MXPA01007352A - Metodo y aparato para la generacion automatizada de ligandos de acido nucleico. - Google Patents
Metodo y aparato para la generacion automatizada de ligandos de acido nucleico.Info
- Publication number
- MXPA01007352A MXPA01007352A MXPA01007352A MXPA01007352A MXPA01007352A MX PA01007352 A MXPA01007352 A MX PA01007352A MX PA01007352 A MXPA01007352 A MX PA01007352A MX PA01007352 A MXPA01007352 A MX PA01007352A MX PA01007352 A MXPA01007352 A MX PA01007352A
- Authority
- MX
- Mexico
- Prior art keywords
- nucleic acid
- acid ligands
- automated generation
- selex
- automated
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1048—SELEX
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
- B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
- B01J2219/00315—Microtiter plates
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00364—Pipettes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/005—Beads
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00585—Parallel processes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00596—Solid-phase processes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00659—Two-dimensional arrays
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00686—Automatic
- B01J2219/00689—Automatic using computers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00686—Automatic
- B01J2219/00691—Automatic using robots
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00702—Processes involving means for analysing and characterising the products
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00722—Nucleotides
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- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Abstract
El invento actual incluye un metodo y dispositivo para llevar a cabo el SELEX automatizado. Los pasos del proceso SELEX son llevados a cabo en un o mas estaciones de trabajo o en una superficie de trabajo por un manipulador robotico cartesiano controlado por una computadora.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/232,946 US6569620B1 (en) | 1990-06-11 | 1999-01-19 | Method for the automated generation of nucleic acid ligands |
US35623399A | 1999-07-16 | 1999-07-16 | |
PCT/US2000/001001 WO2000043534A1 (en) | 1999-01-19 | 2000-01-14 | Method and apparatus for the automated generation of nucleic acid ligands |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA01007352A true MXPA01007352A (es) | 2003-06-06 |
Family
ID=26926487
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA01007352A MXPA01007352A (es) | 1999-01-19 | 2000-01-14 | Metodo y aparato para la generacion automatizada de ligandos de acido nucleico. |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1144669A4 (es) |
JP (1) | JP2002534985A (es) |
KR (1) | KR20010101573A (es) |
AU (1) | AU777823B2 (es) |
CA (1) | CA2360748A1 (es) |
MX (1) | MXPA01007352A (es) |
WO (1) | WO2000043534A1 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001096559A2 (en) * | 2000-06-15 | 2001-12-20 | Board Of Regents The University Of Texas System | Regulatable, catalytically active nucleic acids |
JP2004507732A (ja) | 2000-08-23 | 2004-03-11 | イメゴ アーベー | 磁気粒子を井戸内へまた井戸から移送するためのミクロ流体デバイスおよび方法 |
US7998746B2 (en) | 2000-08-24 | 2011-08-16 | Robert Otillar | Systems and methods for localizing and analyzing samples on a bio-sensor chip |
US20020048821A1 (en) | 2000-08-24 | 2002-04-25 | David Storek | Sample preparing arrangement and a method relating to such an arrangement |
US20030003018A1 (en) * | 2001-04-02 | 2003-01-02 | Prolinx Incorporated | Systems and apparatus for the analysis of molecular interactions |
