MXPA00012586A - Glicosulfopeptidos y metodos de sintesis y uso de los mismos. - Google Patents
Glicosulfopeptidos y metodos de sintesis y uso de los mismos.Info
- Publication number
- MXPA00012586A MXPA00012586A MXPA00012586A MXPA00012586A MXPA00012586A MX PA00012586 A MXPA00012586 A MX PA00012586A MX PA00012586 A MXPA00012586 A MX PA00012586A MX PA00012586 A MXPA00012586 A MX PA00012586A MX PA00012586 A MXPA00012586 A MX PA00012586A
- Authority
- MX
- Mexico
- Prior art keywords
- glycan
- gsps
- methods
- synthesis
- group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La presente invencion se refiere a una nueva clase de glicosulfopeptidos sinteticos (GSPs) los cuales tiene uno o mas residuos de tirosina sulfatados y un glicano ligado al peptido, el glicano preferiblemente incluye un grupo Lewis* de sialilo o un grupo Lewis* de sialilo. En una version preferida del GSPs tiene un O-glicano que comprende un enlace (1,6 a un GalNAc. La presente invencion ademas contempla metodos in vitro de la sintesis de estos GSPs sin el uso de las celulas y metodos de su uso in vivo como compuestos antimetastasicos o antitromboticos anti-inflamatorios poderosos. La invencion tambien contempla un metodo de sintetizar los oligosacaridos por el desdoblamiento del glicano a partir de GSP.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8947298P | 1998-06-16 | 1998-06-16 | |
PCT/US1999/013455 WO1999065712A2 (en) | 1998-06-16 | 1999-06-15 | Glycosulfopeptides and methods of synthesis and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA00012586A true MXPA00012586A (es) | 2004-05-21 |
Family
ID=22217840
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA00012586A MXPA00012586A (es) | 1998-06-16 | 1999-06-15 | Glicosulfopeptidos y metodos de sintesis y uso de los mismos. |
Country Status (8)
Country | Link |
---|---|
US (4) | US6593459B1 (es) |
EP (1) | EP1087996B1 (es) |
JP (1) | JP2002518354A (es) |
AU (1) | AU773542B2 (es) |
CA (1) | CA2332563A1 (es) |
DE (1) | DE69934890D1 (es) |
MX (1) | MXPA00012586A (es) |
WO (1) | WO1999065712A2 (es) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7223845B2 (en) | 1998-06-16 | 2007-05-29 | The Board Of Regents Of The University Of Oklahoma | Synthetic glycosulfopeptides and methods of synthesis thereof |
US20030143662A1 (en) * | 1998-06-16 | 2003-07-31 | Cummings Richard D. | Glycosulfopeptide inhibitors of leukocyte rolling and methods of use thereof |
WO1999065712A2 (en) * | 1998-06-16 | 1999-12-23 | The Board Of Regents Of The University Of Oklahoma | Glycosulfopeptides and methods of synthesis and use thereof |
US6492152B1 (en) | 1999-06-15 | 2002-12-10 | The Board Of Regents Of The University Of Oklahoma | Core 1 β3-galactosyl transferases and methods of use thereof |
WO2001044478A2 (en) * | 1999-12-15 | 2001-06-21 | The Board Of Regents Of The University Of Oklahoma | CORE 1 β3-GALACTOSYL TRANSFERASES AND METHODS OF USE THEREOF |
EP1325123A4 (en) * | 2000-09-12 | 2004-07-21 | Inst Genetics Llc | STENOSE- OR RESEARCH INHIBITION BY P-SELECTIN ANTAGONISTS |
SE0004828D0 (sv) * | 2000-12-22 | 2000-12-22 | Pharmacia Ab | Protein cluster II |
CZ20031982A3 (cs) * | 2000-12-29 | 2004-09-15 | Bio-Technology General Corp. | Izolované molekuly zahrnující epitopy obsahující sulfatované sloučeniny, protilátky proti takovým epitopům a jejich použití |
US20040001822A1 (en) * | 2000-12-29 | 2004-01-01 | Avigdor Levanon | Y1-isolated molecules comprising epitopes containing sulfated moieties, antibodies to such epitopes, and uses thereof |
