MX9708077A - Cyclobutane derivatives as inhibitors of squalene synthase and protein farnesyltransferase. - Google Patents

Cyclobutane derivatives as inhibitors of squalene synthase and protein farnesyltransferase.

Info

Publication number
MX9708077A
MX9708077A MX9708077A MX9708077A MX9708077A MX 9708077 A MX9708077 A MX 9708077A MX 9708077 A MX9708077 A MX 9708077A MX 9708077 A MX9708077 A MX 9708077A MX 9708077 A MX9708077 A MX 9708077A
Authority
MX
Mexico
Prior art keywords
inhibitors
squalene synthase
protein farnesyltransferase
cyclobutane derivatives
compounds
Prior art date
Application number
MX9708077A
Other languages
Spanish (es)
Inventor
David L Arendesen
William R Baker
Stephen A Fakhoury
K L Anthony Fung
David S Garvey
William J Mcclellan
Stephen J O'connor
Rajnandan N Prasad
Todd W Rockway
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/626,859 external-priority patent/US5831115A/en
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of MX9708077A publication Critical patent/MX9708077A/en

Links

Abstract

The present invention provides a compound of formula (I) or (II) or a pharmaceutically acceptable salt thereof, which is useful for inhibiting protein farnesyltransferase and the farnesylation of the oncogene protein Ras or inhibiting de novo squalene production resulting in the inhibition of cholesterol biosynthesis, processes for the preparation of the compounds of the invention in addition to intermediates useful in these processes, a pharmaceutical composition, and to methods of using such compounds.
MX9708077A 1995-04-21 1996-04-18 Cyclobutane derivatives as inhibitors of squalene synthase and protein farnesyltransferase. MX9708077A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US42835795A 1995-04-21 1995-04-21
US56452495A 1995-11-29 1995-11-29
US08/626,859 US5831115A (en) 1995-04-21 1996-04-12 Inhibitors of squalene synthase and protein farnesyltransferase
PCT/US1996/005529 WO1996033159A1 (en) 1995-04-21 1996-04-18 Cyclobutane derivatives as inhibitors of squalene synthase and protein farnesyltransferase

Publications (1)

Publication Number Publication Date
MX9708077A true MX9708077A (en) 1998-01-31

Family

ID=39165688

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9708077A MX9708077A (en) 1995-04-21 1996-04-18 Cyclobutane derivatives as inhibitors of squalene synthase and protein farnesyltransferase.

Country Status (1)

Country Link
MX (1) MX9708077A (en)

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