US7208322B2 (en) | 2001-04-02 | 2007-04-24 | Agilent Technologies, Inc. | Sensor surfaces for detecting analytes |
JP4532264B2 (ja) | 2002-05-17 | 2010-08-25 | ベクトン・ディキンソン・アンド・カンパニー | 自動システム及び自動処理方法並びに核酸自動抽出方法 |
US20040110235A1 (en) | 2002-07-25 | 2004-06-10 | David Epstein | Regulated aptamer therapeutics |
DE10241938A1 (de) * | 2002-09-10 | 2004-03-25 | Noxxon Pharma Ag | Verfahren zur Selektion von Nukleinsäureliganden |
JP5156905B2 (ja) * | 2007-04-20 | 2013-03-06 | 独立行政法人科学技術振興機構 | アプタマー生成装置、アプタマー生成方法 |
WO2009053691A1 (en) * | 2007-10-22 | 2009-04-30 | Pronota Nv | Method of selecting aptamers |
JP5393610B2 (ja) * | 2010-07-28 | 2014-01-22 | 株式会社日立ハイテクノロジーズ | 核酸分析装置 |
US9175332B2 (en) | 2010-07-29 | 2015-11-03 | Roche Molecular Systems, Inc. | Generic PCR |
CN103270171B (zh) * | 2010-07-29 | 2014-09-17 | 霍夫曼-拉罗奇有限公司 | 通用pcr |
EP2426222A1 (en) * | 2010-09-07 | 2012-03-07 | F. Hoffmann-La Roche AG | Generic buffer for amplification |
DE102013200193A1 (de) | 2013-01-09 | 2014-07-10 | Hamilton Bonaduz Ag | Probenverarbeitungssystem mit Dosiervorrichtung und Thermocycler |
CN103614291A (zh) * | 2013-11-13 | 2014-03-05 | 戴小波 | 全自动荧光定量基因扩增仪 |
CN114276896B (zh) * | 2021-12-22 | 2023-12-29 | 成都瀚辰光翼科技有限责任公司 | 一种自动化核酸提取方法及存储介质 |
CN114923839B (zh) * | 2022-07-18 | 2022-10-28 | 高分(北京)生物科技有限公司 | 全自动超高通量细胞成像计数仪及样品检测方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1339653C (en) * | 1986-02-25 | 1998-02-03 | Larry J. Johnson | Appartus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps |
ATE154981T1 (de) * | 1990-04-06 | 1997-07-15 | Perkin Elmer Corp | Automatisiertes labor für molekularbiologie |
WO1995008003A1 (en) * | 1993-09-17 | 1995-03-23 | University Research Corporation | Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex |
US5475096A (en) * | 1990-06-11 | 1995-12-12 | University Research Corporation | Nucleic acid ligands |
US5861254A (en) * | 1997-01-31 | 1999-01-19 | Nexstar Pharmaceuticals, Inc. | Flow cell SELEX |
US5985548A (en) * | 1993-02-04 | 1999-11-16 | E. I. Du Pont De Nemours And Company | Amplification of assay reporters by nucleic acid replication |
AU727460B2 (en) * | 1995-05-03 | 2000-12-14 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligands of tissue target |
US5737498A (en) * | 1995-07-11 | 1998-04-07 | Beckman Instruments, Inc. | Process automation method and apparatus |
US5866336A (en) * | 1996-07-16 | 1999-02-02 | Oncor, Inc. | Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon |
-
2000
- 2000-01-14 EP EP00909909A patent/EP1144669A4/en not_active Withdrawn
- 2000-01-14 CA CA002360748A patent/CA2360748A1/en not_active Abandoned
- 2000-01-14 MX MXPA01007352A patent/MXPA01007352A/es not_active Application Discontinuation
- 2000-01-14 JP JP2000594942A patent/JP2002534985A/ja active Pending
- 2000-01-14 KR KR1020017009027A patent/KR20010101573A/ko not_active Application Discontinuation
- 2000-01-14 WO PCT/US2000/001001 patent/WO2000043534A1/en not_active Application Discontinuation
- 2000-01-14 AU AU32092/00A patent/AU777823B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
JP2002534985A (ja) | 2002-10-22 |
WO2000043534A1 (en) | 2000-07-27 |
EP1144669A4 (en) | 2005-01-05 |
KR20010101573A (ko) | 2001-11-14 |
EP1144669A1 (en) | 2001-10-17 |
CA2360748A1 (en) | 2000-07-27 |
AU777823B2 (en) | 2004-11-04 |
AU3209200A (en) | 2000-08-07 |
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Legal Events
Date | Code | Title | Description |
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FA | Abandonment or withdrawal |