MXPA01013171A - Inhibidores triciclicos de sulfonamida de metaloproteinasa de matriz. - Google Patents
Inhibidores triciclicos de sulfonamida de metaloproteinasa de matriz.Info
- Publication number
- MXPA01013171A MXPA01013171A MXPA01013171A MXPA01013171A MXPA01013171A MX PA01013171 A MXPA01013171 A MX PA01013171A MX PA01013171 A MXPA01013171 A MX PA01013171A MX PA01013171 A MXPA01013171 A MX PA01013171A MX PA01013171 A MXPA01013171 A MX PA01013171A
- Authority
- MX
- Mexico
- Prior art keywords
- matrix metalloproteinase
- metalloproteinase inhibitors
- tricyclic
- biphenyl sulfonamide
- sulfonamide matrix
- Prior art date
Links
- 239000003771 matrix metalloproteinase inhibitor Substances 0.000 title abstract 2
- 229940121386 matrix metalloproteinase inhibitor Drugs 0.000 title abstract 2
- SBXDENYROQKXBE-UHFFFAOYSA-N 2-phenylbenzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1C1=CC=CC=C1 SBXDENYROQKXBE-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000005605 benzo group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 229940124530 sulfonamide Drugs 0.000 abstract 1
- 150000003456 sulfonamides Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
Inhibidores de metaloproteinasas de matriz son triciclicosulfonamidas de la Formula I (ver formula) o una sal farmaceuticamente aceptable de las mismas, en donde R1 y R2 incluyen hidrogeno, alquilo y alquilo substituido; R3 es OH o NHOH; X es O u S(O)n; n es 0, 1 o 2; p es 0, 1, 2, o 3; - - - esta ausente o es un enlace; y el atomo de azufre que lleva (O)q esta unido a la cadena benzo en la posicion a o en la posicion b.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26875401P | 2001-02-14 | 2001-02-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA01013171A true MXPA01013171A (es) | 2004-05-21 |
Family
ID=23024317
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA01013171A MXPA01013171A (es) | 2001-02-14 | 2001-12-18 | Inhibidores triciclicos de sulfonamida de metaloproteinasa de matriz. |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6555535B2 (es) |
| EP (1) | EP1233018A3 (es) |
| JP (1) | JP2002275181A (es) |
| BR (1) | BR0200476A (es) |
| CA (1) | CA2371487A1 (es) |
| MX (1) | MXPA01013171A (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006516548A (ja) | 2002-12-30 | 2006-07-06 | アンジオテック インターナショナル アクツィエン ゲゼルシャフト | 迅速ゲル化ポリマー組成物からの薬物送達法 |
| EP1613269B1 (en) | 2003-04-04 | 2015-02-25 | Incyte Corporation | Compositions, methods and kits relating to her-2 cleavage |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6008243A (en) | 1996-10-24 | 1999-12-28 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use |
| IL128545A0 (en) | 1996-12-09 | 2000-01-31 | Warner Lambert Co | Method for treating and preventing heart failure and ventricular dilatation |
| TR199901926T2 (xx) * | 1997-02-11 | 1999-12-21 | Pfizer Inc. | Arils�lfonil hidroksamik asit t�revleri |
| KR20010072089A (ko) * | 1998-07-30 | 2001-07-31 | 로즈 암스트롱, 크리스틴 에이. 트러트웨인 | 매트릭스 메탈로프로테이나제 억제제로서 트리시클릭술폰아미드 및 그의 유도체 |
| AUPP982399A0 (en) * | 1999-04-19 | 1999-05-13 | Fujisawa Pharmaceutical Co., Ltd. | Mmp inhibitor |
| US6934639B1 (en) | 2000-02-25 | 2005-08-23 | Wyeth | Methods for designing agents that interact with MMP-13 |
-
2001
- 2001-12-18 MX MXPA01013171A patent/MXPA01013171A/es not_active Application Discontinuation
-
2002
- 2002-02-08 BR BR0200476-3A patent/BR0200476A/pt not_active IP Right Cessation
- 2002-02-08 EP EP02002816A patent/EP1233018A3/en not_active Withdrawn
- 2002-02-12 CA CA002371487A patent/CA2371487A1/en not_active Abandoned
- 2002-02-13 JP JP2002035627A patent/JP2002275181A/ja not_active Ceased
- 2002-02-13 US US10/075,431 patent/US6555535B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| BR0200476A (pt) | 2003-04-29 |
| JP2002275181A (ja) | 2002-09-25 |
| CA2371487A1 (en) | 2002-08-14 |
| EP1233018A2 (en) | 2002-08-21 |
| US6555535B2 (en) | 2003-04-29 |
| US20020156071A1 (en) | 2002-10-24 |
| EP1233018A3 (en) | 2002-09-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |