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Application filed by Connaught LabfiledCriticalConnaught Lab
Priority claimed from PCT/CA1996/000279external-prioritypatent/WO1996034883A1/en
Publication of MX9708480ApublicationCriticalpatent/MX9708480A/en
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents
(AREA)
Abstract
A fimbrial agglutinogen preparation is prepared from a <u>Bordetella</u> strain, particularly a <u>B. pertussis</u> strain, by a multiple step procedure involving extraction of the fimbrial agglutinogens from cell paste and concentrating and purifying the extracted material. The fimbrial agglutinogen preparation may be used to prepare acellular pertussis vaccines with other pertussis antigens, including pertussis toxin or toxoid thereof, the 69 kDa protein and filamentous haemagglutonin and other <u>Bordetella</u> antigens. Such vaccines confer protection to at least 70 percent of an at-risk human population.
MX9708480A1995-07-121996-05-02Acellular pertussis vaccines and methods of preparation thereof.
MX9708480A
(en)
A process for the purification, solubilization and/or detoxification of protein antigens of bacteria of the bordetella genus using a carbonate buffer and an acellular anti-whooping cough vaccine
A method for modifying a wild strain of a "shigella", in order to produce a modified strain suitable for preparing a vaccine against the wild strain, and a "shigella" strain thus modified.