no) | 2002-06-05 |
HUP0301333A3 (en) | 2005-06-28 |
US20050100600A1 (en) | 2005-05-12 |
EP1244428A1 (en) | 2002-10-02 |
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