US7132510B2 (en) * | 2000-12-29 | 2006-11-07 | Bio-Technology General (Israel) Ltd. | Specific human antibodies for selective cancer therapy |
US20040002450A1 (en) * | 2000-12-29 | 2004-01-01 | Janette Lazarovits | Y17 - isolated molecules comprising epitopes containing sulfated moieties, antibodies to such epitopes, and uses thereof |
US20040001839A1 (en) * | 2000-12-29 | 2004-01-01 | Avigdor Levanon | Multimers - isolated molecules comprising epitopes containing sulfated moieties, antibodies to such epitopes, and uses thereof |
US6537780B2 (en) * | 2001-03-28 | 2003-03-25 | Applera Corporation | Isolated nucleic acid molecules encoding transferase enzymes |
AU2002337913A1 (en) * | 2001-10-19 | 2003-04-28 | Richard D. Cummings | Glycosulfopeptide inhibitors and methods of use thereof |
EP1534725A2 (en) | 2002-05-16 | 2005-06-01 | Glycomimetics, Inc. | Compounds and methods for inhibiting selectin-mediated function |
US20040202665A1 (en) * | 2002-07-01 | 2004-10-14 | Janette Lazarovits | Compositions and methods for therapeutic treatment |
WO2004004636A2 (en) * | 2002-07-03 | 2004-01-15 | Glycomimetics, Inc. | Compositions and methods for diagnosis and therapy of medical conditions involving angiogenesis |
US20040219158A1 (en) * | 2003-05-02 | 2004-11-04 | Glycomimetics, Inc. | Compositions and methods for diagnosis and therapy of medical conditions involving infection with pseudomonas bacteria |
US20050152906A1 (en) * | 2003-06-30 | 2005-07-14 | Avigdor Levanon | Specific human antibodies |
US20050069955A1 (en) * | 2003-06-30 | 2005-03-31 | Daniel Plaksin | Antibodies and uses thereof |
US20050266009A1 (en) * | 2003-06-30 | 2005-12-01 | Savient Pharmaceuticals, Inc. | Antibodies and uses thereof |
WO2005054264A2 (en) * | 2003-11-19 | 2005-06-16 | Glycomimetics, Inc. | Glycomimetic antagonists for both e- and p-selectins |
EP1763533B1 (en) * | 2003-11-19 | 2008-01-09 | GlycoMimetics, Inc. | Specific antagonist for both e- and p-selectins |
EP1720888A4 (en) * | 2004-02-20 | 2009-09-16 | Burnham Inst | ANTIMICROBIAL GLUCOSE AND METHODS OF MAKING |
US8201377B2 (en) * | 2004-11-05 | 2012-06-19 | Faus Group, Inc. | Flooring system having multiple alignment points |
TWI264608B (en) * | 2005-04-08 | 2006-10-21 | Delta Electronics Inc | Light tunnel module |
WO2006127906A1 (en) * | 2005-05-25 | 2006-11-30 | Glycomimetics, Inc. | Heterobifunctional compounds for selectin inhibition |
CA2618638C (en) * | 2005-08-09 | 2014-03-11 | Glycomimetics, Inc. | Glycomimetic inhibitors of the pa-il lectin, pa-iil lectin or both the lectins from pseudomonas |
PT1934236E (pt) | 2005-09-02 | 2012-12-26 | Glycomimetics Inc | Inibidores de pan-selectina heterobifuncionais |
WO2007143052A1 (en) * | 2006-06-01 | 2007-12-13 | Glycomimetics, Inc. | Galactosides and thiodigalactosides as inhibitors of pa-il lectin from pseudomonas |
WO2008060378A2 (en) | 2006-10-12 | 2008-05-22 | Glycomimetics, Inc. | Glycomimetic replacements for hexoses and n-acetyl hexosamines |
WO2008100453A1 (en) * | 2007-02-09 | 2008-08-21 | Glycomimetics, Inc. | Methods of use of glycomimetics with replacements for hexoses and n-acetyl hexosamines |
US8039442B2 (en) | 2007-07-18 | 2011-10-18 | Glycomimetics, Inc. | Compounds and methods for treatment of sickle cell disease or complications associated therewith |
AU2008336249B2 (en) | 2007-12-10 | 2015-01-29 | The University Of Queensland | Treatment and prophylaxis |
US8895510B2 (en) | 2008-04-08 | 2014-11-25 | Glycomimetics, Inc. | Pan-selectin inhibitor with enhanced pharmacokinetic activity |
AU2009257536B2 (en) * | 2008-06-13 | 2015-07-02 | Glycomimetics, Inc. | Treatment of cancers of the blood using selected glycomimetic compounds |
AU2010241807B2 (en) | 2009-05-01 | 2014-08-14 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectins and CXCR4 chemokine receptors |
US8921328B2 (en) | 2010-09-14 | 2014-12-30 | Glycomimetics, Inc. | E-selectin antagonists |
JP6054879B2 (ja) | 2010-12-21 | 2016-12-27 | セレクシス ファーマシューティカルズ コーポレイション | 抗p−セレクチン抗体ならびにそれらの使用および同定方法 |
EP3296310A1 (en) | 2011-12-22 | 2018-03-21 | GlycoMimetics, Inc. | E-selectin antagonist compounds, compositions, and methods of use |
HUE038423T2 (hu) | 2012-12-07 | 2018-10-29 | Glycomimetics Inc | E-szelektin antagonistákat felhasználó vegyületek, készítmények és eljárások vérképzõ sejtek mobilizációjára |
CA2914470C (en) | 2013-06-03 | 2022-09-27 | Emory University | Selectin inhibitors, composition, and uses related thereto |
WO2016089872A1 (en) | 2014-12-03 | 2016-06-09 | Glycomimetics, Inc. | Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors |
US11045485B2 (en) | 2016-01-22 | 2021-06-29 | Glycomimetics, Inc. | Glycomimetic inhibitors of PA-IL and PA-IIL lectins |
WO2017151708A1 (en) | 2016-03-02 | 2017-09-08 | Glycomimetics, Inc. | Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin |
WO2018031445A1 (en) | 2016-08-08 | 2018-02-15 | Glycomimetics, Inc. | Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4 |
WO2018068010A1 (en) | 2016-10-07 | 2018-04-12 | Glycomimetics, Inc. | Highly potent multimeric e-selectin antagonists |
EP3596096A1 (en) | 2017-03-15 | 2020-01-22 | GlycoMimetics, Inc. | Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists |
WO2019108750A1 (en) | 2017-11-30 | 2019-06-06 | Glycomimetics, Inc. | Methods of mobilizing marrow infiltrating lymphocytes and uses thereof |
JP7304863B2 (ja) | 2017-12-29 | 2023-07-07 | グリコミメティクス, インコーポレイテッド | E-セレクチンおよびガレクチン-3のヘテロ二機能性阻害剤 |
CA3091454A1 (en) | 2018-03-05 | 2019-09-12 | Glycomimetics, Inc. | Methods for treating acute myeloid leukemia and related conditions |
EA202092934A1 (ru) * | 2018-06-11 | 2021-04-05 | Дзе Уистар Инститьют Оф Энэтоми Энд Байолоджи | Композиции и способы для посттрансляционной модификации in vivo |
US11845771B2 (en) | 2018-12-27 | 2023-12-19 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
MX2021008479A (es) | 2019-01-15 | 2021-10-13 | Optimvia Llc | Enzimas dependientes de aril sulfato modificadas por ingenieria genetica. |
CA3144968A1 (en) | 2019-07-09 | 2021-01-14 | Optimvia Llc | Methods for synthesizing anticoagulant polysaccharides |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
JPS60197699A (ja) * | 1984-03-19 | 1985-10-07 | Fuji Yakuhin Kogyo Kk | コレシストキニンパンクレオザイミンc端ペプチドおよびその類縁体の製造方法 |
US5874261A (en) | 1988-09-02 | 1999-02-23 | The Trustees Of The University Of Pennsylvania | Method for the purification of glycosyltransferases |
US5047335A (en) | 1988-12-21 | 1991-09-10 | The Regents Of The University Of Calif. | Process for controlling intracellular glycosylation of proteins |
US5929036A (en) | 1989-03-08 | 1999-07-27 | The Board Of Regents Of The University Of Oklahoma | Ligand or GMP-140 selectin and methods of use thereof |
EP0481038B1 (en) | 1990-04-16 | 2002-10-02 | The Trustees Of The University Of Pennsylvania | Saccharide compositions, methods and apparatus for their synthesis |
US5766897A (en) * | 1990-06-21 | 1998-06-16 | Incyte Pharmaceuticals, Inc. | Cysteine-pegylated proteins |
EP0602194A1 (en) * | 1991-12-18 | 1994-06-22 | Centocor, Inc. | Peptide inhibitors of inflammation mediated by selectins |
JPH0686684A (ja) | 1992-05-26 | 1994-03-29 | Monsanto Co | シアロ抱合体の合成 |
US5382657A (en) * | 1992-08-26 | 1995-01-17 | Hoffmann-La Roche Inc. | Peg-interferon conjugates |
WO1994005314A1 (en) * | 1992-09-08 | 1994-03-17 | Centocor, Inc. | Peptide inhibitors of leukocyte adhesion |
US5843707A (en) | 1992-10-23 | 1998-12-01 | Genetics Institute, Inc. | Nucleic acid encoding a novel P-selectin ligand protein |
AU681369B2 (en) | 1992-11-16 | 1997-08-28 | Board Of Regents Of The University Of Oklahoma, The | Glycoprotein ligand for P-selectin and methods of use thereof |
SE504074C2 (sv) * | 1993-07-05 | 1996-11-04 | Pharmacia Ab | Proteinberedning för subkutan, intramuskulär eller intradermal administrering |
US5730990A (en) * | 1994-06-24 | 1998-03-24 | Enzon, Inc. | Non-antigenic amine derived polymers and polymer conjugates |
FR2723962B1 (fr) * | 1994-08-25 | 1996-10-31 | Univ Paris Curie | Hsv1-tk modifiee fonctionnelle |
US5821329A (en) | 1996-06-06 | 1998-10-13 | Tanabe Seiyaku Co., Ltd. | Cyclic peptide inhibitors of β1 and β2 integrin-mediated adhesion |
JPH11510543A (ja) * | 1995-08-03 | 1999-09-14 | ボード オブ リージェンツ オブ ザ ユニヴァーシティー オブ オクラホマ | ペプチド及びセレクチン介在炎症のo−グリカン阻害剤 |
ES2335557T3 (es) * | 1997-01-21 | 2010-03-29 | Sanofi Pasteur | Conjugados de peptido-polisacarido. |
US6180096B1 (en) * | 1998-03-26 | 2001-01-30 | Schering Corporation | Formulations for protection of peg-interferon alpha conjugates |
WO1999065712A2 (en) * | 1998-06-16 | 1999-12-23 | The Board Of Regents Of The University Of Oklahoma | Glycosulfopeptides and methods of synthesis and use thereof |
US6165509A (en) * | 1998-09-01 | 2000-12-26 | University Of Washington | Pegylated drug complexed with bioadhesive polymer suitable for drug delivery and methods relating thereto |
US6432409B1 (en) * | 1999-09-14 | 2002-08-13 | Antigen Express, Inc. | Hybrid peptides modulate the immune response |
-
1999
- 1999-06-15 WO PCT/US1999/013455 patent/WO1999065712A2/en active IP Right Grant
- 1999-06-15 JP JP2000554568A patent/JP2002518354A/ja not_active Withdrawn
- 1999-06-15 US US09/334,013 patent/US6593459B1/en not_active Expired - Fee Related
- 1999-06-15 MX MXPA00012586A patent/MXPA00012586A/es not_active IP Right Cessation
- 1999-06-15 DE DE69934890T patent/DE69934890D1/de not_active Expired - Lifetime
- 1999-06-15 AU AU45673/99A patent/AU773542B2/en not_active Ceased
- 1999-06-15 CA CA002332563A patent/CA2332563A1/en not_active Abandoned
- 1999-06-15 EP EP99928662A patent/EP1087996B1/en not_active Expired - Lifetime
-
2001
- 2001-05-04 US US09/849,562 patent/US6545123B2/en not_active Expired - Fee Related
- 2001-05-04 US US09/849,031 patent/US6569998B2/en not_active Expired - Fee Related
-
2002
- 2002-12-20 US US10/329,068 patent/US20030144183A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DE69934890D1 (de) | 2007-03-08 |
US20020042102A1 (en) | 2002-04-11 |
EP1087996A2 (en) | 2001-04-04 |
WO1999065712A2 (en) | 1999-12-23 |
AU773542B2 (en) | 2004-05-27 |
CA2332563A1 (en) | 1999-12-23 |
US6569998B2 (en) | 2003-05-27 |
US20030144183A1 (en) | 2003-07-31 |
US20020026033A1 (en) | 2002-02-28 |
US6593459B1 (en) | 2003-07-15 |
AU4567399A (en) | 2000-01-05 |
WO1999065712A3 (en) | 2000-04-20 |
EP1087996B1 (en) | 2007-01-17 |
JP2002518354A (ja) | 2002-06-25 |
US6545123B2 (en) | 2003-04-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration | ||
MM | Annulment or lapse due to non-payment of fees |